{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:35:31Z","timestamp":1762101331262},"reference-count":158,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Oncology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1053\/j.seminoncol.2012.05.002","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T08:13:18Z","timestamp":1343463198000},"page":"384-398","source":"Crossref","is-referenced-by-count":45,"title":["Surveillance for Hepatocellular Carcinoma"],"prefix":"10.1053","volume":"39","author":[{"given":"Cristina","family":"Della Corte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminoncol.2012.05.002_bib2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/hep.24710","article-title":"Hepatocellular carcinoma confirmation, treatment and survival in surveillance, epidemiology and survival registries 1992-2008","volume":"55","author":"Altekruse","year":"2012","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib3","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S1470-2045(01)00486-7","article-title":"Global cancer statistics in the year 2000","volume":"2","author":"Parkin","year":"2001","journal-title":"Lancet Oncol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib4","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.gastro.2005.05.001","article-title":"Mortality and hospital utilization for hepatocellular carcinoma in the United States","volume":"129","author":"Kim","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib5","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0168-8278(01)00130-1","article-title":"Clinical management of hepatocellular carcinoma: conclusions of the Barcelona\u20132000 EASL conference","volume":"35","author":"Bruix","year":"2001","journal-title":"J Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/hep.23615","article-title":"Use of surveillance for hepatocellular carcinoma among patients with cirrhosis in the United States","volume":"52","author":"Davila","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.7326\/0003-4819-154-2-201101180-00006","article-title":"Utilization of surveillance for hepatocellular carcinoma among hepatitis C virus\u2013infected veterans in the United States","volume":"154","author":"Davila","year":"2011","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib8","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/hep.24199","article-title":"Management of hepatocellular carcinoma: an update","volume":"53","author":"Bruix","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib9","doi-asserted-by":"crossref","first-page":"S35","DOI":"10.1053\/j.gastro.2004.09.014","article-title":"Hepatocellular carcinoma in cirrhosis: incidence and risk factors","volume":"127","author":"Fattovich","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib10","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/00042737-200012080-00015","article-title":"Hepatocellular carcinoma in Austria: aetiological and clinical characteristics at presentation","volume":"12","author":"Schoniger-Hekele","year":"2000","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib11","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.1001\/archinte.160.21.3227","article-title":"Risk factors for the rising rates of primary liver cancer in the United States","volume":"160","author":"El-Serag","year":"2000","journal-title":"Arch Intern Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib12","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1053\/gast.2002.34168","article-title":"Expanding the natural history of nonalcoholic steatohepatitis: from cryptogenic cirrhosis to hepatocellular carcinoma","volume":"123","author":"Bugianesi","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib13","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1007\/s00595-005-3167-4","article-title":"Hepatocellular carcinoma arising from nonalcoholic steatohepatitis: report of two cases","volume":"36","author":"Hai","year":"2006","journal-title":"Surg Today"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib14","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1136\/gut.2004.052167","article-title":"Diabetes increases the risk of hepatocellular carcinoma in the United States: a population based case control study","volume":"54","author":"Davila","year":"2005","journal-title":"Gut"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib15","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/BF02599016","article-title":"The meaning of life expectancy: what is a clinically significant gain?","volume":"9","author":"Naimark","year":"1994","journal-title":"J Gen Intern Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib16","first-page":"473","article-title":"How attractive does a new technology have to be to warrant adoption and utilization?","volume":"146","author":"Laupacis","year":"1992","journal-title":"CMAJ"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib17","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0002-9343(96)00197-0","article-title":"Cost-effectiveness of screening for detection of small hepatocellular carcinoma in western patients with Child-Pugh class A cirrhosis","volume":"101","author":"Sarasin","year":"1996","journal-title":"Am J Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1572-0241.2003.07327.x","article-title":"Screening for hepatocellular carcinoma in patients with hepatitis C cirrhosis: a costutility analysis","volume":"98","author":"Arguedas","year":"2003","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib19","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1111\/j.1365-2036.2004.01963.x","article-title":"Cost-effectiveness of screening for hepatocellular carcinoma in patients with cirrhosis due to chronic hepatitis C","volume":"19","author":"Lin","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib20","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ejca.2011.12.021","article-title":"European Association for the Study of the Liver, European Organisation for Research and Treatment of Cancer","volume":"48","year":"2012","journal-title":"Eur J