{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:01:09Z","timestamp":1785441669640,"version":"3.56.0"},"reference-count":6,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Hematology"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1053\/j.seminhematol.2026.06.004","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T13:09:37Z","timestamp":1785330577000},"page":"1-2","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sickle Cell Disease: Expanding the Frontiers of Pathophysiology and Therapeutics"],"prefix":"10.1053","volume":"63","author":[{"given":"Swee Lay","family":"Thein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1053\/j.seminhematol.2026.06.004_bib0001","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1053\/j.seminhematol.2026.05.006","article-title":"Pain in SCD \u2013 many mechanisms and mysteries","volume":"63","author":"Martin","year":"2026","journal-title":"Semin Hematol."},{"issue":"1","key":"10.1053\/j.seminhematol.2026.06.004_bib0002","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1053\/j.seminhematol.2026.05.007","article-title":"The Many Facets of Cardiopulmonary Complications in Sickle Cell Disease","volume":"63","author":"d\u2019Humi\u00e8res","year":"2026","journal-title":"Semin Hematol."},{"issue":"1","key":"10.1053\/j.seminhematol.2026.06.004_bib0003","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1053\/j.seminhematol.2026.04.001","article-title":"More disease-modifying therapies for sickle cell disease: Are small molecules and drug repurposing the way forward?","volume":"63","author":"Quinn","year":"2026","journal-title":"Semin Hematol"},{"issue":"1","key":"10.1053\/j.seminhematol.2026.06.004_bib0004","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1053\/j.seminhematol.2026.05.003","article-title":"Evolving insights into mitochondrial presence in RBC in sickle cell disease: Red blood cell and reticulocyte pathophysiology, therapeutic strategies, and future directions","volume":"63","author":"Ansong-Ansongton","year":"2026","journal-title":"Semin Hematol."},{"issue":"1","key":"10.1053\/j.seminhematol.2026.06.004_bib0005","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.seminhematol.2026.05.001","article-title":"The paradox of HbSC disease-Not so benign after all","volume":"63","author":"Lyde","year":"2026","journal-title":"Semin Hematol."},{"issue":"1","key":"10.1053\/j.seminhematol.2026.06.004_bib0006","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1053\/j.seminhematol.2026.05.002","article-title":"Cellular pathogenesis of HbSC disease","volume":"63","author":"Gibson","year":"2026","journal-title":"Semin Hematol."}],"container-title":["Seminars in Hematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196326000673?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0037196326000673?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:24:06Z","timestamp":1785439446000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0037196326000673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":6,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0037196326000673"],"URL":"https:\/\/doi.org\/10.1053\/j.seminhematol.2026.06.004","relation":{},"ISSN":["0037-1963"],"issn-type":[{"value":"0037-1963","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sickle Cell Disease: Expanding the Frontiers of Pathophysiology and Therapeutics","name":"articletitle","label":"Article Title"},{"value":"Seminars in Hematology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminhematol.2026.06.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}