{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:38:47Z","timestamp":1789958327439,"version":"4.0.1"},"reference-count":83,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Diagnostic Pathology"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1053\/j.semdp.2023.11.001","type":"journal-article","created":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T04:35:32Z","timestamp":1699418132000},"page":"32-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Hereditary succinate dehydrogenase-deficient renal cell carcinoma"],"prefix":"10.1053","volume":"41","author":[{"given":"Joanna","family":"Rogala","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0324-7178","authenticated-orcid":false,"given":"Ming","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1053\/j.semdp.2023.11.001_bib0001","first-page":"285","article-title":"Succinate dehydrogenase (SDH) and mitochondrial driven neoplasia","volume":"44","author":"Gill","year":"2012","journal-title":"Pathology (Phila)"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0002","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/his.13277","article-title":"Succinate dehydrogenase (SDH)-deficient neoplasia","volume":"72","author":"Gill","year":"2018","journal-title":"Histopathology"},{"issue":"4","key":"10.1053\/j.semdp.2023.11.001_bib0003","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1097\/PAS.0000000000000149","article-title":"Succinate dehydrogenase deficiency is rare in pituitary adenomas","volume":"38","author":"Gill","year":"2014","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"10.1053\/j.semdp.2023.11.001_bib0004","doi-asserted-by":"crossref","DOI":"10.1097\/PAS.0000000000000292","article-title":"Succinate Dehydrogenase (SDH)-deficient Renal Carcinoma: A Morphologically Distinct Entity: A Clinicopathologic Series of 36 Tumors From 27 Patients","volume":"38","author":"Gill","year":"2014","journal-title":"Am J Surg Pathol"},{"issue":"10","key":"10.1053\/j.semdp.2023.11.001_bib0005","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1097\/PAS.0b013e318227e7f4","article-title":"Renal tumors associated with germline SDHB mutation show distinctive morphology","volume":"35","author":"Gill","year":"2011","journal-title":"Am J Surg Pathol"},{"issue":"9","key":"10.1053\/j.semdp.2023.11.001_bib0006","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1056\/NEJMc1012357","article-title":"Renal Tumors and Hereditary Pheochromocytoma-Paraganglioma Syndrome Type 4","volume":"364","author":"Gill","year":"2011","journal-title":"N Engl J Med"},{"issue":"5","key":"10.1053\/j.semdp.2023.11.001_bib0007","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/PAS.0b013e3181d6150d","article-title":"Immunohistochemistry for SDHB Divides Gastrointestinal Stromal Tumors (GISTs) into 2 Distinct Types","volume":"34","author":"Gill","year":"2010","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"10.1053\/j.semdp.2023.11.001_bib0008","doi-asserted-by":"crossref","first-page":"E1103","DOI":"10.1210\/jc.2013-1400","article-title":"Familial SDHA Mutation Associated With Pituitary Adenoma and Pheochromocytoma\/Paraganglioma","volume":"98","author":"Dwight","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.semdp.2023.11.001_bib0009","series-title":"Endocrine and Neuroendocrine Tumours (WHO Classification of Tumours Series","author":"WCoTE","year":"2022"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0010","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/s12022-022-09705-5","article-title":"Overview of the 2022 WHO Classification of Familial Endocrine Tumor Syndromes","volume":"33","author":"Nos\u00e9","year":"2022","journal-title":"Endocr Pathol"},{"issue":"16","key":"10.1053\/j.semdp.2023.11.001_bib0011","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/jnci\/djg024","article-title":"Pheochromocytoma: The Expanding Genetic Differential Diagnosis","volume":"95","author":"Bryant","year":"2003","journal-title":"J Natl Cancer Inst"},{"issue":"2","key":"10.1053\/j.semdp.2023.11.001_bib0012","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/ajmg.10235","article-title":"Familial paraganglioma and gastric stromal sarcoma: a new syndrome distinct from the Carney triad","volume":"108","author":"Carney","year":"2002","journal-title":"Am J Med Genet"},{"key":"10.1053\/j.semdp.2023.11.001_bib0013","series-title":"Endocrine and Neuroendocrine Tumours","article-title":"WHO Classification of Tumours Editorial Board","author":"Gill","year":"2022"},{"issue":"11","key":"10.1053\/j.semdp.2023.11.001_bib0014","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/jmedgenet-2018-105427","article-title":"Bayesian approach to determining penetrance of pathogenic SDH variants","volume":"55","author":"Benn","year":"2018","journal-title":"J