{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:01:51Z","timestamp":1791295311125,"version":"4.1.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Hematology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1053\/j.seminhematol.2010.11.003","type":"journal-article","created":{"date-parts":[[2011,1,12]],"date-time":"2011-01-12T05:43:28Z","timestamp":1294811008000},"page":"4-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":81,"title":["Pathogenesis of Monoclonal Gammopathy of Undetermined Significance and Progression to Multiple Myeloma"],"prefix":"10.1053","volume":"48","author":[{"given":"Adriana","family":"Zingone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Michael","family":"Kuehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminhematol.2010.11.003_bib1","first-page":"225","article-title":"Cancer statistics, 2009","volume":"59","author":"Jemal","year":"2009","journal-title":"CA Cancer J Clin"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib2","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.3324\/haematol.2009.013961","article-title":"The significance of monoclonal gammopathy of undetermined significance","volume":"94","author":"Kyle","year":"2009","journal-title":"Haematologica"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.blre.2007.01.002","article-title":"Monoclonal gammopathy of undetermined significance and smoldering multiple myeloma","volume":"21","author":"Rajkumar","year":"2007","journal-title":"Blood Rev"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib4","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nri1572","article-title":"Regulation of plasma-cell development","volume":"5","author":"Shapiro-Shelef","year":"2005","journal-title":"Nat Rev Immunol"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib5","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1182\/blood-2002-10-3161","article-title":"Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation","volume":"102","author":"Tarte","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib6","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrc746","article-title":"Multiple myeloma: evolving genetic events and host interactions","volume":"2","author":"Kuehl","year":"2002","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib7","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1056\/NEJMoa054494","article-title":"Prevalence of monoclonal gammopathy of undetermined significance","volume":"354","author":"Kyle","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib8","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1365-2141.2010.08207.x","article-title":"Monoclonal gammopathy of undetermined significance: a consensus statement","volume":"150","author":"Berenson","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib9","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/S0140-6736(10)60482-5","article-title":"Prevalence and risk of progression of light-chain monoclonal gammopathy of undetermined significance: a retrospective population-based cohort study","volume":"375","author":"Dispenzieri","year":"2010","journal-title":"Lancet"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib10","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1634\/theoncologist.11-7-824","article-title":"Primary (AL) amyloidosis in plasma cell disorders","volume":"11","author":"Muller","year":"2006","journal-title":"Oncologist"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib11","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1182\/blood-2003-03-0801","article-title":"Long-term follow-up of IgM monoclonal gammopathy of undetermined significance","volume":"102","author":"Kyle","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib12","doi-asserted-by":"crossref","first-page":"5418","DOI":"10.1182\/blood-2008-12-195008","article-title":"A monoclonal gammopathy precedes multiple myeloma in most patients","volume":"113","author":"Weiss","year":"2009","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib13","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1182\/blood-2005-08-3449","article-title":"Risk of monoclonal gammopathy of undetermined significance (MGUS) and subsequent multiple myeloma among African American and white veterans in the United States","volume":"107","author":"Landgren","year":"2006","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib14","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1182\/blood-2008-12-191676","article-title":"Risk of plasma cell and lymphoproliferative disorders among 14621 first-degree relatives of 4458 patients with monoclonal gammopathy of undetermined significance in Sweden","volume":"114","author":"Landgren","year":"2009","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib15","doi-asserted-by":"crossref","first-page":"5412","DOI":"10.1182\/blood-2008-12-194241","article-title":"Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study","volume":"113","author":"Landgren","year":"2009","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib16","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1182\/blood-2007-08-108357","article-title":"Immunoglobulin free light chain ratio is an independent risk factor for progression of smoldering (asymptomatic) multiple myeloma","volume":"111","author":"Dispenzieri","year":"2008","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib17","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1046\/j.1365-2141.2003.04654.x","article-title":"Smoldering multiple myeloma: natural history and recognition of an evolving type","volume":"123","author":"Rosinol","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib18","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/leu.2010.60","article-title":"Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management","volume":"24","author":"Kyle","year":"2010","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib19","doi-asserted-by":"crossref","first-page":"248","DOI":"10.3816\/CLML.2010.n.053","article-title":"Smoldering (asymptomatic) multiple myeloma: revisiting the clinical dilemma and looking into the future","volume":"10","author":"Waxman","year":"2010","journal-title":"Clin Lymphoma Myeloma Leuk"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib20","first-page":"1655","article-title":"Immunophenotypic characterization of plasma cells from monoclonal gammopathy of undetermined significance patients","volume":"152","author":"Ocqueteau","year":"1998","journal-title":"Am J Pathol"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib21","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-2141.2010.08121.x","article-title":"Review of phenotypic markers used in flow cytometric analysis of MGUS and MM, and applicability of flow cytometry in other plasma cell disorders","volume":"149","author":"Raja","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib22","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1182\/blood.V99.5.1745","article-title":"Global gene expression