{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:39:34Z","timestamp":1783633174933,"version":"3.55.0"},"reference-count":66,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["seminoncol.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Oncology"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1053\/j.seminoncol.2016.08.007","type":"journal-article","created":{"date-parts":[[2016,9,21]],"date-time":"2016-09-21T20:25:40Z","timestamp":1474489540000},"page":"582-590","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Genetic predisposition to endocrine tumors: Diagnosis, surveillance and challenges in care"],"prefix":"10.1053","volume":"43","author":[{"given":"Elisabeth Joye","family":"Petr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Else","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminoncol.2016.08.007_bib1","unstructured":"SEER Stat Fact Sheets: Thyroid cancer. 2016. http:\/\/seer.cancer.gov\/statfacts\/html\/thyro.html 2016 (accessed 3\/26\/2016)."},{"issue":"18","key":"10.1053\/j.seminoncol.2016.08.007_bib2","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1200\/JCO.2007.15.4377","article-title":"One hundred years after \"carcinoid\": epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States","volume":"26","author":"Yao","year":"2008","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1053\/j.seminoncol.2016.08.007_bib3","doi-asserted-by":"crossref","first-page":"T147","DOI":"10.1530\/ERC-15-0221","article-title":"Fifteen years of paraganglioma: pheochromocytoma, paraganglioma and genetic syndromes: a historical perspective","volume":"22","author":"Else","year":"2015","journal-title":"Endocr Rel Cancer"},{"issue":"5","key":"10.1053\/j.seminoncol.2016.08.007_bib4","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1245\/s10434-013-2942-5","article-title":"Inherited mutations in pheochromocytoma and paraganglioma: why all patients should be offered genetic testing","volume":"20","author":"Fishbein","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10.1053\/j.seminoncol.2016.08.007_bib5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.mce.2011.12.008","article-title":"Association of adrenocortical carcinoma with familial cancer susceptibility syndromes","volume":"351","author":"Else","year":"2012","journal-title":"Mol Cell Endocrinol"},{"issue":"6","key":"10.1053\/j.seminoncol.2016.08.007_bib6","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1089\/thy.2008.0403","article-title":"Medullary thyroid cancer: management guidelines of the American Thyroid Association","volume":"19","author":"Kloos","year":"2009","journal-title":"Thyroid"},{"issue":"1","key":"10.1053\/j.seminoncol.2016.08.007_bib7","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.3747\/co.21.1579","article-title":"Pheochromocytoma and paraganglioma syndromes: genetics and management update","volume":"21","author":"Lefebvre","year":"2014","journal-title":"Curr Oncol"},{"issue":"6","key":"10.1053\/j.seminoncol.2016.08.007_bib8","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1210\/jc.2014-1498","article-title":"Pheochromocytoma and paraganglioma: an Endocrine Society clinical practice guideline","volume":"99","author":"Lenders","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1053\/j.seminoncol.2016.08.007_bib9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.hoc.2015.09.006","article-title":"Pheochromocytoma and paraganglioma: genetics, diagnosis, and treatment","volume":"30","author":"Fishbein","year":"2016","journal-title":"Hematol Oncol Clin North Am"},{"issue":"8","key":"10.1053\/j.seminoncol.2016.08.007_bib10","doi-asserted-by":"crossref","first-page":"3650","DOI":"10.1158\/0008-5472.CAN-08-4057","article-title":"Clinical predictors for germline mutations in head and neck paraganglioma patients: cost reduction strategy in genetic diagnostic process as fall-out","volume":"69","author":"Neumann","year":"2009","journal-title":"Cancer Res"},{"issue":"2","key":"10.1053\/j.seminoncol.2016.08.007_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/nrc3648","article-title":"Pheochromocytoma and paraganglioma pathogenesis: learning from genetic heterogeneity","volume":"14","author":"Dahia","year":"2014","journal-title":"Nature Rev Cancer"},{"issue":"10","key":"10.1053\/j.seminoncol.2016.08.007_bib12","doi-asserted-by":"crossref","first-page":"E2046","DOI":"10.1210\/jc.2014-1659","article-title":"Germline FH mutations presenting with