{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:07:30Z","timestamp":1791994050952,"version":"4.4.0"},"reference-count":107,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Hematology"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1053\/j.seminhematol.2021.06.003","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T13:43:32Z","timestamp":1625665412000},"page":"153-160","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Advances in understanding the crosstalk between mother and fetus on iron utilization"],"prefix":"10.1053","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7797-1567","authenticated-orcid":false,"given":"Samira","family":"Lakhal-Littleton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1053\/j.seminhematol.2021.06.003_bib0001","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0308-2261(21)00496-3","article-title":"Blood volume changes in normal pregnancy","volume":"14","author":"Hytten","year":"1985","journal-title":"Clin Haematol"},{"issue":"6947","key":"10.1053\/j.seminhematol.2021.06.003_bib0002","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/bmj.309.6947.79","article-title":"Absorption of non-haem iron from food during normal pregnancy","volume":"309","author":"Barrett","year":"1994","journal-title":"BMJ"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0003","series-title":"Food and Agricultural Organization of the United Nations. Vitamin and mineral requirements in human nutrition","year":"2004"},{"issue":"1 Suppl","key":"10.1053\/j.seminhematol.2021.06.003_bib0004","article-title":"Iron requirements in pregnancy and strategies to meet them","volume":"72","author":"Bothwell","year":"2000","journal-title":"Am J Clin Nutr"},{"issue":"Suppl 6","key":"10.1053\/j.seminhematol.2021.06.003_bib0005","article-title":"Iron homeostasis during pregnancy","volume":"106","author":"Fisher","year":"2017","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"10.1053\/j.seminhematol.2021.06.003_bib0006","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1753-4887.2012.00550.x","article-title":"Pregnancy and iron homeostasis: an update","volume":"71","author":"Cao","year":"2013","journal-title":"Nutr Rev"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0007","series-title":"The prevalence of anaemia in women: a tabulation of available information","year":"1992"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0008","unstructured":"ACC\/SCN (United Nations Administrative Committee on Coordination\/Standing Committee on Nutrition), \u201cFifth report on the world nutrition situation: Nutrition for improved development outcomes,\u201d Geneva, Switzerland, accscn@who.org, 2004."},{"issue":"9","key":"10.1053\/j.seminhematol.2021.06.003_bib0009","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/sj.ejcn.1602429","article-title":"Iron status and its association with pregnancy outcome in Korean pregnant women","volume":"60","author":"Lee","year":"2006","journal-title":"Eur J Clin Nutr"},{"issue":"5 Suppl","key":"10.1053\/j.seminhematol.2021.06.003_bib0010","article-title":"Anemia and iron deficiency: effects on pregnancy outcome","volume":"71","author":"Allen","year":"2000","journal-title":"Am J Clin Nutr"},{"issue":"11","key":"10.1053\/j.seminhematol.2021.06.003_bib0011","first-page":"14","article-title":"The consequences of iron deficiency and anaemia in pregnancy on maternal health, the fetus and the infant","author":"Viteri","year":"1994","journal-title":"SCN News"},{"issue":"12","key":"10.1053\/j.seminhematol.2021.06.003_bib0012","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/j.amjmed.2017.06.025","article-title":"Results of the First American prospective study of intravenous iron in oral iron-intolerant iron-deficient gravidas","volume":"130","author":"Auerbach","year":"2017","journal-title":"Am J Med"},{"issue":"12","key":"10.1053\/j.seminhematol.2021.06.003_bib0013","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1111\/trf.13252","article-title":"Iron deficiency anemia at admission for labor and delivery is associated with an increased risk for Cesarean section and adverse maternal and neonatal outcomes","volume":"55","author":"Drukker","year":"2015","journal-title":"Transfusion"},{"issue":"12","key":"10.1053\/j.seminhematol.2021.06.003_bib0014","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1017\/S1368980009005497","article-title":"Anaemia among pregnant Palestinian women in the Occupied Palestinian Territory","volume":"12","author":"Khader","year":"2009","journal-title":"Public Health Nutr"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0015","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9135625","article-title":"Prevalence of anemia and iron deficiency among palestinian pregnant women and its association with pregnancy outcome","volume":"2018","author":"Srour","year":"2018","journal-title":"Anemia."