{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T07:18:26Z","timestamp":1790147906613,"version":"4.0.1"},"reference-count":58,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["seminoncol.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Oncology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1053\/j.seminoncol.2016.08.002","type":"journal-article","created":{"date-parts":[[2016,9,10]],"date-time":"2016-09-10T00:55:13Z","timestamp":1473468913000},"page":"536-542","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Genetic predisposition to colorectal cancer: Implications for treatment and prevention"],"prefix":"10.1053","volume":"43","author":[{"given":"Elena M.","family":"Stoffel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Yurgelun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminoncol.2016.08.002_bib1","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2008.02.002","article-title":"Screening and surveillance for the early detection of colorectal cancer and adenomatous polyps, 2008: a joint guideline from the American Cancer Society, the US Multi-Society Task Force on Colorectal Cancer, and the American College of Radiology","volume":"134","author":"Levin","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib2","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1200\/JCO.2013.50.9257","article-title":"American Society of Clinical Oncology Expert Statement: collection and use of a cancer family history for oncology providers","volume":"32","author":"Lu","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib3","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/BF02053699","article-title":"The International Collaborative Group on Hereditary Non-Polyposis Colorectal Cancer (ICG-HNPCC)","volume":"34","author":"Vasen","year":"1991","journal-title":"Dis Colon Rectum"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib4","doi-asserted-by":"crossref","first-page":"5783","DOI":"10.1200\/JCO.2008.17.5950","article-title":"Feasibility of screening for Lynch syndrome among patients with colorectal cancer","volume":"26","author":"Hampel","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib5","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/GIM.0b013e31818fa2ff","article-title":"Recommendations from the EGAPP Working Group: genetic testing strategies in newly diagnosed individuals with colorectal cancer aimed at reducing morbidity and mortality from Lynch syndrome in relatives","volume":"11","year":"2009","journal-title":"Genet Med"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib6","unstructured":"NCCN. Genetic\/Familial High Risk Assessment: colorectal. NCCN Clinical Practice Guidelines in Oncology 2015; v. 2.2015 nccn.org."},{"key":"10.1053\/j.seminoncol.2016.08.002_bib7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/jmg.2004.024299","article-title":"Risk of colorectal and endometrial cancer for carriers of mutations of the hMLH1 and hMSH2 gene: correction for ascertainment","volume":"42","author":"Quehenberger","year":"2005","journal-title":"J Med Genet"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib8","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.cgh.2006.01.002","article-title":"Cancer risks for mismatch repair gene mutation carriers: a population-based early onset case-family study","volume":"4","author":"Jenkins","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib9","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1053\/j.gastro.2009.07.039","article-title":"Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome","volume":"137","author":"Stoffel","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib10","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/(SICI)1097-0215(19990412)81:2<214::AID-IJC8>3.0.CO;2-L","article-title":"Cancer risk in mutation carriers of DNA-mismatch-repair genes","volume":"81","author":"Aarnio","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib11","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1053\/j.gastro.2014.04.001","article-title":"Guidelines on genetic evaluation and management of Lynch syndrome: a consensus statement by the US Multi-Society Task Force on colorectal cancer","volume":"147","author":"Giardiello","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib12","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1053\/j.gastro.2003.12.023","article-title":"Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer","volume":"126","author":"Carethers","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib13","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1056\/NEJM200001133420201","article-title":"Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer","volume":"342","author":"Gryfe","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib14","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1056\/NEJMoa1500596","article-title":"PD-1 blockade in tumors with mismatch-repair deficiency","volume":"372","author":"Le","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ajg.2014.435","article-title":"ACG clinical guideline: Genetic testing and management of hereditary gastrointestinal cancer syndromes","volume":"110","author":"Syngal","year":"2015","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1053\/j.gastro.2010.08.021","article-title":"The PREMM(1,2,6) model predicts risk of MLH1, MSH2, and MSH6 germline mutations based on cancer history","volume":"140","author":"Kastrinos","year":"2011","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib17","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1001\/jama.296.12.1479","article-title":"Prediction of germline mutations and cancer risk in the Lynch syndrome","volume":"296","author":"Chen","year":"2006","journal-title":"JAMA"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib18","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1053\/j.gastro.2014.08.041","article-title":"Colon and endometrial cancers with mismatch repair deficiency can arise from somatic, rather than germline, mutations","volume":"147","author":"Haraldsdottir","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib19","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1001\/jama.293.16.1979","article-title":"Lower