pheochromocytoma","volume":"99","author":"Clark","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1053\/j.seminoncol.2016.08.007_bib13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1530\/ERC-13-0308","article-title":"Calculating optimal surveillance for detection of von Hippel-Lindau-related manifestations","volume":"21","author":"Kruizinga","year":"2014","journal-title":"Endocr Rel Cancer"},{"issue":"1","key":"10.1053\/j.seminoncol.2016.08.007_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association Guidelines Task Force on Thyroid Nodules and Differentiated Thyroid Cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"issue":"7","key":"10.1053\/j.seminoncol.2016.08.007_bib15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1089\/thy.2010.1641","article-title":"Familial syndromes associated with thyroid cancer in the era of personalized medicine","volume":"20","author":"Richards","year":"2010","journal-title":"Thyroid"},{"issue":"12","key":"10.1053\/j.seminoncol.2016.08.007_bib16","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jcem.86.12.8070","article-title":"Guidelines for diagnosis and therapy of MEN type 1 and type 2","volume":"86","author":"Brandi","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.seminoncol.2016.08.007_bib17","unstructured":"VHL Family Alliance. In Wilcox Graff J. editor. The VHL handbook. Ed 4. Boston, MA: VHL Family Alliance 2012"},{"issue":"3","key":"10.1053\/j.seminoncol.2016.08.007_bib18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1542\/peds.2007-3364","article-title":"Health supervision for children with neurofibromatosis","volume":"121","author":"Hersh","year":"2008","journal-title":"Pediatrics"},{"issue":"4","key":"10.1053\/j.seminoncol.2016.08.007_bib19","first-page":"T91","article-title":"15 Years of paraganglioma: clinical manifestations of paraganglioma syndromes types 1-5. Endocr Rel","volume":"22","author":"Benn","year":"2015","journal-title":"Cancer"},{"issue":"8","key":"10.1053\/j.seminoncol.2016.08.007_bib20","doi-asserted-by":"crossref","first-page":"E1482","DOI":"10.1210\/jc.2013-3853","article-title":"The clinical phenotype of SDHC-associated hereditary paraganglioma syndrome (PGL3)","volume":"99","author":"Else","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.seminoncol.2016.08.007_bib21","unstructured":"http:\/\/exac.broadinstitute.org\/gene\/ENSG00000073578. Accessed 3\/26\/2016."},{"issue":"2","key":"10.1053\/j.seminoncol.2016.08.007_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10689-013-9639-6","article-title":"Role of rapid sequence whole-body MRI screening in SDH-associated hereditary paraganglioma families","volume":"13","author":"Jasperson","year":"2014","journal-title":"Fam Cancer"},{"issue":"3","key":"10.1053\/j.seminoncol.2016.08.007_bib23","doi-asserted-by":"crossref","first-page":"E531","DOI":"10.1210\/jc.2014-3399","article-title":"Heterogeneous genetic background of the association of pheochromocytoma\/paraganglioma and pituitary adenoma: results from a large patient cohort","volume":"100","author":"Denes","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1053\/j.seminoncol.2016.08.007_bib24","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/sj.ejhg.5201904","article-title":"Clinical and molecular genetics of patients with the Carney-Stratakis syndrome and germline mutations of the genes coding for the succinate dehydrogenase subunits SDHB, SDHC, and SDHD","volume":"16","author":"Pasini","year":"2008","journal-title":"Eur J Hum Genet"},{"issue":"5","key":"10.1053\/j.seminoncol.2016.08.007_bib25","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1053\/j.semdp.2015.02.017","article-title":"Genotyping and immunohistochemistry of gastrointestinal stromal tumors: an update","volume":"32","author":"Rubin","year":"2015","journal-title":"Semin Diagn Pathol"},{"issue":"10","key":"10.1053\/j.seminoncol.2016.08.007_bib26","doi-asserted-by":"crossref","first-page":"E1386","DOI":"10.1210\/jc.2015-2689","article-title":"Succinate dehydrogenase (SDH)-deficient pancreatic neuroendocrine tumor expands the SDH-related tumor spectrum","volume":"100","author":"Niemeijer","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"10.1053\/j.seminoncol.2016.08.007_bib27","doi-asserted-by":"crossref","first-page":"2428","DOI":"10.1093\/hmg\/ddt638","article-title":"The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function","volume":"23","author":"Qin","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1053\/j.seminoncol.2016.08.007_bib28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1210\/er.2013-1029","article-title":"Adrenocortical