},{"issue":"9","key":"10.1053\/j.seminhematol.2021.06.003_bib0016","doi-asserted-by":"crossref","first-page":"3436","DOI":"10.1210\/jc.2007-1082","article-title":"Iron deficiency predicts poor maternal thyroid status during pregnancy","volume":"92","author":"Zimmermann","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"10.1053\/j.seminhematol.2021.06.003_bib0017","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jchf.2013.04.011","article-title":"Characteristics, adverse events, and racial differences among delivering mothers with peripartum cardiomyopathy","volume":"1","author":"Kao","year":"2013","journal-title":"JACC Heart Fail"},{"issue":"Pt 6","key":"10.1053\/j.seminhematol.2021.06.003_bib0018","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1042\/BST0361267","article-title":"The role of iron in neurodevelopment: fetal iron deficiency and the developing hippocampus","volume":"36","author":"Georgieff","year":"2008","journal-title":"Biochem Soc Trans"},{"issue":"2S-2","key":"10.1053\/j.seminhematol.2021.06.003_bib0019","article-title":"A review of studies on the effect of iron deficiency on cognitive development in children","volume":"131","author":"Grantham-McGregor","year":"2001","journal-title":"J Nutr"},{"issue":"2","key":"10.1053\/j.seminhematol.2021.06.003_bib0020","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1067\/mpd.2002.120688","article-title":"Cord serum ferritin concentrations and mental and psychomotor development of children at five years of age","volume":"140","author":"Tamura","year":"2002","journal-title":"J Pediatr"},{"issue":"1","key":"10.1053\/j.seminhematol.2021.06.003_bib0021","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/ajcn\/76.1.198","article-title":"Iron absorption in breast-fed infants: effects of age, iron status, iron supplements, and complementary foods","volume":"76","author":"Domellof","year":"2002","journal-title":"Am J Clin Nutr"},{"issue":"6","key":"10.1053\/j.seminhematol.2021.06.003_bib0022","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0143-4004(05)80199-7","article-title":"Transferrin receptor expression in early postimplantation mouse trophoblast and associated tissues","volume":"11","author":"Drake","year":"1990","journal-title":"Placenta"},{"issue":"2","key":"10.1053\/j.seminhematol.2021.06.003_bib0023","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/aja.1001340209","article-title":"Placental iron transfer: relationship to placental anatomy and phylogeny of the mammals","volume":"134","author":"Seal","year":"1972","journal-title":"Am J Anat"},{"issue":"24","key":"10.1053\/j.seminhematol.2021.06.003_bib0024","doi-asserted-by":"crossref","first-page":"12629","DOI":"10.1016\/S0021-9258(19)86360-3","article-title":"Transferrin receptor in human placental brush border membranes. Studies on the binding of transferrin to placental membrane vesicles and the identification of a placental brush border glycoprotein with high affinity for transferrin","volume":"254","author":"Wada","year":"1979","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1053\/j.seminhematol.2021.06.003_bib0025","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1182\/blood-2006-02-003681","article-title":"The Steap proteins are metalloreductases","volume":"108","author":"Ohgami","year":"2006","journal-title":"Blood"},{"issue":"31","key":"10.1053\/j.seminhematol.2021.06.003_bib0026","doi-asserted-by":"crossref","first-page":"4934","DOI":"10.1038\/sj.onc.1208677","article-title":"Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer","volume":"24","author":"Korkmaz","year":"2005","journal-title":"Oncogene"},{"issue":"8","key":"10.1053\/j.seminhematol.2021.06.003_bib0027","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1053\/plac.2000.0566","article-title":"Identification and localization of divalent metal transporter-1 (DMT-1) in term human