{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:44:52Z","timestamp":1787168692390,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Oncology"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1053\/j.seminoncol.2016.02.028","type":"journal-article","created":{"date-parts":[[2016,2,24]],"date-time":"2016-02-24T12:40:12Z","timestamp":1456317612000},"page":"341-346","source":"Crossref","is-referenced-by-count":15,"title":["The cutaneous manifestations of gastrointestinal malignancy"],"prefix":"10.1053","volume":"43","author":[{"given":"Courtney R.","family":"Schadt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminoncol.2016.02.028_bib1","doi-asserted-by":"crossref","first-page":"180","DOI":"10.20452\/pamw.642","article-title":"Acanthosis nigricans as a paraneoplastic syndrome. Case reports and review of literature","volume":"119","author":"Krawczyk","year":"2009","journal-title":"Pol Arch Med Wewnetrz"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/BF01213299","article-title":"Transforming growth factor-alpha (TGF alpha)-producing gastric carcinoma with acanthosis nigricans: an endocrine effect of TGF alpha in the pathogenesis of cutaneous paraneoplastic syndrome and epithelial hyperplasia of the esophagus","volume":"32","author":"Koyama","year":"1997","journal-title":"J Gastroenterol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jaad.2012.10.037","article-title":"Cutaneous manifestations of gastrointestinal disease: part I","volume":"68","author":"Shah","year":"2013","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib4","first-page":"14","article-title":"Sign and pseudo-sign of Leser-Trelat","volume":"13","author":"Kowalzick","year":"2014","journal-title":"J Drugs Dermatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib5","first-page":"565","article-title":"Inflammation of seborrheic keratoses caused by cytarabine: a pseudo sign of Leser-Trelat","volume":"3","author":"Patton","year":"2004","journal-title":"J Drugs Dermatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0738-081X(93)90114-R","article-title":"Tripe palms and cancer","volume":"11","author":"Cohen","year":"1993","journal-title":"Clin Dermatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-4362.1991.tb03850.x","article-title":"Florid cutaneous papillomatosis, malignant acanthosis nigricans, and pulmonary squamous cell carcinoma","volume":"30","author":"Gheeraert","year":"1991","journal-title":"Int J Dermatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib8","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1001\/jamadermatol.2014.5622","article-title":"Acute Onset of Acrokeratosis Paraneoplastica (Bazex Syndrome)","volume":"151","author":"Humphrey","year":"2015","journal-title":"JAMA Dermatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib9","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1365-2133.2007.08253.x","article-title":"Paraneoplastic hypertrichosis lanuginosa acquisita: uncommon or overlooked?","volume":"157","author":"Slee","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00432-008-0432-0","article-title":"Cutaneous metastases of visceral tumours: a review","volume":"135","author":"Nashan","year":"2009","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0190-9622(90)70002-Y","article-title":"Skin involvement as the presenting sign of internal carcinoma. A retrospective study of 7316 cancer patients","volume":"22","author":"Lookingbill","year":"1990","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib12","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0190-9622(93)70173-Q","article-title":"Cutaneous metastases in patients with metastatic carcinoma: a retrospective study of 4020 patients","volume":"29","author":"Lookingbill","year":"1993","journal-title":"J Am Acad Dermatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib13","doi-asserted-by":"crossref","first-page":"531","DOI":"10.7863\/ultra.33.3.531","article-title":"Sister Mary Joseph nodule: a tip of an iceberg","volume":"33","author":"Wronski","year":"2014","journal-title":"J Ultrasound Med"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s40257-013-0028-6","article-title":"Cutaneous dermatomyositis: an updated review of treatment options and internal associations","volume":"14","author":"Femia","year":"2013","journal-title":"Am J Clin Dermatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib15","first-page":"525","article-title":"Cancer risk in dermatomyositis: a systematic review of the literature","volume":"149","author":"Di Rollo","year":"2014","journal-title":"G Ital Dermatol Venereol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1084\/jem.20041367","article-title":"Enhanced autoantigen expression in regenerating muscle cells in idiopathic inflammatory myopathy","volume":"201","author":"Casciola-Rosen","year":"2005","journal-title":"J Exp Med"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib17","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.autrev.2009.12.005","article-title":"Polymyositis, dermatomyositis and malignancy: a further intriguing link","volume":"9","author":"Zampieri","year":"2010","journal-title":"Autoimmun Rev"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib18","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1007\/s11926-015-0511-6","article-title":"Multicentric reticulohistiocytosis: a critical review","volume":"17","author":"Selmi","year":"2015","journal-title":"Curr Rheumatol