{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:17:57Z","timestamp":1758817077161,"version":"3.44.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Hematology"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1053\/j.seminhematol.2007.01.003","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T07:13:10Z","timestamp":1176361990000},"page":"126-129","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["The Essential Role of Genetic Counseling in Inherited Thrombophilia"],"prefix":"10.1053","volume":"44","author":[{"given":"Paul","family":"Lochhead","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zosia","family":"Miedzybrodzka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminhematol.2007.01.003_bib1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3109\/00365516509077290","article-title":"Thrombophilia caused by inheritable deficiency of blood antithrombin","volume":"17","author":"Egeberg","year":"1965","journal-title":"Scand J Clin Lab Invest"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib2","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1056\/NEJM199011293232202","article-title":"Deficiencies of coagulation-inhibiting and fibrinolytic proteins in outpatients with deep-vein thrombosis","volume":"323","author":"Heijboer","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/369064a0","article-title":"Mutation in blood coagulation factor V associated with resistance to activated protein C","volume":"369","author":"Bertina","year":"1994","journal-title":"Nature"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib4","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1073\/pnas.90.3.1004","article-title":"Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C","volume":"90","author":"Dahlback","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib5","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1016\/S0140-6736(95)91803-5","article-title":"World distribution of factor V Leiden","volume":"346","author":"Rees","year":"1995","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib6","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","article-title":"A common genetic variation in the 3\u2032-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis","volume":"88","author":"Poort","year":"1996","journal-title":"Blood"},{"year":"2004","series-title":"Practical Genetic Counseling","author":"Harper","key":"10.1053\/j.seminhematol.2007.01.003_bib7"},{"year":"2002","series-title":"Inside Information: Balancing Interests in the Use of Personal Genetic Data","key":"10.1053\/j.seminhematol.2007.01.003_bib8"},{"year":"2006","series-title":"Consent and Confidentiality in Genetic Practice: Guidance on Genetic Testing and Sharing Genetic Information","key":"10.1053\/j.seminhematol.2007.01.003_bib9"},{"year":"2006","series-title":"Good Medical Practice","key":"10.1053\/j.seminhematol.2007.01.003_bib10"},{"year":"1998","series-title":"Seeking Patients\u2019 Consent: The Ethical Considerations","key":"10.1053\/j.seminhematol.2007.01.003_bib11"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib12","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1046\/j.1365-2141.2001.02981.x","article-title":"Investigation and management of heritable thrombophilia","volume":"114","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib13","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.5858\/2002-126-1277-COAPCC","article-title":"Diagnostic issues in thrombophilia","volume":"126","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1136\/bmj.316.7125.95","article-title":"Decision analysis model of prolonged oral anticoagulant treatment in factor V Leiden carriers with first episode of deep vein thrombosis","volume":"316","author":"Sarasin","year":"1998","journal-title":"BMJ"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib15","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1055\/s-0037-1614111","article-title":"Duration of oral anticoagulant treatment in patients with venous thromboembolism and a deficiency of antithrombin, protein C or protein S\u2014A decision analysis","volume":"84","author":"van den Belt","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib16","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1055\/s-0037-1614110","article-title":"Extended anticoagulation for prevention of recurrent venous thromboembolism in carriers of factor V Leiden\u2014Cost-effectiveness analysis","volume":"84","author":"Marchetti","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib17","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1182\/blood.V85.6.1504.bloodjournal8561504","article-title":"High risk of thrombosis in patients homozygous for factor V Leiden (activated protein C resistance)","volume":"85","author":"Rosendaal","year":"1995","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib18","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1056\/NEJM199909093411104","article-title":"The risk of recurrent deep venous thrombosis among heterozygous carriers of both factor V Leiden and the G20210A prothrombin mutation","volume":"341","author":"De Stefano","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib19","first-page":"256","article-title":"Familial thrombophilia: A complex genetic disorder","volume":"34","author":"Koeleman","year":"1997","journal-title":"Semin Hematol"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib20","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1055\/s-0038-1650289","article-title":"Factor V Leiden (FV R506Q) in families with inherited antithrombin deficiency","volume":"75","author":"van Boven","year":"1996","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib21","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1182\/blood.V94.8.2590.420k40_2590_2594","article-title":"Gene-gene and gene-environment interactions determine risk of thrombosis in families with inherited antithrombin deficiency","volume":"94","author":"van Boven","year":"1999","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib22","doi-asserted-by":"crossref","first-page":"15","DOI":"10.7326\/0003-4819-128-1-199801010-00003","article-title":"The incidence of venous thromboembolism in family members of patients with factor V Leiden mutation and venous thrombosis","volume":"128","author":"Middeldorp","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S0140-6736(00)02476-4","article-title":"Factor V Leiden paradox: risk of deep-vein thrombosis but not of pulmonary embolism","volume":"356","author":"Bounameaux","year":"2000","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib24","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1182\/blood.V89.6.1963","article-title":"Mortality and causes of death in families with the factor V Leiden mutation (resistance to activated protein C)","volume":"89","author":"Hille","year":"1997","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib25","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1136\/jmg.31.10.785","article-title":"The genetic testing of children: Report of a Working Party of the Clinical Genetics Society (UK)","volume":"31","year":"1994","journal-title":"J Med Genet"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib26","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(94)90286-0","article-title":"Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation","volume":"344","author":"Vandenbroucke","year":"1994","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib27","doi-asserted-by":"crossref","unstructured":"Vandenbroucke JP, van der Meer FJM, Helmerhorst FM, Rosendaal FR: Factor V Leiden: Should we screen oral contraceptive users and pregnant women? BMJ 313:1127-1130","DOI":"10.1136\/bmj.313.7065.1127"},{"year":"2006","series-title":"British National Formulary 52","key":"10.1053\/j.seminhematol.2007.01.003_bib28"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta10110","article-title":"Screening for thrombophilia in high-risk situations","volume":"10","author":"Wu","year":"2006","journal-title":"Health Technol Assess"},{"key":"10.1053\/j.seminhematol.2007.01.003_bib30","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1046\/j.1365-2141.2000.02236.x","article-title":"Factor V Leiden: The venous thrombotic risk in thrombophilic families","volume":"110","author":"Lensen","year":"2000","journal-title":"Br J Haematol"}],"container-title":["Seminars in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196307000042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196307000042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T06:18:39Z","timestamp":1758521919000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0037196307000042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S0037196307000042"],"URL":"https:\/\/doi.org\/10.1053\/j.seminhematol.2007.01.003","relation":{},"ISSN":["0037-1963"],"issn-type":[{"type":"print","value":"0037-1963"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Essential Role of Genetic Counseling in Inherited Thrombophilia","name":"articletitle","label":"Article Title"},{"value":"Seminars in Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminhematol.2007.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}