{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:39:50Z","timestamp":1791257990040,"version":"4.1.0"},"reference-count":95,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,7,1]],"date-time":"2014-07-01T00:00:00Z","timestamp":1404172800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Hematology"],"published-print":{"date-parts":[[2014,7]]},"DOI":"10.1053\/j.seminhematol.2014.05.002","type":"journal-article","created":{"date-parts":[[2014,5,15]],"date-time":"2014-05-15T12:01:17Z","timestamp":1400155277000},"page":"168-176","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["Microenvironmental Interactions in Chronic Lymphocytic Leukemia: The Master Role of CD49d"],"prefix":"10.1053","volume":"51","author":[{"given":"Michele","family":"Dal Bo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika","family":"Tissino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dania","family":"Benedetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Caldana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Bomben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Del Poeta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca Maria","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Zucchetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valter","family":"Gattei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminhematol.2014.05.002_bib1","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1056\/NEJMra041720","article-title":"Chronic lymphocytic leukemia","volume":"352","author":"Chiorazzi","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib2","doi-asserted-by":"crossref","first-page":"15524","DOI":"10.1073\/pnas.242606799","article-title":"Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia","volume":"99","author":"Calin","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib3","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ccr.2009.11.019","article-title":"The DLEU2\/miR-15a\/16-1 cluster controls B cell proliferation and its deletion leads to chronic lymphocytic leukemia","volume":"17","author":"Klein","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib4","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1146\/annurev.immunol.21.120601.141018","article-title":"B cell chronic lymphocytic leukemia: lessons learned from studies of the B cell antigen receptor","volume":"21","author":"Chiorazzi","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib5","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1182\/blood-2010-07-155663","article-title":"Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities","volume":"117","author":"Chiorazzi","year":"2011","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib6","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1200\/JCO.2013.50.8515","article-title":"CD49d is the strongest flow cytometry-based predictor of overall survival in chronic lymphocytic leukemia","volume":"32","author":"Bulian","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib7","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","article-title":"Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia","volume":"94","author":"Damle","year":"1999","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib8","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1056\/NEJM200012283432602","article-title":"Genomic aberrations and survival in chronic lymphocytic leukemia","volume":"343","author":"Dohner","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib9","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1182\/blood-2007-05-092486","article-title":"Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia","volume":"111","author":"Gattei","year":"2008","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib10","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","article-title":"genes are associated with a more aggressive form of chronic lymphocytic leukemia","volume":"94","author":"Hamblin","year":"1999","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib11","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1158\/1078-0432.CCR-08-1630","article-title":"The prognostic value of TP53 mutations in chronic lymphocytic leukemia is independent of Del17p13: implications for overall survival and chemorefractoriness","volume":"15","author":"Rossi","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib12","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1200\/JCO.2009.27.8762","article-title":"TP53 mutation and survival in chronic lymphocytic leukemia","volume":"28","author":"Zenz","year":"2010","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib13","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.2174\/138161212801227078","article-title":"Microenvironmental interactions in chronic lymphocytic leukemia: hints for pathogenesis and identification of targets for rational therapy","volume":"18","author":"Dal","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib14","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1182\/blood-2010-05-284984","article-title":"The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia","volume":"117","author":"Herishanu","year":"2011","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/S1470-2045(13)70513-8","article-title":"Ibrutinib as initial therapy for elderly patients with chronic lymphocytic leukaemia or small lymphocytic lymphoma: an open-label, multicentre, phase 1b\/2 trial","volume":"15","author":"O\u05f3Brien","year":"2014","journal-title":"Lancet Oncol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib16","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1182\/blood-2009-08-236471","article-title":"Inhibition of Syk with fostamatinib disodium has significant clinical activity in non-Hodgkin lymphoma and chronic lymphocytic leukemia","volume":"115","author":"Friedberg","year":"2010","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib17","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1182\/blood-2011-05-352492","article-title":"The phosphoinositide 3\u05f3-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia","volume":"118","author":"Hoellenriegel","year":"2011","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib18","doi-asserted-by":"crossref","first-page":"3121","DOI":"10.1158\/0008-5472.CAN-08-4136","article-title":"Circulating