{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T20:12:25Z","timestamp":1791663145711,"version":"4.3.4"},"reference-count":206,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003390","name":"Fritz Thyssen Stiftung","doi-asserted-by":"publisher","award":["10.20.1.008MN"],"award-info":[{"award-number":["10.20.1.008MN"]}],"id":[{"id":"10.13039\/501100003390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1530-455784452"],"award-info":[{"award-number":["SFB1530-455784452"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010571","name":"BMBF Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010571","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Hematology"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1053\/j.seminhematol.2023.12.004","type":"journal-article","created":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T01:54:36Z","timestamp":1703555676000},"page":"142-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Role of the tumor microenvironment in CLL pathogenesis"],"prefix":"10.1053","volume":"61","author":[{"given":"Alexander F.","family":"vom Stein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hallek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3249-7264","authenticated-orcid":false,"given":"Phuong-Hien","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0001","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41375-018-0366-8","article-title":"New roles for B cell receptor associated kinases: when the B cell is not the target","volume":"33","author":"Nguyen","year":"2019","journal-title":"Leukemia"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2021.08.011","article-title":"The landscape of tumor cell states and ecosystems in diffuse large B cell lymphoma","author":"Steen","year":"2021","journal-title":"Cancer Cell"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0003","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.3324\/haematol.2020.268037","article-title":"Targeting the tumor microenvironment in chronic lymphocytic leukemia","volume":"106","author":"Svanberg","year":"2021","journal-title":"Haematologica"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0004","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.3389\/fonc.2020.01422","article-title":"Importance of crosstalk between chronic lymphocytic leukemia cells and the stromal microenvironment: direct contact, soluble factors, and extracellular vesicles","volume":"10","author":"Dubois","year":"2020","journal-title":"Front Oncol"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0005","article-title":"Cells in chronic lymphocytic leukemia: a two-edged sword","volume":"11","author":"Vlachonikola","year":"2020","journal-title":"Front Immunol."},{"issue":"23","key":"10.1053\/j.seminhematol.2023.12.004_bib0006","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.3390\/cancers14235787","article-title":"Natural killer cells in chronic lymphocytic leukemia: functional impairment and therapeutic potential","volume":"14","author":"Yano","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"2","key":"10.1053\/j.seminhematol.2023.12.004_bib0007","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3390\/cells10020217","article-title":"Nurse-like cells and chronic lymphocytic leukemia b cells: a mutualistic crosstalk inside tissue microenvironments","volume":"10","author":"Fiorcari","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0008","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of cancer: new dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov"},{"issue":"7203","key":"10.1053\/j.seminhematol.2023.12.004_bib0009","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0010","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0011","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.immuni.2019.06.025","article-title":"Inflammation and cancer: triggers, mechanisms, and consequences","volume":"51","author":"Greten","year":"2019","journal-title":"Immunity"},{"issue":"8","key":"10.1053\/j.seminhematol.2023.12.004_bib0012","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1182\/blood.V96.8.2655","article-title":"Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell\u2013derived factor-1","volume":"96","author":"Burger","year":"2000","journal-title":"Blood"},{"issue":"7","key":"10.1053\/j.seminhematol.2023.12.004_bib0013","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.3109\/10428194.2011.568078","article-title":"Genomic and phenotypic characterization of nurse-like cells that promote drug resistance in chronic lymphocytic leukemia","volume":"52","author":"Ysebaert","year":"2011","journal-title":"Leuk Lymphoma"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0014","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1182\/blood.V99.3.1030","article-title":"Distinctive features of \u201cnurselike\u201d cells that differentiate in the context of chronic lymphocytic leukemia","volume":"99","author":"Tsukada","year":"2002","journal-title":"Blood."},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0015","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.3109\/10428194.2014.991731","article-title":"Nurse like cells: chronic lymphocytic leukemia associated macrophages","volume":"56","author":"Boissard","year":"2015","journal-title":"Leuk Lymphoma"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0016","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1038\/leu.2015.305","article-title":"Depletion of CLL-associated patrolling monocytes and macrophages controls disease development and repairs immune dysfunction in vivo","volume":"30","author":"Hanna","year":"2016","journal-title":"Leukemia"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0017","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3390\/cancers14010016","article-title":"IL-10 rescues CLL survival through repolarization of inflammatory nurse-like cells","volume":"14","author":"Domagala","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"11","key":"10.1053\/j.seminhematol.2023.12.004_bib0018","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1182\/blood-2013-10-529610","article-title":"Extracellular HMGB1 promotes differentiation of nurse-like cells in chronic lymphocytic leukemia","volume":"123","author":"Jia","year":"2014","journal-title":"Blood"},{"issue":"6","key":"10.1053\/j.seminhematol.2023.12.004_bib0019","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.cell.2020.02.041","article-title":"Toll-like receptors and the control of immunity","volume":"180","author":"Fitzgerald","year":"2020","journal-title":"Cell"},{"issue":"22","key":"10.1053\/j.seminhematol.2023.12.004_bib0020","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1182\/blood.2022016272","article-title":"Macrophage- and BCR-derived but not TLR-derived signals support the growth of CLL and RIChter syndrome murine models in vivo","volume":"140","author":"Martines","year":"2022","journal-title":"Blood"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0021","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1182\/blood-2014-07-589069","article-title":"Extracellular nicotinamide phosphoribosyltransferase (NAMPT) promotes M2 macrophage polarization in chronic lymphocytic leukemia","volume":"125","author":"Audrito","year":"2015","journal-title":"Blood"},{"issue":"6","key":"10.1053\/j.seminhematol.2023.12.004_bib0022","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.4049\/jimmunol.2100931","article-title":"Disruption of nurse-like cell differentiation as a therapeutic strategy for chronic lymphocytic leukemia","volume":"209","author":"Merchand-Reyes","year":"2022","journal-title":"J Immunol"},{"issue":"4","key":"10.1053\/j.seminhematol.2023.12.004_bib0023","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.ccell.2016.09.007","article-title":"LYN kinase in the tumor microenvironment is essential for the progression of chronic lymphocytic leukemia","volume":"30","author":"Nguyen","year":"2016","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0024","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1600-065X.2008.00758.x","article-title":"Multiple roles of lyn kinase in myeloid cell signaling and function","volume":"228","author":"Scapini","year":"2009","journal-title":"Immunol Rev"},{"issue":"16","key":"10.1053\/j.seminhematol.2023.12.004_bib0025","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1182\/blood-2010-02-269894","article-title":"Platelet-derived growth factor (PDGF)-PDGF receptor interaction activates bone marrow-derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch","volume":"116","author":"Ding","year":"2010","journal-title":"Blood"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0026","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.ccr.2012.12.003","article-title":"Protein kinase c-\u03b2-dependent activation of NF-\u03baB in stromal