{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T03:49:01Z","timestamp":1793677741333,"version":"4.5.1"},"reference-count":79,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,4,1]],"date-time":"2007-04-01T00:00:00Z","timestamp":1175385600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Hematology"],"published-print":{"date-parts":[[2007,4]]},"DOI":"10.1053\/j.seminhematol.2007.02.004","type":"journal-article","created":{"date-parts":[[2007,4,12]],"date-time":"2007-04-12T07:13:10Z","timestamp":1176361990000},"page":"62-69","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":620,"title":["Epidemiology and Risk Factors for Venous Thrombosis"],"prefix":"10.1053","volume":"44","author":[{"given":"Mary","family":"Cushman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminhematol.2007.02.004_bib1","doi-asserted-by":"crossref","first-page":"I-4","DOI":"10.1161\/01.CIR.0000078468.11849.66","article-title":"The epidemiology of venous thromboembolism","volume":"107","author":"White","year":"2003","journal-title":"Circulation"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.thromres.2004.04.007","article-title":"The impact of venous thrombosis on quality of life","volume":"114","author":"van Korlaar","year":"2004","journal-title":"Thromb Res"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib3","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1001\/archinte.165.10.1173","article-title":"Prospective evaluation of health-related quality of life in patients with deep venous thrombosis","volume":"165","author":"Kahn","year":"2005","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.amjmed.2004.01.018","article-title":"Deep vein thrombosis and pulmonary embolism in two cohorts: The Longitudinal Investigation of Thromboembolism Etiology","volume":"117","author":"Cushman","year":"2004","journal-title":"Am J Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib5","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1001\/archinte.159.5.445","article-title":"Predictors of survival after deep vein thrombosis and pulmonary embolism: A population-based cohort study","volume":"159","author":"Heit","year":"1999","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib6","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1001\/archinte.158.6.585","article-title":"Trends in the incidence of deep vein thrombosis and pulmonary embolism: A 25-year population-based study","volume":"158","author":"Silverstein","year":"1998","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib7","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1001\/archinte.162.10.1182","article-title":"Cardiovascular risk factors and venous thromboembolism incidence: The Longitudinal Investigation of Thromboembolism Etiology","volume":"162","author":"Tsai","year":"2002","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib8","doi-asserted-by":"crossref","first-page":"737","DOI":"10.7326\/0003-4819-128-9-199805010-00006","article-title":"Incidence of idiopathic deep venous thrombosis and secondary thromboembolism among ethnic groups in California","volume":"128","author":"White","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib9","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.amjmed.2003.11.020","article-title":"Pulmonary thromboembolism in Asians\/Pacific Islanders in the United States: Analysis of data from the National Hospital Discharge Survey and the United States Bureau of the Census","volume":"116","author":"Stein","year":"2004","journal-title":"Am J Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib10","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.1111\/j.1538-7836.2005.01621.x","article-title":"Deep-vein thrombosis rates after major orthopedic surgery in Asia","volume":"3","author":"Piovella","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.thromres.2005.12.014","article-title":"Incidence of deep vein thrombosis in hospitalized Chinese medical patients is similar to that in western populations","volume":"118","author":"Leung","year":"2006","journal-title":"Thromb Res"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib12","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1002\/bjs.4454","article-title":"Epidemiology of venous thromboembolism in a Chinese population","volume":"91","author":"Cheuk","year":"2004","journal-title":"Br J Surg"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib13","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/(SICI)1096-8628(19971219)73:3<334::AID-AJMG20>3.0.CO;2-J","article-title":"Prevalence of the factor V-Leiden mutation in four distinct American ethnic populations","volume":"73","author":"Gregg","year":"1997","journal-title":"Am J Med Genet"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib14","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1001\/jama.1997.03540400055031","article-title":"Ethnic distribution of factor V Leiden in 4047 men and women: Implications for venous thromboembolism screening","volume":"277","author":"Ridker","year":"1998","journal-title":"JAMA"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib15","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1182\/blood.V99.8.2720","article-title":"A prospective study of venous thromboembolism in relation to factor V Leiden and related factors","volume":"99","author":"Folsom","year":"2002","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/ajh.10229","article-title":"Prospective study of the G20210A polymorphism in the prothrombin gene, plasma prothrombin concentration, and incidence of venous thromboembolism","volume":"71","author":"Folsom","year":"2002","journal-title":"Am J Hematol"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib17","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1365-2257.2006.00757.x","article-title":"Prevalence of factor V Leiden and prothrombin G20210A mutations in Chinese patients with deep venous thrombosis and pulmonary embolism","volume":"28","author":"Jun","year":"2006","journal-title":"Clin Lab Haematol"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1093\/oxfordjournals.aje.a009363","article-title":"Relation of three genetic traits to venous thrombosis in an African-American