carcinoma","volume":"35","author":"Else","year":"2014","journal-title":"Endocr Rev"},{"issue":"1","key":"10.1053\/j.seminoncol.2016.08.007_bib29","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/jmg.38.1.43","article-title":"Sensitivity and predictive value of criteria for p53 germline mutation screening","volume":"38","author":"Chompret","year":"2001","journal-title":"J Med Genet"},{"issue":"10","key":"10.1053\/j.seminoncol.2016.08.007_bib30","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1136\/jmg.2008.058958","article-title":"High frequency of de novo mutations in Li-Fraumeni syndrome","volume":"46","author":"Gonzalez","year":"2009","journal-title":"J Med Genet"},{"issue":"6","key":"10.1053\/j.seminoncol.2016.08.007_bib31","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1200\/JCO.2013.52.6863","article-title":"Prevalence and functional consequence of TP53 mutations in pediatric adrenocortical carcinoma: a Children\u02bcs Oncology Group study","volume":"33","author":"Wasserman","year":"2015","journal-title":"J Clin Oncol"},{"issue":"6","key":"10.1053\/j.seminoncol.2016.08.007_bib32","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1470-2045(11)70119-X","article-title":"Biochemical and imaging surveillance in germline TP53 mutation carriers with Li-Fraumeni syndrome: a prospective observational study","volume":"12","author":"Villani","year":"2011","journal-title":"Lancet Oncol"},{"issue":"20","key":"10.1053\/j.seminoncol.2016.08.007_bib33","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1200\/JCO.2012.46.3711","article-title":"Impact of neonatal screening and surveillance for the TP53 R337H mutation on early detection of childhood adrenocortical tumors","volume":"31","author":"Custodio","year":"2013","journal-title":"J Clin Oncol"},{"issue":"24","key":"10.1053\/j.seminoncol.2016.08.007_bib34","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1200\/JCO.2012.48.0988","article-title":"Adrenocortical carcinoma is a lynch syndrome-associated cancer","volume":"31","author":"Raymond","year":"2013","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1053\/j.seminoncol.2016.08.007_bib35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1530\/EJE-11-0679","article-title":"Adrenal involvement in MEN1. Analysis of 715 cases from the Groupe d\u02bcetude des Tumeurs Endocrines database","volume":"166","author":"Gatta-Cherifi","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"1","key":"10.1053\/j.seminoncol.2016.08.007_bib36","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/ajmg.c.30064","article-title":"Risk of tumorigenesis in overgrowth syndromes: a comprehensive review","volume":"137c","author":"Lapunzina","year":"2005","journal-title":"Am J Med Genet"},{"issue":"12","key":"10.1053\/j.seminoncol.2016.08.007_bib37","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1007\/BF02236860","article-title":"Adrenal masses are associated with familial adenomatous polyposis","volume":"43","author":"Smith","year":"2000","journal-title":"Dis Colon Rect"},{"issue":"9","key":"10.1053\/j.seminoncol.2016.08.007_bib38","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/BF02050923","article-title":"Adrenal masses in patients with familial adenomatous polyposis","volume":"40","author":"Marchesa","year":"1997","journal-title":"Dis Colon Rectum"},{"issue":"1","key":"10.1053\/j.seminoncol.2016.08.007_bib39","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12022-013-9295-2","article-title":"Neuroendocrine tumors of the pancreas: current concepts and controversies","volume":"25","author":"Reid","year":"2014","journal-title":"Endocr Pathol"},{"issue":"5","key":"10.1053\/j.seminoncol.2016.08.007_bib40","first-page":"95","article-title":"Pancreatic neuroendocrine tumors: an update","volume":"77","author":"Paniccia","year":"2015","journal-title":"Ind J Surg"},{"issue":"9","key":"10.1053\/j.seminoncol.2016.08.007_bib41","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1210\/jc.2012-1230","article-title":"Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1)","volume":"97","author":"Thakker","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"10.1053\/j.seminoncol.2016.08.007_bib42","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1056\/NEJM199003153221103","article-title":"Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome","volume":"322","author":"Pipeleers-Marichal","year":"1990","journal-title":"N