{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T18:22:28Z","timestamp":1792606948081,"version":"4.5.0"},"reference-count":83,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Hematology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1053\/j.seminhematol.2012.01.003","type":"journal-article","created":{"date-parts":[[2012,3,24]],"date-time":"2012-03-24T11:25:58Z","timestamp":1332588358000},"page":"138-148","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":41,"title":["Lymphoproliferative Disorders Associated With Hypereosinophilia"],"prefix":"10.1053","volume":"49","author":[{"given":"Florence","family":"Roufosse","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soizic","family":"Garaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"de Leval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminhematol.2012.01.003_bib1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jaci.2010.04.011","article-title":"Practical approach to the patient with hypereosinophilia","volume":"126","author":"Roufosse","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1081-1206(10)62426-X","article-title":"T-cell subsets (Th1 versus Th2)","volume":"85","author":"Romagnani","year":"2000","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib3","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/ajh.20789","article-title":"Non-small-cell lung cancer associated with excessive eosinophilia and secretion of interleukin-5 as a paraneoplastic syndrome","volume":"82","author":"Pandit","year":"2007","journal-title":"Am J Hematol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0065-2776(08)01003-1","article-title":"Biology of the eosinophil","volume":"101","author":"Blanchard","year":"2009","journal-title":"Adv Immunol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib5","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.iac.2007.07.001","article-title":"Cardiovascular manifestations of hypereosinophilic syndromes","volume":"27","author":"Ogbogu","year":"2007","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib6","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1034\/j.1600-0609.2003.00051.x","article-title":"Peripheral T-cell lymphoma associated consecutively with hemophagocytic lymphohistiocytosis and hypereosinophilic syndrome","volume":"71","author":"Gutierrez","year":"2003","journal-title":"Eur J Haematol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib7","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.iac.2007.06.001","article-title":"Chronic eosinophilic leukemias and the myeloproliferative variant of the hypereosinophilic syndrome","volume":"27","author":"Bain","year":"2007","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib8","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1172\/JCI24826","article-title":"Immunopathogenesis and therapy of cutaneous T cell lymphoma","volume":"115","author":"Kim","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib9","doi-asserted-by":"crossref","first-page":"68","DOI":"10.2340\/00015555-0786","article-title":"Leukaemic cutaneous T-cell lymphoma-manifesting papuloerythroderma with CD3(-) CD4(+) phenotype","volume":"90","author":"Shimauchi","year":"2010","journal-title":"Acta Derm Venereol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib10","doi-asserted-by":"crossref","first-page":"372","DOI":"10.7326\/0003-4819-109-5-372","article-title":"Histopathologic staging at initial diagnosis of mycosis fungoides and the Sezary syndrome","volume":"109","author":"Sausville","year":"1988","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jaad.2004.03.003","article-title":"In situ eosinophil activation in 26 primary cutaneous T-cell lymphomas with blood eosinophilia","volume":"52","author":"Ionescu","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib12","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1001\/archderm.140.9.1057","article-title":"Prognostic value of blood eosinophilia in primary cutaneous T-cell lymphomas","volume":"140","author":"Tancrede-Bohin","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib13","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/1523-1747.ep12611877","article-title":"Aberrant cytokine production by Sezary syndrome patients: cytokine secretion pattern resembles murine Th2 cells","volume":"99","author":"Vowels","year":"1992","journal-title":"J Invest Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib14","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/1523-1747.ep12398454","article-title":"Th2 cytokine mRNA expression in skin in cutaneous T-cell lymphoma","volume":"103","author":"Vowels","year":"1994","journal-title":"J Invest Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib15","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.4049\/jimmunol.163.7.4073","article-title":"Depressed IL-12-mediated signal transduction in T cells from patients with Sezary syndrome is associated with the absence of IL-12 receptor beta 2 mRNA and highly reduced levels of STAT4","volume":"163","author":"Showe","year":"1999","journal-title":"J Immunol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib16","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1182\/blood.V88.4.1383.bloodjournal8841383","article-title":"Sezary syndrome T-cell clones display T-helper 2 cytokines and express the accessory factor-1 (interferon-gamma receptor beta-chain)","volume":"88","author":"Dummer","year":"1996","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib17","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1080\/10428190801910920","article-title":"Cardiac