Cancer"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib21","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s12072-010-9165-7","article-title":"Asian Pacific Association for the Study of the Liver consensus recommendations on hepatocellular carcinoma","volume":"4","author":"Omata","year":"2010","journal-title":"Hepatol Int"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib22","series-title":"PDQ liver (hepatocellular) cancer screening","year":"2010"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib23","doi-asserted-by":"crossref","first-page":"387","DOI":"10.7326\/0003-4819-156-5-201203060-00012","article-title":"Screening for liver cancer: the rush to judgment","volume":"156","author":"Lederle","year":"2012","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib24","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/gut.32.3.294","article-title":"Natural history and prognostic factors for chronic hepatitis type B","volume":"32","author":"Fattovich","year":"1991","journal-title":"Gut"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib25","doi-asserted-by":"crossref","DOI":"10.1053\/j.gastro.2004.06.021","article-title":"Natural history of chronic HBV carriers in northern Italy: morbidity and mortality after 30 years","volume":"127","author":"Manno","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib26","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1053\/jhep.2002.33638","article-title":"Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B","volume":"35","author":"Hsu","year":"2002","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib27","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1093\/jnci\/92.14.1159","article-title":"Familial risk of hepatocellular carcinoma among chronic hepatitis B carriers and their relatives","volume":"92","author":"Yu","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib28","first-page":"306","article-title":"Some characteristics of Mozambican Shangaans with primary hepatocellular cancer","volume":"51","author":"Kew","year":"1977","journal-title":"S Afr Med J"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib29","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0016-5085(88)90434-9","article-title":"Effect of age on the etiologic role of the hepatitis B virus in hepatocellular carcinoma in blacks","volume":"94","author":"Kew","year":"1988","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.7326\/0003-4819-118-3-199302010-00006","article-title":"The natural history of asymptomatic hepatitis B surface antigen carriers","volume":"118","author":"de Franchis","year":"1993","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib31","doi-asserted-by":"crossref","first-page":"228S","DOI":"10.1016\/S0168-8278(02)80819-4","article-title":"Natural history of HBV infection: a nine years follow-up of the Dionysius cohort","volume":"36","author":"Bellentani","year":"2002","journal-title":"J Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib32","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1001\/jama.295.1.65","article-title":"Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level","volume":"295","author":"Chen","year":"2006","journal-title":"JAMA"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib33","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1111\/j.1572-0241.2006.00647.x","article-title":"Past HBV viral load as predictor of mortality and morbidity from HCC and chronic liver disease in a prospective study","volume":"101","author":"Chen","year":"2006","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib34","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/hep.22432","article-title":"Evaluation of risk factors in the development of hepatocellular carcinoma in autoimmune hepatitis: implications for follow-up and screening","volume":"48","author":"Yeoman","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib35","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1002\/hep.510290312","article-title":"Long-term beneficial effect of interferon therapy in patients with chronic hepatitis B virus infection","volume":"29","author":"Lin","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib36","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1056\/NEJM199605303342202","article-title":"Long-term follow-up of HBeAg-positive patients treated with interferon alfa for chronic hepatitis B","volume":"334","author":"Niederau","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/jhep.2001.25273","article-title":"Long-term follow-up of interferon alfa treatment in Chinese patients with chronic hepatitis B infection: the effect on hepatitis B e antigen seroconversion and the development of cirrhosis-related complications","volume":"34","author":"Yuen","year":"2001","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib38","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1056\/NEJMoa013215","article-title":"Hepatitis B e antigen and the risk of hepatocellular carcinoma","volume":"347","author":"Yang","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib39","first-page":"369","article-title":"Eight-year follow-up of the 90,000-person Haimen City cohort: I. Hepatocellular carcinoma mortality, risk factors, and gender differences","volume":"11","author":"Evans","year":"2002","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib40","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/hep.510280130","article-title":"Sero-clearance of hepatitis B surface antigen in chronic carriers does not necessarily imply a good prognosis","volume":"28","author":"Huo","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib41","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1002\/hep.20240","article-title":"HBsAg seroclearance in chronic hepatitis B in the Chinese: virological, histological, and clinical aspects","volume":"39","author":"Yuen","year":"2004","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib42","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1002\/hep.510260536","article-title":"Longterm outcome of hepatitis B e antigen-positive patients with compensated cirrhosis treated with interferon