{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:06:57Z","timestamp":1791295617428,"version":"4.1.0"},"reference-count":69,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,10,1]],"date-time":"2005-10-01T00:00:00Z","timestamp":1128124800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Hematology"],"published-print":{"date-parts":[[2005,10]]},"DOI":"10.1053\/j.seminhematol.2005.05.023","type":"journal-article","created":{"date-parts":[[2005,11,3]],"date-time":"2005-11-03T08:58:14Z","timestamp":1131008294000},"page":"239-247","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":77,"title":["Pathogenesis of Thrombosis in Essential Thrombocythemia and Polycythemia Vera: The Role of Neutrophils"],"prefix":"10.1053","volume":"42","author":[{"given":"Anna","family":"Falanga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziano","family":"Barbui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Wayne","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminhematol.2005.05.023_bib1","series-title":"Textbook of Malignant Hematology","first-page":"847","article-title":"Chronic myeloid disorders, excluding CML","author":"Barbui","year":"1999"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib2","doi-asserted-by":"crossref","first-page":"656","DOI":"10.7326\/0003-4819-123-9-199511010-00003","article-title":"Polycythemia vera","volume":"123","year":"1995","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.7326\/0003-4819-103-3-329","article-title":"Primary myeloproliferative disorder and hepatic vein thrombosis","volume":"103","author":"Valla","year":"1985","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib4","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1200\/JCO.2005.07.062","article-title":"Vascular and neoplastic risk in a large cohort of patients with polycythemia vera","volume":"23","author":"Marchioli","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib5","first-page":"215","article-title":"Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation","volume":"89","author":"Barbui","year":"2004","journal-title":"Haematologica"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib6","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1200\/JCO.1990.8.3.556","article-title":"Incidence and risk factors for thrombotic complications in a historical cohort of 100 patients with essential thrombocythemia","volume":"8","author":"Cortelazzo","year":"1990","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib7","series-title":"Clinical Aspects of Blood Viscosity and Cell Deformability","first-page":"97","article-title":"Haematocrit, blood viscosity, cerebral blood flow and vascular occlusion","author":"Pearson","year":"1981"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib8","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-0609.1993.tb01604.x","article-title":"Brain perfusion in polycythemia using 99TcmHMPAO","volume":"51","author":"Messinezy","year":"1993","journal-title":"Eur J Haematol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib9","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1161\/01.STR.3.4.409","article-title":"Hemoglobin and the risk of cerebral infarction","volume":"3","author":"Kannel","year":"1972","journal-title":"Stroke"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib10","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1056\/NEJM199504273321704","article-title":"Hydroxyurea for patients with essential thrombocythemia and a high risk of thrombosis","volume":"332","author":"Cortelazzo","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib11","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1056\/NEJMoa043800","article-title":"A randomized comparison of hydroxyurea with anagrelide in high-risk essential thrombocythemia","volume":"353","author":"Harrison","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/(SICI)1096-8652(199804)57:4<277::AID-AJH2>3.0.CO;2-R","article-title":"Aspirin increases the bleeding side effects in essential thrombocythemia independent of the cyclooxygenase pathway","volume":"57","author":"Cortelazzo","year":"1998","journal-title":"Am J Hematol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib13","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(05)71142-9","article-title":"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders","volume":"365","author":"Baxter","year":"2005","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib14","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1001\/jama.279.18.1477","article-title":"Association of fibrinogen, C-reactive protein, albumin, or leukocyte count with coronary heart disease. Meta-analyses of prospective studies","volume":"279","author":"Danesh","year":"1998","journal-title":"JAMA"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib15","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1161\/01.CIR.87.6.1915","article-title":"Blood viscosity, fibrinogen, and activation of coagulation and leukocytes in peripheral arterial disease and the normal population in the Edinburg Artery Study","volume":"87","author":"Lowe","year":"1983","journal-title":"Circulation"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib16","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.1182\/blood.V93.8.2506","article-title":"Neutrophil activation and hemostatic changes in healthy donors given granulocyte-colony stimulating factor","volume":"93","author":"Falanga","year":"1999","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib17","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1182\/blood.V86.5.1649.bloodjournal8651649","article-title":"Chemoattractant signaling and leukocyte