{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:38:34Z","timestamp":1792589914484,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Oncology"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1053\/j.seminoncol.2004.07.026","type":"journal-article","created":{"date-parts":[[2005,11,3]],"date-time":"2005-11-03T13:58:14Z","timestamp":1131026294000},"page":"67-72","source":"Crossref","is-referenced-by-count":20,"special_numbering":"S10","title":["Ibandronate in metastatic bone pain"],"prefix":"10.1053","volume":"31","author":[{"given":"Axel","family":"Heidenreich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Ohlmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Body","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"suppl","key":"10.1053\/j.seminoncol.2004.07.026_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1399-6576.1982.tb01852.x","article-title":"Management of cancer pain","volume":"74","author":"Bonica","year":"1982","journal-title":"Acta Anaesthesiol Scand Suppl"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib2","series-title":"Skeletal Metastases","author":"Galasko","year":"1986"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1023\/A:1006308619659","article-title":"Metastatic breast cancer","volume":"59","author":"Solomayer","year":"2000","journal-title":"Breast Cancer Res Treat"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib4","first-page":"895","article-title":"Therapy of metastatic bone pain","volume":"42","author":"Serafini","year":"2001","journal-title":"J Nucl Med"},{"issue":"suppl 11","key":"10.1053\/j.seminoncol.2004.07.026_bib5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1053\/sonc.2001.25444","article-title":"Bone metastases","volume":"28","author":"Janjan","year":"2001","journal-title":"Semin Oncol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0304-3959(96)03267-8","article-title":"Malignant bone pain","volume":"69","author":"Mercadante","year":"1997","journal-title":"Pain"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib7","series-title":"Cancer pain relief and palliative care","year":"1990"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib8","doi-asserted-by":"crossref","first-page":"3890","DOI":"10.1200\/JCO.1998.16.12.3890","article-title":"Current use of bisphosphonates in oncology","volume":"16","author":"Body","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib9","first-page":"377","article-title":"Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma","volume":"7","author":"Rosen","year":"2001","journal-title":"Cancer J"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib10","first-page":"CD003474","article-title":"Pavlakis N, Stockler M","volume":"1","year":"2002","journal-title":"Bisphosphonates for breast cancer. Cochrane Database Syst Rev"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib11","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1093\/jnci\/94.19.1458","article-title":"A randomized, placebo-controlled trial of zoledronic acid in patients with hormone-refractory metastatic prostate carcinoma","volume":"94","author":"Saad","year":"2002","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib12","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1093\/annonc\/mdg367","article-title":"Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases","volume":"14","author":"Body","year":"2003","journal-title":"Ann Oncol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib13","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/sj.bjc.6601663","article-title":"Oral ibandronate reduces the risk of skeletal complications in breast cancer patients with metastatic bone disease","volume":"90","author":"Body","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib14","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1056\/NEJM199602223340802","article-title":"Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma","volume":"334","author":"Berenson","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib15","doi-asserted-by":"crossref","first-page":"2552","DOI":"10.1200\/JCO.1996.14.9.2552","article-title":"Delay in progression of bone metastases in breast cancer patients treated with intravenous pamidronate","volume":"14","author":"Conte","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib16","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/0885-3924(92)90101-M","article-title":"A double-blind, crossover trial of intravenous clodronate in metastatic bone pain","volume":"7","author":"Ernst","year":"1992","journal-title":"J Pain Symptom Manage"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib17","first-page":"136","article-title":"Heidenreich A, Hofmann R, Engelmann UH","volume":"165","year":"2001","journal-title":"The use of bisphosphonates for the palliative treatment of painful bone metastasis due to hormone refractory prostate cancer. J Urol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib18","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1023\/A:1008238422151","article-title":"Relationships between biochemical and symptomatic response in a double-blind randomised trial of pamidronate for metastatic bone disease","volume":"8","author":"Vinholes","year":"1997","journal-title":"Ann Oncol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib19","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1016\/j.ejca.2004.03.025","article-title":"Improved quality of life after long-term treatment with the bisphosphonate ibandronate in patients with metastatic bone disease due to breast cancer","volume":"401","author":"Diel","year":"2004","journal-title":"Eur J Cancer"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib20","series-title":"Bone Metastases","first-page":"99","article-title":"Assessment of response to treatment","author":"Coleman","year":"1991"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib21","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/jnci\/85.5.365","article-title":"The European Organization for Research and Treatment of Cancer QLQ-C30","volume":"85","author":"Aaronson","year":"1993","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib22","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1200\/JCO.2004.07.054","article-title":"Efficacy