involvement with mycosis fungoides: could this explain alemtuzumab toxicity?","volume":"49","author":"Sleigh","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib18","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1111\/j.1365-4632.2007.03190.x","article-title":"Erythrodermic cutaneous T cell lymphoma with hypereosinophilic syndrome: treatment with interferon alfa and extracorporeal photopheresis","volume":"46","author":"Lee","year":"2007","journal-title":"Int J Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib19","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1038\/jid.2010.128","article-title":"Eotaxins and CCR3 interaction regulates the Th2 environment of cutaneous T-cell lymphoma","volume":"130","author":"Miyagaki","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1067\/mjd.2003.132","article-title":"Thymus and activation-regulated chemokine (TARC\/CCL17) in mycosis fungoides: serum TARC levels reflect the disease activity of mycosis fungoides","volume":"48","author":"Kakinuma","year":"2003","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib21","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1200\/JCO.2008.16.4558","article-title":"International peripheral T-cell and natural killer\/T-cell lymphoma study: pathology findings and clinical outcomes","volume":"26","author":"Vose","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib22","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1182\/blood-2007-08-105759","article-title":"Clinical, biologic, and pathologic features in 157 patients with angioimmunoblastic T-cell lymphoma treated within the Groupe d'Etude des Lymphomes de l'Adulte (GELA) trials","volume":"111","author":"Mourad","year":"2008","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib23","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1111\/j.1365-2141.2009.08003.x","article-title":"Advances in the understanding and management of angioimmunoblastic T-cell lymphoma","volume":"148","author":"de Leval","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1309\/28YP0DELGKEJGRXG","article-title":"Morphologic and immunophenotypic analysis of angioimmunoblastic T-cell lymphoma: emphasis on phenotypic aberrancies for early diagnosis","volume":"126","author":"Merchant","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib25","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1053\/j.semdp.2011.03.003","article-title":"Follicular helper T cells: implications in neoplastic hematopathology","volume":"28","author":"Gaulard","year":"2011","journal-title":"Semin Diagn Pathol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib26","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/j.leukres.2008.02.016","article-title":"TARC and IL-5 expression correlates with tissue eosinophilia in peripheral T-cell lymphomas","volume":"32","author":"Thielen","year":"2008","journal-title":"Leuk Res"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib27","doi-asserted-by":"crossref","first-page":"541","DOI":"10.3109\/10428190009059273","article-title":"Cytoplasmic cytokines in lymphoproliferative disorders: multiple cytokine production in angioimmunoblastic lymphadenopathy with dysproteinemia","volume":"38","author":"Ohshima","year":"2000","journal-title":"Leuk Lymphoma"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib28","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1081\/JCMR-200053524","article-title":"Heart involvement in T cell lymphoma through hypereosinophilic syndrome: a common complication of a rare condition","volume":"7","author":"Genovesi-Ebert","year":"2005","journal-title":"J Cardiovasc Magn Reson"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib29","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1136\/jcp.2007.052456","article-title":"Adult T-cell leukaemia\/lymphoma","volume":"60","author":"Matutes","year":"2007","journal-title":"J Clin Pathol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib30","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/j.1349-7006.2010.01833.x","article-title":"Leukemic T cells are specifically enriched in a unique CD3(dim) CD7(low) subpopulation of CD4(+) T cells in acute-type adult T-cell leukemia","volume":"102","author":"Tian","year":"2011","journal-title":"Cancer Sci"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib31","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1002\/1097-0142(19920215)69:4<966::AID-CNCR2820690422>3.0.CO;2-H","article-title":"Frequency of eosinophilia in adult T-cell leukemia\/lymphoma","volume":"69","author":"Murata","year":"1992","journal-title":"Cancer"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib32","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.leukres.2006.10.017","article-title":"Clinical significance of a blood eosinophilia in adult T-cell leukemia\/lymphoma: a blood eosinophilia is a significant unfavorable prognostic factor","volume":"31","author":"Utsunomiya","year":"2007","journal-title":"Leuk Res"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib33","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.169.5.1853","article-title":"Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related","volume":"169","author":"Noma","year":"1989","journal-title":"J Exp Med"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib34","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/(SICI)1096-8652(199811)59:3<242::AID-AJH11>3.0.CO;2-O","article-title":"Eosinophilia associated with adult T-cell leukemia: role of interleukin 5 and