activation","volume":"86","author":"Bokoch","year":"1985","journal-title":"Blood Rev"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib18","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/BF01740763","article-title":"Is sepsis a mediator-inhibitor mismatch?","volume":"21","author":"Lamy","year":"1995","journal-title":"Intensive Care Med"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib19","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM198902093200606","article-title":"Tissue destruction by neutrophils","volume":"320","author":"Weiss","year":"1989","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib20","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S0065-2776(08)60791-9","article-title":"Neutrophil-derived proteins","volume":"73","author":"Cassatella","year":"1999","journal-title":"Adv Immunol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib21","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1600-065X.2000.17706.x","article-title":"The neutrophil as a cellular source of chemokines","volume":"177","author":"Scapini","year":"2000","journal-title":"Immunol Rev"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000071553","article-title":"Transcription factor activation in human neutrophils","volume":"83","author":"Cloutier","year":"2003","journal-title":"Chem Immunol Allergy"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1159\/000071565","article-title":"Phenotypic and functional change of neutrophils activated by cytokines utilizing the common cytokine receptor gamma chain","volume":"83","author":"Girard","year":"2003","journal-title":"Chem Immunol Allergy"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib24","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/jcb.10526","article-title":"Gene expression in human neutrophils during activation and priming by bacterial lipopolysaccharide","volume":"89","author":"Tsukahara","year":"2003","journal-title":"J Cell Biochem"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib25","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000071555","article-title":"Phenotypic and functional changes of cytokine-activated neutrophils","volume":"83","author":"Galligan","year":"2003","journal-title":"Chem Immunol Allergy"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib26","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1152\/ajplung.00094.2002","article-title":"Microarray analysis of lipopolysaccharide-treated human neutrophils","volume":"284","author":"Malcolm","year":"2003","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib27","doi-asserted-by":"crossref","first-page":"7684","DOI":"10.4049\/jimmunol.172.12.7684","article-title":"The transcriptional activation program of human neutrophils in skin lesions supports their important role in wound healing","volume":"172","author":"Theilgaard-Monch","year":"2004","journal-title":"J Immunol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib28","doi-asserted-by":"crossref","first-page":"636","DOI":"10.4049\/jimmunol.172.1.636","article-title":"Gene expression profiling provides insight into the pathophysiology of chronic granulomatous disease","volume":"172","author":"Kobayashi","year":"2004","journal-title":"J Immunol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib29","doi-asserted-by":"crossref","first-page":"3357","DOI":"10.4049\/jimmunol.170.6.3357","article-title":"Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes","volume":"170","author":"Kobayashi","year":"2003","journal-title":"J Immunol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib30","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1083\/jcb.200307178","article-title":"Signal-dependent distribution of cell surface P-selectin in clathrin-coated pits affects leukocyte rolling under flow","volume":"163","author":"Setiadi","year":"2003","journal-title":"J Cell Biol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib31","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.thromres.2004.07.020","article-title":"Platelet physiology and thrombosis","volume":"114","author":"Andrews","year":"2004","journal-title":"Thromb Res"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib32","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.bbrc.2005.01.146","article-title":"Preferential binding of platelets to monocytes over neutrophils under flow","volume":"329","author":"Ahn","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib33","doi-asserted-by":"crossref","first-page":"13519","DOI":"10.1073\/pnas.0403608101","article-title":"Dynamic alterations of membrane tethers stabilize leukocyte rolling on P-selectin","volume":"101","author":"Ramachandran","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib34","doi-asserted-by":"crossref","first-page":"C1568","DOI":"10.1152\/ajpcell.2001.281.5.C1568","article-title":"Effects of IL-8, Gro-alpha, and LTB(4) on the adhesive kinetics of LFA-1 and Mac-1 on human neutrophils","volume":"281","author":"Seo","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib35","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1182\/blood-2004-03-1108","article-title":"P-selectin binding to P-selectin glycoprotein ligand-1 induces an intermediate state of alphaMbeta2 activation and acts cooperatively with extracellular stimuli to support maximal adhesion of human neutrophils","volume":"104","author":"Ma","year":"2004","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1073\/pnas.0405193102","article-title":"Myeloperoxidase mediates neutrophil activation by association with CD11b\/CD18 