cells is indispensable for the survival of chronic lymphocytic leukemia B cells in vivo","volume":"23","author":"Lutzny","year":"2013","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0027","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1038\/s41467-018-06069-5","article-title":"Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia","volume":"9","author":"Mangolini","year":"2018","journal-title":"Nat Commun"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0028","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1038\/s41467-023-36824-2","article-title":"LYN kinase programs stromal fibroblasts to facilitate leukemic survival via regulation of c-JUN and THBS1","volume":"14","author":"Vom Stein","year":"2023","journal-title":"Nat Commun"},{"issue":"526","key":"10.1053\/j.seminhematol.2023.12.004_bib0029","doi-asserted-by":"crossref","first-page":"eaax9340","DOI":"10.1126\/scitranslmed.aax9340","article-title":"Stromal cell protein kinase C-\u03b2 inhibition enhances chemosensitivity in B cell malignancies and overcomes drug resistance","volume":"12","author":"Park","year":"2020","journal-title":"Sci Transl Med"},{"issue":"39","key":"10.1053\/j.seminhematol.2023.12.004_bib0030","doi-asserted-by":"crossref","first-page":"42130","DOI":"10.18632\/oncotarget.6239","article-title":"Cross-talk between chronic lymphocytic leukemia (CLL) tumor B cells and mesenchymal stromal cells (MSCs): implications for neoplastic cell survival","volume":"6","author":"Trimarco","year":"2015","journal-title":"Oncotarget"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0031","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1182\/blood-2014-12-618025","article-title":"Exosomes released by chronic lymphocytic leukemia cells induce the transition of stromal cells into cancer-associated fibroblasts","volume":"126","author":"Paggetti","year":"2015","journal-title":"Blood"},{"issue":"Supplement 1","key":"10.1053\/j.seminhematol.2023.12.004_bib0032","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1182\/blood-2021-152236","article-title":"CLL-derived exosomes turn endothelial cells into IL-6 producing cells","volume":"138","author":"Uziel","year":"2021","journal-title":"Blood"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0033","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1158\/2159-8290.CD-14-0096","article-title":"Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B-cell activation and proliferation","volume":"4","author":"Heinig","year":"2014","journal-title":"Cancer Discov"},{"issue":"19","key":"10.1053\/j.seminhematol.2023.12.004_bib0034","doi-asserted-by":"crossref","first-page":"5201","DOI":"10.1182\/blood-2011-03-342436","article-title":"Identification of outcome-correlated cytokine clusters in chronic lymphocytic leukemia","volume":"118","author":"Yan","year":"2011","journal-title":"Blood"},{"issue":"4","key":"10.1053\/j.seminhematol.2023.12.004_bib0035","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1038\/s41375-019-0630-6","article-title":"Influence of obesity and gender on treatment outcomes in patients with chronic lymphocytic leukemia (CLL) undergoing rituximab-based chemoimmunotherapy","volume":"34","author":"F\u00fcrstenau","year":"2020","journal-title":"Leukemia"},{"issue":"6","key":"10.1053\/j.seminhematol.2023.12.004_bib0036","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/ijc.23176","article-title":"Overweight and obesity and incidence of leukemia: a meta-analysis of cohort studies","volume":"122","author":"Larsson","year":"2008","journal-title":"Int J Cancer"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0037","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.3324\/haematol.2021.280455","article-title":"The gut microbiome in patients with chronic lymphocytic leukemia","volume":"107","author":"Faitov\u00e1","year":"2022","journal-title":"Haematologica"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0038","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1172\/JCI23409","article-title":"In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells","volume":"115","author":"Messmer","year":"2005","journal-title":"J Clin Invest"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0039","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1182\/bloodadvances.2021006941","article-title":"The immune microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia","volume":"7","author":"Sun","year":"2023","journal-title":"Blood Adv"},{"issue":"2","key":"10.1053\/j.seminhematol.2023.12.004_bib0040","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1182\/blood-2010-05-284984","article-title":"The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia","volume":"117","author":"Herishanu","year":"2011","journal-title":"Blood"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0041","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/bjh.13844","article-title":"Proliferation centres of chronic lymphocytic leukaemia\/small lymphocytic lymphoma have enhanced expression of MYC protein, which does not result from rearrangement or gain of the MYC gene","volume":"175","author":"Gibson","year":"2016","journal-title":"Br J Haematol"},{"issue":"6","key":"10.1053\/j.seminhematol.2023.12.004_bib0042","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1182\/blood.2021013990","article-title":"Characterization of metabolic alterations of chronic lymphocytic leukemia in the lymph node microenvironment","volume":"140","author":"Chen","year":"2022","journal-title":"Blood"},{"issue":"4","key":"10.1053\/j.seminhematol.2023.12.004_bib0043","doi-asserted-by":"crossref","first-page":"e001889","DOI":"10.1136\/jitc-2020-001889","article-title":"Control of PD-L1 expression in CLL-cells by stromal triggering of the Notch-c-Myc-EZH2 oncogenic signaling axis","volume":"9","author":"B\u00f6ttcher","year":"2021","journal-title":"J Immunother Cancer"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0044","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2119\/molmed.2012.00303","article-title":"Chronic lymphocytic leukemia cells in a lymph node microenvironment depict molecular signature associated with an aggressive disease","volume":"20","author":"Mittal","year":"2014","journal-title":"Mol Med"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0045","article-title":"NF-kB and the CLL microenvironment","volume":"13","author":"O'Donnell","year":"2023","journal-title":"Front Oncol"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0046","doi-asserted-by":"crossref","first-page":"e938","DOI":"10.1097\/HS9.0000000000000938","article-title":"In Vitro 3D Spheroid Culture System Displays Sustained T Cell-dependent CLL Proliferation and Survival","volume":"7","author":"Haselager","year":"2023","journal-title":"Hemasphere"},{"issue":"11","key":"10.1053\/j.seminhematol.2023.12.004_bib0047","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1038\/leu.2009.145","article-title":"Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles","volume":"23","author":"Plander","year":"2009","journal-title":"Leukemia"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0048","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41598-018-36853-8","article-title":"BCR-associated factors driving chronic lymphocytic leukemia cells proliferation ex vivo","volume":"9","author":"Schleiss","year":"2019","journal-title":"Sci Rep"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0049","doi-asserted-by":"crossref","first-page":"1004717","DOI":"10.3389\/frhem.2022.1004717","article-title":"Ex vivo culture of malignant primary B cells","volume":"1","author":"Canonne","year":"2022","journal-title":"Front Hematol"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0050","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-023-01426-w","article-title":"A tumor microenvironment model of chronic lymphocytic leukemia enables drug sensitivity testing to guide precision medicine","volume":"9","author":"Hermansen","year":"2023","journal-title":"Cell Death Discov"},{"issue":"32","key":"10.1053\/j.seminhematol.2023.12.004_bib0051","doi-asserted-by":"crossref","first-page":"52225","DOI":"10.18632\/oncotarget.13660","article-title":"Nurse-like cells promote CLL survival through LFA-3\/CD2 interactions","volume":"8","author":"Boissard","year":"2017","journal-title":"Oncotarget"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0052","doi-asserted-by":"crossref","first-page":"e15992","DOI":"10.1371\/journal.pone.0015992","article-title":"Stereotypical chronic lymphocytic leukemia B-cell receptors recognize survival promoting antigens on stromal cells","volume":"5","author":"Binder","year":"2010","journal-title":"PLoS One"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0053","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.592205","article-title":"Proliferative signals in chronic lymphocytic