population","volume":"147","author":"Dilley","year":"1998","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib19","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1182\/blood-2006-10-052100","article-title":"Update on factor V Leiden association with venous thromboembolism in the LITE Study","volume":"109","author":"Folsom","year":"2007","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib20","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1046\/j.1538-7836.2003.00031.x","article-title":"The epidemiology of venous thromboembolism in Caucasians and African-Americans: The GATE Study","volume":"1","author":"Dowling","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib21","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1111\/j.1538-7836.2006.02237.x","article-title":"Plasma hemostatic factors and endothelial markers in four racial\/ethnic groups: The MESA study","volume":"4","author":"Lutsey","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib22","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0140-6736(98)10266-0","article-title":"Venous thrombosis: A multicausal disease","volume":"353","author":"Rosendaal","year":"1999","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib23","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1055\/s-2006-955458","article-title":"Prevention of venous thromboembolism","volume":"32","author":"Pini","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib24","doi-asserted-by":"crossref","first-page":"3415","DOI":"10.1001\/archinte.160.22.3415","article-title":"An epidemiologic study of risk factors for deep vein thrombosis in medical outpatients: The Sirius study","volume":"160","author":"Samama","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1055\/s-0037-1613379","article-title":"Obesity: risk of venous thrombosis and the interaction with coagulation factor levels and oral contraceptive use","volume":"89","author":"Abdollahi","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib26","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.amjmed.2005.03.012","article-title":"Obesity as a risk factor in venous thromboembolism","volume":"118","author":"Stein","year":"2005","journal-title":"Am J Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib27","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1001\/jama.292.13.1573","article-title":"Estrogen plus progestin and risk of venous thrombosis","volume":"292","author":"Cushman","year":"2004","journal-title":"JAMA"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib28","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1038\/oby.2007.505","article-title":"Increasing trends in waist circumference and abdominal obesity among U.S. adults","volume":"15","author":"Li","year":"2007","journal-title":"Obesity (Silver Spring)"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib29","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1055\/s-2006-951456","article-title":"Hyperhomocysteinemia and venous thromboembolism","volume":"32","author":"Cattaneo","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib30","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1182\/blood-2006-04-014654","article-title":"Homocysteine lowering by B vitamins and the secondary prevention of deep vein thrombosis and pulmonary embolism: A randomized, placebo-controlled, double-blind trial","volume":"109","author":"den Heijer","year":"2007","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib31","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1111\/j.1538-7836.2004.00991.x","article-title":"Risk factors for venous thrombosis in medical inpatients: Validation of a thrombosis risk score","volume":"2","author":"Zakai","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib32","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/jcp.50.7.609","article-title":"Fatal pulmonary embolism in hospitalised medical patients","volume":"50","author":"Baglin","year":"1997","journal-title":"J Clin Pathol"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib33","doi-asserted-by":"crossref","first-page":"338S","DOI":"10.1378\/chest.126.3_suppl.338S","article-title":"Prevention of venous thromboembolism: The Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy","volume":"126","author":"Geerts","year":"2004","journal-title":"Chest"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib34","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1046\/j.1538-7836.2004.00848.x","article-title":"Effect of age on the incidence of venous thromboembolism after major surgery","volume":"2","author":"White","year":"2004","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib35","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1055\/s-0037-1613828","article-title":"Minor events and the risk of deep venous thrombosis","volume":"83","author":"Eekhoff","year":"2000","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib36","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1055\/s-2006-951297","article-title":"Cancer and venous thromboembolism","volume":"32","author":"Piccioli","year":"2006","journal-title":"Semin Thromb Hemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib37","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1538-7836.2006.01804.x","article-title":"Incidence of venous thrombosis in a large cohort of 66,329 cancer patients: Results of a record linkage study","volume":"4","author":"Blom","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib38","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/j.1365-2141.2004.05327.x","article-title":"Factor V Leiden, prothrombin 20210A and the risk of venous thrombosis among cancer patients","volume":"128","author":"Kennedy","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib39","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1001\/jama.293.6.715","article-title":"Malignancies, prothrombotic mutations, and the risk of venous thrombosis","volume":"293","author":"Blom","year":"2005","journal-title":"JAMA"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0030307","article-title":"Travel-related venous rhrombosis: Results from a large population-based case control study (MEGA Study)","volume":"3","author":"Cannegieter","year":"2006","journal-title":"PLoS Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib41","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1056\/NEJMoa010378","article-title":"Severe