integrins","volume":"102","author":"Lau","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib37","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2174\/1570161043385420","article-title":"Regulation of hemostasis by singlet-oxygen (1DeltaO2*)","volume":"2","author":"Stief","year":"2004","journal-title":"Curr Vasc Pharmacol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib38","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1055\/s-0038-1648199","article-title":"Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells","volume":"65","author":"Ishii","year":"1991","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib39","doi-asserted-by":"crossref","first-page":"3164","DOI":"10.1182\/blood.V85.11.3164.bloodjournal85113164","article-title":"Reactive oxygen intermediates induce regulated secretion of von Willebrand factor from cultured human vascular endothelial cells","volume":"85","author":"Vischer","year":"1995","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib40","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1172\/JCI110390","article-title":"Neutrophil-mediated endothelial injury in vitro. Mechanisms of cell detachment","volume":"68","author":"Harlan","year":"1981","journal-title":"J Clin Invest"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib41","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1055\/s-0038-1648825","article-title":"Neutrophils derived cathepsin G induces potentially thrombogenic changes in human endothelial cells","volume":"72","author":"Kolpakov","year":"1994","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib42","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1182\/blood.V74.5.1627.1627","article-title":"Human leukocyte cathepsin G and elastase specifically suppress thrombin-induced prostacyclin production in human endothelial cells","volume":"74","author":"Weksler","year":"1989","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib43","first-page":"69","article-title":"Cathepsin G-induced release of PAI-1 in the culture medium of endothelial cells","volume":"122","author":"Pintucci","year":"1993","journal-title":"J Lab Clin Med"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib44","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1182\/blood.V81.11.2947.2947","article-title":"Cathepsin G-dependent platelet stimulation by activated polymorphonuclear leukocytes and its inhibition by antiproteinases","volume":"81","author":"Evangelista","year":"1993","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib45","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1515\/bchm3.1991.372.2.1007","article-title":"Protein C degradation in vitro by neutrophil elastase","volume":"372","author":"Eckle","year":"1991","journal-title":"Biol Chem Hoppe Seyler"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib46","doi-asserted-by":"crossref","first-page":"281","DOI":"10.3109\/00365519309088420","article-title":"Protein S degradation in vitro by neutrophil elastase","volume":"53","author":"Eckle","year":"1993","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib47","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1182\/blood.V79.7.1712.1712","article-title":"The effect of leukocyte elastase on tissue factor pathway inhibitor","volume":"79","author":"Higuchi","year":"1992","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib48","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1126\/science.3649921","article-title":"Heparin promotes the inactivation of antithrombin by neutrophil elastase","volume":"237","author":"Jordan","year":"1987","journal-title":"Science"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib49","doi-asserted-by":"crossref","first-page":"11896","DOI":"10.1021\/bi980520v","article-title":"Proteolysis of factor V by cathepsin G and elastase indicates that cleavage at Arg1545 optimizes cofactor function by facilitating factor Xa binding","volume":"37","author":"Camire","year":"1998","journal-title":"Biochemistry"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib50","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1083\/jcb.131.3.775","article-title":"Cell surface-bound elastase and cathepsin G on human neutrophils focus and preserve catalytic activity of serine proteinases","volume":"131","author":"Owen","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib51","first-page":"4185","article-title":"Platelet\/polymorphonuclear leukocyte interaction in dinamic conditions","volume":"88","author":"Evangelista","year":"1996","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib52","first-page":"41","article-title":"Recent advances in platelet-polymorphonuclear leukocyte interaction","volume":"29","author":"de Gaetano","year":"1999","journal-title":"Haemostasis"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib53","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1002\/jlb.58.5.575","article-title":"A novel biological effect of platelet factor 4 (PF4)","volume":"58","author":"Engstad","year":"1995","journal-title":"J Leukoc Biol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib54","doi-asserted-by":"crossref","first-page":"8767","DOI":"10.1073\/pnas.91.19.8767","article-title":"P-selectin induces the expression of tissue factor on monocytes","volume":"91","author":"Celi","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib55","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1172\/JCI118575","article-title":"Activated platelets signal chemokine synthesis by human monocytes","volume":"97","author":"Weyrich","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib56","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.4049\/jimmunol.151.6.3267","article-title":"Activated platelets induce superoxide anion release by