B-cell chronic lymphocytic leukemia cells display impaired migration to lymph nodes and bone marrow","volume":"69","author":"Hartmann","year":"2009","journal-title":"Cancer Res"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib19","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1046\/j.1365-2141.1996.00305.x","article-title":"Human bone marrow stromal cells prevent apoptosis and support the survival of chronic lymphocytic leukaemia cells in vitro","volume":"92","author":"Panayiotidis","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib20","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1182\/blood.V91.7.2387","article-title":"Chronic lymphocytic leukemic B cells but not normal B cells are rescued from apoptosis by contact with normal bone marrow stromal cells","volume":"91","author":"Lagneaux","year":"1998","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib21","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1046\/j.1365-2141.2003.04679.x","article-title":"Role of the microenvironment in chronic lymphocytic leukaemia","volume":"123","author":"Caligaris-Cappio","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib22","first-page":"135","article-title":"Differential effects on CLL cell survival exerted by different microenvironmental elements","volume":"294","author":"Ghia","year":"2005","journal-title":"Curr Top Microbiol Immunol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib23","doi-asserted-by":"crossref","first-page":"3367","DOI":"10.1182\/blood-2009-06-225326","article-title":"The microenvironment in mature B-cell malignancies: a target for new treatment strategies","volume":"114","author":"Burger","year":"2009","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib24","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1189\/jlb.71.3.495","article-title":"Engagement of alpha4beta1 integrin by fibronectin induces in vitro resistance of B chronic lymphocytic leukemia cells to fludarabine","volume":"71","author":"de la Fuente","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1034\/j.1600-065X.2002.18611.x","article-title":"Alpha4 integrins and the immune response","volume":"186","author":"Rose","year":"2002","journal-title":"Immunol Rev"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI114957","article-title":"Integrins","volume":"87","author":"Ruoslahti","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib27","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1083\/jcb.201008013","article-title":"EMILIN1-alpha4\/alpha9 integrin interaction inhibits dermal fibroblast and keratinocyte proliferation","volume":"195","author":"Danussi","year":"2011","journal-title":"J Cell Biol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib28","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.1128\/MCB.00872-13","article-title":"EMILIN1\/alpha9beta1 integrin interaction is crucial in lymphatic valve formation and maintenance","volume":"33","author":"Danussi","year":"2013","journal-title":"Mol Cell Biol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib29","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1182\/blood.V99.8.2977","article-title":"The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes","volume":"99","author":"Till","year":"2002","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib30","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1182\/blood-2004-10-4054","article-title":"but not normal, B cells are dependent on autocrine VEGF and alpha4beta1 integrin for chemokine-induced motility on and through endothelium","volume":"105","author":"Till","year":"2005","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib31","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.ccr.2009.12.044","article-title":"Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain","volume":"17","author":"Redondo-Munoz","year":"2010","journal-title":"Cancer Cell"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib32","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/sj.leu.2402472","article-title":"Production of matrix metalloproteinase-9 in early stage B-CLL: suppression by interferons","volume":"16","author":"Bauvois","year":"2002","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib33","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1365-2141.2004.04877.x","article-title":"The role of matrix metalloproteinase 9 in the pathogenesis of chronic lymphocytic leukaemia","volume":"125","author":"Kamiguti","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib34","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1182\/blood-2006-03-007294","article-title":"MMP-9 in B-cell chronic lymphocytic leukemia is up-regulated by alpha4beta1 integrin or CXCR4 engagement via distinct signaling pathways, localizes to podosomes, and is involved in cell invasion and migration","volume":"108","author":"Redondo-Munoz","year":"2006","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib35","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1182\/blood-2007-08-109249","article-title":"Alpha4beta1 integrin and 190-kDa CD44v constitute a cell surface docking complex for gelatinase B\/MMP-9 in chronic leukemic but not in normal B cells","volume":"112","author":"Redondo-Munoz","year":"2008","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib36","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.leukres.2010.10.022","article-title":"CD49d is an independent prognostic marker that is associated with CXCR4 expression in CLL","volume":"35","author":"Majid","year":"2011","journal-title":"Leuk Res"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib37","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0301-472X(00)00668-8","article-title":"Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-dependent adhesion to fibronectin and VCAM-1 on bone marrow hematopoietic progenitor cells","volume":"29","author":"Hidalgo","year":"2001","journal-title":"Exp Hematol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib38","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1182\/blood.V97.2.346","article-title":"Chemokine