placenta","volume":"21","author":"Georgieff","year":"2000","journal-title":"Placenta"},{"issue":"5","key":"10.1053\/j.seminhematol.2021.06.003_bib0028","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1172\/JCI24356","article-title":"Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver","volume":"115","author":"Gunshin","year":"2005","journal-title":"J Clin Invest"},{"issue":"7215","key":"10.1053\/j.seminhematol.2021.06.003_bib0029","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1038\/nature07311","article-title":"The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel","volume":"455","author":"Dong","year":"2008","journal-title":"Nature"},{"issue":"5","key":"10.1053\/j.seminhematol.2021.06.003_bib0030","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1124\/mol.107.043588","article-title":"Slc39a14 gene encodes ZIP14, a metal\/bicarbonate symporter: similarities to the ZIP8 transporter","volume":"73","author":"Girijashanker","year":"2008","journal-title":"Mol Pharmacol"},{"issue":"41","key":"10.1053\/j.seminhematol.2021.06.003_bib0031","doi-asserted-by":"crossref","first-page":"34032","DOI":"10.1074\/jbc.M112.367284","article-title":"ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading","volume":"287","author":"Wang","year":"2012","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1053\/j.seminhematol.2021.06.003_bib0032","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/7727","article-title":"Transferrin receptor is necessary for development of erythrocytes and the nervous system","volume":"21","author":"Levy","year":"1999","journal-title":"Nat Genet"},{"issue":"1","key":"10.1053\/j.seminhematol.2021.06.003_bib0033","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0143-4004(80)80014-2","article-title":"Immunological studies of transferrin and transferrin receptors of human placental trophoblast","volume":"1","author":"Galbraith","year":"1980","journal-title":"Placenta"},{"issue":"19","key":"10.1053\/j.seminhematol.2021.06.003_bib0034","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1242\/dev.01342","article-title":"Dysregulation of ferroportin 1 interferes with spleen organogenesis in polycythaemia mice","volume":"131","author":"Mok","year":"2004","journal-title":"Development"},{"issue":"2","key":"10.1053\/j.seminhematol.2021.06.003_bib0035","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1530\/JME-11-0123","article-title":"The effect of pre-existing maternal obesity on the placental proteome: two-dimensional difference gel electrophoresis coupled with mass spectrometry","volume":"48","author":"Oliva","year":"2012","journal-title":"J Mol Endocrinol"},{"issue":"7","key":"10.1053\/j.seminhematol.2021.06.003_bib0036","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3945\/jn.110.135798","article-title":"Placental expression of the heme transporter, feline leukemia virus subgroup C receptor, is related to maternal iron status in pregnant adolescents","volume":"141","author":"Jaacks","year":"2011","journal-title":"J Nutr"},{"issue":"6771","key":"10.1053\/j.seminhematol.2021.06.003_bib0037","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/35001596","article-title":"Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter","volume":"403","author":"Donovan","year":"2000","journal-title":"Nature"},{"issue":"19","key":"10.1053\/j.seminhematol.2021.06.003_bib0038","doi-asserted-by":"crossref","first-page":"10812","DOI":"10.1073\/pnas.96.19.10812","article-title":"Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux","volume":"96","author":"Harris","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1053\/j.seminhematol.2021.06.003_bib0039","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1365-2141.1978.tb03663.x","article-title":"Iron deficiency anaemia in newborn sla mice: a genetic defect of placental iron transport","volume":"40","author":"Kingston","year":"1978","journal-title":"Br J Haematol"},{"issue":"3","key":"10.1053\/j.seminhematol.2021.06.003_bib0040","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/0143-4004(91)90008-4","article-title":"Development of the early human placenta: a morphometric study","volume":"12","author":"Jauniaux","year":"1991","journal-title":"Placenta"},{"issue":"6","key":"10.1053\/j.seminhematol.2021.06.003_bib0041","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1046\/j.1469-0705.1991.01060435.x","article-title":"In vivo investigations of the anatomy and the physiology of early human placental