leukemia; what are we missing?","volume":"10","author":"Haselager","year":"2020","journal-title":"Front Oncol"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0054","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.bbamcr.2015.07.009","article-title":"Microenvironment interactions and B-cell receptor signaling in chronic lymphocytic leukemia: implications for disease pathogenesis and treatment","volume":"1863","author":"Ten Hacken","year":"2016","journal-title":"Biochim Biophys Acta"},{"issue":"8","key":"10.1053\/j.seminhematol.2023.12.004_bib0055","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1182\/blood-2004-10-3873","article-title":"CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival","volume":"105","author":"Deaglio","year":"2005","journal-title":"Blood"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0056","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.3390\/cancers14122997","article-title":"Multiple mechanisms of NOTCH1 activation in chronic lymphocytic leukemia: NOTCH1 mutations and beyond","volume":"14","author":"Pozzo","year":"2022","journal-title":"Cancers (Basel)"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0057","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1038\/leu.2013.319","article-title":"Functional impact of NOTCH1 mutations in chronic lymphocytic leukemia","volume":"28","author":"Arruga","year":"2014","journal-title":"Leukemia"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0058","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.3324\/haematol.2014.117705","article-title":"Chronic lymphocytic leukemia cells in lymph nodes show frequent NOTCH1 activation","volume":"100","author":"Onaindia","year":"2015","journal-title":"Haematologica"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0059","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1038\/bcj.2012.17","article-title":"Role of stromal cell-mediated notch signaling in CLL resistance to chemotherapy","volume":"2","author":"Nwabo Kamdje","year":"2012","journal-title":"Blood Cancer J"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0060","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.celrep.2013.07.011","article-title":"Chronic lymphocytic leukemia cells are activated and proliferate in response to specific T helper cells","volume":"4","author":"Os","year":"2013","journal-title":"Cell Rep"},{"issue":"17","key":"10.1053\/j.seminhematol.2023.12.004_bib0061","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1182\/bloodadvances.2019000360","article-title":"Distinct immune composition in lymph node and peripheral blood of CLL patients is reshaped during venetoclax treatment","volume":"3","author":"de Weerdt","year":"2019","journal-title":"Blood Adv"},{"issue":"8","key":"10.1053\/j.seminhematol.2023.12.004_bib0062","doi-asserted-by":"crossref","first-page":"2012","DOI":"10.1038\/s41375-020-0873-2","article-title":"T-cells in chronic lymphocytic leukemia: guardians or drivers of disease?","volume":"34","author":"Roessner","year":"2020","journal-title":"Leukemia"},{"issue":"17","key":"10.1053\/j.seminhematol.2023.12.004_bib0063","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1182\/blood-2012-11-467670","article-title":"IL-21 and CD40L signals from autologous T cells can induce antigen-independent proliferation of CLL cells","volume":"122","author":"Pascutti","year":"2013","journal-title":"Blood"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0064","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1182\/blood-2007-07-099531","article-title":"IL-21 mediates apoptosis through up-regulation of the BH3 family member BIM and enhances both direct and antibody-dependent cellular cytotoxicity in primary chronic lymphocytic leukemia cells in vitro","volume":"111","author":"Gowda","year":"2008","journal-title":"Blood"},{"issue":"2","key":"10.1053\/j.seminhematol.2023.12.004_bib0065","doi-asserted-by":"crossref","first-page":"e20200517","DOI":"10.1084\/jem.20200517","article-title":"Pathological RANK signaling in B cells drives autoimmunity and chronic lymphocytic leukemia","volume":"218","author":"Alankus","year":"2021","journal-title":"J Exp Med"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0066","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1182\/blood-2004-03-0889","article-title":"Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1\u03b1","volume":"106","author":"Nishio","year":"2005","journal-title":"Blood"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0067","doi-asserted-by":"crossref","first-page":"6071","DOI":"10.4049\/jimmunol.1102066","article-title":"Stromal endothelial cells establish a bidirectional crosstalk with chronic lymphocytic leukemia cells through the TNF-related factors BAFF, APRIL, and CD40L","volume":"188","author":"Cols","year":"2012","journal-title":"J Immunol"},{"issue":"6","key":"10.1053\/j.seminhematol.2023.12.004_bib0068","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.3390\/cancers15061791","article-title":"The BAFF-APRIL system in cancer","volume":"15","author":"Ullah","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"8","key":"10.1053\/j.seminhematol.2023.12.004_bib0069","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1038\/leu.2015.50","article-title":"Neutralization of (NK-cell-derived) B-cell activating factor by belimumab restores sensitivity of chronic lymphoid leukemia cells to direct and rituximab-induced NK lysis","volume":"29","author":"Wild","year":"2015","journal-title":"Leukemia"},{"issue":"2","key":"10.1053\/j.seminhematol.2023.12.004_bib0070","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1182\/blood-2006-06-027755","article-title":"BAFF and APRIL support chronic lymphocytic leukemia B-cell survival through activation of the canonical NF-\u03baB pathway","volume":"109","author":"Endo","year":"2007","journal-title":"Blood"},{"issue":"11","key":"10.1053\/j.seminhematol.2023.12.004_bib0071","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.3324\/haematol.2017.170571","article-title":"SYK inhibition thwarts the BAFF - B-cell receptor crosstalk and thereby antagonizes Mcl-1 in chronic lymphocytic leukemia","volume":"102","author":"Paiva","year":"2017","journal-title":"Haematologica"},{"issue":"8","key":"10.1053\/j.seminhematol.2023.12.004_bib0072","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1182\/blood.V96.8.2655","article-title":"Blood-derived nurse-like cells protect chronic lymphocytic leukemia B cells from spontaneous apoptosis through stromal cell-derived factor-1","volume":"96","author":"Burger","year":"2000","journal-title":"Blood"},{"issue":"4","key":"10.1053\/j.seminhematol.2023.12.004_bib0073","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3324\/haematol.2011.052779","article-title":"AMD3100 disrupts the cross-talk between chronic lymphocytic leukemia cells and a mesenchymal stromal or nurse-like cell-based microenvironment: pre-clinical evidence for its association with chronic lymphocytic leukemia treatments","volume":"97","author":"Stamatopoulos","year":"2012","journal-title":"Haematologica"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0074","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/s41375-018-0306-7","article-title":"Wnt5a causes ROR1 to complex and activate cortactin to enhance migration of chronic lymphocytic leukemia cells","volume":"33","author":"Hasan","year":"2019","journal-title":"Leukemia"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41420-022-00884-y","article-title":"Aberrantly expressed Wnt5a in nurse-like cells drives resistance to venetoclax in chronic lymphocytic leukemia","volume":"8","author":"Guo","year":"2022","journal-title":"Cell Death Discov"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0076","doi-asserted-by":"crossref","first-page":"901","DOI":"10.4049\/jimmunol.1403189","article-title":"TLR-9 and IL-15 synergy promotes the in vitro clonal expansion of chronic lymphocytic leukemia B cells","volume":"195","author":"Mongini","year":"2015","journal-title":"J Immunol"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0077","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.4049\/jimmunol.1800591","article-title":"Mechanistic insights into CpG DNA and IL-15 synergy in promoting B cell chronic lymphocytic leukemia clonal expansion","volume":"201","author":"Gupta","year":"2018","journal-title":"J Immunol"},{"issue":"2","key":"10.1053\/j.seminhematol.2023.12.004_bib0078","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1182\/blood-2007-04-087882","article-title":"The opposite effects of IL-15 and IL-21 on CLL B cells correlate with differential activation of the JAK\/STAT and ERK1\/2 pathways","volume":"111","author":"de Totero","year":"2008","journal-title":"Blood"},{"issue":"17","key":"10.1053\/j.seminhematol.2023.12.004_bib0079","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1182\/bloodadvances.2020003944","article-title":"Extrinsic interactions in the microenvironment in vivo activate an antiapoptotic multidrug-resistant phenotype in CLL","volume":"5","author":"Jayappa","year":"2021","journal-title":"Blood Adv"},{"issue":"14","key":"10.1053\/j.seminhematol.2023.12.004_bib0080","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1182\/bloodadvances.2016004176","article-title":"Microenvironmental agonists generate de novo phenotypic resistance to combined ibrutinib plus venetoclax in CLL and MCL","volume":"1","author":"Jayappa","year":"2017","journal-title":"Blood Adv."