Rep"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib19","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s12016-013-8362-2","article-title":"Multicentric reticulohistiocytosis: a rare yet challenging disease","volume":"45","author":"Islam","year":"2013","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib20","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/RHU.0b013e31829cf32b","article-title":"Treatment of multicentric reticulohistiocytosis with tocilizumab","volume":"19","author":"Pacheco-Tena","year":"2013","journal-title":"J Clin Rheumatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1756-185X.2012.01762.x","article-title":"Treatment of multicentric reticulohistiocytosis with adalimumab, minocycline, methotrexate","volume":"16","author":"Yeter","year":"2013","journal-title":"Int J Rheumat Dis"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib22","first-page":"413","article-title":"Carcinoma of the oesophagus with keratosis palmaris et plantaris (tylosis): a study of two families","volume":"27","author":"Howel-Evans","year":"1958","journal-title":"Q J Med"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib23","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.ajhg.2011.12.008","article-title":"RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome","volume":"90","author":"Blaydon","year":"2012","journal-title":"Am J Hum Genet"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib24","doi-asserted-by":"crossref","first-page":"4064","DOI":"10.1093\/hmg\/ddu120","article-title":"iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function","volume":"23","author":"Brooke","year":"2014","journal-title":"Hum Mol Genet"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib25","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1001\/archderm.1996.03890300056010","article-title":"Linkage of an American pedigree with palmoplantar keratoderma and malignancy (palmoplantar ectodermal dysplasia type III) to 17q24. Literature survey and proposed updated classification of the keratodermas","volume":"132","author":"Stevens","year":"1996","journal-title":"Arch Dermatol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/gut.2005.069062","article-title":"Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis","volume":"55","author":"Jansen","year":"2006","journal-title":"Gut"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib27","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/ajg.2009.725","article-title":"High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendations","volume":"105","author":"van Lier","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/1750-1172-9-101","article-title":"Hamartomatous polyposis syndromes: a review","volume":"9","author":"Jelsig","year":"2014","journal-title":"Orphanet J Rare Dis"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib29","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1097\/PAS.0b013e31815b0cc2","article-title":"Site and tumor type predicts DNA mismatch repair status in cutaneous sebaceous neoplasia","volume":"32","author":"Singh","year":"2008","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib30","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/S1470-2045(05)70465-4","article-title":"Muir-Torre syndrome","volume":"6","author":"Ponti","year":"2005","journal-title":"Lancet Oncol"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib31","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1097\/DCR.000000000000000","article-title":"Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on Colorectal Cancer","volume":"57","author":"Giardiello","year":"2014","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib32","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1093\/jnci\/djt277","article-title":"Cowden syndrome and the PTEN hamartoma tumor syndrome: systematic review and revised diagnostic criteria","volume":"105","author":"Pilarski","year":"2013","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib33","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/sj.ejhg.5201823","article-title":"Segmental overgrowth, lipomatosis, arteriovenous malformation and epidermal nevus (SOLAMEN) syndrome is related to mosaic PTEN nullizygosity","volume":"15","author":"Caux","year":"2007","journal-title":"Eur J Hum Genet"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib34","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1126\/science.275.5307.1787","article-title":"Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC","volume":"275","author":"Morin","year":"1997","journal-title":"Science"},{"key":"10.1053\/j.seminoncol.2016.02.028_bib35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.critrevonc.2012.07.001","article-title":"Cancer-associated genodermatoses: skin neoplasms as clues to hereditary tumor syndromes","volume":"85","author":"Ponti","year":"2013","journal-title":"Crit Rev Oncol Hematol"}],"container-title":["Seminars in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775416000531?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775416000531?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T10:04:48Z","timestamp":1748772288000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0093775416000531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,6]]}},"alternative-id":["S0093775416000531"],"URL":"https:\/\/doi.org\/10.1053\/j.seminoncol.2016.02.028","relation":{},"ISSN":["0093-7754"],"issn-type":[{"value":"0093-7754","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]}}}