granulocyte-macrophage colony-stimulating factor","volume":"59","author":"Ogata","year":"1998","journal-title":"Am J Hematol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1159\/000204689","article-title":"Adult T cell leukemia associated with eosinophilia: analysis of eosinophil-stimulating factors produced by leukemic cells","volume":"88","author":"Yano","year":"1992","journal-title":"Acta Haematol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib36","first-page":"671","article-title":"Activation of the GM-CSF promoter by HTLV-I and -II tax proteins","volume":"4","author":"Nimer","year":"1989","journal-title":"Oncogene"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib37","doi-asserted-by":"crossref","first-page":"4272","DOI":"10.1128\/MCB.17.8.4272","article-title":"Triple synergism of human T-lymphotropic virus type 1-encoded tax, GATA-binding protein, and AP-1 is required for constitutive expression of the interleukin-5 gene in adult T-cell leukemia cells","volume":"17","author":"Yamagata","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib38","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1002\/1097-0142(19881015)62:8<1527::AID-CNCR2820620813>3.0.CO;2-X","article-title":"Eosinophilia associated with adult T-cell leukemia\/lymphoma","volume":"62","author":"Vukelja","year":"1988","journal-title":"Cancer"},{"issue":"Suppl 1","key":"10.1053\/j.seminhematol.2012.01.003_bib39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.0303-6987.2006.00548.x","article-title":"CD30+ lymphoproliferative disorders: histopathology, differential diagnosis, new variants, and simulators","volume":"33","author":"Kempf","year":"2006","journal-title":"J Cutan Pathol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib40","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1046\/j.1365-2559.1998.00335.x","article-title":"Anaplastic large cell malignant lymphoma with extensive eosinophilic or neutrophilic infiltration","volume":"32","author":"McCluggage","year":"1998","journal-title":"Histopathology"},{"issue":"5 Suppl","key":"10.1053\/j.seminhematol.2012.01.003_bib41","doi-asserted-by":"crossref","first-page":"S133","DOI":"10.1067\/mjd.2002.107233","article-title":"Necrotic cutaneous lesions induced by hypereosinophilic syndrome secondary to a T-cell lymphoma","volume":"46","author":"Aractingi","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib42","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1177\/1066896908323969","article-title":"Peripheral eosinophilia camouflaging anaplastic large cell lymphoma","volume":"19","author":"Powers","year":"2011","journal-title":"Int J Surg Pathol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib43","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1111\/j.1600-0560.2007.00778.x","article-title":"The morphologic spectrum of primary cutaneous anaplastic large T-cell lymphoma: a histopathologic study on 66 biopsy specimens from 47 patients with report of rare variants","volume":"35","author":"Massone","year":"2008","journal-title":"J Cutan Pathol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib44","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2559.2009.03359.x","article-title":"Neutrophil\/eosinophil-rich type of primary cutaneous anaplastic large cell lymphoma: a clinicopathological, immunophenotypic and molecular study of nine cases","volume":"55","author":"Kong","year":"2009","journal-title":"Histopathology"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib45","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1182\/blood-2002-02-0475","article-title":"Functional expression of the eotaxin receptor CCR3 in CD30+ cutaneous T-cell lymphoma","volume":"101","author":"Kleinhans","year":"2003","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib46","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0190-9622(88)70049-3","article-title":"Lymphomatoid papulosis and its relationship to \u201cidiopathic\u201d hypereosinophilic syndrome","volume":"18","author":"Whittaker","year":"1988","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib47","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/j.1365-2133.2006.07416.x","article-title":"Platelet-derived growth factor receptor-alpha-associated hypereosinophilic syndrome and lymphomatoid papulosis","volume":"155","author":"McPherson","year":"2006","journal-title":"Br J Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib48","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/j.1468-3083.2009.03382.x","article-title":"Chronic eosinophilic leukaemia revealed by lymphomatoid papulosis: the role of the FIP1-like 1-platelet-derived growth factor receptor alpha fusion gene","volume":"24","author":"Thuny","year":"2010","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib49","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/1523-1747.ep12330845","article-title":"Th2 cytokine mRNA expression in primary cutaneous CD30-positive lymphoproliferative disorders: successful treatment with recombinant interferon-gamma","volume":"107","author":"Yagi","year":"1996","journal-title":"J Invest Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib50","first-page":"155","article-title":"Intestinal T-cell lymphoma with massive tissue and blood eosinophilia mediated by IL-5","volume":"17","author":"Gallamini","year":"1995","journal-title":"Leuk Lymphoma"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib51","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2559.1987.tb02616.x","article-title":"Malignant lymphoma with eosinophilia