},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0081","doi-asserted-by":"crossref","first-page":"1658","DOI":"10.1038\/s41418-020-00692-w","article-title":"Regulation of Bcl-XL by non-canonical NF-\u03baB in the context of CD40-induced drug resistance in CLL","volume":"28","author":"Haselager","year":"2021","journal-title":"Cell Death Differ"},{"issue":"16","key":"10.1053\/j.seminhematol.2023.12.004_bib0082","doi-asserted-by":"crossref","first-page":"3249","DOI":"10.1007\/s00018-019-03058-9","article-title":"Abnormalities in chemokine receptor recycling in chronic lymphocytic leukemia","volume":"76","author":"Patrussi","year":"2019","journal-title":"Cell Mol Life Sci"},{"issue":"16","key":"10.1053\/j.seminhematol.2023.12.004_bib0083","doi-asserted-by":"crossref","first-page":"4691","DOI":"10.1182\/bloodadvances.2021006169","article-title":"Nurselike cells sequester B cells in disorganized lymph nodes in chronic lymphocytic leukemia via alternative production of CCL21","volume":"6","author":"Zaaboub","year":"2022","journal-title":"Blood Adv"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0084","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1089\/scd.2012.0255","article-title":"Study of the quantitative, functional, cytogenetic, and immunoregulatory properties of bone marrow mesenchymal stem cells in patients with B-cell chronic lymphocytic leukemia","volume":"22","author":"Pontikoglou","year":"2013","journal-title":"Stem Cells Dev"},{"issue":"11","key":"10.1053\/j.seminhematol.2023.12.004_bib0085","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1182\/blood.V94.11.3658","article-title":"Chronic lymphocytic leukemia B cells express functional CXCR4 chemokine receptors that mediate spontaneous migration beneath bone marrow stromal cells","volume":"94","author":"Burger","year":"1999","journal-title":"Blood"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0086","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1038\/sj.leu.2401602","article-title":"Overexpression of the chemokine receptor CXCR4 in B cell chronic lymphocytic leukemia is associated with increased functional response to stromal cell-derived factor-1 (SDF-1)","volume":"13","author":"M\u00f6hle","year":"1999","journal-title":"Leukemia"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0087","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1038\/s41598-021-84695-8","article-title":"Tissue factor pathway inhibitor upregulates CXCR7 expression and enhances CXCL12-mediated migration in chronic lymphocytic leukemia","volume":"11","author":"Cui","year":"2021","journal-title":"Sci Rep."},{"issue":"11\u201312","key":"10.1053\/j.seminhematol.2023.12.004_bib0088","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.2119\/molmed.2011.00360","article-title":"Intraclonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born\/divided and older\/quiescent cells","volume":"17","author":"Calissano","year":"2011","journal-title":"Mol Med"},{"issue":"10","key":"10.1053\/j.seminhematol.2023.12.004_bib0089","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1038\/s41375-021-01376-1","article-title":"CXCR4 hyperactivation cooperates with TCL1 in CLL development and aggressiveness","volume":"35","author":"Lewis","year":"2021","journal-title":"Leukemia"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0090","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/leu.2010.36","article-title":"CD38 increases CXCL12-mediated signals and homing of chronic lymphocytic leukemia cells","volume":"24","author":"Vaisitti","year":"2010","journal-title":"Leukemia"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0091","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3324\/haematol.10649","article-title":"The prognostic role of CXCR3 expression by chronic lymphocytic leukemia B cells","volume":"92","author":"Oca\u00f1a","year":"2007","journal-title":"Haematologica"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0092","doi-asserted-by":"crossref","first-page":"e99","DOI":"10.3324\/haematol.2015.133470","article-title":"Combined CXCR3\/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative co-operativity of the receptors","volume":"101","author":"Ganghammer","year":"2016","journal-title":"Haematologica"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0093","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7084268","article-title":"High CXCR3 on leukemic cells distinguishes IgHV mut from IgHV unmut in chronic lymphocytic leukemia: evidence from CD5high and CD5low clones","volume":"2020","author":"Manukyan","year":"2020","journal-title":"J Immunol Res"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0094","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0092-8674(00)80059-8","article-title":"CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs","volume":"99","author":"F\u00f6rster","year":"1999","journal-title":"Cell"},{"issue":"8","key":"10.1053\/j.seminhematol.2023.12.004_bib0095","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1182\/blood.V99.8.2977","article-title":"The chemokine receptor CCR7 and alpha4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes","volume":"99","author":"Till","year":"2002","journal-title":"Blood"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0096","doi-asserted-by":"crossref","first-page":"3316","DOI":"10.1182\/blood-2007-05-089409","article-title":"Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia","volume":"110","author":"B\u00fcrkle","year":"2007","journal-title":"Blood"},{"issue":"6","key":"10.1053\/j.seminhematol.2023.12.004_bib0097","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41375-020-01063-7","article-title":"CXCL13 plasma levels function as a biomarker for disease activity in patients with chronic lymphocytic leukemia","volume":"35","author":"Sivina","year":"2021","journal-title":"Leukemia"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0098","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/j.1365-2559.1994.tb00553.x","article-title":"Proliferation centres in B-cell malignant lymphoma, lymphocytic (B-CLL): an immunophenotypic study","volume":"24","author":"Schmid","year":"1994","journal-title":"Histopathology"},{"issue":"11","key":"10.1053\/j.seminhematol.2023.12.004_bib0099","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1182\/blood-2015-02-626291","article-title":"L-selectin controls trafficking of chronic lymphocytic leukemia cells in lymph node high endothelial venules in vivo","volume":"126","author":"Lafouresse","year":"2015","journal-title":"Blood."},{"issue":"20","key":"10.1053\/j.seminhematol.2023.12.004_bib0100","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1158\/1078-0432.CCR-13-1037","article-title":"CD62L as a therapeutic target in chronic lymphocytic leukemia","volume":"19","author":"Burgess","year":"2013","journal-title":"Clin Cancer Res."},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0101","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1053\/j.seminhematol.2014.05.002","article-title":"Microenvironmental interactions in chronic lymphocytic leukemia: the master role of CD49d","volume":"51","author":"Dal Bo","year":"2014","journal-title":"Semin Hematol"},{"issue":"17","key":"10.1053\/j.seminhematol.2023.12.004_bib0102","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1182\/blood-2013-06-511527","article-title":"Reciprocal leukemia-stroma VCAM-1\/VLA-4-dependent activation of NF-\u03baB mediates chemoresistance","volume":"123","author":"Jacamo","year":"2014","journal-title":"Blood"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0103","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1200\/JCO.2013.50.8515","article-title":"CD49d is the strongest flow cytometry\u2013based predictor of overall survival in chronic lymphocytic leukemia","volume":"32","author":"Bulian","year":"2014","journal-title":"J Clin Oncol"},{"issue":"18","key":"10.1053\/j.seminhematol.2023.12.004_bib0104","doi-asserted-by":"crossref","first-page":"3612","DOI":"10.1158\/1078-0432.CCR-22-3217","article-title":"CD49d expression identifies a biologically distinct subtype of chronic lymphocytic leukemia with inferior progression-free survival on BTK inhibitor therapy","volume":"29","author":"Alsadhan","year":"2023","journal-title":"Clin