and safety of ibandronate in the treatment of opioid-resistant bone pain associated with metastatic bone disease","volume":"22","author":"Mancini","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib23","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s005200000172","article-title":"Multidisciplinary symptom control clinic in a cancer center","volume":"9","author":"Bruera","year":"2001","journal-title":"Support Care Cancer"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib24","series-title":"Management of cancer pain. Quick reference guide for clinicians. Clinical Practice Guideline No. 9","author":"Jacox","year":"1994"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib25","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/0885-3924(95)00052-Z","article-title":"A prospective multicenter assessment of the Edmonton staging system for cancer pain","volume":"10","author":"Bruera","year":"1995","journal-title":"J Pain Symptom Manage"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib26","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/S0885-3924(96)00206-0","article-title":"The Edmonton Functional Assessment Tool","volume":"13","author":"Kaasa","year":"1997","journal-title":"J Pain Symptom Manage"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib27","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/00000421-198212000-00014","article-title":"Toxicity and response criteria of the Eastern Cooperative Oncology Group","volume":"5","author":"Oken","year":"1993","journal-title":"Am J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib28","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/sj.pcan.4500574","article-title":"Ibandronate in the treatment of prostate cancer associated painful osseous metastases","volume":"5","author":"Heidenreich","year":"2002","journal-title":"Prostate Cancer Prostatic Dis"},{"issue":"suppl 5","key":"10.1053\/j.seminoncol.2004.07.026_bib29","doi-asserted-by":"crossref","first-page":"S270","DOI":"10.1016\/S1359-6349(03)90923-2","article-title":"High-dose ibandronate is effective and well tolerated in the treatment of pain and hypercalcemia due to metastatic urologic cancer [abstract 897]","volume":"1","author":"Heidenreich","year":"2003","journal-title":"Eur J Cancer"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib30","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.pain.2004.07.011","article-title":"Oral ibandronate improves bone pain and preserves quality of life in patients with skeletal metastases due to breast cancer","volume":"111","author":"Body","year":"2004","journal-title":"Pain"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF02549644","article-title":"Effect of oral clodronate on bone pain - A controlled study in patients with metastatic prostate cancer","volume":"24","author":"Elomaa","year":"1992","journal-title":"Int Urol Nephrol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib32","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0140-6736(92)93075-X","article-title":"Randomised, placebo-controlled multicentre trial of clodronate in multiple myeloma","volume":"340","author":"Lahtinen","year":"1992","journal-title":"Lancet"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib33","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1200\/JCO.1995.13.4.929","article-title":"Double-blind, placebo-controlled, dose-response trial of oral clodronate in patients with bone metastases","volume":"13","author":"O\u2019Rourke","year":"1995","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib34","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1056\/NEJM199612123352401","article-title":"Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases","volume":"335","author":"Hortobagyi","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib35","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1082::AID-CNCR20>3.0.CO;2-Z","article-title":"Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases","volume":"88","author":"Lipton","year":"2000","journal-title":"Cancer"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib36","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1200\/JCO.1998.16.6.2038","article-title":"Long-term prevention of skeletal complications of metastatic breast cancer with pamidronate","volume":"16","author":"Hortobagyi","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib37","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1200\/JCO.1999.17.3.846","article-title":"Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions","volume":"17","author":"Theriault","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib38","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.1200\/JCO.2003.05.147","article-title":"Combined analysis of two multicenter, randomized, placebo-controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancer","volume":"21","author":"Small","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib39","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/cncr.11701","article-title":"Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma","volume":"98","author":"Rosen","year":"2003","journal-title":"Cancer"},{"key":"10.1053\/j.seminoncol.2004.07.026_bib40","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1046\/j.1365-2796.1999.00507.x","article-title":"Oral clodronate in breast cancer patients with bone metastases","volume":"246","author":"Kristensen","year":"1999","journal-title":"J Intern Med"}],"container-title":["Seminars in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775404003732?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775404003732?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,4]],"date-time":"2019-04-04T04:36:55Z","timestamp":1554352615000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0093775404003732"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":40,"alternative-id":["S0093775404003732"],"URL":"https:\/\/doi.org\/10.1053\/j.seminoncol.2004.07.026","relation":{},"ISSN":["0093-7754"],"issn-type":[{"value":"0093-7754","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}