of the gastrointestinal tract","volume":"11","author":"Shepherd","year":"1987","journal-title":"Histopathology"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib52","first-page":"25","article-title":"Enteropathy-associated T-cell lymphoma presenting with eosinophilia","volume":"61","author":"Hovenga","year":"2003","journal-title":"Neth J Med"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib53","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.critrevonc.2010.07.007","article-title":"Peripheral T-cell lymphoma\u2014not otherwise specified","volume":"79","author":"Savage","year":"2010","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib54","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1309\/AJCP0SBHYVLY5EML","article-title":"Expression of master regulators of helper T-cell differentiation in peripheral T-cell lymphoma, not otherwise specified, by immunohistochemical analysis","volume":"133","author":"Matsumoto","year":"2010","journal-title":"Am J Clin Pathol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib55","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1177\/030089169107700616","article-title":"A case of T-cell lymphoma accompanying marked eosinophilia, chronic eosinophilic pneumonia and eosinophilic pleural effusion","volume":"77","author":"Kawasaki","year":"1991","journal-title":"Tumori"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib56","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.iac.2007.07.002","article-title":"Lymphocytic variant hypereosinophilic syndromes","volume":"27","author":"Roufosse","year":"2007","journal-title":"Immunol Allergy Clin North Am"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib57","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.leukres.2006.10.005","article-title":"'Idiopathic' eosinophilia with an Occult T-cell clone: prevalence and clinical course","volume":"31","author":"Vaklavas","year":"2007","journal-title":"Leuk Res"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib58","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1056\/NEJM199910073411503","article-title":"Abnormal clones of T cells producing interleukin-5 in idiopathic eosinophilia","volume":"341","author":"Simon","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib59","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1084\/jem.183.3.1071","article-title":"Expansion of cytokine-producing CD4\u2212CD8\u2212 T cells associated with abnormal Fas expression and hypereosinophilia","volume":"183","author":"Simon","year":"1996","journal-title":"J Exp Med"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib60","doi-asserted-by":"crossref","first-page":"4285","DOI":"10.1182\/blood.V96.13.4285","article-title":"Interferon alpha prevents spontaneous apoptosis of clonal Th2 cells associated with chronic hypereosinophilia","volume":"96","author":"Schandene","year":"2000","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib61","first-page":"753","article-title":"6q- is an early and persistent chromosomal aberration in CD3\u2212CD4+ T-cell clones associated with the lymphocytic variant of hypereosinophilic syndrome","volume":"90","author":"Ravoet","year":"2005","journal-title":"Haematologica"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib62","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1182\/blood-2008-08-175091","article-title":"Molecular profiling of CD3\u2212CD4+ T cells from patients with the lymphocytic variant of hypereosinophilic syndrome reveals targeting of growth control pathways","volume":"114","author":"Ravoet","year":"2009","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib63","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1001\/archderm.141.3.361","article-title":"Monoclonal T-cell dyscrasia of undetermined significance associated with recalcitrant erythroderma","volume":"141","author":"Gniadecki","year":"2005","journal-title":"Arch Dermatol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib64","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1002\/1097-0142(19891015)64:8<1682::AID-CNCR2820640821>3.0.CO;2-X","article-title":"B-cell lymphoma associated with eosinophilia","volume":"64","author":"Watanabe","year":"1989","journal-title":"Cancer"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib65","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1365-2141.2010.08394.x","article-title":"Molecular characterization of paediatric idiopathic hypereosinophilia","volume":"151","author":"Rapanotti","year":"2010","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib66","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1365-2559.2010.03705.x","article-title":"The molecular pathogenesis of Hodgkin lymphoma","volume":"58","author":"Farrell","year":"2011","journal-title":"Histopathology"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib67","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1182\/blood.V93.8.2463","article-title":"Differential chemokine expression in tissues involved by Hodgkin's disease: direct correlation of eotaxin expression and tissue eosinophilia","volume":"93","author":"Teruya-Feldstein","year":"1999","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib68","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1111\/j.1365-2141.2007.06964.x","article-title":"Serum chemokine levels in Hodgkin lymphoma patients: highly increased levels of CCL17 and CCL22","volume":"140","author":"Niens","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib69","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/S0002-9440(10)65424-7","article-title":"High