Cancer Res"},{"issue":"Supplement 1","key":"10.1053\/j.seminhematol.2023.12.004_bib0105","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1182\/blood-2022-170042","article-title":"Integrin signaling pathway is crucial for the recently divided fraction of CLL cells and facilitates cell migration in a disease progressive manner","volume":"140","author":"Yan","year":"2022","journal-title":"Blood"},{"issue":"14","key":"10.1053\/j.seminhematol.2023.12.004_bib0106","doi-asserted-by":"crossref","first-page":"2279","DOI":"10.1242\/jcs.017905","article-title":"Regulation of integrin activation through the B-cell receptor","volume":"121","author":"Arana","year":"2008","journal-title":"J Cell Sci"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0107","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1182\/blood.2020008101","article-title":"FoxO1-GAB1 axis regulates homing capacity and tonic AKT activity in chronic lymphocytic leukemia","volume":"138","author":"Seda","year":"2021","journal-title":"Blood"},{"issue":"7","key":"10.1053\/j.seminhematol.2023.12.004_bib0108","doi-asserted-by":"crossref","first-page":"1794","DOI":"10.1038\/s41375-022-01586-1","article-title":"The scaffold protein NEDD9 is necessary for leukemia-cell migration and disease progression in a mouse model of chronic lymphocytic leukemia","volume":"36","author":"Rusyn","year":"2022","journal-title":"Leukemia"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0109","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/1521-4141(200205)32:5<1403::AID-IMMU1403>3.0.CO;2-Y","article-title":"Chronic lymphocytic leukemia B cells are endowed with the capacity to attract CD4+, CD40L+ T cells by producing CCL22","volume":"32","author":"Ghia","year":"2002","journal-title":"Eur J Immunol"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0110","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1046\/j.1365-2141.2003.04118.x","article-title":"Plasma interleukin 8 level predicts for survival in chronic lymphocytic leukaemia","volume":"120","author":"Wierda","year":"2003","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0111","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00262-016-1921-7","article-title":"Neutrophils from chronic lymphocytic leukemia patients exhibit an increased capacity to release extracellular traps (NETs)","volume":"66","author":"Podaza","year":"2017","journal-title":"Cancer Immunol Immunother"},{"issue":"18","key":"10.1053\/j.seminhematol.2023.12.004_bib0112","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1158\/0008-5472.CAN-15-3486","article-title":"Splenic marginal zone granulocytes acquire an accentuated neutrophil B-cell helper phenotype in chronic lymphocytic leukemia","volume":"76","author":"G\u00e4tjen","year":"2016","journal-title":"Cancer Res"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0113","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.3390\/ijms21051825","article-title":"Immune response dysfunction in chronic lymphocytic leukemia: dissecting molecular mechanisms and microenvironmental conditions","volume":"21","author":"Arruga","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0114","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.3324\/haematol.2020.267914","article-title":"T-cell dysfunction in chronic lymphocytic leukemia from an epigenetic perspective","volume":"106","author":"Peters","year":"2021","journal-title":"Haematologica"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0115","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3324\/haematol.2016.142679","article-title":"Chronic lymphocytic leukemia cells are active participants in microenvironmental cross-talk","volume":"102","author":"van Attekum","year":"2017","journal-title":"Haematologica"},{"issue":"7","key":"10.1053\/j.seminhematol.2023.12.004_bib0116","first-page":"2427","article-title":"Chronic lymphocytic leukemia T cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug","volume":"118","author":"Ramsay","year":"2008","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1053\/j.seminhematol.2023.12.004_bib0117","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1182\/blood-2012-02-411678","article-title":"Multiple inhibitory ligands induce impaired T-cell immunologic synapse function in chronic lymphocytic leukemia that can be blocked with lenalidomide: establishing a reversible immune evasion mechanism in human cancer","volume":"120","author":"Ramsay","year":"2012","journal-title":"Blood"},{"issue":"10","key":"10.1053\/j.seminhematol.2023.12.004_bib0118","doi-asserted-by":"crossref","first-page":"2042","DOI":"10.1038\/sj.bjc.6601833","article-title":"Alterations of the expression of T-cell-related costimulatory CD28 and downregulatory CD152 (CTLA-4) molecules in patients with B-cell chronic lymphocytic leukaemia","volume":"90","author":"Frydecka","year":"2004","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1053\/j.seminhematol.2023.12.004_bib0119","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/ejh.12880","article-title":"Frequency and functional characterization of exhausted CD8+T cells in chronic lymphocytic leukemia","volume":"98","author":"Taghiloo","year":"2017","journal-title":"Eur J Haematol"},{"issue":"13","key":"10.1053\/j.seminhematol.2023.12.004_bib0120","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.3390\/cancers13133255","article-title":"T cell defects and immunotherapy in chronic lymphocytic leukemia","volume":"13","author":"Vlachonikola","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0121","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/leu.2012.165","article-title":"Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function","volume":"27","author":"DiLillo","year":"2013","journal-title":"Leukemia"},{"issue":"6","key":"10.1053\/j.seminhematol.2023.12.004_bib0122","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3324\/haematol.2012.077537","article-title":"The PD-1\/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia","volume":"98","author":"Brusa","year":"2013","journal-title":"Haematologica"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0123","doi-asserted-by":"crossref","first-page":"5465","DOI":"10.1172\/JCI96610","article-title":"CD84 regulates PD-1\/PD-L1 expression and function in chronic lymphocytic leukemia","volume":"128","author":"Lewinsky","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0124","doi-asserted-by":"crossref","first-page":"943354","DOI":"10.3389\/fimmu.2022.943354","article-title":"Regulatory T cells (Tregs) in lymphoid malignancies and the impact of novel therapies","volume":"13","author":"Maharaj","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0125","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40164-022-00296-9","article-title":"Myeloid-derived suppressor cells in hematologic malignancies: two sides of the same coin","volume":"11","author":"Yu","year":"2022","journal-title":"Exp Hematol Oncol"},{"issue":"22","key":"10.1053\/j.seminhematol.2023.12.004_bib0126","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1182\/blood.2020010527","article-title":"SOX11, CD70, and treg cells configure the tumor immune microenvironment of aggressive mantle cell lymphoma","volume":"138","author":"Balsas","year":"2021","journal-title":"Blood"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0127","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1182\/blood.V85.12.3556.bloodjournal85123556","article-title":"Expression of CD27 and its ligand, CD70, on chronic lymphocytic leukemia B cells","volume":"85","author":"Ranheim","year":"1995","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0128","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.molimm.2017.11.014","article-title":"Beyond bystanders: myeloid cells in chronic lymphocytic leukemia","volume":"110","author":"Hanna","year":"2019","journal-title":"Mol Immunol"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0129","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1182\/blood-2013-12-546416","article-title":"CLL-cells induce IDOhi CD14+HLA-DRlo myeloid-derived suppressor cells that inhibit T-cell responses and promote TRegs","volume":"124","author":"Jitschin","year":"2014","journal-title":"Blood"},{"issue":"11","key":"10.1053\/j.seminhematol.2023.12.004_bib0130","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1038\/s41375-021-01249-7","article-title":"Myeloid-derived suppressor cell subtypes differentially influence T-cell function, T-helper subset differentiation, and clinical course in CLL","volume":"35","author":"Ferrer","year":"2021","journal-title":"Leukemia"},{"issue":"19","key":"10.1053\/j.seminhematol.2023.12.004_bib0131","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1182\/blood.2020007445","article-title":"Tumor interferon signaling and suppressive myeloid cells are associated