circulations","volume":"1","author":"Jauniaux","year":"1991","journal-title":"Ultrasound Obstet Gynecol"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0042","first-page":"180","article-title":"Development of structures and transport functions in the mouse placenta","volume":"20","author":"Watson","year":"2005","journal-title":"Physiology (Bethesda)"},{"issue":"3","key":"10.1053\/j.seminhematol.2021.06.003_bib0043","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cmet.2005.01.003","article-title":"The iron exporter ferroportin\/Slc40a1 is essential for iron homeostasis","volume":"1","author":"Donovan","year":"2005","journal-title":"Cell Metab"},{"issue":"18","key":"10.1053\/j.seminhematol.2021.06.003_bib0044","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1242\/dev.048744","article-title":"The iron exporter ferroportin 1 is essential for development of the mouse embryo, forebrain patterning and neural tube closure","volume":"137","author":"Mao","year":"2010","journal-title":"Development"},{"issue":"5704","key":"10.1053\/j.seminhematol.2021.06.003_bib0045","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1126\/science.1104742","article-title":"Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization","volume":"306","author":"Nemeth","year":"2004","journal-title":"Science"},{"issue":"1","key":"10.1053\/j.seminhematol.2021.06.003_bib0046","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bcmd.2007.07.009","article-title":"Posttranslational processing of hepcidin in human hepatocytes is mediated by the prohormone convertase furin","volume":"40","author":"Valore","year":"2008","journal-title":"Blood Cells Mol Dis"},{"issue":"4","key":"10.1053\/j.seminhematol.2021.06.003_bib0047","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/ng.320","article-title":"Lack of the bone morphogenetic protein BMP6 induces massive iron overload","volume":"41","author":"Meynard","year":"2009","journal-title":"Nat Genet"},{"issue":"4","key":"10.1053\/j.seminhematol.2021.06.003_bib0048","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/ng.335","article-title":"BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism","volume":"41","author":"Andriopoulos","year":"2009","journal-title":"Nat Genet"},{"issue":"11","key":"10.1053\/j.seminhematol.2021.06.003_bib0049","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1002\/ajh.24888","article-title":"Bone morphogenetic protein 2 controls iron homeostasis in mice independent of Bmp6","volume":"92","author":"Canali","year":"2017","journal-title":"Am J Hematol"},{"issue":"1","key":"10.1053\/j.seminhematol.2021.06.003_bib0050","doi-asserted-by":"crossref","first-page":"126","DOI":"10.3945\/an.116.013961","article-title":"Regulation of the Iron Homeostatic Hormone Hepcidin","volume":"8","author":"Sangkhae","year":"2017","journal-title":"Adv Nutr"},{"issue":"5","key":"10.1053\/j.seminhematol.2021.06.003_bib0051","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1038\/ng1777","article-title":"Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression","volume":"38","author":"Babitt","year":"2006","journal-title":"Nat Genet"},{"issue":"4","key":"10.1053\/j.seminhematol.2021.06.003_bib0052","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1002\/hep.24178","article-title":"Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice","volume":"53","author":"Ramos","year":"2011","journal-title":"Hepatology"},{"issue":"8","key":"10.1053\/j.seminhematol.2021.06.003_bib0053","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1182\/blood-2014-01-552281","article-title":"HFE interacts with the BMP type I receptor ALK3 to regulate hepcidin expression","volume":"124","author":"Wu","year":"2014","journal-title":"Blood"},{"issue":"3","key":"10.1053\/j.seminhematol.2021.06.003_bib0054","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.cmet.2009.01.010","article-title":"Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression","volume":"9","author":"Gao","year":"2009","journal-title":"Cell Metab"},{"issue":"5","key":"10.1053\/j.seminhematol.2021.06.003_bib0055","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1053\/j.gastro.2011.06.077","article-title":"Iron regulation of hepcidin despite attenuated Smad1,5,8 signaling in mice without transferrin receptor 2 or Hfe","volume":"141","author":"Corradini","year":"2011","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1053\/j.seminhematol.2021.06.003_bib0056","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3324\/haematol.2010.033449","article-title":"A