{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T01:53:23Z","timestamp":1772848403907,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["seminoncol.org","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Oncology"],"published-print":{"date-parts":[[2017,6]]},"DOI":"10.1053\/j.seminoncol.2017.10.003","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T07:00:46Z","timestamp":1507878046000},"page":"218-225","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment"],"prefix":"10.1053","volume":"44","author":[{"given":"Lekha","family":"Mikkilineni","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Whitaker-Menezes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina","family":"Domingo-Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Sprandio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Avena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Cotzia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Dulau-Florea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerald","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guldeep","family":"Uppal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tingting","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Leiby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhao","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Pro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"Sotgia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Lisanti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubaldo","family":"Martinez-Outschoorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.seminoncol.2017.10.003_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21332","article-title":"Cancer statistics, 2016","volume":"66","author":"Siegel","year":"2016","journal-title":"CA Cancer J Clin"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib2","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1182\/blood-2014-09-551556","article-title":"How I treat advanced classical Hodgkin lymphoma","volume":"125","author":"Johnson","year":"2015","journal-title":"Blood"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib3","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1056\/NEJMe1604026","article-title":"Fine-tuning the treatment of Hodgkin's lymphoma","volume":"374","author":"Bartlett","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/djv018","article-title":"Late morbidity and mortality in patients with Hodgkin's lymphoma treated during adulthood","volume":"107","author":"Matasar","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib5","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1182\/blood-2014-07-537480","article-title":"Risk assessment in the management of newly diagnosed classical Hodgkin lymphoma","volume":"125","author":"Connors","year":"2015","journal-title":"Blood"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib6","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1056\/NEJMc1609333","article-title":"Interim PET-CT scan in advanced Hodgkin's lymphoma","volume":"375","author":"Johnson","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib7","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1172\/JCI61245","article-title":"Hodgkin lymphoma","volume":"122","author":"Kuppers","year":"2012","journal-title":"J Clin Invest"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib8","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1053\/j.seminhematol.2016.05.007","article-title":"Hodgkin lymphoma: pathology and biology","volume":"53","author":"Mathas","year":"2016","journal-title":"Semin Hematol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib9","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1056\/NEJMoa0905680","article-title":"Tumor-associated macrophages and survival in classic Hodgkin's lymphoma","volume":"362","author":"Steidl","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib10","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1136\/jcp.55.3.162","article-title":"Hodgkin's lymphoma: the pathologist's viewpoint","volume":"55","author":"Pileri","year":"2002","journal-title":"J Clin Pathol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib11","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1002\/path.2711","article-title":"The classical Hodgkin's lymphoma microenvironment and its role in promoting tumour growth and immune escape","volume":"221","author":"Aldinucci","year":"2010","journal-title":"J Pathol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib12","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1200\/JCO.2010.32.8401","article-title":"Molecular pathogenesis of Hodgkin's lymphoma: increasing evidence of the importance of the microenvironment","volume":"29","author":"Steidl","year":"2011","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib13","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1200\/JCO.2006.08.1331","article-title":"Plasma cytokine and soluble receptor signature predicts outcome of patients with classical Hodgkin's lymphoma: a study from the Groupe d'Etude des Lymphomes de l'Adulte","volume":"25","author":"Casasnovas","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib14","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1600-0609.2006.00725.x","article-title":"Very high levels of soluble CD30 recognize the patients with classical Hodgkin's lymphoma retaining a very poor prognosis","volume":"77","author":"Visco","year":"2006","journal-title":"Eur J Haematol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib15","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1023\/A:1008301602785","article-title":"Interleukin-10 levels are often elevated in serum of adults with Hodgkin's disease and are associated with inferior failure-free survival","volume":"10","author":"Sarris","year":"1999","journal-title":"Ann Oncol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib16","first-page":"274","article-title":"Serum interleukin-10 levels are an independent prognostic factor for patients with Hodgkin's lymphoma","volume":"86","author":"Vassilakopoulos","year":"2001","journal-title":"Haematologica"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib17","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1200\/JCO.2011.38.0410","article-title":"Results of a pivotal phase II study of brentuximab vedotin for patients with relapsed or refractory Hodgkin's lymphoma","volume":"30","author":"Younes","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib18","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1200\/JCO.2012.43.4589","article-title":"Gene expression-based