Engl J Med"},{"issue":"9374","key":"10.1053\/j.seminoncol.2016.08.007_bib43","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1016\/S0140-6736(03)13643-4","article-title":"von Hippel-Lindau disease","volume":"361","author":"Lonser","year":"2003","journal-title":"Lancet"},{"issue":"3","key":"10.1053\/j.seminoncol.2016.08.007_bib44","doi-asserted-by":"crossref","first-page":"360","DOI":"10.3109\/00365521.2014.992364","article-title":"Clinical features of pancreatic involvement in von Hippel-Lindau disease: a retrospective study of 55 cases in a single center","volume":"50","author":"Park","year":"2015","journal-title":"Scand J Gastroenterol"},{"issue":"6","key":"10.1053\/j.seminoncol.2016.08.007_bib45","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1016\/j.surg.2007.09.012","article-title":"Clinical, genetic and radiographic analysis of 108 patients with von Hippel-Lindau disease (VHL) manifested by pancreatic neuroendocrine neoplasms (PNETs)","volume":"142","author":"Blansfield","year":"2007","journal-title":"Surgery"},{"issue":"6","key":"10.1053\/j.seminoncol.2016.08.007_bib46","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1007\/s11605-009-1123-0","article-title":"Periampullary and duodenal neoplasms in neurofibromatosis type 1: two cases and an updated 20-year review of the literature yielding 76 cases","volume":"14","author":"Relles","year":"2010","journal-title":"J Gastrointest Surg"},{"issue":"4","key":"10.1053\/j.seminoncol.2016.08.007_bib47","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.clcc.2012.01.006","article-title":"The prevalence of thyroid cancer and benign thyroid disease in patients with familial adenomatous polyposis may be higher than previously recognized","volume":"11","author":"Steinhagen","year":"2012","journal-title":"Clin Colorectal Cancer"},{"issue":"1","key":"10.1053\/j.seminoncol.2016.08.007_bib48","doi-asserted-by":"crossref","first-page":"57","DOI":"10.4065\/75.1.57","article-title":"Care of patients and their families with familial adenomatous polyposis","volume":"75","author":"King","year":"2000","journal-title":"Mayo Clin Proc"},{"issue":"3","key":"10.1053\/j.seminoncol.2016.08.007_bib49","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1089\/thy.2014.0107","article-title":"Characteristics of benign and malignant thyroid disease in familial adenomatous polyposis patients and recommendations for disease surveillance","volume":"25","author":"Feng","year":"2015","journal-title":"Thyroid"},{"issue":"2","key":"10.1053\/j.seminoncol.2016.08.007_bib50","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s10689-015-9862-4","article-title":"Risk of thyroid cancer among Caribbean Hispanic patients with familial adenomatous polyposis","volume":"15","author":"Casellas-Cabrera","year":"2016","journal-title":"Fam Cancer"},{"issue":"5","key":"10.1053\/j.seminoncol.2016.08.007_bib51","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1007\/s00268-005-0368-3","article-title":"Mutational analysis of the APC gene in cribriform-morula variant of papillary thyroid carcinoma","volume":"30","author":"Uchino","year":"2006","journal-title":"World J Surg"},{"issue":"2","key":"10.1053\/j.seminoncol.2016.08.007_bib52","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/ajg.2014.435","article-title":"ACG clinical guideline: genetic testing and management of hereditary gastrointestinal cancer syndromes","volume":"110","author":"Syngal","year":"2015","journal-title":"Am J Gastroenterol"},{"issue":"8","key":"10.1053\/j.seminoncol.2016.08.007_bib53","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.ctrv.2010.04.002","article-title":"Cowden syndrome","volume":"36","author":"Farooq","year":"2010","journal-title":"Cancer Treat Rev"},{"issue":"10","key":"10.1053\/j.seminoncol.2016.08.007_bib54","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1097\/GIM.0b013e3181ac9aea","article-title":"PTEN hamartoma tumor syndrome: an overview","volume":"11","author":"Hobert","year":"2009","journal-title":"Genet Med"},{"issue":"4","key":"10.1053\/j.seminoncol.2016.08.007_bib55","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1136\/jmedgenet-2012-101339","article-title":"High cumulative risks of cancer in patients with PTEN hamartoma tumour syndrome","volume":"50","author":"Bubien","year":"2013","journal-title":"J