stromal cell-derived factor-1alpha modulates VLA-4 integrin-mediated multiple myeloma cell adhesion to CS-1\/fibronectin and VCAM-1","volume":"97","author":"Sanz-Rodriguez","year":"2001","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib39","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1158\/0008-5472.CAN-08-4173","article-title":"CD38\/CD31, the CCL3 and CCL4 chemokines, and CD49d\/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival","volume":"69","author":"Zucchetto","year":"2009","journal-title":"Cancer Res"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib40","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1359-6101(02)00045-X","article-title":"Macrophage inflammatory protein-1","volume":"13","author":"Menten","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib41","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1182\/blood-2008-07-170415","article-title":"High-level expression of the T-cell chemokines CCL3 and CCL4 by chronic lymphocytic leukemia B cells in nurselike cell cocultures and after BCR stimulation","volume":"113","author":"Burger","year":"2009","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib42","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0031-6997(24)01439-X","article-title":"International union of pharmacology. XXII. Nomenclature for chemokine receptors","volume":"52","author":"Murphy","year":"2000","journal-title":"Pharmacol Rev"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib43","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1189\/jlb.69.2.248","article-title":"Increase of CCR1 and CCR5 expression and enhanced functional response to MIP-1 alpha during differentiation of human monocytes to macrophages","volume":"69","author":"Kaufmann","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib44","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1182\/blood-2007-12-127688","article-title":"BCR ligation induced by IgM stimulation results in gene expression and functional changes only in IgV H unmutated chronic lymphocytic leukemia (CLL) cells","volume":"112","author":"Guarini","year":"2008","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib45","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1182\/blood.V96.8.2655","article-title":"Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1","volume":"96","author":"Burger","year":"2000","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib46","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1182\/blood.V99.3.1030","article-title":"Distinctive features of \"nurselike\" cells that differentiate in the context of chronic lymphocytic leukemia","volume":"99","author":"Tsukada","year":"2002","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib47","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/1521-4141(200205)32:5<1403::AID-IMMU1403>3.0.CO;2-Y","article-title":"Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22","volume":"32","author":"Ghia","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib48","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1046\/j.1365-2141.1999.01642.x","article-title":"Bryostatin and CD40-ligand enhance apoptosis resistance and induce expression of cell survival genes in B-cell chronic lymphocytic leukaemia","volume":"106","author":"Kitada","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib49","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1111\/j.1365-2141.2011.08725.x","article-title":"Evidence for a macromolecular complex in poor prognosis CLL that contains CD38, CD49d, CD44 and MMP-9","volume":"154","author":"Buggins","year":"2011","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib50","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1182\/blood-2006-12-061812","article-title":"CD38\/CD19: a lipid raft-dependent signaling complex in human B cells","volume":"109","author":"Deaglio","year":"2007","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/ncb0107-7","article-title":"Lipid rafts: at a crossroad between cell biology and physics","volume":"9","author":"Jacobson","year":"2007","journal-title":"Nat Cell Biol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib52","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0955-0674(98)80032-X","article-title":"Integrin associated proteins","volume":"10","author":"Hemler","year":"1998","journal-title":"Curr Opin Cell Biol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib53","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/leu.2011.369","article-title":"The CD49d\/CD29 complex is physically and functionally associated with CD38 in B-cell chronic lymphocytic leukemia cells","volume":"26","author":"Zucchetto","year":"2012","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib54","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.yexcr.2004.12.001","article-title":"Vav promotes differentiation of human tumoral myeloid precursors","volume":"306","author":"Bertagnolo","year":"2005","journal-title":"Exp Cell Res"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib55","doi-asserted-by":"crossref","first-page":"6372","DOI":"10.1038\/sj.onc.1204780","article-title":"Vav proteins, adaptors and cell signaling","volume":"20","author":"Bustelo","year":"2001","journal-title":"Oncogene"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib56","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0092-8674(95)90370-4","article-title":"Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia","volume":"81","author":"Nobes","year":"1995","journal-title":"Cell"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib57","doi-asserted-by":"crossref","first-page":"2391","DOI":"10.1182\/blood-2004-12-4894","article-title":"Vav proteins regulate peripheral B-cell survival","volume":"106","author":"Vigorito","year":"2005","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib58","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1182\/blood-2011-11-390989","article-title":"The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia","volume":"119","author":"de