Med Genet"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0015","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s12022-018-9555-2","article-title":"The Role of Immunohistochemistry and Molecular Analysis of Succinate Dehydrogenase in the Diagnosis of Endocrine and Non-Endocrine Tumors and Related Syndromes","volume":"30","author":"Oudijk","year":"2019","journal-title":"Endocr Pathol"},{"key":"10.1053\/j.semdp.2023.11.001_bib0016","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.biocel.2014.05.033","article-title":"Succinate dehydrogenase deficient gastrointestinal stromal tumors (GISTs) \u2013 A review","volume":"53","author":"Miettinen","year":"2014","journal-title":"Int J Biochem Cell Biol"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0017","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2796.2009.02111.x","article-title":"SDH mutations in tumorigenesis and inherited endocrine tumours: lesson from the phaeochromocytoma-paraganglioma syndromes","volume":"266","author":"Pasini","year":"2009","journal-title":"J Intern Med"},{"issue":"3","key":"10.1053\/j.semdp.2023.11.001_bib0018","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1097\/PAS.0000000000001415","article-title":"Morphologic Clues to Succinate Dehydrogenase (SDH) Deficiency in Pheochromocytomas and Paragangliomas","volume":"44","author":"Turchini","year":"2020","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.semdp.2023.11.001_bib0019","series-title":"Digestive System tumoursWHO Classification of Tumours Series","article-title":"Markku Miettinen WHO Classification of Tumours Editorial Board","author":"Angelo Paolo Dei Tos","year":"2019"},{"issue":"7","key":"10.1053\/j.semdp.2023.11.001_bib0020","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1001\/jamaoncol.2016.0256","article-title":"Molecular Subtypes of KIT\/PDGFRA Wild-Type Gastrointestinal Stromal Tumors: A Report From the National Institutes of Health Gastrointestinal Stromal Tumor Clinic","volume":"2","author":"Boikos","year":"2016","journal-title":"JAMA Oncol"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0021","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1073\/pnas.1009199108","article-title":"Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations","volume":"108","author":"Janeway","year":"2011","journal-title":"Proc Nat Acad Sci USA"},{"issue":"5","key":"10.1053\/j.semdp.2023.11.001_bib0022","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/PAS.0b013e3181d6150d","article-title":"Immunohistochemistry for SDHB divides gastrointestinal stromal tumors (GISTs) into 2 distinct types","volume":"34","author":"Gill","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.semdp.2023.11.001_bib0023","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1746-1596-6-52","article-title":"Multifocal gastric gastrointestinal stromal tumors (GISTs) with lymph node metastases in children and young adults: a comparative clinical and histomorphological study of three cases including a new case of Carney triad","volume":"6","author":"Otto","year":"2011","journal-title":"Diagn Pathol"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0024","first-page":"9","article-title":"Epithelioid gastric stromal tumours of the antrum in young females with the Carney triad: a report of three new cases with mutational analysis and comparative genomic hybridization","volume":"18","author":"Agaimy","year":"2007","journal-title":"Oncol Rep"},{"issue":"3","key":"10.1053\/j.semdp.2023.11.001_bib0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/j.1365-2559.2008.02977.x","article-title":"Clinical significance of oncogenic KIT and PDGFRA mutations in gastrointestinal stromal tumours","volume":"53","author":"Lasota","year":"2008","journal-title":"Histopathology"},{"issue":"10","key":"10.1053\/j.semdp.2023.11.001_bib0026","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/01.pas.0000172190.79552.8b","article-title":"Gastrointestinal stromal tumors of the stomach in children and young adults: a clinicopathologic, immunohistochemical, and molecular genetic study of 44 cases with long-term follow-up and review of the literature","volume":"29","author":"Miettinen","year":"2005","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"10.1053\/j.semdp.2023.11.001_bib0027","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1097\/PAS.0b013e3182260752","article-title":"Succinate dehydrogenase-deficient GISTs: a clinicopathologic, immunohistochemical, and molecular genetic study of 66 gastric GISTs with predilection to young age","volume":"35","author":"Miettinen","year":"2011","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.semdp.2023.11.001_bib0028","doi-asserted-by":"crossref","DOI":"10.1210\/jc.2017-00165","article-title":"A