{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:16:09Z","timestamp":1791353769803,"version":"4.3.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T00:00:00Z","timestamp":1285891200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Hematology"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1053\/j.seminhematol.2010.07.001","type":"journal-article","created":{"date-parts":[[2010,9,29]],"date-time":"2010-09-29T05:04:19Z","timestamp":1285736659000},"page":"302-311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":103,"title":["Chronic Myeloid Leukemia: A Historical Perspective"],"prefix":"10.1053","volume":"47","author":[{"given":"John M.","family":"Goldman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminhematol.2010.07.001_bib1","first-page":"413","article-title":"Case of hypertrophy of the spleen and liver in which death took place from the suppuration of the blood","volume":"64","author":"Bennett","year":"1845","journal-title":"Edinburgh Med Surg J"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib2","first-page":"151","article-title":"Weisses Blut","volume":"36","author":"Virchow","year":"1845","journal-title":"Frorieps Notizen"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib3","first-page":"366","article-title":"De l'origine des globules du sang, de leur mode de formation, de leur fin","volume":"4","author":"Donne","year":"1842","journal-title":"CR Acad Sci"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib4","first-page":"190","article-title":"Die Leuk\u00e4mie","author":"Virchow","year":"1856"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib5","series-title":"Leucocythaemia, or white cell blood in relation to the physiology and pathology of the lymphatic glandular system","author":"Bennett","year":"1852"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib6","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1365-2141.2000.02137.x","article-title":"The story of chronic myeloid leukaemia","volume":"110","author":"Geary","year":"2000","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib7","first-page":"1497","article-title":"A minute chromosome in human chronic granulocytic leukemia","volume":"132","author":"Nowell","year":"1960","journal-title":"Science"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib8","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/243290a0","article-title":"A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining","volume":"243","author":"Rowley","year":"1973","journal-title":"Nature"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib9","first-page":"2213","article-title":"Lymphosarcoma: virus-induced thymic-independent disease in mice","volume":"30","author":"Abelson","year":"1970","journal-title":"Cancer Res"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib10","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1182\/blood.V68.6.1369.1369","article-title":"bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia","volume":"68","author":"de Klein","year":"1986","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib11","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/306239a0","article-title":"Localization of the c-ab1 oncogene adjacent to a translocation break point in chronic myelocytic leukaemia","volume":"306","author":"Heisterkamp","year":"1983","journal-title":"Nature"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib12","first-page":"3231","article-title":"The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia","volume":"7","author":"Bernards","year":"1987","journal-title":"Mol Cell Biol."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib13","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0092-8674(84)90077-1","article-title":"Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22","volume":"36","author":"Groffen","year":"1984","journal-title":"Cell"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib14","first-page":"163","article-title":"Chronic myelogenous leukemia\u2014the unfolding saga","volume":"4","author":"Goldman","year":"1990","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1182\/blood.V45.3.321.321","article-title":"Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome","volume":"45","author":"Lozzio","year":"1975","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib16","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/0092-8674(84)90438-0","article-title":"An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity","volume":"37","author":"Konopka","year":"1984","journal-title":"Cell"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib17","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0140-6736(84)90997-8","article-title":"Altered transcription of an oncogene in chronic myeloid leukaemia","volume":"1","author":"Canaani","year":"1984","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib18","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/315550a0","article-title":"Fused transcript of abl and bcr genes in chronic myelogenous leukaemia","volume":"315","author":"Shtivelman","year":"1985","journal-title":"Nature"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib19","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1126\/science.2406902","article-title":"Induction of chronic myelogenous leukemia in mice by the P210bcr\/abl gene of the Philadelphia chromosome","volume":"247","author":"Daley","year":"1990","journal-title":"Science"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib20","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1002\/j.1460-2075.1990.tb08212.x","article-title":"bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice","volume":"9","author":"Elefanty","year":"1990","journal-title":"EMBO J"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib21","doi-asserted-by":"crossref","first-page":"6649","DOI":"10.1073\/pnas.87.17.6649","article-title":"Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR\/ABL","volume":"87","author":"Kelliher","year":"1990","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/344251a0","article-title":"Acute leukaemia in bcr\/abl transgenic mice","volume":"344","author":"Heisterkamp","year":"1990","journal-title":"Nature"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib23","first-page":"126","article-title":"Leukemia and allied disorders","author":"Forkner","year":"1938"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib24","first-page":"403","article-title":"Zwei Falle von Leucaemie","volume":"2","author":"Lissauer","year":"1865","journal-title":"Berl Klin Wochenshrift"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib25","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/S0140-6736(02)21638-4","article-title":"Notes on a case