with CAR T-cell failure in large B-cell lymphoma","volume":"137","author":"Jain","year":"2021","journal-title":"Blood"},{"issue":"13","key":"10.1053\/j.seminhematol.2023.12.004_bib0132","doi-asserted-by":"crossref","first-page":"e166070","DOI":"10.1172\/JCI166070","article-title":"Tumor-activated lymph node fibroblasts suppress T cell function in diffuse large B cell lymphoma","volume":"133","author":"Apollonio","year":"2023","journal-title":"J Clin Invest"},{"issue":"26","key":"10.1053\/j.seminhematol.2023.12.004_bib0133","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1182\/blood.2021012811","article-title":"Targeting cancer-associated fibroblasts in the bone marrow prevents resistance to CART-cell therapy in multiple myeloma","volume":"139","author":"Sakemura","year":"2022","journal-title":"Blood"},{"issue":"8","key":"10.1053\/j.seminhematol.2023.12.004_bib0134","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.3324\/haematol.2022.282177","article-title":"The immunomodulatory molecule TIGIT is expressed by chronic lymphocytic leukemia cells and contributes to anergy","volume":"108","author":"Arruga","year":"2023","journal-title":"Haematologica"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0135","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1084\/jem.20040119","article-title":"The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor\u2013dependent mechanisms during anti-CD20 antibody immunotherapy","volume":"199","author":"Uchida","year":"2004","journal-title":"J Exp Med"},{"issue":"11","key":"10.1053\/j.seminhematol.2023.12.004_bib0136","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41573-022-00520-5","article-title":"Macrophages as tools and targets in cancer therapy","volume":"21","author":"Mantovani","year":"2022","journal-title":"Nat Rev Drug Discov"},{"issue":"7","key":"10.1053\/j.seminhematol.2023.12.004_bib0137","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3324\/haematol.2012.073080","article-title":"The monocytic population in chronic lymphocytic leukemia shows altered composition and deregulation of genes involved in phagocytosis and inflammation","volume":"98","author":"Maffei","year":"2013","journal-title":"Haematologica"},{"issue":"20","key":"10.1053\/j.seminhematol.2023.12.004_bib0138","doi-asserted-by":"crossref","first-page":"3053","DOI":"10.1111\/jcmm.17868","article-title":"Effects of blocking CD24 and CD47 \u201cdon't eat me\u201d signals in combination with rituximab in mantle-cell lymphoma and chronic lymphocytic leukaemia","volume":"27","author":"Aroldi","year":"2023","journal-title":"J Cell Mol Med"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0139","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001796","article-title":"CD47 agonist peptides induce programmed cell death in refractory chronic lymphocytic leukemia B cells via PLC\u03b31 activation: evidence from mice and humans","volume":"12","author":"Martinez-Torres","year":"2015","journal-title":"PLoS Med"},{"issue":"11","key":"10.1053\/j.seminhematol.2023.12.004_bib0140","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/15233","article-title":"CD47 ligation induces caspase-independent cell death in chronic lymphocytic leukemia","volume":"5","author":"Mateo","year":"1999","journal-title":"Nat Med"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0141","doi-asserted-by":"crossref","first-page":"e000413","DOI":"10.1136\/jitc-2019-000413","article-title":"The Fully human anti-CD47 antibody SRF231 exerts dual-mechanism antitumor activity via engagement of the activating receptor CD32a","volume":"8","author":"Peluso","year":"2020","journal-title":"J Immunother Cancer"},{"issue":"20","key":"10.1053\/j.seminhematol.2023.12.004_bib0142","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1182\/bloodadvances.2019000350","article-title":"Targeting chronic lymphocytic leukemia with N-methylated thrombospondin-1-derived peptides overcomes drug resistance","volume":"3","author":"Pramil","year":"2019","journal-title":"Blood Adv"},{"issue":"18","key":"10.1053\/j.seminhematol.2023.12.004_bib0143","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1182\/blood-2013-01-476606","article-title":"Soluble ligands for NK cell receptors promote evasion of chronic lymphocytic leukemia cells from NK cell anti-tumor activity","volume":"121","author":"Reiners","year":"2013","journal-title":"Blood"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0144","doi-asserted-by":"crossref","unstructured":"MacFarlane AW IV, Jillab M, Smith MR, et al. NK cell dysfunction in chronic lymphocytic leukemia is associated with loss of the mature cells expressing inhibitory killer cell Ig-like receptors. Oncoimmunology. 2017;6(7):e1330235.","DOI":"10.1080\/2162402X.2017.1330235"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0145","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.3389\/fimmu.2018.02917","article-title":"Ig-like transcript 2 (ILT2) blockade and lenalidomide restore NK cell function in chronic lymphocytic leukemia","volume":"9","author":"Villa-\u00c1lvarez","year":"2018","journal-title":"Front Immunol"},{"issue":"4","key":"10.1053\/j.seminhematol.2023.12.004_bib0146","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1159\/000497208","article-title":"Dysregulated expression of Tim-3 and NKp30 receptors on NK cells of patients with chronic lymphocytic leukemia","volume":"42","author":"Hadadi","year":"2019","journal-title":"Oncol Res Treat"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0147","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/leu.2011.313","article-title":"Glucocorticoid-induced TNFR-related protein (GITR) ligand modulates cytokine release and NK cell reactivity in chronic lymphocytic leukemia (CLL)","volume":"26","author":"Buechele","year":"2012","journal-title":"Leukemia"},{"issue":"13","key":"10.1053\/j.seminhematol.2023.12.004_bib0148","doi-asserted-by":"crossref","first-page":"6665","DOI":"10.3390\/ijms22136665","article-title":"NK cells in chronic lymphocytic leukemia and their therapeutic implications","volume":"22","author":"Sportoletti","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"6","key":"10.1053\/j.seminhematol.2023.12.004_bib0149","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11912-021-01058-2","article-title":"Extracellular vesicles and their associated miRNAs as potential prognostic biomarkers in chronic lymphocytic leukemia","volume":"23","author":"Aguilar-Hernandez","year":"2021","journal-title":"Curr Oncol Rep"},{"issue":"21","key":"10.1053\/j.seminhematol.2023.12.004_bib0150","doi-asserted-by":"crossref","first-page":"3297","DOI":"10.1182\/blood-2014-12-618470","article-title":"Characterization of CLL exosomes reveals a distinct microRNA signature and enhanced secretion by activation of BCR signaling","volume":"125","author":"Yeh","year":"2015","journal-title":"Blood"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0151","doi-asserted-by":"crossref","first-page":"8146","DOI":"10.4049\/jimmunol.180.12.8146","article-title":"Induction of exosome release in primary B cells stimulated via CD40 and the IL-4 receptor","volume":"180","author":"Saunderson","year":"2008","journal-title":"J Immunol"},{"issue":"4","key":"10.1053\/j.seminhematol.2023.12.004_bib0152","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1182\/blood-2015-11-682377","article-title":"Extracellular vesicles released by CD40\/IL-4-stimulated CLL cells confer altered functional properties to CD4+ T cells","volume":"128","author":"Smallwood","year":"2016","journal-title":"Blood"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0153","doi-asserted-by":"crossref","first-page":"e100","DOI":"10.3324\/haematol.2016.153197","article-title":"Extracellular vesicles released from chronic lymphocytic leukemia cells exhibit a disease relevant mRNA signature and transfer mRNA to bystander cells","volume":"102","author":"Reiners","year":"2017","journal-title":"Haematologica"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0154","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1182\/blood-2009-09-242719","article-title":"Circulating microvesicles in B-cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression","volume":"115","author":"Ghosh","year":"2010","journal-title":"Blood"},{"issue":"13","key":"10.1053\/j.seminhematol.2023.12.004_bib0155","doi-asserted-by":"crossref","first-page":"eaah5509","DOI":"10.1126\/sciimmunol.aah5509","article-title":"Tumor-derived exosomes modulate PD-L1 expression in monocytes","volume":"2","author":"Haderk","year":"2017","journal-title":"Sci Immunol"},{"issue":"14","key":"10.1053\/j.seminhematol.2023.12.004_bib0156","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.3390\/cells11142176","article-title":"CLL-derived extracellular vesicles impair T-cell activation and foster T-cell exhaustion via multiple immunological