profiling of multiple myeloma, monoclonal gammopathy of undetermined significance, and normal bone marrow plasma cells","volume":"99","author":"Zhan","year":"2002","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib23","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1182\/blood-2002-06-1737","article-title":"Gene expression profiling of human plasma cell differentiation and classification of multiple myeloma based on similarities to distinct stages of late-stage B-cell development","volume":"101","author":"Zhan","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib24","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1182\/blood-2006-07-037077","article-title":"Gene-expression signature of benign monoclonal gammopathy evident in multiple myeloma is linked to good prognosis","volume":"109","author":"Zhan","year":"2007","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib25","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.beha.2007.08.004","article-title":"Genetic events in the pathogenesis of multiple myeloma","volume":"20","author":"Chng","year":"2007","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib26","doi-asserted-by":"crossref","first-page":"12885","DOI":"10.1073\/pnas.0806202105","article-title":"MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis","volume":"105","author":"Pichiorri","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ydbio.2006.08.028","article-title":"microRNAs as oncogenes and tumor suppressors","volume":"302","author":"Zhang","year":"2007","journal-title":"Dev Biol"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1126\/science.1091903","article-title":"MicroRNAs modulate hematopoietic lineage differentiation","volume":"303","author":"Chen","year":"2004","journal-title":"Science"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib29","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00277-009-0818-3","article-title":"DNA methylation analysis of tumor suppressor genes in monoclonal gammopathy of undetermined significance","volume":"89","author":"Stanganelli","year":"2010","journal-title":"Ann Hematol"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib30","doi-asserted-by":"crossref","first-page":"6934","DOI":"10.1158\/0008-5472.CAN-10-0282","article-title":"DNA methylation analysis determines the high frequency of genic hypomethylation and low frequency of hypermethylation events in plasma cell tumors","volume":"70","author":"Salhia","year":"2010","journal-title":"Cancer Res"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib31","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1751-553X.2009.01146.x","article-title":"Detecting methylation patterns of p16, MGMT, DAPK and E-cadherin genes in multiple myeloma patients","volume":"32","author":"Yuregir","year":"2009","journal-title":"Int J Lab Hematol"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib32","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1158\/1078-0432.CCR-03-0716","article-title":"DNA methylation profiles of lymphoid and hematopoietic malignancies","volume":"10","author":"Takahashi","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib33","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1038\/sj.thj.6200084","article-title":"p16\/INK4a gene inactivation by hypermethylation is associated with aggressive variants of monoclonal gammopathies","volume":"2","author":"Mateos","year":"2001","journal-title":"Hematol J"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib34","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1182\/blood-2006-09-049510","article-title":"Methylation and expression of the p16INK4A tumor suppressor gene in multiple myeloma","volume":"109","author":"Dib","year":"2007","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib35","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1182\/blood-2006-05-024661","article-title":"Tumor suppressor p16 methylation in multiple myeloma: biological and clinical implications","volume":"109","author":"Gonzalez-Paz","year":"2007","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib36","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1182\/blood-2005-03-1038","article-title":"Serum free light chain ratio is an independent risk factor for progression in monoclonal gammopathy of undetermined significance","volume":"106","author":"Rajkumar","year":"2005","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib37","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1182\/blood-2007-05-088443","article-title":"New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells","volume":"110","author":"Perez-Persona","year":"2007","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib38","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1365-2141.2009.07929.x","article-title":"Risk of progression in smouldering myeloma and monoclonal gammopathies of unknown significance: comparative analysis of the evolution of monoclonal component and multiparameter flow cytometry of bone marrow plasma cells","volume":"148","author":"Perez-Persona","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib39","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.3324\/haematol.2009.011064","article-title":"Timing of acquisition of deletion 13 in plasma cell dyscrasias is dependent on genetic context","volume":"94","author":"Chiecchio","year":"2009","journal-title":"Haematologica"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib40","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1038\/leu.2009.174","article-title":"International Myeloma Working Group molecular classification of multiple myeloma: spotlight review","volume":"23","author":"Fonseca","year":"2009","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib41","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/em.20528","article-title":"Centrosomes and myeloma; aneuploidy and proliferation","volume":"50","author":"Chng","year":"2009","journal-title":"Environ Mol Mutagen"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib42","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2005-01-0034","article-title":"Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma","volume":"106","author":"Bergsagel","year":"2005","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib43","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1182\/blood.V99.6.2185","article-title":"Oncogenesis of multiple myeloma: 14q32 and 13q chromosomal abnormalities are not randomly distributed, but correlate with natural history, immunological features, and clinical presentation","volume":"99","author":"Avet-Loiseau","year":"2002","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib44","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1038\/sj.onc.1204641","article-title":"Chromosome translocations in multiple myeloma","volume":"20","author":"Bergsagel","year":"2001","journal-title":"Oncogene"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib45","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.dnarep.2006.05.012","article-title":"Distinguishing