alfa","volume":"26","author":"Fattovich","year":"1997","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib43","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1111\/j.1572-0241.1998.00272.x","article-title":"Delayed clearance of serum HBsAg in compensated cirrhosis B: relation to interferon alpha therapy and disease prognosis","volume":"93","author":"Fattovich","year":"1998","journal-title":"Am J Gastroenterol"},{"issue":"Suppl 1","key":"10.1053\/j.seminoncol.2012.05.002_bib44","doi-asserted-by":"crossref","first-page":"S50","DOI":"10.1016\/S0168-8278(03)00139-9","article-title":"Natural history of hepatitis B","volume":"39","author":"Fattovich","year":"2003","journal-title":"J Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib45","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/0016-5085(94)90760-9","article-title":"A long-term follow-up study of asymptomatic hepatitis B surface antigen-positive carriers in Montreal","volume":"106","author":"Villeneuve","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib46","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1136\/gut.2003.033324","article-title":"Genotype C hepatitis B virus infection is associated with an increased risk of hepatocellular carcinoma","volume":"53","author":"Chan","year":"2004","journal-title":"Gut"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib47","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1053\/gast.2002.33588","article-title":"Hepatitis B virus genotype B is associated with earlier HBeAg seroconversion compared with hepatitis B virus genotype C","volume":"122","author":"Chu","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib48","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/S0016-5085(00)70261-7","article-title":"Hepatitis B genotypes correlate with clinical outcomes in patients with chronic hepatitis B","volume":"118","author":"Kao","year":"2000","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib49","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.jhep.2005.03.018","volume":"43","author":"Chu","year":"2005","journal-title":"J Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib50","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1053\/jhep.2003.50036","article-title":"Influence of hepatitis B virus genotypes on the progression of chronic type B liver disease","volume":"37","author":"Sumi","year":"2003","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib51","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1093\/jnci\/dji043","article-title":"Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men","volume":"97","author":"Yu","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib52","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1053\/gast.2002.37041","article-title":"Influence of hepatitis B virus genotype on the long-term outcome of chronic hepatitis B in western patients","volume":"123","author":"Sanchez-Tapias","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib53","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1136\/gut.2004.060327","article-title":"Response to interferon alfa is hepatitis B virus genotype dependent: genotype A is more sensitive to interferon than genotype D","volume":"54","author":"Erhardt","year":"2005","journal-title":"Gut"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib54","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.jhep.2009.12.028","article-title":"Impact of peginterferon and ribavirin therapy on hepatocellular carcinoma: incidence and survival in hepatitis C patients with advanced fibrosis","volume":"52","author":"Cardoso","year":"2010","journal-title":"J Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib55","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1053\/gast.1997.v112.pm9024300","article-title":"Morbidity and mortality in compensated cirrhosis type C: a retrospective follow-up study of 384 patients","volume":"112","author":"Fattovich","year":"1997","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib56","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1002\/hep.510280632","article-title":"Prognosis of chronic hepatitis C: results of a large, prospective cohort study","volume":"28","author":"Niederau","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib57","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1093\/aje\/kwg041","article-title":"Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma: a prospective study of 12,008 men in Taiwan","volume":"157","author":"Sun","year":"2003","journal-title":"Am J Epidemiol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib58","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1053\/j.gastro.2008.09.014","article-title":"Incidence of hepatocellular carcinoma and associated risk factors in hepatitis C-related advanced liver disease","volume":"136","author":"Lok","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib59","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/hep.23691","article-title":"Effect of aging on risk for hepatocellular carcinoma in chronic hepatitis C virus infection","volume":"52","author":"Asahina","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib60","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/hep.21492","article-title":"Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study","volume":"45","author":"Bruno","year":"2007","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib61","doi-asserted-by":"crossref","first-page":"677","DOI":"10.7326\/0003-4819-147-10-200711200-00003","article-title":"Sustained virological response and clinical outcomes in patients with chronic hepatitis C and advanced fibrosis","volume":"147","author":"Veldt","year":"2007","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib62","doi-asserted-by":"crossref","first-page":"105","DOI":"10.7326\/0003-4819-142-2-200501180-00009","article-title":"Antiviral therapy for cirrhotic hepatitis C: association with reduced hepatocellular carcinoma development and improved survival","volume":"142","author":"Shiratori","year":"2005","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib63","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-2893.2005.00707.x","article-title":"Long-term