expression of the CC chemokine TARC in Reed-Sternberg cells","volume":"154","author":"van den Berg","year":"1999","journal-title":"Am J Pathol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib70","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1136\/jcp.40.3.247","article-title":"Selective peripheral blood eosinophilia associated with survival advantage in Hodgkin's disease (BNLI Report No 31)","volume":"40","author":"Vaughan Hudson","year":"1987","journal-title":"J Clin Pathol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib71","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1182\/blood.V75.1.13.13","article-title":"Detection of interleukin-5 messenger RNA in Reed-Sternberg cells of Hodgkin's disease with eosinophilia","volume":"75","author":"Samoszuk","year":"1990","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib72","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1159\/000237294","article-title":"Eosinophilia in Hodgkin's disease: a role for interleukin 5","volume":"110","author":"Di Biagio","year":"1996","journal-title":"Int Arch Allergy Immunol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib73","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1182\/blood-2010-01-265827","article-title":"Mechanisms of aberrant GATA3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed\/Sternberg cells","volume":"116","author":"Stanelle","year":"2010","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib74","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1182\/blood.V95.4.1207.004k34_1207_1213","article-title":"Tissue eosinophilia correlates strongly with poor prognosis in nodular sclerosing Hodgkin's disease, allowing for known prognostic factors","volume":"95","author":"von Wasielewski","year":"2000","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib75","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s00246-007-9135-6","article-title":"Mitral valve destruction by Hodgkin's lymphoma-associated Loefler endocarditis","volume":"29","author":"Yalonetsky","year":"2008","journal-title":"Pediatr Cardiol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib76","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/00005792-199007000-00005","article-title":"Acute lymphoblastic leukemia with eosinophilia","volume":"69","author":"Fishel","year":"1990","journal-title":"Medicine (Baltimore)"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib77","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1200\/JCO.1987.5.3.382","article-title":"Acute lymphoblastic leukemia with chromosomal 5;14 translocation and hypereosinophilia: case report and literature review","volume":"5","author":"Hogan","year":"1987","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib78","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1182\/blood.V42.3.377.377","article-title":"Lymphoblastic leukemia with marked eosinophilia: a report of two cases","volume":"42","author":"Spitzer","year":"1973","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib79","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1038\/sj.leu.2405096","article-title":"Two cases of hypereosinophilia and high-risk acute lymphoblastic leukemia","volume":"22","author":"Sutton","year":"2008","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib80","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1182\/blood.V76.2.285.285","article-title":"Activation of the interleukin-3 gene by chromosome translocation in acute lymphocytic leukemia with eosinophilia","volume":"76","author":"Meeker","year":"1990","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib81","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1756-8722-2-26","article-title":"Adult B lymphoblastic leukaemia\/lymphoma with hypodiploidy (\u22129) and a novel chromosomal translocation t(7;12)(q22;p13) presenting with severe eosinophilia\u2014case report and review of literature","volume":"2","author":"Bhatti","year":"2009","journal-title":"J Hematol Oncol"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib82","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1002\/1097-0142(19840915)54:6<1058::AID-CNCR2820540621>3.0.CO;2-0","article-title":"The hypereosinophilic syndrome in acute lymphocytic leukemia","volume":"54","author":"Troxell","year":"1984","journal-title":"Cancer"},{"key":"10.1053\/j.seminhematol.2012.01.003_bib83","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s00246-008-9360-7","article-title":"A child with eosinophilia, Loeffler endocarditis, and acute lymphoblastic leukemia","volume":"30","author":"Files","year":"2009","journal-title":"Pediatr Cardiol"}],"container-title":["Seminars in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196312000042?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196312000042?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T06:21:28Z","timestamp":1758522088000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0037196312000042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":83,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0037196312000042"],"URL":"https:\/\/doi.org\/10.1053\/j.seminhematol.2012.01.003","relation":{},"ISSN":["0037-1963"],"issn-type":[{"value":"0037-1963","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lymphoproliferative Disorders Associated With Hypereosinophilia","name":"articletitle","label":"Article Title"},{"value":"Seminars in Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminhematol.2012.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}