monocytes and neutrophils through P-selectin (CD62)","volume":"151","author":"Nagata","year":"1993","journal-title":"J Immunol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib57","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1161\/01.CIR.95.10.2387","article-title":"Induction of cytokine expression in leukocytes by binding of thrombin-stimulated platelets","volume":"95","author":"Neumann","year":"1997","journal-title":"Circulation"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib58","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/01.CIR.98.12.1164","article-title":"Activated platelets induce monocyte chemotactic protein-1 secretion and surface expression of intercellular adhesion molecule-1 on endothelial cells","volume":"98","author":"Gawaz","year":"1998","journal-title":"Circulation"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib59","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1046\/j.1365-2141.1997.4993305.x","article-title":"A sensitive flow cytometric assay for circulating platelet-leukocyte aggregates","volume":"99","author":"Li","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib60","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000063063","article-title":"Increased CD11\/18 expression and altered metabolic activity in polymorphonuclear leukocytes from patients with polycythemia vera and essential thrombocythemia","volume":"108","author":"Burgaleta","year":"2002","journal-title":"Acta Haematol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib61","doi-asserted-by":"crossref","first-page":"4261","DOI":"10.1182\/blood.V96.13.4261","article-title":"Polymorphonuclear leukocyte activation and hemostasis in patients with essential thrombocythemia and polycythemia vera","volume":"96","author":"Falanga","year":"2000","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib62","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1055\/s-2007-1001921","article-title":"Hemostatic system activation in patients with lupus anticoagulant and essential thrombocythemia","volume":"20","author":"Falanga","year":"1994","journal-title":"Semin Thromb Hemost"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib63","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/ajh.2830400408","article-title":"Relationship of thrombohemorrhagic complications to endothelial cell function in patients with chronic myeloproliferative disorders","volume":"40","author":"Friedenberg","year":"1992","journal-title":"Am J Hematol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib64","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1055\/s-0038-1649661","article-title":"Platelet hyperactivation in patients with essential thrombocythemia is not associated with vascular endothelial cell damage as judged by the level of plasma thrombomodulin, protein S, PAI-1, tPA and vWF","volume":"70","author":"Bellucci","year":"1993","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib65","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1161\/01.CIR.94.6.1239","article-title":"Increased neutrophil-platelet adhesion in patients with unstable angina","volume":"94","author":"Ott","year":"1996","journal-title":"Circulation"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib66","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1034\/j.1600-0609.2001.00359.x","article-title":"Increased circulating platelet-leukocyte aggregates in myeloproliferative disorders is correlated to previous thrombosis, platelet activation and platelet count","volume":"66","author":"Jensen","year":"2001","journal-title":"Eur J Haematol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib67","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1046\/j.1365-2141.2003.04770.x","article-title":"Increased CD11b neutrophil expression in Budd-Chiari syndrome or portal vein thrombosis secondary to polycythaemia vera","volume":"124","author":"Alvarez-Larr\u00e0n","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib68","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0049-3848(02)00354-7","article-title":"Markers of platelet activation and platelet-leukocyte interaction in patients with myeloproliferative syndromes","volume":"108","author":"Villmow","year":"2002","journal-title":"Thromb Res"},{"key":"10.1053\/j.seminhematol.2005.05.023_bib69","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.exphem.2005.01.015","article-title":"Leukocyte-platelet interaction in patients with essential thrombocytemia and polycythemia vera","volume":"33","author":"Falanga","year":"2005","journal-title":"Exp Hematol"}],"container-title":["Seminars in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196305000831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196305000831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T06:17:38Z","timestamp":1758521858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0037196305000831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,10]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,10]]}},"alternative-id":["S0037196305000831"],"URL":"https:\/\/doi.org\/10.1053\/j.seminhematol.2005.05.023","relation":{},"ISSN":["0037-1963"],"issn-type":[{"value":"0037-1963","type":"print"}],"subject":[],"published":{"date-parts":[[2005,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathogenesis of Thrombosis in Essential Thrombocythemia and Polycythemia Vera: The Role of Neutrophils","name":"articletitle","label":"Article Title"},{"value":"Seminars in Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminhematol.2005.05.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2005 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}