checkpoints","volume":"11","author":"B\u00f6ttcher","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0157","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1158\/2643-3230.BCD-22-0029","article-title":"Extracellular vesicle secretion by leukemia cells in vivo promotes CLL progression by hampering antitumor T-cell responses","volume":"4","author":"Gargiulo","year":"2022","journal-title":"Blood Cancer Discov"},{"issue":"4","key":"10.1053\/j.seminhematol.2023.12.004_bib0158","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.ymthe.2020.12.033","article-title":"Leukemic extracellular vesicles induce chimeric antigen receptor T cell dysfunction in chronic lymphocytic leukemia","volume":"29","author":"Cox","year":"2021","journal-title":"Mol Ther"},{"issue":"9","key":"10.1053\/j.seminhematol.2023.12.004_bib0159","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.3324\/haematol.2016.163337","article-title":"Extracellular vesicles of bone marrow stromal cells rescue chronic lymphocytic leukemia B cells from apoptosis, enhance their migration and induce gene expression modifications","volume":"102","author":"Crompot","year":"2017","journal-title":"Haematologica"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0160","article-title":"Stromal cells support the survival of human primary chronic lymphocytic leukemia (CLL) cells through lyn-driven extracellular vesicles","volume":"9","author":"de Oliveira","year":"2022","journal-title":"Front Med (Lausanne)"},{"issue":"10","key":"10.1053\/j.seminhematol.2023.12.004_bib0161","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.neo.2017.07.004","article-title":"The stromal microenvironment modulates mitochondrial oxidative phosphorylation in chronic lymphocytic leukemia cells","volume":"19","author":"Vangapandu","year":"2017","journal-title":"Neoplasia"},{"issue":"22","key":"10.1053\/j.seminhematol.2023.12.004_bib0162","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1182\/blood-2014-10-607036","article-title":"Stromal cell\u2013mediated glycolytic switch in CLL cells involves notch-c-Myc signaling","volume":"125","author":"Jitschin","year":"2015","journal-title":"Blood"},{"issue":"17","key":"10.1053\/j.seminhematol.2023.12.004_bib0163","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1182\/blood-2013-10-532200","article-title":"Mitochondrial metabolism contributes to oxidative stress and reveals therapeutic targets in chronic lymphocytic leukemia","volume":"123","author":"Jitschin","year":"2014","journal-title":"Blood"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0164","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1038\/ncb2432","article-title":"Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia","volume":"14","author":"Zhang","year":"2012","journal-title":"Nat Cell Biol"},{"issue":"4","key":"10.1053\/j.seminhematol.2023.12.004_bib0165","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.3324\/haematol.2019.217430","article-title":"HIF-1\u03b1 is over-expressed in leukemic cells from TP53-disrupted patients and is a promising therapeutic target in chronic lymphocytic leukemia","volume":"105","author":"Griggio","year":"2020","journal-title":"Haematologica"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0166","doi-asserted-by":"crossref","unstructured":"Vitale C, Griggio V, Riganti C, et al. Targeting HIF-1\u03b1 regulatory pathways as a strategy to hamper tumor-microenvironment interactions in CLL. Cancers (Basel). 2021;13(12):2883.","DOI":"10.3390\/cancers13122883"},{"issue":"16","key":"10.1053\/j.seminhematol.2023.12.004_bib0167","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1182\/blood-2015-07-657056","article-title":"HIF-1\u03b1 regulates the interaction of chronic lymphocytic leukemia cells with the tumor microenvironment","volume":"127","author":"Valsecchi","year":"2016","journal-title":"Blood"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0168","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1182\/blood.2018885863","article-title":"Chronic lymphocytic leukemia cells impair mitochondrial fitness in CD8+ T cells and impede CAR T-cell efficacy","volume":"134","author":"van Bruggen","year":"2019","journal-title":"Blood"},{"issue":"2","key":"10.1053\/j.seminhematol.2023.12.004_bib0169","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1038\/leu.2016.214","article-title":"The PD-1\/PD-L1 axis contributes to immune metabolic dysfunctions of monocytes in chronic lymphocytic leukemia","volume":"31","author":"Qorraj","year":"2017","journal-title":"Leukemia"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0170","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1182\/bloodadvances.2016000984","article-title":"Adenosine signaling mediates hypoxic responses in the chronic lymphocytic leukemia microenvironment","volume":"1","author":"Serra","year":"2016","journal-title":"Blood Adv"},{"issue":"4","key":"10.1053\/j.seminhematol.2023.12.004_bib0171","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3390\/ijms19041167","article-title":"Targeting the adenosinergic axis in chronic lymphocytic leukemia: a way to disrupt the tumor niche?","volume":"19","author":"Vaisitti","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"7980","key":"10.1053\/j.seminhematol.2023.12.004_bib0172","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/s41586-023-06546-y","article-title":"Reductive carboxylation epigenetically instructs T cell differentiation","volume":"621","author":"Jaccard","year":"2023","journal-title":"Nature"},{"issue":"3","key":"10.1053\/j.seminhematol.2023.12.004_bib0173","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/s41375-023-01817-z","article-title":"Chronic lymphocytic leukemia presence impairs antigen-specific CD8+ T-cell responses through epigenetic reprogramming towards short-lived effectors","volume":"37","author":"Martens","year":"2023","journal-title":"Leukemia"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0174","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.1038\/leu.2017.129","article-title":"Targeting antigen-independent proliferation in chronic lymphocytic leukemia through differential kinase inhibition","volume":"31","author":"Slinger","year":"2017","journal-title":"Leukemia"},{"issue":"20","key":"10.1053\/j.seminhematol.2023.12.004_bib0175","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1158\/1078-0432.CCR-15-0781","article-title":"Treatment with ibrutinib inhibits BTK- and VLA-4-dependent adhesion of chronic lymphocytic leukemia cells in vivo","volume":"21","author":"Herman","year":"2015","journal-title":"Clin Cancer Res"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0176","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1182\/blood-2011-10-386417","article-title":"The bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo","volume":"119","author":"Ponader","year":"2012","journal-title":"Blood"},{"issue":"11","key":"10.1053\/j.seminhematol.2023.12.004_bib0177","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1182\/blood-2011-11-390989","article-title":"The clinically active BTK inhibitor PCI-32765 targets B-cell receptor\u2013 and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia","volume":"119","author":"de Rooij","year":"2012","journal-title":"Blood"},{"issue":"7","key":"10.1053\/j.seminhematol.2023.12.004_bib0178","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.3324\/haematol.2022.281999","article-title":"Sialylation regulates migration in chronic lymphocytic leukemia","volume":"108","author":"Natoni","year":"2023","journal-title":"Haematologica"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0179","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1182\/blood-2016-04-709519","article-title":"Ibrutinib inhibits CD20 upregulation on CLL B cells mediated by the CXCR4\/SDF-1 axis","volume":"128","author":"Pavlasova","year":"2016","journal-title":"Blood"},{"issue":"6","key":"10.1053\/j.seminhematol.2023.12.004_bib0180","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1038\/s41375-023-01898-w","article-title":"Ibrutinib sensitizes CLL cells to venetoclax by interrupting TLR9-induced CD40 upregulation and protein translation","volume":"37","author":"Kielbassa","year":"2023","journal-title":"Leukemia"},{"issue":"106432","key":"10.1053\/j.seminhematol.2023.12.004_bib0181","article-title":"Ibrutinib restores immune cell numbers and function in first-line and relapsed\/refractory chronic lymphocytic leukemia","volume":"97","author":"Solman","year":"2020","journal-title":"Leuk Res"},{"issue":"8","key":"10.1053\/j.seminhematol.2023.12.004_bib0182","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1172\/JCI89756","article-title":"Ibrutinib treatment improves T cell number and function in CLL patients","volume":"127","author":"Long","year":"2017","journal-title":"J Clin