effect of interferon alpha-2b plus ribavirin therapy on incidence of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis","volume":"13","author":"Hung","year":"2006","journal-title":"J Viral Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib64","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1111\/j.1478-3231.2006.01406.x","article-title":"Development of hepatocellular carcinoma in patients with chronic hepatitis C who had a sustained virological response to interferon therapy: a multicenter, retrospective cohort study of 1124 patients","volume":"27","author":"Kobayashi","year":"2007","journal-title":"Liver Int"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib65","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1053\/gast.2002.34785","article-title":"Interferon therapy prolonged life expectancy among chronic hepatitis C patients","volume":"123","author":"Yoshida","year":"2002","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib66","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1177\/135965350601100811","article-title":"A sustaine dvirological response to interferon or interferon\/ribavirin reduces hepatocellular carcinoma and improves survival in chronic hepatitis C: a nationwide multicenter study in Taiwan","volume":"11","author":"Yu","year":"2006","journal-title":"Antivir Ther"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib67","doi-asserted-by":"crossref","first-page":"399","DOI":"10.7326\/0003-4819-149-6-200809160-00006","article-title":"Brief communication: the relationship of regression of cirrhosis to outcome in chronic hepatitis C","volume":"149","author":"Mallet","year":"2008","journal-title":"Ann Intern Med"},{"issue":"140","key":"10.1053\/j.seminoncol.2012.05.002_bib68","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1053\/j.gastro.2010.11.050","article-title":"Maintenance peginterferon therapy and other factors associated with hepatocellular carcinoma in patients with advanced hepatitis C","volume":"140","author":"Lok","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib69","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1053\/j.gastro.2011.03.010","article-title":"Maintenance therapy with interferon-alpha 2b does not prevent hepatocellular carcinoma in cirrhotic patients with chronic hepatitis C","volume":"140","author":"Bruix","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib70","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.jhep.2008.11.018","article-title":"Emerging role of hepatocellular carcinoma among liver-related causes of deaths in HIV-infected patients: the French national Mortalite\u2032 2005 study","volume":"50","author":"Salmon-Ceron","year":"2009","journal-title":"J Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib71","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1097\/00002030-200411190-00009","article-title":"Hepatocellular carcinoma in HIV-infected patients: epidemiological features, clinical presentation and outcome","volume":"18","author":"Puoti","year":"2004","journal-title":"Aids"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib72","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1097\/00002030-200308150-00009","article-title":"Mortality due to hepatitis C-related liver disease in HIV-infected patients in France (Mortavic 2001 study)","volume":"17","author":"Rosenthal","year":"2003","journal-title":"Aids"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib73","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1093\/jnci\/djn514","article-title":"Moderate alcohol intake and cancer incidence in women","volume":"101","author":"Allen","year":"2009","journal-title":"J Natl Cancer Inst"},{"issue":"5 Suppl 1","key":"10.1053\/j.seminoncol.2012.05.002_bib74","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1053\/j.gastro.2004.09.020","article-title":"Alcohol and hepatocellular carcinoma","volume":"127","author":"Morgan","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib75","unstructured":"Jepsen P, Ott P, Andersen P, et al. Risk of hepatocellular carcinoma in patients with alcoholic cirrhosis\u2014a Danish nationwide cohort study. Ann Intern Med. In press."},{"key":"10.1053\/j.seminoncol.2012.05.002_bib76","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1056\/NEJMra011775","article-title":"Nonalcoholic fatty liver disease","volume":"346","author":"Angulo","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib77","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1002\/hep.510290347","article-title":"Cryptogenic cirrhosis: clinical characterization and risk factors for underlying disease","volume":"29","author":"Caldwell","year":"1999","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib78","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1002\/hep.23527","article-title":"The incidence and risk factors of hepatocellular carcinoma in patients with nonalcoholic steatohepatitis","volume":"51","author":"Ascha","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib79","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/annonc\/mdn565","article-title":"The impact of obesity and diabetes mellitus on the risk of hepatocellular carcinoma","volume":"20","author":"Polesel","year":"2009","journal-title":"Ann Oncol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib80","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1056\/NEJMoa021423","article-title":"Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults","volume":"348","author":"Calle","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib81","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S1470-2045(02)00849-5","article-title":"Overweight, obesity, and cancer risk","volume":"3","author":"Bianchini","year":"2002","journal-title":"Lancet Oncol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib82","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/sj.bjc.6603932","article-title":"Overweight, obesity and risk of liver cancer: a meta-analysis of cohort studies","volume":"97","author":"Larsson","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib83","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.jhep.2011.10.027","article-title":"Hepatocellular