Duodenal SDH-Deficient Gastrointestinal Stromal Tumor in a Patient With a Germline SDHB Mutation","volume":"102","author":"Elston","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1053\/j.semdp.2023.11.001_bib0029","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/PAS.0b013e3182671178","article-title":"Immunohistochemical loss of succinate dehydrogenase subunit A (SDHA) in gastrointestinal stromal tumors (GISTs) signals SDHA germline mutation","volume":"37","author":"Miettinen","year":"2013","journal-title":"Am J Surg Pathol"},{"issue":"5","key":"10.1053\/j.semdp.2023.11.001_bib0030","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1111\/j.1365-2559.2012.04300.x","article-title":"Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study","volume":"61","author":"Doyle","year":"2012","journal-title":"Histopathology"},{"issue":"7","key":"10.1053\/j.semdp.2023.11.001_bib0031","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1002\/pbc.21909","article-title":"Sunitinib treatment in pediatric patients with advanced GIST following failure of imatinib","volume":"52","author":"Janeway","year":"2009","journal-title":"Pediatr Blood Cancer"},{"issue":"7","key":"10.1053\/j.semdp.2023.11.001_bib0032","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15072074","article-title":"Molecular Tailored Therapeutic Options for Advanced Gastrointestinal Stromal Tumors (GISTs): Current Practice and Future Perspectives","volume":"15","author":"Catalano","year":"2023","journal-title":"Cancers"},{"issue":"268","key":"10.1053\/j.semdp.2023.11.001_bib0033","doi-asserted-by":"crossref","first-page":"268ra177","DOI":"10.1126\/scitranslmed.3009961","article-title":"Recurrent epimutation of SDHC in gastrointestinal stromal tumors","volume":"6","author":"Killian","year":"2014","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0034","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/PAS.0b013e3181c20f4f","article-title":"Gastric stromal tumors in Carney triad are different clinically, pathologically, and behaviorally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases","volume":"34","author":"Zhang","year":"2010","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.semdp.2023.11.001_bib0035","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1159\/000345672","article-title":"Carney triad","volume":"41","author":"Carney","year":"2013","journal-title":"Front Horm Res"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0036","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.ejhg.5201904","article-title":"Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD","volume":"16","author":"Pasini","year":"2008","journal-title":"Eur J Hum Genet EJHG"},{"issue":"4","key":"10.1053\/j.semdp.2023.11.001_bib0037","doi-asserted-by":"crossref","DOI":"10.1097\/MOU.0000000000000646","article-title":"Inherited kidney cancer syndromes","volume":"29","author":"Ball","year":"2019","journal-title":"Curr Opin Urol"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0038","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1086\/381054","article-title":"Early-Onset Renal Cell Carcinoma as a Novel Extraparaganglial Component of <em>SDHB-<\/em>Associated Heritable Paraganglioma","volume":"74","author":"Vanharanta","year":"2004","journal-title":"Am Hum Genet"},{"key":"10.1053\/j.semdp.2023.11.001_bib0039","article-title":"WHO classification of tumors of the urinary system and male genital organs","author":"Moch","year":"2016","journal-title":"Lyon France Int Agen Res Cancer;"},{"key":"10.1053\/j.semdp.2023.11.001_bib0040","series-title":"(WHO Classification of Tumours Series","article-title":"WCoTE. Urinary and male genital tumours","year":"2022"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0041","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/modpathol.2014.86","article-title":"Succinate dehydrogenase-deficient renal cell carcinoma: detailed characterization of 11 tumors defining a unique subtype of renal cell carcinoma","volume":"28","author":"Williamson","year":"2015","journal-title":"Mod Pathol"},{"issue":"6","key":"10.1053\/j.semdp.2023.11.001_bib0042","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/s41379-021-00998-1","article-title":"Expanding the clinicopathological spectrum of succinate dehydrogenase-deficient renal cell carcinoma with a focus on variant morphologies: a study of 62 new tumors in 59 patients","volume":"35","author":"Fuchs","year":"2022","journal-title":"Mod Pathol"},{"issue":"7","key":"10.1053\/j.semdp.2023.11.001_bib0043","first-page":"689","article-title":"Germline SDHC mutation presenting as recurrent SDH deficient GIST and renal carcinoma","volume":"45","author":"Gill","year":"2013","journal-title":"Pathology (Phila)"},{"issue":"7","key":"10.1053\/j.semdp.2023.11.001_bib0044","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1097\/PAS.0000000000001476","article-title":"Report From the International Society of Urological Pathology (ISUP) Consultation Conference on Molecular Pathology of Urogenital Cancers: III: Molecular Pathology of Kidney Cancer","volume":"44","author":"Williamson","year":"2020","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"10.1053\/j.semdp.2023.11.001_bib0045","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/s41379-021-00779-w","article-title":"New developments in existing WHO entities and evolving molecular concepts: The Genitourinary Pathology Society (GUPS) update on renal neoplasia","volume":"34","author":"Trpkov","year":"2021","journal-title":"Mod Pathol"},{"issue":"6","key":"10.1053\/j.semdp.2023.11.001_bib0046","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41379-021-00737-6","article-title":"Novel, emerging and provisional renal entities: The Genitourinary Pathology Society (GUPS) update on renal neoplasia","volume":"34","author":"Trpkov","year":"2021","journal-title":"Mod Pathol"},{"issue":"6","key":"10.1053\/j.semdp.2023.11.001_bib0047","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/jmedgenet-2017-105127","article-title":"Tumour risks and genotype-phenotype correlations associated with germline variants in succinate dehydrogenase subunit genes SDHB, SDHC and SDHD","volume":"55","author":"Andrews","year":"2018","journal-title":"J Med Genet"},{"issue":"6","key":"10.1053\/j.semdp.2023.11.001_bib0048","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1097\/PAS.0000000000000403","article-title":"A Novel SDHA-deficient Renal Cell Carcinoma Revealed by Comprehensive Genomic Profiling","volume":"39","author":"Yakirevich","year":"2015","journal-title":"Am J Surg Pathol"},{"issue":"12","key":"10.1053\/j.semdp.2023.11.001_bib0049","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1016\/j.humpath.2015.07.027","article-title":"Renal carcinoma associated with a novel succinate dehydrogenase A mutation: a case report and review of literature of a rare subtype of renal carcinoma","volume":"46","author":"Ozluk","year":"2015","journal-title":"Hum Pathol"},{"issue":"10","key":"10.1053\/j.semdp.2023.11.001_bib0050","first-page":"12188","article-title":"A novel germline mutation in SDHA identified in a rare case of gastrointestinal stromal tumor complicated with renal cell carcinoma","volume":"8","author":"Jiang","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0051","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41698-018-0053-2","article-title":"SDH-deficient renal cell carcinoma associated with biallelic mutation in succinate dehydrogenase A: comprehensive genetic profiling and its relation to therapy response","volume":"2","author":"McEvoy","year":"2018","journal-title":"NPJ Precis Oncol"},{"issue":"3","key":"10.1053\/j.semdp.2023.11.001_bib0052","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2559.2010.03482.x","article-title":"Renal carcinoma with giant mitochondria associated with germ-line mutation and somatic loss of the succinate dehydrogenase B gene","volume":"56","author":"Housley","year":"2010","journal-title":"Histopathology"},{"issue":"4","key":"10.1053\/j.semdp.2023.11.001_bib0053","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/his.13395","article-title":"Re-evaluation of 33 'unclassified' eosinophilic renal cell carcinomas in young patients","volume":"72","author":"Li","year":"2018","journal-title":"Histopathology"},{"issue":"5","key":"10.1053\/j.semdp.2023.11.001_bib0054","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.eururo.2014.05.027","article-title":"International Society of Urological Pathology grading and other prognostic factors for renal neoplasia","volume":"66","author":"Delahunt","year":"2014","journal-title":"Eur Urol"},{"issue":"6","key":"10.1053\/j.semdp.2023.11.001_bib0055","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.humpath.2009.12.005","article-title":"Immunohistochemistry for SDHB triages genetic testing of SDHB, SDHC, and SDHD in paraganglioma-pheochromocytoma syndromes","volume":"41","author":"Gill","year":"2010","journal-title":"Hum Pathol"},{"issue":"8","key":"10.1053\/j.semdp.2023.11.001_bib0056","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S1470-2045(09)70164-0","article-title":"An immunohistochemical procedure to detect patients with paraganglioma and phaeochromocytoma with germline SDHB, SDHC, or SDHD gene mutations: a retrospective and prospective analysis","volume":"10","author":"van Nederveen","year":"2009","journal-title":"Lancet Oncol"},{"issue":"9","key":"10.1053\/j.semdp.2023.11.001_bib0057","doi-asserted-by":"crossref","first-page":"E1472","DOI":"10.1210\/jc.2011-1043","article-title":"SDHA