Invest"},{"issue":"7","key":"10.1053\/j.seminhematol.2023.12.004_bib0183","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1158\/1078-0432.CCR-15-1965","article-title":"Disruption of in vivo chronic lymphocytic leukemia tumor\u2013microenvironment interactions by ibrutinib\u2014findings from an investigator-initiated phase II study","volume":"22","author":"Niemann","year":"2016","journal-title":"Clin Cancer Res"},{"issue":"4","key":"10.1053\/j.seminhematol.2023.12.004_bib0184","doi-asserted-by":"crossref","first-page":"e140","DOI":"10.3324\/haematol.2014.119669","article-title":"Ibrutinib impairs the phagocytosis of rituximab-coated leukemic cells from chronic lymphocytic leukemia patients by human macrophages","volume":"100","author":"Borge","year":"2015","journal-title":"Haematologica"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0185","doi-asserted-by":"crossref","first-page":"608625","DOI":"10.3389\/fimmu.2021.608625","article-title":"The PI3K\u2202-selective inhibitor idelalisib induces T- and NK-cell dysfunction independently of B-cell malignancy-associated immunosuppression","volume":"12","author":"Rohrbacher","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0186","first-page":"11","article-title":"Richter syndrome: novel insights into the biology of transformation","volume":"142","author":"Parry","year":"2023","journal-title":"Blood"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0187","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41591-022-02113-6","article-title":"Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome","volume":"29","author":"Parry","year":"2023","journal-title":"Nat Med"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0188","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-34642-6","article-title":"Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis","volume":"14","author":"Bros\u00e9us","year":"2023","journal-title":"Nat Commun"},{"issue":"8","key":"10.1053\/j.seminhematol.2023.12.004_bib0189","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1038\/s41591-022-01927-8","article-title":"Detection of early seeding of Richter transformation in chronic lymphocytic leukemia","volume":"28","author":"Nadeu","year":"2022","journal-title":"Nat Med"},{"issue":"2","key":"10.1053\/j.seminhematol.2023.12.004_bib0190","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1158\/2643-3230.BCD-22-0082","article-title":"In vivo modeling of CLL transformation to Richter syndrome reveals convergent evolutionary paths and therapeutic vulnerabilities","volume":"4","author":"Ten Hacken","year":"2023","journal-title":"Blood Cancer Discov"},{"issue":"12","key":"10.1053\/j.seminhematol.2023.12.004_bib0191","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1182\/blood.2020008276","article-title":"B-cell receptor signaling and genetic lesions in TP53 and CDKN2A\/CDKN2B cooperate in Richter transformation","volume":"138","author":"Chakraborty","year":"2021","journal-title":"Blood"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0192","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41408-021-00477-5","article-title":"Distinct immune signatures in chronic lymphocytic leukemia and Richter syndrome","volume":"11","author":"Wang","year":"2021","journal-title":"Blood Cancer J"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0193","doi-asserted-by":"crossref","unstructured":"Martines C. CXCR4 loss reduces the local growth of Richter syndrome murine and patient-derived xenograft models and impairs BCR and VLA-4 activation. In: 65th ASH Annual Meeting & Exposition; 2023. https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper179183.html","DOI":"10.1182\/blood-2023-179183"},{"issue":"5","key":"10.1053\/j.seminhematol.2023.12.004_bib0194","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1182\/blood.2020005734","article-title":"Active AKT signaling triggers CLL towards Richter's transformation via over-activation of Notch1","volume":"137","author":"Kohlhaas","year":"2020","journal-title":"Blood"},{"issue":"2","key":"10.1053\/j.seminhematol.2023.12.004_bib0195","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/bjh.15514","article-title":"PD-1 is highly expressed by neoplastic B-cells in Richter transformation","volume":"185","author":"Behdad","year":"2019","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1053\/j.seminhematol.2023.12.004_bib0196","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1111\/bjh.17789","article-title":"Characterisation of immune checkpoints in Richter syndrome identifies LAG3 as a potential therapeutic target","volume":"195","author":"Gould","year":"2021","journal-title":"Br J Haematol"},{"issue":"Supplement 1","key":"10.1053\/j.seminhematol.2023.12.004_bib0197","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1182\/blood-2022-160465","article-title":"Immuno-genetic changes underlie response to immune checkpoint blockade therapy in Richter's syndrome mouse models","volume":"140","author":"Ten Hacken","year":"2022","journal-title":"Blood"},{"issue":"26","key":"10.1053\/j.seminhematol.2023.12.004_bib0198","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1182\/blood-2017-02-765685","article-title":"Pembrolizumab in patients with CLL and Richter transformation or with relapsed CLL","volume":"129","author":"Ding","year":"2017","journal-title":"Blood."},{"issue":"6","key":"10.1053\/j.seminhematol.2023.12.004_bib0199","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1200\/JCO.18.00766","article-title":"Nivolumab for relapsed\/refractory diffuse large B-cell lymphoma in patients ineligible for or having failed autologous transplantation: a single-arm, phase II study","volume":"37","author":"Ansell","year":"2019","journal-title":"J Clin Oncol"},{"issue":"8","key":"10.1053\/j.seminhematol.2023.12.004_bib0200","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1182\/blood.2019000847","article-title":"The immune landscape and response to immune checkpoint blockade therapy in lymphoma","volume":"135","author":"Kline","year":"2020","journal-title":"Blood"},{"issue":"10","key":"10.1053\/j.seminhematol.2023.12.004_bib0201","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1016\/j.ccell.2023.08.013","article-title":"ZNF683 marks a CD8+ T cell population associated with anti-tumor immunity following anti-PD-1 therapy for Richter syndrome","volume":"41","author":"Parry","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0202","doi-asserted-by":"crossref","unstructured":"Al-Sawaf O. Tislelizumab plus zanubrutinib in patients with Richter transformation: primary endpoint analysis of the prospective, multi-center, phase-II RT1 trial of the German CLL study group. In: 65th ASH Annual Meeting & Exposition; 2023 https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper188705.html","DOI":"10.1182\/blood-2023-188705"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0203","unstructured":"Shouse G. Safety, efficacy and T-cell predictive biomarkers in a phase I trial of copanlisib+nivolumab in patients with Richter's transformation (RT) or transformed non-Hodgkin lymphoma (tNHL). In: 65th ASH Annual Meeting & Exposition; 2023 https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper182559.html"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0204","unstructured":"Cheah C. Mosunetuzumab monotherapy demonstrates activity and a manageable safety profile in patients with relapsed or refractory Richter's transformation. In: 65th ASH Annual Meeting & Exposition; 2023 https:\/\/ash.confex.com\/ash\/2023\/webprogram\/Paper173796.html"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0205","article-title":"Practical management of Richter transformation in 2023 and beyond","volume":"43","author":"Ryan","year":"2023","journal-title":"Am Soc Clin Oncol Educ Book"},{"key":"10.1053\/j.seminhematol.2023.12.004_bib0206","article-title":"Coevolution of leukemia and host immune cells in chronic lymphocytic leukemia","volume":"43","author":"Purroy","year":"2023","journal-title":"Am Soc Clin Oncol Educ Book"}],"container-title":["Seminars in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196323000987?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196323000987?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:53:57Z","timestamp":1777442037000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0037196323000987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":206,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S0037196323000987"],"URL":"https:\/\/doi.org\/10.1053\/j.seminhematol.2023.12.004","relation":{},"ISSN":["0037-1963"],"issn-type":[{"value":"0037-1963","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of the tumor microenvironment in CLL pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Seminars in Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminhematol.2023.12.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}