time course of hepcidin response to iron challenge in patients with HFE and TFR2 hemochromatosis","volume":"96","author":"Girelli","year":"2011","journal-title":"Haematologica"},{"issue":"6","key":"10.1053\/j.seminhematol.2021.06.003_bib0057","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.cmet.2008.09.012","article-title":"The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin","volume":"8","author":"Silvestri","year":"2008","journal-title":"Cell Metab"},{"issue":"2","key":"10.1053\/j.seminhematol.2021.06.003_bib0058","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1182\/blood-2007-07-100677","article-title":"Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis","volume":"111","author":"Silvestri","year":"2008","journal-title":"Blood"},{"issue":"7","key":"10.1053\/j.seminhematol.2021.06.003_bib0059","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/ng.2996","article-title":"Identification of erythroferrone as an erythroid regulator of iron metabolism","volume":"46","author":"Kautz","year":"2014","journal-title":"Nat Genet"},{"issue":"1","key":"10.1053\/j.seminhematol.2021.06.003_bib0060","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1182\/blood-2006-07-033969","article-title":"STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation","volume":"109","author":"Verga Falzacappa","year":"2007","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0061","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/105325","article-title":"Effects of pregnancy and lactation on iron metabolism in rats","volume":"2015","author":"Gao","year":"2015","journal-title":"Biomed Res Int"},{"issue":"2","key":"10.1053\/j.seminhematol.2021.06.003_bib0062","first-page":"127","article-title":"Effect of dietary iron on fetal growth in pregnant mice","volume":"63","author":"Hubbard","year":"2013","journal-title":"Comp Med"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0063","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/9135625","article-title":"Prevalence of anemia and iron deficiency among palestinian pregnant women and its association with pregnancy outcome","volume":"2018","author":"Srour","year":"2018","journal-title":"Anemia."},{"issue":"6","key":"10.1053\/j.seminhematol.2021.06.003_bib0064","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3945\/jn.116.245373","article-title":"Serum hepcidin concentrations decline during pregnancy and may identify iron deficiency: analysis of a longitudinal pregnancy cohort in the gambia","volume":"147","author":"Bah","year":"2017","journal-title":"J Nutr"},{"issue":"7","key":"10.1053\/j.seminhematol.2021.06.003_bib0065","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1515\/cclm-2012-0576","article-title":"The iron regulatory hormone hepcidin is decreased in pregnancy: a prospective longitudinal study","volume":"51","author":"van Santen","year":"2013","journal-title":"Clin Chem Lab Med"},{"issue":"1","key":"10.1053\/j.seminhematol.2021.06.003_bib0066","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3945\/jn.111.145961","article-title":"Maternal hepcidin is associated with placental transfer of iron derived from dietary heme and nonheme sources","volume":"142","author":"Young","year":"2012","journal-title":"J Nutr"},{"issue":"19","key":"10.1053\/j.seminhematol.2021.06.003_bib0067","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1182\/blood.2020005745","article-title":"Maternal hepcidin determines embryo iron homeostasis in mice","volume":"136","author":"Sangkhae","year":"2020","journal-title":"Blood"},{"issue":"3","key":"10.1053\/j.seminhematol.2021.06.003_bib0068","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/bjh.17049","article-title":"Disordered serum erythroferrone and hepcidin levels as indicators of the spontaneous abortion occurrence during early pregnancy in humans","volume":"192","author":"Wei","year":"2021","journal-title":"Br J Haematol"},{"issue":"4","key":"10.1053\/j.seminhematol.2021.06.003_bib0069","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bcmd.2012.02.001","article-title":"Hepcidin is correlated to soluble hemojuvelin but not to increased GDF15 during pregnancy","volume":"48","author":"Finkenstedt","year":"2012","journal-title":"Blood Cells Mol