immunohistochemistry detects germline SDHA gene mutations in apparently sporadic paragangliomas and pheochromocytomas","volume":"96","author":"Korpershoek","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1053\/j.semdp.2023.11.001_bib0058","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/modpathol.2012.153","article-title":"Loss of expression of SDHA predicts SDHA mutations in gastrointestinal stromal tumors","volume":"26","author":"Wagner","year":"2013","journal-title":"Mod Pathol"},{"issue":"3","key":"10.1053\/j.semdp.2023.11.001_bib0059","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1053\/j.semdp.2013.06.006","article-title":"Paragangliomas: Update on differential diagnostic considerations, composite tumors, and recent genetic developments","volume":"30","author":"Papathomas","year":"2013","journal-title":"Semin Diagn Pathol"},{"issue":"4","key":"10.1053\/j.semdp.2023.11.001_bib0060","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1677\/ERC-09-0316","article-title":"SDHB loss predicts malignancy in pheochromocytomas\/sympathethic paragangliomas, but not through hypoxia signalling","volume":"17","author":"Blank","year":"2010","journal-title":"Endocr Relat Cancer"},{"issue":"2","key":"10.1053\/j.semdp.2023.11.001_bib0061","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1111\/his.14681","article-title":"An exploration in pitfalls in interpreting SDHB immunohistochemistry","volume":"81","author":"Ding","year":"2022","journal-title":"Histopathology"},{"issue":"3","key":"10.1053\/j.semdp.2023.11.001_bib0062","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/path.1461","article-title":"SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology","volume":"201","author":"Douwes Dekker","year":"2003","journal-title":"J Pathol"},{"issue":"4","key":"10.1053\/j.semdp.2023.11.001_bib0063","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s12022-013-9269-4","article-title":"Usefulness of negative and weak-diffuse pattern of SDHB immunostaining in assessment of SDH mutations in paragangliomas and pheochromocytomas","volume":"24","author":"Castelblanco","year":"2013","journal-title":"Endocr Pathol"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0064","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1371\/journal.pgen.0010008","article-title":"A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas","volume":"1","author":"Dahia","year":"2005","journal-title":"PLos Genet"},{"issue":"6","key":"10.1053\/j.semdp.2023.11.001_bib0065","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.humpath.2015.02.013","article-title":"Succinate dehydrogenase B: a new prognostic biomarker in clear cell renal cell carcinoma","volume":"46","author":"Cornejo","year":"2015","journal-title":"Hum Pathol"},{"issue":"6","key":"10.1053\/j.semdp.2023.11.001_bib0066","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/modpathol.2015.41","article-title":"SDHB\/SDHA immunohistochemistry in pheochromocytomas and paragangliomas: a multicenter interobserver variation analysis using virtual microscopy: a Multinational Study of the European Network for the Study of Adrenal Tumors (ENS@T)","volume":"28","author":"Papathomas","year":"2015","journal-title":"Mod Pathol"},{"issue":"3","key":"10.1053\/j.semdp.2023.11.001_bib0067","doi-asserted-by":"crossref","first-page":"E357","DOI":"10.1210\/jc.2011-1179","article-title":"Succinate dehydrogenase (SDH) D subunit (SDHD) inactivation in a growth-hormone-producing pituitary tumor: a new association for SDH?","volume":"97","author":"Xekouki","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0068","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/EJE-13-0623","article-title":"Non-pheochromocytoma (PCC)\/paraganglioma (PGL) tumors in patients with succinate dehydrogenase-related PCC-PGL syndromes: a clinicopathological and molecular analysis","volume":"170","author":"Papathomas","year":"2014","journal-title":"Eur J Endocrinol"},{"issue":"9","key":"10.1053\/j.semdp.2023.11.001_bib0069","doi-asserted-by":"crossref","first-page":"E1472","DOI":"10.1210\/jc.2011-1043","article-title":"SDHA Immunohistochemistry Detects Germline SDHA Gene Mutations in Apparently Sporadic Paragangliomas and Pheochromocytomas","volume":"96","author":"Korpershoek","year":"2011","journal-title":"J Clin Endocrinol Metabol"},{"issue":"2","key":"10.1053\/j.semdp.2023.11.001_bib0070","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/PAS.0b013e3182671155","article-title":"Loss of SDHA Expression Identifies SDHA Mutations in Succinate Dehydrogenase\u2013deficient Gastrointestinal Stromal Tumors","volume":"37","author":"Dwight","year":"2013","journal-title":"Am J Surg