carcinoma in nonalcoholic fatty liver disease: an emerging menace","volume":"56","author":"Baffy","year":"2012","journal-title":"J Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib84","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1053\/j.gastro.2003.09.035","article-title":"Cancer risk in patients with hereditary hemochromatosis and in their first-degree relatives","volume":"125","author":"Elmberg","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib85","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1053\/jhep.2001.22506","article-title":"Increased cancer risk in a cohort of 230 patients with hereditary hemochromatosis in comparison to matched control patients with non-iron-related chronic liver disease","volume":"33","author":"Fracanzani","year":"2001","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib86","first-page":"1160","article-title":"Hepatocellular carcinoma in primary biliary cirrhosis: similar incidence to that in hepatitis C virus-related cirrhosis","volume":"96","author":"Caballeria","year":"2001","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib87","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/hep.22432","article-title":"Evaluation of risk factors in the development of hepatocellular carcinoma in autoimmune hepatitis: implications for follow-up and screening","volume":"48","author":"Yeoman","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib88","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1056\/NEJM198603203141202","article-title":"Risk of cirrhosis and primary liver cancer in alpha 1-antitrypsin deficiency","volume":"314","author":"Eriksson","year":"1986","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib89","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1097\/00042737-199610000-00010","article-title":"Risk of hepatobiliary disease in adults with severe alpha 1-antitrypsin deficiency (PiZZ): is chronic viral hepatitis B or C an additional risk factor for cirrhosis and hepatocellular carcinoma?","volume":"8","author":"Elzouki","year":"1996","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib90","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1056\/NEJM199903113401001","article-title":"Rising incidence of hepatocellular carcinoma in the United States","volume":"340","author":"El-Serag","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib91","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1016\/S0168-8278(98)80122-0","article-title":"Characterisctics of hepatocellular carcinoma in Italy","volume":"29","author":"Stroffolini","year":"1998","journal-title":"J Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib92","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jhep.2005.03.019","article-title":"Serum alpha-fetoprotein levels in patients with advanced hepatitis C: results from the HALT-C trial","volume":"43","author":"Di Bisceglie","year":"2005","journal-title":"J Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib93","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1158\/0008-5472.CAN-07-6013","article-title":"EpCAM and alphafetoprotein expression defines novel prognostic subtypes of hepatocellular carcinoma","volume":"68","author":"Yamashita","year":"2008","journal-title":"Cancer Res"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib94","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.med.080608.100623","article-title":"Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy","volume":"61","author":"Villanueva","year":"2010","journal-title":"Annu Rev Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib95","doi-asserted-by":"crossref","first-page":"7385","DOI":"10.1158\/0008-5472.CAN-09-1089","article-title":"Integrative transcriptome analysis reveals common molecular subclasses of human hepatocellular carcinoma","volume":"69","author":"Hoshida","year":"2009","journal-title":"Cancer Res"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib96","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1007\/s00432-009-0547-y","article-title":"Intrahepatic cholangiocarcinoma: report of 272 patients compared with 5829 patients with hepatocellular carcinoma","volume":"135","author":"Zhou","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib97","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1016\/j.cgh.2007.05.020","article-title":"Risk factors for intrahepatic and extrahepatic cholangiocarcinoma in the United States: a population-based case\u2013control study","volume":"5","author":"Welzel","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib98","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/1097-0142(20010201)91:3<561::AID-CNCR1035>3.0.CO;2-N","article-title":"Des-gamma-carboxy prothrombin as a useful predisposing factor for the development of portal venous invasion in patients with hepatocellular carcinoma: a prospective analysis of 227 patients","volume":"91","author":"Koike","year":"2001","journal-title":"Cancer"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib99","first-page":"5419","article-title":"A collaborative study for the evaluation of lectin-reactive alpha-fetoproteins in early detection of hepatocellular carcinoma","volume":"53","author":"Taketa","year":"1993","journal-title":"Cancer Res"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib100","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/hep.1840220317","article-title":"A clinical study of lectin-reactive alpha-fetoprotein as an early indicator of hepatocellular carcinoma in the follow-up of cirrhotic patients","volume":"22","author":"Shiraki","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib101","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1056\/NEJM199306243282502","article-title":"Early recognition of hepatocellular carcinoma based on altered profiles of alpha-fetoprotein","volume":"328","author":"Sato","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib102","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0168-8278(99)80016-6","article-title":"Clinical utility of Lens culinaris agglutinin-reactive alpha-fetoprotein