Dis"},{"issue":"1","key":"10.1053\/j.seminhematol.2021.06.003_bib0070","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/ng1274","article-title":"Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis","volume":"36","author":"Papanikolaou","year":"2004","journal-title":"Nat Genet"},{"issue":"8","key":"10.1053\/j.seminhematol.2021.06.003_bib0071","doi-asserted-by":"crossref","first-page":"4656","DOI":"10.1523\/JNEUROSCI.14-08-04656.1994","article-title":"The developmental expression in rat of proteases furin, PC1, PC2, and carboxypeptidase E: implications for early maturation of proteolytic processing capacity","volume":"14","author":"Zheng","year":"1994","journal-title":"J Neurosci"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0072","doi-asserted-by":"crossref","first-page":"e593","DOI":"10.1038\/cddis.2013.106","article-title":"The proprotein convertase furin is required for trophoblast syncytialization","volume":"4","author":"Zhou","year":"2013","journal-title":"Cell Death Dis"},{"issue":"3","key":"10.1053\/j.seminhematol.2021.06.003_bib0073","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.cmet.2005.02.005","article-title":"Cellular iron: ferroportin is the only way out","volume":"1","author":"Ganz","year":"2005","journal-title":"Cell Metab"},{"issue":"3","key":"10.1053\/j.seminhematol.2021.06.003_bib0074","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1182\/blood-2014-01-551150","article-title":"Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis","volume":"124","author":"Willemetz","year":"2014","journal-title":"Blood"},{"issue":"5","key":"10.1053\/j.seminhematol.2021.06.003_bib0075","doi-asserted-by":"crossref","first-page":"661","DOI":"10.3324\/haematol.2011.055046","article-title":"Fetal iron levels are regulated by maternal and fetal Hfe genotype and dietary iron","volume":"97","author":"Balesaria","year":"2012","journal-title":"Haematologica"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0076","article-title":"Iron transport across the human placenta is regulated by hepcidin","author":"McDonald","year":"2020","journal-title":"Pediatr Res"},{"issue":"13","key":"10.1053\/j.seminhematol.2021.06.003_bib0077","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1182\/blood.2019003907","article-title":"Fetal liver hepcidin secures iron stores in utero","volume":"136","author":"Kammerer","year":"2020","journal-title":"Blood"},{"issue":"2","key":"10.1053\/j.seminhematol.2021.06.003_bib0078","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1172\/JCI127341","article-title":"Effects of maternal iron status on placental and fetal iron homeostasis","volume":"130","author":"Sangkhae","year":"2020","journal-title":"J Clin Invest"},{"issue":"4","key":"10.1053\/j.seminhematol.2021.06.003_bib0079","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/ijo.2015.3","article-title":"The impact of maternal obesity on iron status, placental transferrin receptor expression and hepcidin expression in human pregnancy","volume":"39","author":"Garcia-Valdes","year":"2015","journal-title":"Int J Obes (Lond)"},{"issue":"7","key":"10.1053\/j.seminhematol.2021.06.003_bib0080","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1073\/pnas.072632499","article-title":"Severe iron deficiency anemia in transgenic mice expressing liver hepcidin","volume":"99","author":"Nicolas","year":"2002","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"4","key":"10.1053\/j.seminhematol.2021.06.003_bib0081","doi-asserted-by":"crossref","first-page":"R1063","DOI":"10.1152\/ajpregu.90793.2008","article-title":"Fetal iron status regulates maternal iron metabolism during pregnancy in the rat","volume":"296","author":"Gambling","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"1-3","key":"10.1053\/j.seminhematol.2021.06.003_bib0082","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.febslet.2004.08.010","article-title":"Transferrin receptor 1 mRNA is downregulated in placenta of hepcidin transgenic embryos","volume":"574","author":"Martin","year":"2004","journal-title":"FEBS Lett"},{"issue":"8","key":"10.1053\/j.seminhematol.2021.06.003_bib0083","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nchembio807","article-title":"The role of iron regulatory proteins in mammalian iron homeostasis and disease","volume":"2","author":"Rouault","year":"2006","journal-title":"Nat Chem Biol"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0084","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2137(97)80001-5","article-title":"Regulation