Rooij","year":"2012","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib59","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1182\/blood-2011-10-386417","article-title":"The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo","volume":"119","author":"Ponader","year":"2012","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib60","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1182\/blood-2009-03-212837","article-title":"B-cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel spleen tyrosine kinase inhibitor, R406","volume":"114","author":"Quiroga","year":"2009","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib61","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S1074-7613(00)80131-4","article-title":"Alpha4 integrins regulate the proliferation\/differentiation balance of multilineage hematopoietic progenitors in vivo","volume":"11","author":"Arroyo","year":"1999","journal-title":"Immunity"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib62","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1084\/jem.173.3.599","article-title":"Evidence for a role of the integrin VLA-4 in lympho-hemopoiesis","volume":"173","author":"Miyake","year":"1991","journal-title":"J Exp Med"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib63","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1084\/jem.193.6.741","article-title":"Conditional vascular cell adhesion molecule 1 deletion in mice: impaired lymphocyte migration to bone marrow","volume":"193","author":"Koni","year":"2001","journal-title":"J Exp Med"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib64","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1074-7613(01)00261-8","article-title":"Chemokines and the tissue-specific migration of lymphocytes","volume":"16","author":"Kunkel","year":"2002","journal-title":"Immunity"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib65","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1111\/j.1600-065X.1997.tb00963.x","article-title":"Germinal center development","volume":"156","author":"Liu","year":"1997","journal-title":"Immunol Rev"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib66","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.1697696","article-title":"Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110","volume":"249","author":"Freedman","year":"1990","journal-title":"Science"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib67","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.4049\/jimmunol.148.8.2331","article-title":"Follicular dendritic cell-dependent adhesion and proliferation of B cells in vitro","volume":"148","author":"Kosco","year":"1992","journal-title":"J Immunol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib68","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1146\/annurev.immunol.17.1.555","article-title":"Genetic analysis of B cell antigen receptor signaling","volume":"17","author":"Kurosaki","year":"1999","journal-title":"Annu Rev Immunol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib69","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/nri801","article-title":"Regulation of B-cell signal transduction by adaptor proteins","volume":"2","author":"Kurosaki","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib70","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1038\/nri955","article-title":"Regulation of B-cell fate by antigen-receptor signals","volume":"2","author":"Niiro","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib71","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1084\/jem.20011866","article-title":"The B cell antigen receptor controls integrin activity through Btk and PLCgamma2","volume":"198","author":"Spaargaren","year":"2003","journal-title":"J Exp Med"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib72","doi-asserted-by":"crossref","first-page":"e83830","DOI":"10.1371\/journal.pone.0083830","article-title":"The PI3-kinase delta inhibitor idelalisib (GS-1101) targets integrin-mediated adhesion of chronic lymphocytic leukemia (CLL) cell to endothelial and marrow stromal cells","volume":"8","author":"Fiorcari","year":"2013","journal-title":"PLoS One"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib73","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1182\/blood-2013-06-507335","article-title":"CD49d is overexpressed by trisomy 12 chronic lymphocytic leukemia cells: evidence for a methylation-dependent regulation mechanism","volume":"122","author":"Zucchetto","year":"2013","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib74","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1200\/JCO.2008.16.7874","article-title":"Karyotype evolution on fluorescent in situ hybridization analysis is associated with short survival in patients with chronic lymphocytic leukemia and is related to CD49d expression","volume":"26","author":"Shanafelt","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib75","first-page":"212","article-title":"Evaluation of trisomy 12 by fluorescence in situ hybridization in peripheral blood, bone marrow and lymph nodes of patients with B-cell chronic lymphocytic leukemia","volume":"84","author":"Liso","year":"1999","journal-title":"Haematologica"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib76","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nrc2748","article-title":"Integrins in cancer: biological implications and therapeutic opportunities","volume":"10","author":"Desgrosellier","year":"2010","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib77","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/sj.leu.2401275","article-title":"Fibronectin interaction with alpha4beta1 integrin prevents apoptosis in B cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax","volume":"13","author":"de la Fuente","year":"1999","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib78","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.bbrc.2003.10.054","article-title":"Involvement of p53 in alpha4beta1 integrin-mediated resistance of B-CLL cells to fludarabine","volume":"311","author":"de la Fuente","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib79","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1182\/blood-2009-07-233692","article-title":"Spleen tyrosine kinase