in small hepatocellular carcinoma: special reference to imaging diagnosis","volume":"30","author":"Kumada","year":"1999","journal-title":"J Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib103","first-page":"265","article-title":"Evaluation of curability and prediction of prognosis after surgical treatment for hepatocellular carcinoma by lens culinaris agglutinin-reactive alpha-fetoprotein","volume":"14","author":"Okuda","year":"1999","journal-title":"Int J Oncol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib104","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1016\/S0002-9270(99)00434-7","article-title":"Usefulness of measurement of Lens culinaris agglutininreactive fraction of alpha-fetoprotein as a marker of prognosis and recurrence of small hepatocellular carcinoma","volume":"94","author":"Hayashi","year":"1999","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib105","first-page":"627","article-title":"Monitoring of lectin-reactive alpha-fetoproteins in patients with hepatocellular carcinoma treated using transcatheter arterial embolization","volume":"7","author":"Yamashita","year":"1995","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib106","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1002\/(SICI)1097-0142(19981215)83:12<2468::AID-CNCR9>3.0.CO;2-Y","article-title":"Serum alpha-L-fucosidase activity and early detection of hepatocellular carcinoma: a prospective study of patients with cirrhosis","volume":"83","author":"Giardina","year":"1998","journal-title":"Cancer"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib107","doi-asserted-by":"crossref","first-page":"927","DOI":"10.2169\/internalmedicine.38.927","article-title":"Prediction of the development of hepato-cellular-carcinoma in patients with liver cirrhosis by the serial determinations of serum alpha-L-fucosidase activity","volume":"38","author":"Ishizuka","year":"1999","journal-title":"Intern Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib108","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S0006-291X(03)00908-2","article-title":"Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker","volume":"306","author":"Nakatsura","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib109","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0016-5085(03)00689-9","article-title":"Glypican-3: a novel serum and histochemical marker for hepatocellularcarcinoma","volume":"125","author":"Capurro","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib110","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.jhep.2008.11.014","article-title":"The application of markers (HSP70 GPC3 and GS) in liver biopsies is useful for detection of hepatocellular carcinoma","volume":"50","author":"Di Tommaso","year":"2009","journal-title":"J Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib111","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1002\/hep.20505","article-title":"Identification of a new marker of hepatocellular carcinoma by serum protein profiling of patients with chronic liver diseases","volume":"41","author":"Paradis","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib112","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1111\/j.1365-2036.2004.02212.x","article-title":"The new DR-70 immunoassay detects cancer of the gastrointestinal tract: a validation study","volume":"20","author":"Kerber","year":"2004","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib113","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1440-1746.2011.06896.x","article-title":"DR-70 immunoassay for the surveillance of hepatocellular carcinoma","volume":"27","author":"Lin","year":"2012","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib114","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/hep.24703","article-title":"Identification of osteopontin as a novel marker for early hepatocellular carcinoma","volume":"55","author":"Shang","year":"2012","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib115","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1136\/gut.48.2.251","article-title":"Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis","volume":"48","author":"Bolondi","year":"2001","journal-title":"Gut"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib116","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1053\/bega.1999.0052","article-title":"Screening for hepatocellular carcinoma","volume":"13","author":"Sherman","year":"1999","journal-title":"Baillieres Best Pract Res Clin Gastroenterol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib117","first-page":"47","article-title":"Liver Malignancies","author":"Bartolozzi","year":"1999"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib118","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1002\/ijc.10122","article-title":"Ultrasound screening and risk factors for death from hepatocellular carcinoma in a high risk group in Taiwan","volume":"98","author":"Chen","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib119","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2214\/ajr.171.2.9694470","article-title":"Sonographic screening for hepatocellular carcinoma in patients with chronic hepatitis or cirrhosis: an evaluation","volume":"171","author":"Larcos","year":"1998","journal-title":"AJR Am J Roentgenol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib120","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1136\/jms.6.2.108","article-title":"Combined alpha fetoprotein testing and ultrasonography as a screening test for primary liver cancer","volume":"6","author":"Zhang","year":"1999","journal-title":"J Med Screen"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib121","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1111\/j.1872-034X.2007.00216.x","article-title":"Development of evidence-based clinical guidelines for the diagnosis and treatment of hepatocellular carcinoma in Japan","volume":"38","author":"Makuuchi","year":"2008","journal-title":"Hepatol Res"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib122","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1002\/hep.24545","article-title":"Ultrasonographic