of leucocythaemia","volume":"25","author":"Conan Doyle","year":"1882","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib26","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0140-6736(53)90885-X","article-title":"Myleran in chronic myeloid leukaemia; results of treatment","volume":"264","author":"Galton","year":"1953","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib27","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1056\/NEJM198604243141701","article-title":"Hematologic remission and cytogenetic improvement induced by recombinant human IFN alpha A in chronic myelogenous leukemia","volume":"314","author":"Talpaz","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S0140-6736(82)92736-2","article-title":"Marrow transplantation for patients in the chronic phase of chronic granulocytic leukaemia","volume":"2","author":"Goldman","year":"1982","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib29","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJM197902153000702","article-title":"Disappearance of Ph1-positive cells in four patients with chronic granulocytic leukemia after chemotherapy, irradiation and marrow transplantation from an identical twin","volume":"300","author":"Fefer","year":"1979","journal-title":"N Engl J Med"},{"issue":"Suppl 3","key":"10.1053\/j.seminhematol.2010.07.001_bib30","first-page":"5","article-title":"Allogeneic bone marrow transplantation for CML: a report from the International Bone Marrow Transplant Registry","author":"Horowitz","year":"1996","journal-title":"Bone Marrow Transplant."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib31","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1200\/JCO.2009.26.7757","article-title":"Relapse and late mortality in 5-year survivors of myeloablative allogeneic hematopoietic cell transplantation for chronic myeloid leukemia in first chronic phase","volume":"28","author":"Goldman","year":"2010","journal-title":"J Clin Oncol."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib32","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1056\/NEJM199707243370402","article-title":"IFN alfa-2b combined with cytarabine versus IFN alone in chronic myelogenous leukemia","volume":"337","author":"Guilhot","year":"1997","journal-title":"N Engl J Med."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib33","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1182\/blood.V99.5.1527","article-title":"A randomized study of IFN-alpha versus IFN-alpha and low-dose arabinosyl cytosine in chronic myeloid leukemia","volume":"99","author":"Baccarani","year":"2002","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib34","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1182\/blood.V63.4.789.789","article-title":"Prognostic discrimination in \u201dgood-risk\u201d chronic granulocytic leukemia","volume":"63","author":"Sokal","year":"1984","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib35","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1093\/jnci\/90.11.850","article-title":"A new prognostic score for survival of patients with chronic myeloid leukemia treated with interferon alfa","volume":"90","author":"Hasford","year":"1998","journal-title":"J Natl Cancer Inst."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib36","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/S0140-6736(95)92596-1","article-title":"UK Medical Research Council randomised, multicentre trial of interferon-alpha n1 for chronic myeloid leukaemia: improved survival irrespective of cytogenetic response","volume":"345","author":"Allan","year":"1995","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib37","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1182\/blood.V66.6.1352.1352","article-title":"Prognostic discrimination among younger patients with chronic granulocytic leukemia: relevance to bone marrow transplantation","volume":"66","author":"Sokal","year":"1985","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib38","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1136\/bmj.1.5586.201","article-title":"Report of the Medical Research Council's Working Party for Therapeutic Trials in Leukaemia","volume":"1","year":"1968","journal-title":"Br Med J"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib39","first-page":"1493","article-title":"Chronic myelogenous leukemia","volume":"82","author":"Minot","year":"1924","journal-title":"JAMA"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2141.1993.tb08672.x","article-title":"Hydroxyurea treatment for chronic myeloid leukaemia during pregnancy","volume":"85","author":"Jackson","year":"1993","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib41","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1182\/blood.V84.12.4064.bloodjournal84124064","article-title":"Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia","volume":"84","author":"Hehlmann","year":"1994","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib42","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1056\/NEJM199403243301204","article-title":"Interferon alfa-2a as compared with conventional chemotherapy for the treatment of chronic myeloid leukemia","volume":"330","year":"1994","journal-title":"N Engl J Med."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib43","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1182\/blood.V86.3.906.906","article-title":"A randomized trial comparing interferon-alpha with busulfan for newly diagnosed chronic myelogenous leukemia in chronic phase","volume":"86","author":"Ohnishi","year":"1995","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib44","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1093\/jnci\/89.21.1616","article-title":"Interferon alfa versus chemotherapy for chronic myeloid leukemia: a meta-analysis of seven randomized trials","volume":"89","year":"1997","journal-title":"J Natl Cancer Inst."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib45","first-page":"1517","article-title":"An evidence-based analysis of the effect of busulfan, hydroxyurea, interferon, and allogeneic bone marrow transplantation in treating the chronic phase of chronic myeloid leukemia: developed for the American Society of Hematology","volume":"94","author":"Silver","year":"1999","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib46","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1182\/blood.V87.4.1549.bloodjournal8741549","article-title":"Quantification of residual disease in chronic myelogenous leukemia patients on interferon-alpha therapy by competitive polymerase chain reaction","volume":"87","author":"Hochhaus","year":"1996","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib47","doi-asserted-by":"crossref","first-page":"254","DOI":"10.7326\/0003-4819-122-4-199502150-00003","article-title":"Prolonged survival in chronic myelogenous leukemia after cytogenetic response to interferon-alpha therapy","volume":"122","author":"Kantarjian","year":"1995","journal-title":"Ann Intern Med."