Med Genet"},{"issue":"5","key":"10.1053\/j.seminoncol.2016.08.007_bib56","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1089\/thy.2010.0365","article-title":"Frequency of germline PTEN mutations in differentiated thyroid cancer","volume":"21","author":"Nagy","year":"2011","journal-title":"Thyroid"},{"issue":"12","key":"10.1053\/j.seminoncol.2016.08.007_bib57","doi-asserted-by":"crossref","first-page":"E2063","DOI":"10.1210\/jc.2011-1616","article-title":"Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations","volume":"96","author":"Ngeow","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"10.1053\/j.seminoncol.2016.08.007_bib58","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1210\/jc.2010-1315","article-title":"Thyroid nodules and cancer in children with PTEN hamartoma tumor syndrome","volume":"96","author":"Smith","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"issue":"2","key":"10.1053\/j.seminoncol.2016.08.007_bib59","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s12032-011-9896-x","article-title":"Cowden syndrome: a major indication for extensive cancer surveillance","volume":"29","author":"Tutluer","year":"2012","journal-title":"Med Onc"},{"issue":"4","key":"10.1053\/j.seminoncol.2016.08.007_bib60","doi-asserted-by":"crossref","first-page":"M85","DOI":"10.1530\/EJE-15-0209","article-title":"Carney complex: an update","volume":"173","author":"Correa","year":"2015","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"10.1053\/j.seminoncol.2016.08.007_bib61","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1002\/(SICI)1097-0142(19990315)85:6<1345::AID-CNCR18>3.0.CO;2-#","article-title":"Unusual features of thyroid carcinomas in Japanese patients with Werner syndrome and possible genotype-phenotype relations to cell type and race","volume":"85","author":"Ishikawa","year":"1999","journal-title":"Cancer"},{"issue":"6","key":"10.1053\/j.seminoncol.2016.08.007_bib62","doi-asserted-by":"crossref","first-page":"E1072","DOI":"10.1210\/jc.2013-4206","article-title":"Exploring the association between DICER1 mutations and differentiated thyroid carcinoma","volume":"99","author":"de Kock","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"10.1053\/j.seminoncol.2016.08.007_bib63","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/ijc.29426","article-title":"CHEK2 mutations and the risk of papillary thyroid cancer","volume":"137","author":"Siolek","year":"2015","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1053\/j.seminoncol.2016.08.007_bib64","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s12020-009-9219-6","article-title":"Successful chemotherapy of hepatic metastases in a case of succinate dehydrogenase subunit B-related paraganglioma","volume":"36","author":"He","year":"2009","journal-title":"Endocrine"},{"issue":"25","key":"10.1053\/j.seminoncol.2016.08.007_bib65","doi-asserted-by":"crossref","first-page":"4162","DOI":"10.1200\/JCO.2008.21.3496","article-title":"Phase II study of high-dose [131I]metaiodobenzylguanidine therapy for patients with metastatic pheochromocytoma and paraganglioma","volume":"27","author":"Gonias","year":"2009","journal-title":"J Clin Oncol"},{"issue":"12","key":"10.1053\/j.seminoncol.2016.08.007_bib66","doi-asserted-by":"crossref","first-page":"2661","DOI":"10.1093\/annonc\/mdr011","article-title":"Pilot trial of sunitinib therapy in patients with von Hippel-Lindau disease","volume":"22","author":"Jonasch","year":"2011","journal-title":"Ann Oncol"}],"container-title":["Seminars in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775416300422?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775416300422?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,8]],"date-time":"2018-09-08T07:53:59Z","timestamp":1536393239000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0093775416300422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":66,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["S0093775416300422"],"URL":"https:\/\/doi.org\/10.1053\/j.seminoncol.2016.08.007","relation":{},"ISSN":["0093-7754"],"issn-type":[{"value":"0093-7754","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic predisposition to endocrine tumors: Diagnosis, surveillance and challenges in care","name":"articletitle","label":"Article Title"},{"value":"Seminars in Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminoncol.2016.08.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}