cancer incidence in Amsterdam-I criteria families without mismatch repair deficiency: familial colorectal cancer type X","volume":"293","author":"Lindor","year":"2005","journal-title":"JAMA"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib20","doi-asserted-by":"crossref","first-page":"7304","DOI":"10.1158\/1078-0432.CCR-05-0965","article-title":"Differential features of colorectal cancers fulfilling Amsterdam criteria without involvement of the mutator pathway","volume":"11","author":"Llor","year":"2005","journal-title":"Clin Cancer Res"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib21","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","author":"Cancer Genome Atlas","year":"2012","journal-title":"Nature"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib22","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cgh.2006.12.025","article-title":"Identification of MYH mutation carriers in colorectal cancer: a multicenter, case-control, population-based study","volume":"5","author":"Balaguer","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib23","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1053\/j.gastro.2014.01.022","article-title":"Risk of colorectal cancer for carriers of mutations in MUTYH, with and without a family history of cancer","volume":"146","author":"Win","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/ng.2503","article-title":"Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas","volume":"45","author":"Palles","year":"2013","journal-title":"Nat Genet"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1093\/jnci\/dju402","article-title":"Prognostic significance of POLE proofreading mutations in endometrial cancer","volume":"107","author":"Church","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib26","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.ejca.2013.12.005","article-title":"Genetic and clinical determinants of constitutional mismatch repair deficiency syndrome: report from the Constitutional Mismatch Repair Deficiency Consortium","volume":"50","author":"Bakry","year":"2014","journal-title":"Eur J Cancer"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ajg.2015.392","article-title":"Gastrointestinal findings in the largest series of patients with hereditary biallelic mismatch repair deficiency syndrome: report from the International Consortium","volume":"111","author":"Aronson","year":"2016","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib28","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1053\/j.gastro.2010.01.054","article-title":"Hereditary and familial colon cancer","volume":"138","author":"Jasperson","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib29","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.cgh.2005.11.005","article-title":"Peutz-Jeghers syndrome and management recommendations","volume":"4","author":"Giardiello","year":"2006","journal-title":"Clin Gastroenterol Hepatol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib30","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/ajg.2009.725","article-title":"High cancer risk in Peutz-Jeghers syndrome: a systematic review and surveillance recommendations","volume":"105","author":"van Lier","year":"2010","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib31","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jso.23735","article-title":"Cowden syndrome: recognizing and managing a not-so-rare hereditary cancer syndrome","volume":"11","author":"Mester","year":"2015","journal-title":"J Surg Oncol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib32","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1053\/j.gastro.2010.06.061","article-title":"Frequent gastrointestinal polyps and colorectal adenocarcinomas in a prospective series of PTEN mutation carriers","volume":"139","author":"Heald","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib33","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1053\/j.gastro.2009.12.066","article-title":"Role of the serrated pathway in colorectal cancer pathogenesis","volume":"138","author":"Leggett","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.humpath.2010.06.002","article-title":"Update on the serrated pathway to colorectal carcinoma","volume":"42","author":"Snover","year":"2011","journal-title":"Hum Pathol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib35","series-title":"Serrated polyps of the colon and rectum and serrated polyposis","year":"2010"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib36","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/ng.2263","article-title":"Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1","volume":"44","author":"Jaeger","year":"2012","journal-title":"Nat Genet"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib37","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1200\/JCO.2011.40.7171","article-title":"Screening patients with colorectal cancer for Lynch syndrome: what are we waiting for?","volume":"30","author":"Kastrinos","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib38","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djh034","article-title":"Revised Bethesda guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability","volume":"96","author":"Umar","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib39","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.6004\/jnccn.2014.0128","article-title":"Gene panel testing for inherited cancer risk","volume":"12","author":"Hall","year":"2014","journal-title":"J Natl Compr Cancer Network"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib40","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1053\/j.gastro.2015.05.006","article-title":"Identification of a variety of mutations in cancer predisposition genes in patients with suspected Lynch syndrome","volume":"149","author":"Yurgelun","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib41","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1001\/jamaoncol.2015.0197","article-title":"Germline TP53 mutations in patients with early-onset colorectal cancer in the Colon Cancer Family