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib48","doi-asserted-by":"crossref","first-page":"3074","DOI":"10.1182\/blood.V98.10.3074","article-title":"Chronic myeloid leukemia and interferon-alpha: a study of complete cytogenetic responders","volume":"98","author":"Bonifazi","year":"2001","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib49","first-page":"904a","article-title":"Molecular responder patients in chronic myeloid leukemia are mainly cured after treatment by interferon alpha","volume":"102","author":"Mahon","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib50","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1200\/JCO.2002.20.1.214","article-title":"Follow-up of complete cytogenetic remission in patients with chronic myeloid leukemia after cessation of interferon alfa","volume":"20","author":"Mahon","year":"2002","journal-title":"J Clin Oncol."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib51","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0950-3536(97)80008-X","article-title":"The M.D. Anderson Cancer Center experience with interferon-alpha therapy in chronic myelogenous leukaemia","volume":"10","author":"Talpaz","year":"1997","journal-title":"Baillieres Clin Haematol."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib52","doi-asserted-by":"crossref","first-page":"4408","DOI":"10.1182\/blood-2003-10-3605","article-title":"Randomized comparison of low-dose versus high-dose interferon-alfa in chronic myeloid leukemia: prospective collaboration of 3 joint trials by the MRC and HOVON groups","volume":"103","author":"Kluin-Nelemans","year":"2004","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib53","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1056\/NEJM198601233140403","article-title":"Bone marrow transplantation for patients with chronic myeloid leukemia","volume":"314","author":"Goldman","year":"1986","journal-title":"N Engl J Med."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib54","first-page":"421","article-title":"Bone marrow transplantation for chronic myeloid leukemia: the use of histocompatible unrelated volunteer donors","volume":"18","author":"Mackinnon","year":"1990","journal-title":"Exp Hematol."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib55","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1056\/NEJM199804023381405","article-title":"Bone marrow transplants from unrelated donors for patients with chronic myeloid leukemia","volume":"338","author":"Hansen","year":"1998","journal-title":"N Engl J Med."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib56","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1182\/blood.V76.12.2462.2462","article-title":"Donor leukocyte transfusions for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients","volume":"76","author":"Kolb","year":"1990","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib57","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1056\/NEJM199810223391702","article-title":"Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype","volume":"339","author":"Aversa","year":"1998","journal-title":"N Engl J Med."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib58","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1200\/JCO.1997.15.2.433","article-title":"Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation","volume":"15","author":"Collins","year":"1997","journal-title":"J Clin Oncol."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib59","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1182\/blood.V96.8.2712","article-title":"Durability of responses following donor lymphocyte infusions for patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia","volume":"96","author":"Dazzi","year":"2000","journal-title":"Blood"},{"issue":"Suppl 1","key":"10.1053\/j.seminhematol.2010.07.001_bib60","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1080\/10245330512331390122","article-title":"DLI: where are we now?","volume":"10","author":"Kolb","year":"2005","journal-title":"Hematology"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib61","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/sj.bmt.1703883","article-title":"Factors predicting response and graft-versus-host disease after donor lymphocyte infusions: a study on 593 infusions","volume":"31","author":"Raiola","year":"2003","journal-title":"Bone Marrow Transplant"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib62","doi-asserted-by":"crossref","first-page":"4518","DOI":"10.1016\/S0021-9258(18)42864-5","article-title":"Selective interactions of transforming and normal abl proteins with ATP, tyrosine-copolymer substrates, and tyrphostins","volume":"267","author":"Anafi","year":"1992","journal-title":"J Biol Chem."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib63","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nm0596-561","article-title":"Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells","volume":"2","author":"Druker","year":"1996","journal-title":"Nat Med."},{"key":"10.1053\/j.seminhematol.2010.07.001_bib64","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1182\/blood.V90.9.3691","article-title":"The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL positive cells","volume":"90","author":"Deininger","year":"1997","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.07.001_bib65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1172\/JCI9083","article-title":"Lessons learned from the development of an Abl tyrosine kinase inhibitor for chronic myelogenous leukemia","volume":"105","author":"Druker","year":"2000","journal-title":"J Clin Invest."}],"container-title":["Seminars in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196310000831?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196310000831?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T06:20:26Z","timestamp":1758522026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0037196310000831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["S0037196310000831"],"URL":"https:\/\/doi.org\/10.1053\/j.seminhematol.2010.07.001","relation":{},"ISSN":["0037-1963"],"issn-type":[{"value":"0037-1963","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic Myeloid Leukemia: A Historical Perspective","name":"articletitle","label":"Article Title"},{"value":"Seminars in Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminhematol.2010.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}