surveillance of hepatocellular carcinoma in cirrhosis: a randomized trial comparing 3- and 6-month periodicities","volume":"53","author":"Trinchet","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib123","series-title":"Hepatocellular carcinoma","author":"Nakashima","year":"1987"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib124","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/lt.20357","article-title":"Improving the prediction of hepatocellular carcinoma in cirrhotic patients with an arterially-enhancing liver mass","volume":"11","author":"Marrero","year":"2005","journal-title":"Liver Transplant"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib125","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1055\/s-2007-963785","article-title":"Guidelines and good clinical practice recommendations for contrast enhanced ultrasound (CEUS)\u2014update 2008","volume":"29","author":"Claudon","year":"2008","journal-title":"Ultraschall Med"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib126","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1136\/gut.2009.187286","article-title":"The diagnostic and economic impact of contrast imaging techniques in the diagnosis of small hepatocellular carcinoma in cirrhosis","volume":"59","author":"Sangiovanni","year":"2010","journal-title":"Gut"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib127","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/hep.21966","article-title":"Diagnosis of hepatic nodules 20 mm or smaller in cirrhosis: prospective validation of the noninvasive diagnostic criteria for hepatocellular carcinoma","volume":"47","author":"Forner","year":"2008","journal-title":"Hepatology"},{"issue":"Suppl 1","key":"10.1053\/j.seminoncol.2012.05.002_bib128","first-page":"362A","article-title":"Implementation of AASLD hepatocellular carcinoma practice guidelines in North America: two years of experience","volume":"48","author":"Khalili","year":"2008","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib129","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.cgh.2010.09.017","article-title":"CT and MRI improve detection of hepatocellular carcinoma, compared with ultrasound alone, in patients with cirrhosis","volume":"9","author":"Yu","year":"2011","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib130","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1002\/hep.24746","article-title":"Accuracy and disagreement of computed tomography and magnetic resonance imaging for the diagnosis of small hepatocellular carcinoma and dysplastic nodules: role of biopsy","volume":"55","author":"Serst\u00e9","year":"2012","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib131","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1002\/hep.23903","article-title":"Diagnosis of hepatocellular carcinoma in cirrhosis by dynamic contrast imaging: the importance of tumor cell differentiation","volume":"52","author":"Iavarone","year":"2010","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib132","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1002\/hep.24638","article-title":"Indeterminate 1-2-cm nodules found on hepatocellular carcinoma surveillance: biopsy for all, some, or none?","volume":"54","author":"Khalili","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib133","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1053\/j.gastro.2006.09.014","article-title":"A molecular signature to discriminate dysplastic nodules from early hepatocellular carcinoma in HCV cirrhosis","volume":"131","author":"Llovet","year":"2006","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib134","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ctrv.2007.04.001","article-title":"Seeding following percutaneous diagnostic and therapeutic approaches for hepatocellular carcinoma","volume":"33","author":"Stigliano","year":"2007","journal-title":"Cancer Treat Rev"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib135","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1055\/s-2005-871193","article-title":"Early hepatocellular carcinoma and dysplastic nodules","volume":"25","author":"Kojiro","year":"2005","journal-title":"Semin Liver Dis"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib136","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/hep.24218","article-title":"Diagnostic accuracy of clathrin heavy chain staining in a marker panel for the diagnosis of small hepatocellular carcinoma","volume":"53","author":"Di Tommaso","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib137","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/hep.20728","article-title":"Characterization of small nodule sin cirrhosis by assessment of vascularity: the problem of hypovascular hepatocellular carcinoma","volume":"42","author":"Bolondi","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib138","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.1111\/j.1572-0241.2004.30137.x","article-title":"Surveillance for hepatocellular carcinoma in elderly Italian patients with cirrhosis: effects on cancer staging and patient survival","volume":"99","author":"Trevisani","year":"2004","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib139","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1111\/j.1572-0241.2002.05557.x","article-title":"Semiannual and annual surveillance of cirrhotic patients for hepatocellular carcinoma: effects on cancer stage and patient survival (Italian experience)","volume":"97","author":"Trevisani","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib140","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1053\/lv.2000.4875","article-title":"Improved survival with screening for hepatocellular carcinoma","volume":"6","author":"Wong","year":"2000","journal-title":"Liver Transpl"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib141","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00130404-200409000-00009","article-title":"Does screening or surveillance for primary hepatocellular carcinoma with ultrasonography improve the prognosis of patients?","volume":"10","author":"Yu","year":"2004","journal-title":"Cancer