pulmonary embolism associated with air travel","volume":"345","author":"Lapostolle","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib42","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1001\/archinte.163.22.2766","article-title":"Incidence of air travel-related pulmonary embolism at the Madrid-Barajas airport","volume":"163","author":"Perez-Rodriguez","year":"2003","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib43","doi-asserted-by":"crossref","first-page":"128","DOI":"10.7326\/0003-4819-138-2-200301210-00014","article-title":"Congenital thrombophilic states associated with venous thrombosis: A qualitative overview and proposed classification system","volume":"138","author":"Crowther","year":"2003","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib44","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1055\/s-0037-1612942","article-title":"D-dimer as a risk factor for deep vein thrombosis: The Leiden Thrombophilia Study","volume":"87","author":"Andreescu","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib45","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1182\/blood-2002-05-1416","article-title":"Fibrin fragment D-dimer and the risk of future venous thrombosis","volume":"101","author":"Cushman","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib46","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1111\/j.1538-7836.2005.01482.x","article-title":"Strenuous sport activities involving the upper extremities increase the risk of venous thrombosis of the arm","volume":"3","author":"van Stralen","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib47","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1183\/09031936.03.00039403","article-title":"eThrombosis: The 21st century variant of venous thromboembolism associated with immobility","volume":"21","author":"Beasley","year":"2003","journal-title":"Eur Respir J"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib48","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1161\/CIRCULATIONAHA.106.641688","article-title":"Greater fish, fruit, and vegetable intakes are related to lower incidence of venous thromboembolism: The Longitudinal Investigation of Thromboembolism Etiology","volume":"115","author":"Steffen","year":"2007","journal-title":"Circulation"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib49","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1056\/NEJMoa022157","article-title":"An association between atherosclerosis and venous thrombosis","volume":"348","author":"Prandoni","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib50","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1111\/j.1538-7836.2006.02096.x","article-title":"Subclinical atherosclerosis and the risk of future venous thrombosis in the Cardiovascular Health Study","volume":"4","author":"van der Hagen","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib51","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1111\/j.1538-7836.2006.02121.x","article-title":"Prospective study of subclinical atherosclerosis as a risk factor for venous thromboembolism","volume":"4","author":"Reich","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib52","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.amjcard.2003.10.061","article-title":"Analysis of occurrence of venous thromboembolic disease in the four seasons","volume":"93","author":"Stein","year":"2004","journal-title":"Am J Cardiol"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib53","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1016\/S0140-6736(94)90286-0","article-title":"Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation","volume":"344","author":"Vandenbroucke","year":"1994","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib54","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1016\/S0140-6736(99)06092-4","article-title":"Low-dose oral contraceptives and acquired resistance to activated protein C: A randomised cross-over study","volume":"354","author":"Rosing","year":"1999","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7326\/0003-4819-125-1-199607010-00001","article-title":"The long-term clinical course of acute deep venous thrombosis","volume":"125","author":"Prandoni","year":"1996","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib56","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1001\/archinte.160.6.761","article-title":"Predictors of recurrence after deep vein thrombosis and pulmonary embolism: A population-based cohort study","volume":"160","author":"Heit","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib57","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0140-6736(06)69110-1","article-title":"Effect of patient\u2019s sex on risk of recurrent venous thromboembolism: A meta-analysis","volume":"368","author":"McRae","year":"2006","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib58","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.1111\/j.1538-7836.2006.02140.x","article-title":"Hormonal factors and risk of recurrent venous thrombosis: The prevention of recurrent venous thromboembolism trial","volume":"4","author":"Cushman","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib59","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1056\/NEJM200107193450302","article-title":"Three months versus one year of oral anticoagulant therapy for idiopathic deep venous thrombosis","volume":"345","author":"Agnelli","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib60","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.amjmed.2005.04.043","article-title":"Family history for venous thromboembolism and the risk for recurrence","volume":"119","author":"Hron","year":"2006","journal-title":"Am J Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib61","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1161\/01.CIR.92.10.2800","article-title":"Factor V Leiden and risks of recurrent idiopathic venous thromboembolism","volume":"92","author":"Ridker","year":"1995","journal-title":"Circulation"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib62","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1056\/NEJM199702063360602","article-title":"The