Pathol"},{"issue":"6","key":"10.1053\/j.semdp.2023.11.001_bib0071","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.juro.2012.08.030","article-title":"Succinate dehydrogenase kidney cancer: an aggressive example of the Warburg effect in cancer","volume":"188","author":"Ricketts","year":"2012","journal-title":"J Urol"},{"issue":"3","key":"10.1053\/j.semdp.2023.11.001_bib0072","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1530\/ERC-11-0324","article-title":"Biallelic inactivation of the SDHC gene in renal carcinoma associated with paraganglioma syndrome type 3","volume":"19","author":"Malinoc","year":"2012","journal-title":"Endocr Relat Cancer"},{"issue":"17","key":"10.1053\/j.semdp.2023.11.001_bib0073","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1093\/jnci\/djn254","article-title":"Germline SDHB Mutations and Familial Renal Cell Carcinoma","volume":"100","author":"Ricketts","year":"2008","journal-title":"JNCI J Natl Cancer Inst"},{"issue":"8","key":"10.1053\/j.semdp.2023.11.001_bib0074","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/jama.292.8.943","article-title":"Distinct clinical features of paraganglioma syndromes associated with SDHB and SDHD gene mutations","volume":"292","author":"Neumann","year":"2004","journal-title":"JAMA"},{"issue":"4","key":"10.1053\/j.semdp.2023.11.001_bib0075","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/j.1365-2265.2008.03274.x","article-title":"Clinical manifestations of familial paraganglioma and phaeochromocytomas in succinate dehydrogenase B (SDH-B) gene mutation carriers","volume":"69","author":"Srirangalingam","year":"2008","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"3","key":"10.1053\/j.semdp.2023.11.001_bib0076","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10689-009-9234-z","article-title":"SDHB-associated renal oncocytoma suggests a broadening of the renal phenotype in hereditary paragangliomatosis","volume":"8","author":"Henderson","year":"2009","journal-title":"Fam Cancer"},{"issue":"1","key":"10.1053\/j.semdp.2023.11.001_bib0077","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/PAI.0b013e31828bfdd3","article-title":"Mapping of succinate dehydrogenase losses in 2258 epithelial neoplasms","volume":"22","author":"Miettinen","year":"2014","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"10.1053\/j.semdp.2023.11.001_bib0078","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1196\/annals.1353.023","article-title":"Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas","volume":"1073","author":"Dahia","year":"2006","journal-title":"Ann NY Acad Sci"},{"issue":"34","key":"10.1053\/j.semdp.2023.11.001_bib0079","doi-asserted-by":"crossref","first-page":"4675","DOI":"10.1038\/sj.onc.1209594","article-title":"Succinate dehydrogenase and fumarate hydratase: linking mitochondrial dysfunction and cancer","volume":"25","author":"King","year":"2006","journal-title":"Oncogene"},{"issue":"5","key":"10.1053\/j.semdp.2023.11.001_bib0080","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/j.euf.2021.12.002","article-title":"Genomic and Metabolic Hallmarks of SDH- and FH-deficient Renal Cell Carcinomas","volume":"8","author":"Yoo","year":"2022","journal-title":"Eur Urol Focus"},{"issue":"24","key":"10.1053\/j.semdp.2023.11.001_bib0081","first-page":"6822","article-title":"Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma","volume":"60","author":"Gimm","year":"2000","journal-title":"Cancer Res"},{"issue":"3","key":"10.1053\/j.semdp.2023.11.001_bib0082","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1056\/NEJMc070010","article-title":"Somatic SDHB mutation in an extraadrenal pheochromocytoma","volume":"357","author":"van Nederveen","year":"2007","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semdp.2023.11.001_bib0083","series-title":"Genetic Tumour Syndromes (WHO Classification of Tumours Series","author":"WCoTE","year":"2023"}],"container-title":["Seminars in Diagnostic Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740257023000977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0740257023000977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T19:23:53Z","timestamp":1760037833000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0740257023000977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":83,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S0740257023000977"],"URL":"https:\/\/doi.org\/10.1053\/j.semdp.2023.11.001","relation":{},"ISSN":["0740-2570"],"issn-type":[{"value":"0740-2570","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hereditary succinate dehydrogenase-deficient renal cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Seminars in Diagnostic Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.semdp.2023.11.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}