inhibition prevents chemokine- and integrin-mediated stromal protective effects in chronic lymphocytic leukemia","volume":"115","author":"Buchner","year":"2010","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib80","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.1038\/onc.2009.179","article-title":"The tyrosine kinase Syk regulates the survival of chronic lymphocytic leukemia B cells through PKCdelta and proteasome-dependent regulation of Mcl-1 expression","volume":"28","author":"Baudot","year":"2009","journal-title":"Oncogene"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib81","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1182\/blood-2007-05-089037","article-title":"The Akt\/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells","volume":"111","author":"Longo","year":"2008","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib82","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.bbrc.2005.01.076","article-title":"Protein-tyrosine kinase, Syk, is required for CXCL12-induced polarization of B cells","volume":"328","author":"Matsusaka","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib83","doi-asserted-by":"crossref","first-page":"4820","DOI":"10.1182\/blood-2004-07-2669","article-title":"Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells","volume":"105","author":"Petlickovski","year":"2005","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib84","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.1158\/0008-5472.CAN-10-1634","article-title":"Interaction with vascular endothelium enhances survival in primary chronic lymphocytic leukemia cells via NF-kappaB activation and de novo gene transcription","volume":"70","author":"Buggins","year":"2010","journal-title":"Cancer Res"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib85","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.beha.2010.01.007","article-title":"Signalling to drug resistance in CLL","volume":"23","author":"Hertlein","year":"2010","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib86","doi-asserted-by":"crossref","first-page":"e23758","DOI":"10.1371\/journal.pone.0023758","article-title":"Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells","volume":"6","author":"Brachtl","year":"2011","journal-title":"PLoS One"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib87","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1038\/leu.2011.12","article-title":"IGHV unmutated CLL B cells are more prone to spontaneous apoptosis and subject to environmental prosurvival signals than mutated CLL B cells","volume":"25","author":"Coscia","year":"2011","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib88","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/leu.2013.331","article-title":"CD49d expression identifies a chronic-lymphocytic leukemia subset with high levels of mobilized circulating CD34 hemopoietic progenitors cells","volume":"28","author":"Rossi","year":"2014","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib89","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.2119\/molmed.2011.00360","article-title":"Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born\/divided and older\/quiescent cells","volume":"17","author":"Calissano","year":"2011","journal-title":"Mol Med"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib90","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1365-2141.2008.07469.x","article-title":"Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study","volume":"144","author":"Bomben","year":"2009","journal-title":"Br J Haematol"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib91","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.leukres.2008.05.022","article-title":"Computational identification of CDR3 sequence archetypes among immunoglobulin sequences in chronic lymphocytic leukemia","volume":"33","author":"Messmer","year":"2009","journal-title":"Leuk Res"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib92","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1182\/blood-2007-07-099564","article-title":"Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis","volume":"111","author":"Murray","year":"2008","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib93","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1182\/blood-2006-03-012948","article-title":"Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations","volume":"109","author":"Stamatopoulos","year":"2007","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib94","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1182\/blood-2013-02-486209","article-title":"Association between molecular lesions and specific B-cell receptor subsets in chronic lymphocytic leukemia","volume":"121","author":"Rossi","year":"2013","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2014.05.002_bib95","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1038\/leu.2013.98","article-title":"Distinct patterns of novel gene mutations in poor-prognostic stereotyped subsets of chronic lymphocytic leukemia: the case of SF3B1 and subset #2","volume":"27","author":"Strefford","year":"2013","journal-title":"Leukemia"}],"container-title":["Seminars in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196314000286?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196314000286?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T06:24:02Z","timestamp":1758522242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0037196314000286"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7]]},"references-count":95,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2014,7]]}},"alternative-id":["S0037196314000286"],"URL":"https:\/\/doi.org\/10.1053\/j.seminhematol.2014.05.002","relation":{},"ISSN":["0037-1963"],"issn-type":[{"value":"0037-1963","type":"print"}],"subject":[],"published":{"date-parts":[[2014,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microenvironmental Interactions in Chronic Lymphocytic Leukemia: The Master Role of CD49d","name":"articletitle","label":"Article Title"},{"value":"Seminars in Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminhematol.2014.05.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}