risk of recurrent venous thromboembolism in patients with Arg506\u2192Gln mutation in the gene for factor V (factor V Leiden)","volume":"336","author":"Simioni","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib63","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1056\/NEJM200008173430702","article-title":"High plasma level of factor VIII and the risk of recurrent venous thromboembolism","volume":"343","author":"Kyrle","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib64","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1159\/000083836","article-title":"Management of thrombophilia: Who to screen?","volume":"33","author":"Baglin","year":"2003","journal-title":"Pathophysiol Haemost Thromb"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib65","first-page":"180","article-title":"Thrombophilia screening: A matter of debate","volume":"62","author":"Kamphuisen","year":"2004","journal-title":"Neth J Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib66","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1001\/jama.293.19.2352","article-title":"Thrombophilia, clinical factors, and recurrent venous thrombotic events","volume":"293","author":"Christiansen","year":"2005","journal-title":"JAMA"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib67","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/j.1538-7836.2006.01935.x","article-title":"D-dimer, factor VIII coagulant activity, low-intensity warfarin and the risk of recurrent venous thromboembolism","volume":"4","author":"Shrivastava","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib68","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1055\/s-0037-1612936","article-title":"Risk of venous thromboembolism recurrence: High negative predictive value of D-dimer performed after oral anticoagulation is stopped","volume":"87","author":"Palareti","year":"2002","journal-title":"Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib69","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1001\/jama.290.8.1071","article-title":"D-dimer levels and risk of recurrent venous thromboembolism","volume":"290","author":"Eichinger","year":"2003","journal-title":"Jama"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib70","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1056\/NEJMoa054444","article-title":"D-dimer testing to determine the duration of anticoagulation therapy","volume":"355","author":"Palareti","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib71","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1538-7836.2006.01868.x","article-title":"Prediction of recurrent venous thromboembolism by the activated partial thromboplastin time","volume":"4","author":"Hron","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib72","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1001\/jama.296.4.397","article-title":"Identification of patients at low risk for recurrent venous thromboembolism by measuring thrombin generation","volume":"296","author":"Hron","year":"2006","journal-title":"JAMA"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib73","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0268-960X(02)00008-5","article-title":"The post-thrombotic syndrome: current knowledge, controversies, and directions for future research","volume":"16","author":"Kahn","year":"2002","journal-title":"Blood Rev"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib74","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1538-7836.2006.01824.x","article-title":"Comparison of the Villalta and Ginsberg clinical scales to diagnose the post-thrombotic syndrome: Correlation with patient-reported disease burden and venous valvular reflux","volume":"4","author":"Kahn","year":"2006","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib75","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.1111\/j.1538-7836.2005.01648.x","article-title":"The post-thrombotic syndrome: Risk factors and impact on the course of thrombotic disease","volume":"3","author":"Stain","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib76","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/j.1538-7836.2005.01216.x","article-title":"Predictors of the post-thrombotic syndrome during long-term treatment of proximal deep vein thrombosis","volume":"3","author":"Kahn","year":"2005","journal-title":"J Thromb Haemost"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib77","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/S0140-6736(96)12215-7","article-title":"Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis","volume":"349","author":"Brandjes","year":"1997","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib78","doi-asserted-by":"crossref","first-page":"249","DOI":"10.7326\/0003-4819-141-4-200408170-00004","article-title":"Below-knee elastic compression stockings to prevent the post-thrombotic syndrome: A randomized, controlled trial","volume":"141","author":"Prandoni","year":"2004","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminhematol.2007.02.004_bib79","doi-asserted-by":"crossref","DOI":"10.1182\/asheducation-2005.1.452","article-title":"Inherited risk factors for venous thrombosis","author":"Cushman","year":"2005","journal-title":"Hematology Am Soc Hematol Educ Program"}],"container-title":["Seminars in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003719630700025X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003719630700025X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T06:18:48Z","timestamp":1758521928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003719630700025X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,4]]},"references-count":79,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["S003719630700025X"],"URL":"https:\/\/doi.org\/10.1053\/j.seminhematol.2007.02.004","relation":{},"ISSN":["0037-1963"],"issn-type":[{"value":"0037-1963","type":"print"}],"subject":[],"published":{"date-parts":[[2007,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epidemiology and Risk Factors for Venous Thrombosis","name":"articletitle","label":"Article Title"},{"value":"Seminars in Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminhematol.2007.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}