Registry","volume":"1","author":"Yurgelun","year":"2015","journal-title":"JAMA Oncol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib42","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1053\/j.gastro.2013.02.001","article-title":"Prevalence of Germline PTEN, BMPR1A, SMAD4, STK11, and ENG mutations in patients with moderate-load colorectal polyps","volume":"144","author":"Ngeow","year":"2013","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib43","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/cge.12359","article-title":"Panel-based testing for inherited colorectal cancer: a descriptive study of clinical testing performed by a US laboratory","volume":"86","author":"Cragun","year":"2014","journal-title":"Clin Genet"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib44","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1200\/JCO.2012.46.9403","article-title":"Multiplex genetic testing for cancer susceptibility: out on the high wire without a net?","volume":"31","author":"Domchek","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib45","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.1200\/JCO.2014.59.3665","article-title":"Next-generation sequencing panels for the diagnosis of colorectal cancer and polyposis syndromes: a cost-effectiveness analysis","volume":"33","author":"Gallego","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib46","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1200\/JCO.2015.63.0996","article-title":"American Society of Clinical Oncology Policy Statement Update: genetic and genomic testing for cancer susceptibility","volume":"33","author":"Robson","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib47","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1053\/j.gastro.2015.05.056","article-title":"Germline mutations in FAN1 cause hereditary colorectal cancer by impairing DNA repair","volume":"149","author":"Segui","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib48","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1053\/j.gastro.2014.06.009","article-title":"Germline mutation of RPS20, encoding a ribosomal protein, causes predisposition to hereditary nonpolyposis colorectal carcinoma without DNA mismatch repair deficiency","volume":"147","author":"Nieminen","year":"2014","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib49","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1053\/j.gastro.2014.08.046","article-title":"Ribosomopathy association with colorectal cancer","volume":"148","author":"Kessel","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib50","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1038\/ng.3287","article-title":"A germline homozygous mutation in the base-excision repair gene NTHL1 causes adenomatous polyposis and colorectal cancer","volume":"47","author":"Weren","year":"2015","journal-title":"Nat Genet"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib51","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1056\/NEJMc1506878","article-title":"Biallelic NTHL1 mutations in a woman with multiple primary tumors","volume":"373","author":"Rivera","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib52","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1200\/JCO.2014.58.1322","article-title":"Hereditary colorectal cancer syndromes: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the Familial Risk-Colorectal Cancer: European Society for Medical Oncology Clinical Practice Guidelines","volume":"33","author":"Stoffel","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib53","doi-asserted-by":"crossref","first-page":"1872","DOI":"10.1053\/j.gastro.2015.08.052","article-title":"Genetic variants that predispose to DNA double-strand breaks in lymphocytes from a subset of patients with familial colorectal carcinomas","volume":"149","author":"Arora","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib54","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nrc.2016.4","article-title":"Aspirin and colorectal cancer: the promise of precision chemoprevention","volume":"16","author":"Drew","year":"2016","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib55","doi-asserted-by":"crossref","first-page":"2567","DOI":"10.1056\/NEJMoa0801297","article-title":"Effect of aspirin or resistant starch on colorectal neoplasia in the Lynch syndrome","volume":"359","author":"Burn","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib56","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1001\/jama.2016.2522","article-title":"Effect of sulindac and erlotinib vs placebo on duodenal neoplasia in familial adenomatous polyposis: a randomized clinical trial","volume":"315","author":"Samadder","year":"2016","journal-title":"JAMA"},{"key":"10.1053\/j.seminoncol.2016.08.002_bib57","unstructured":"NCCN. Genetic risk assessment: breast and\/or ovarian. NCCN Clinical Practice Guidelines in Oncology 2016; v. 2.2016 nccn.org."},{"key":"10.1053\/j.seminoncol.2016.08.002_bib58","doi-asserted-by":"crossref","first-page":"3544","DOI":"10.1200\/JCO.2015.61.4503","article-title":"High prevalence of hereditary cancer syndromes in adolescents and young adults with colorectal cancer","volume":"33","author":"Mork","year":"2015","journal-title":"J Clin Oncol"}],"container-title":["Seminars in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009377541630029X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S009377541630029X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T15:20:54Z","timestamp":1536420054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S009377541630029X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":58,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S009377541630029X"],"URL":"https:\/\/doi.org\/10.1053\/j.seminoncol.2016.08.002","relation":{},"ISSN":["0093-7754"],"issn-type":[{"value":"0093-7754","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic predisposition to colorectal cancer: Implications for treatment and prevention","name":"articletitle","label":"Article Title"},{"value":"Seminars in Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminoncol.2016.08.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}