of iron metabolism in eukaryotes","volume":"35","author":"Rouault","year":"1997","journal-title":"Curr Top Cell Regul"},{"issue":"2","key":"10.1053\/j.seminhematol.2021.06.003_bib0085","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.bcmd.2005.12.006","article-title":"Complete loss of iron regulatory proteins 1 and 2 prevents viability of murine zygotes beyond the blastocyst stage of embryonic development","volume":"36","author":"Smith","year":"2006","journal-title":"Blood Cells Mol Dis"},{"issue":"5","key":"10.1053\/j.seminhematol.2021.06.003_bib0086","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nsmb1222","article-title":"Iron-regulatory proteins limit hypoxia-inducible factor-2alpha expression in iron deficiency","volume":"14","author":"Sanchez","year":"2007","journal-title":"Nat Struct Mol Biol"},{"issue":"6","key":"10.1053\/j.seminhematol.2021.06.003_bib0087","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1182\/blood-2012-11-427765","article-title":"The gut in iron homeostasis: role of HIF-2 under normal and pathological conditions","volume":"122","author":"Mastrogiannaki","year":"2013","journal-title":"Blood"},{"issue":"1","key":"10.1053\/j.seminhematol.2021.06.003_bib0088","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1172\/JCI122359","article-title":"Hepatic hepcidin\/intestinal HIF-2alpha axis maintains iron absorption during iron deficiency and overload","volume":"129","author":"Schwartz","year":"2019","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1053\/j.seminhematol.2021.06.003_bib0089","doi-asserted-by":"crossref","first-page":"R1973","DOI":"10.1152\/ajpregu.00053.2008","article-title":"Placental HIFs as markers of cerebral hypoxic distress in fetal mice","volume":"295","author":"Trollmann","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"2","key":"10.1053\/j.seminhematol.2021.06.003_bib0090","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1095\/biolreprod63.2.559","article-title":"Expression, ontogeny, and regulation of hypoxia-inducible transcription factors in the human placenta","volume":"63","author":"Rajakumar","year":"2000","journal-title":"Biol Reprod"},{"issue":"11","key":"10.1053\/j.seminhematol.2021.06.003_bib0091","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.3945\/jn.112.162362","article-title":"Maternal serum ferritin concentration is positively associated with newborn iron stores in women with low ferritin status in late pregnancy","volume":"142","author":"Shao","year":"2012","journal-title":"J Nutr"},{"issue":"5","key":"10.1053\/j.seminhematol.2021.06.003_bib0092","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1093\/ajcn\/66.5.1178","article-title":"Effect of iron supplementation on the iron status of pregnant women: consequences for newborns","volume":"66","author":"Preziosi","year":"1997","journal-title":"Am J Clin Nutr"},{"issue":"8","key":"10.1053\/j.seminhematol.2021.06.003_bib0093","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.3945\/jn.114.208678","article-title":"Prenatal iron supplementation reduces maternal anemia, iron deficiency, and iron deficiency anemia in a randomized clinical trial in rural china, but iron deficiency remains widespread in mothers and neonates","volume":"145","author":"Zhao","year":"2015","journal-title":"J Nutr"},{"issue":"24","key":"10.1053\/j.seminhematol.2021.06.003_bib0094","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1242\/dev.125.24.5009","article-title":"Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo","volume":"125","author":"Belaoussoff","year":"1998","journal-title":"Development"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0095","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.exphem.2020.07.008","article-title":"Is extra-embryonic endoderm a source of placental blood cells?","volume":"89","author":"Downs","year":"2020","journal-title":"Exp Hematol"},{"issue":"13","key":"10.1053\/j.seminhematol.2021.06.003_bib0096","doi-asserted-by":"crossref","first-page":"2166","DOI":"10.1080\/14767058.2018.1427723","article-title":"Is cord blood hepcidin influenced by the low-grade acute-phase response occurring during delivery? A small-scale longitudinal study","volume":"32","author":"Hoppe","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"2","key":"10.1053\/j.seminhematol.2021.06.003_bib0097","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000360072","article-title":"Gestational