J"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib142","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.cgh.2006.06.007","article-title":"Impact of surveillance on survival of patients with initial hepatocellular carcinoma: a study from Japan","volume":"4","author":"Toyoda","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib143","doi-asserted-by":"crossref","first-page":"3052","DOI":"10.1001\/jama.1985.03360210068031","article-title":"Early detection of primary hepatocellular carcinoma: screening for primary hepatocellular carcinoma among persons infected with hepatitis B virus","volume":"254","author":"Heyward","year":"1985","journal-title":"JAMA"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib144","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00432-004-0552-0","article-title":"Randomized controlled trial of screening for hepatocellular carcinoma","volume":"130","author":"Zhang","year":"2004","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib145","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1111\/j.1872-034X.2007.00179.x","article-title":"Screening","volume":"37","author":"Colombo","year":"2007","journal-title":"Hepatol Res"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib146","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2753.2006.00656.x","article-title":"A novel method for evaluation of improved survival trend for common cancer: early detection or improvement of medical care","volume":"13","author":"Chie","year":"2007","journal-title":"J Eval Clin Pract"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib147","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/hep.24581","article-title":"Feasibility of conducting a randomised control trial for liver cancer screening: Is a randomized controlled trial for liver cancer screening feasible or still needed?","volume":"53","author":"Poustchi","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib148","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1002\/hep.24684","article-title":"Surveillance for hepatocellular carcinoma: a standard of care, not a clinical option","volume":"54","author":"Sangiovanni","year":"2011","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib149","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta11340","article-title":"Surveillance of cirrhosis for hepatocellular carcinoma: systematic review and economic analysis","volume":"11","author":"Thompson Coon","year":"2007","journal-title":"Health Technol Assess"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib150","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1053\/jhep.2003.50093","article-title":"Prospective analysis of risk factors for hepatocellular carcinoma in patients with liver cirrhosis","volume":"37","author":"Vel\u00e1zquez","year":"2003","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib151","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1159\/000217659","article-title":"The epidermal growth factor","volume":"11","author":"Laurence","year":"1990","journal-title":"Tumor Biol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib152","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/hep.20538","article-title":"Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis","volume":"41","author":"Schiffer","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib153","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1001\/jama.2007.65","article-title":"Epidermal growth factor gene functional polymorphism and the risk of hepatocellular carcinoma in patients with cirrhosis","volume":"299","author":"Tanabe","year":"2008","journal-title":"JAMA"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib154","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1053\/j.gastro.2011.03.045","article-title":"A functional polymorphism in the epidermal growth factor gene is associated with risk for hepatocellular carcinoma","volume":"141","author":"Abu Dayyeh","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib155","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/ng.809","article-title":"Genome-wide association study identifies a susceptibility locus for HCV induced hepatocellular carcinoma","volume":"43","author":"Kumar","year":"2011","journal-title":"Nat Genet"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib156","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1007\/s00432-010-0970-0","article-title":"Evaluation of the association studies of single nucleotide polymorphisms and hepatocellular carcinoma: a systematic review","volume":"137","author":"Jin","year":"2011","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib157","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1053\/gast.2003.50104","article-title":"A quantitative gene expression study suggests a role for angiopoietins in focal nodular hyperplasia","volume":"124","author":"Paradis","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib158","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/hep.20878","article-title":"Molecular changes from dysplastic nodule to hepatocellular carcinoma through gene expression profiling","volume":"42","author":"Nam","year":"2005","journal-title":"Hepatology"},{"key":"10.1053\/j.seminoncol.2012.05.002_bib159","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/hep.21622","article-title":"Genome-wide molecular profiles of HCV-induced dysplasia and hepatocellular carcinoma","volume":"45","author":"Wurmbach","year":"2007","journal-title":"Hepatology"}],"container-title":["Seminars in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775412001054?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775412001054?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T19:04:01Z","timestamp":1687633441000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0093775412001054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":158,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0093775412001054"],"URL":"https:\/\/doi.org\/10.1053\/j.seminoncol.2012.05.002","relation":{},"ISSN":["0093-7754"],"issn-type":[{"value":"0093-7754","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}