primary and secondary translocations in multiple myeloma","volume":"5","author":"Gabrea","year":"2006","journal-title":"DNA Repair (Amst)"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib46","first-page":"4546","article-title":"14q32 translocations and monosomy 13 observed in monoclonal gammopathy of undetermined significance delineate a multistep process for the oncogenesis of multiple myeloma","volume":"59","author":"Avet-Loiseau","year":"1999","journal-title":"Cancer Res"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib47","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood-2002-08-2436","article-title":"Translocation t(11;14)(q13;q32) is the hallmark of IgM, IgE, and nonsecretory multiple myeloma variants","volume":"101","author":"Avet-Loiseau","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib48","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1182\/blood-2007-11-122101","article-title":"Evaluation of the cytogenetic aberration pattern in amyloid light chain amyloidosis as compared with monoclonal gammopathy of undetermined significance reveals common pathways of karyotypic instability","volume":"111","author":"Bochtler","year":"2008","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib49","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1365-2141.2002.03438.x","article-title":"Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis","volume":"117","author":"Harrison","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib50","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1182\/blood.V98.7.2266","article-title":"Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis","volume":"98","author":"Hayman","year":"2001","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib51","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/gcc.20563","article-title":"Secondary genomic rearrangements involving immunoglobulin or MYC loci show similar prevalences in hyperdiploid and nonhyperdiploid myeloma tumors","volume":"47","author":"Gabrea","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib52","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1182\/blood.V98.10.3082","article-title":"Rearrangements of the c-myc oncogene are present in 15% of primary human multiple myeloma tumors","volume":"98","author":"Avet-Loiseau","year":"2001","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib53","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/gcc.10275","article-title":"Further cytogenetic characterization of multiple myeloma confirms that 14q32 translocations are a very rare event in hyperdiploid cases","volume":"38","author":"Smadja","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib54","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1182\/blood-2003-02-0493","article-title":"The recurrent IgH translocations are highly associated with nonhyperdiploid variant multiple myeloma","volume":"102","author":"Fonseca","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib55","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/sj.leu.2402125","article-title":"Deletions of chromosome 13 in multiple myeloma identified by interphase FISH usually denote large deletions of the q arm or monosomy","volume":"15","author":"Fonseca","year":"2001","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib56","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1182\/blood-2005-02-0761","article-title":"A validated FISH trisomy index demonstrates the hyperdiploid and nonhyperdiploid dichotomy in MGUS","volume":"106","author":"Chng","year":"2005","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib57","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1038\/sj.leu.2401909","article-title":"Deletions of chromosome 13q in monoclonal gammopathy of undetermined significance","volume":"14","author":"Konigsberg","year":"2000","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib58","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ccr.2007.07.003","article-title":"Promiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myeloma","volume":"12","author":"Keats","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib59","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ccr.2007.07.004","article-title":"Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma","volume":"12","author":"Annunziata","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib60","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1182\/blood-2004-03-0833","article-title":"Possible roles for activating RAS mutations in the MGUS to MM transition and in the intramedullary to extramedullary transition in some plasma cell tumors","volume":"105","author":"Rasmussen","year":"2005","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib61","doi-asserted-by":"crossref","first-page":"2280","DOI":"10.1038\/leu.2008.142","article-title":"Clinical and biological significance of RAS mutations in multiple myeloma","volume":"22","author":"Chng","year":"2008","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib62","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/humu.1177","article-title":"High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis","volume":"18","author":"Bezieau","year":"2001","journal-title":"Hum Mutat"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib63","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/ng.115","article-title":"Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon","volume":"40","author":"Haigis","year":"2008","journal-title":"Nat Genet"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib64","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ccr.2008.01.007","article-title":"AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies","volume":"13","author":"Chesi","year":"2008","journal-title":"Cancer Cell"},{"key":"10.1053\/j.seminhematol.2010.11.003_bib65","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1093\/jncimonographs\/lgn011","article-title":"Characterization of MYC translocations in multiple myeloma cell lines","author":"Dib","year":"2008","journal-title":"J Natl Cancer Inst Monogr"}],"container-title":["Seminars in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003719631000106X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003719631000106X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T06:20:57Z","timestamp":1758522057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003719631000106X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S003719631000106X"],"URL":"https:\/\/doi.org\/10.1053\/j.seminhematol.2010.11.003","relation":{},"ISSN":["0037-1963"],"issn-type":[{"value":"0037-1963","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathogenesis of Monoclonal Gammopathy of Undetermined Significance and Progression to Multiple Myeloma","name":"articletitle","label":"Article Title"},{"value":"Seminars in Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminhematol.2010.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}