age-specific reference ranges of hepcidin in cord blood","volume":"106","author":"Lorenz","year":"2014","journal-title":"Neonatology"},{"issue":"4","key":"10.1053\/j.seminhematol.2021.06.003_bib0098","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1600-0609.2010.01479.x","article-title":"Maternal serum hepcidin is low at term and independent of cord blood iron status","volume":"85","author":"Rehu","year":"2010","journal-title":"Eur J Haematol"},{"issue":"5","key":"10.1053\/j.seminhematol.2021.06.003_bib0099","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/j.1365-2141.2006.06216.x","article-title":"Localisation of proteins of iron metabolism in the human placenta and liver","volume":"134","author":"Bastin","year":"2006","journal-title":"Br J Haematol"},{"issue":"7","key":"10.1053\/j.seminhematol.2021.06.003_bib0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004470","article-title":"Regulation of feto-maternal barrier by matriptase- and PAR-2-mediated signaling is required for placental morphogenesis and mouse embryonic survival","volume":"10","author":"Szabo","year":"2014","journal-title":"PLoS Genet"},{"issue":"15","key":"10.1053\/j.seminhematol.2021.06.003_bib0101","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1242\/dev.038430","article-title":"Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in mice","volume":"136","author":"Szabo","year":"2009","journal-title":"Development"},{"issue":"5","key":"10.1053\/j.seminhematol.2021.06.003_bib0102","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1046\/j.1365-2141.2003.04215.x","article-title":"Haematological effects of the C282Y HFE mutation in homozygous and heterozygous states among subjects of northern and southern European ancestry","volume":"120","author":"Beutler","year":"2003","journal-title":"Br J Haematol"},{"issue":"5","key":"10.1053\/j.seminhematol.2021.06.003_bib0103","doi-asserted-by":"crossref","first-page":"e240","DOI":"10.1097\/MPH.0000000000000826","article-title":"HFE gene mutations and iron status in 100 healthy polish children","volume":"39","author":"Kaczorowska-Hac","year":"2017","journal-title":"J Pediatr Hematol Oncol"},{"issue":"7","key":"10.1053\/j.seminhematol.2021.06.003_bib0104","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1002\/pbc.22236","article-title":"Hereditary hemochromatosis gene (HFE) variants are associated with birth weight and childhood leukemia risk","volume":"53","author":"Dorak","year":"2009","journal-title":"Pediatr Blood Cancer"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0105","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.preghy.2017.12.008","article-title":"Maternal serum levels and placental expression of hepcidin in preeclampsia","volume":"11","author":"Cardaropoli","year":"2018","journal-title":"Pregnancy Hypertens"},{"key":"10.1053\/j.seminhematol.2021.06.003_bib0106","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.nutres.2018.03.005","article-title":"Increased serum iron in preeclamptic women is likely due to low hepcidin levels","volume":"53","author":"Brunacci","year":"2018","journal-title":"Nutr Res"},{"issue":"9","key":"10.1053\/j.seminhematol.2021.06.003_bib0107","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1055\/s-0038-1626711","article-title":"Hepcidin, an iron regulatory hormone of innate immunity, is differentially expressed in premature fetuses with early-onset neonatal sepsis","volume":"35","author":"Tabbah","year":"2018","journal-title":"Am J Perinatol"}],"container-title":["Seminars in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196321000354?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196321000354?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T06:28:25Z","timestamp":1758522505000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0037196321000354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":107,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S0037196321000354"],"URL":"https:\/\/doi.org\/10.1053\/j.seminhematol.2021.06.003","relation":{},"ISSN":["0037-1963"],"issn-type":[{"value":"0037-1963","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Advances in understanding the crosstalk between mother and fetus on iron utilization","name":"articletitle","label":"Article Title"},{"value":"Seminars in Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminhematol.2021.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}