model using formalin-fixed paraffin-embedded biopsies predicts overall survival in advanced-stage classical Hodgkin lymphoma","volume":"31","author":"Scott","year":"2013","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib19","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1182\/blood-2009-12-257345","article-title":"Genome-wide copy number analysis of Hodgkin Reed-Sternberg cells identifies recurrent imbalances with correlations to treatment outcome","volume":"116","author":"Steidl","year":"2010","journal-title":"Blood"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib20","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1182\/blood-2008-07-168096","article-title":"Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome","volume":"113","author":"Chetaille","year":"2009","journal-title":"Blood"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib21","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1200\/JCO.2011.41.0910","article-title":"International prognostic score in advanced-stage Hodgkin's lymphoma: altered utility in the modern era","volume":"30","author":"Moccia","year":"2012","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib22","doi-asserted-by":"crossref","first-page":"26844","DOI":"10.1074\/jbc.273.41.26844","article-title":"Functional analysis of human mitochondrial receptor Tom20 for protein import into mitochondria","volume":"273","author":"Yano","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib23","doi-asserted-by":"crossref","first-page":"10808","DOI":"10.1074\/jbc.M311710200","article-title":"Mitochondrial import receptors Tom20 and Tom22 have chaperone-like activity","volume":"279","author":"Yano","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib24","doi-asserted-by":"crossref","first-page":"13546","DOI":"10.1073\/pnas.1107553108","article-title":"Nanoscale distribution of mitochondrial import receptor Tom20 is adjusted to cellular conditions and exhibits an inner-cellular gradient","volume":"108","author":"Wurm","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib25","doi-asserted-by":"crossref","first-page":"4047","DOI":"10.4161\/cc.10.23.18151","article-title":"Hyperactivation of oxidative mitochondrial metabolism in epithelial cancer cells in situ: visualizing the therapeutic effects of metformin in tumor tissue","volume":"10","author":"Whitaker-Menezes","year":"2011","journal-title":"Cell Cycle"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib26","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.4161\/cc.24092","article-title":"Cancer metabolism, stemness and tumor recurrence: MCT1 and MCT4 are functional biomarkers of metabolic symbiosis in head and neck cancer","volume":"12","author":"Curry","year":"2013","journal-title":"Cell Cycle"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib27","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.cmet.2014.12.007","article-title":"PINK1 and Parkin control localized translation of respiratory chain component mRNAs on mitochondria outer membrane","volume":"21","author":"Gehrke","year":"2015","journal-title":"Cell Metab"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib28","doi-asserted-by":"crossref","first-page":"26291","DOI":"10.1074\/jbc.M116.740209","article-title":"TIGAR metabolically reprograms carcinoma and stromal cells in breast cancer","volume":"291","author":"Ko","year":"2016","journal-title":"J Biol Chem"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib29","doi-asserted-by":"crossref","first-page":"C1129","DOI":"10.1152\/ajpcell.00233.2006","article-title":"Assembly of mitochondrial cytochrome c-oxidase, a complicated and highly regulated cellular process","volume":"291","author":"Fontanesi","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/15513","article-title":"Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene","volume":"23","author":"Papadopoulou","year":"1999","journal-title":"Nat Genet"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib31","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/1531-8249(199911)46:5<787::AID-ANA17>3.0.CO;2-8","article-title":"Mitochondrial enzyme activity in amyotrophic lateral sclerosis: implications for the role of mitochondria in neuronal cell death","volume":"46","author":"Borthwick","year":"1999","journal-title":"Ann Neurol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib32","first-page":"e3266","article-title":"Visualization of mitochondrial respiratory function using cytochrome c oxidase\/succinate dehydrogenase (COX\/SDH) double-labeling histochemistry","author":"Ross","year":"2011","journal-title":"J Vis Exp"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib33","first-page":"3930","article-title":"Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice","volume":"118","author":"Sonveaux","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib34","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s004210100516","article-title":"The expression of lactate transporters (MCT1 and MCT4) in heart and muscle","volume":"86","author":"Bonen","year":"2001","journal-title":"Eur J Appl Physiol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib35","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrclinonc.2016.60","article-title":"Cancer metabolism: a therapeutic perspective","volume":"14","author":"Martinez-Outschoorn","year":"2017","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib36","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1042\/bj3500219","article-title":"The low-affinity monocarboxylate transporter MCT4 is adapted to the export of lactate in highly glycolytic cells","volume":"350","author":"Dimmer","year":"2000","journal-title":"Biochem J"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib37","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1113\/jphysiol.2009.178350","article-title":"Cell-cell and intracellular lactate shuttles","volume":"587","author":"Brooks","year":"2009","journal-title":"J Physiol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib38","doi-asserted-by":"crossref","first-page":"9030","DOI":"10.1074\/jbc.M511397200","article-title":"The plasma membrane lactate transporter MCT4, but not MCT1, is up-regulated by hypoxia through a HIF-1alpha-dependent mechanism","volume":"281","author":"Ullah","year":"2006","journal-title":"J Biol Chem"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib39","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1038\/nrc3949","article-title":"Metabolic dysregulation in monogenic disorders and cancer - finding method in madness","volume":"15","author":"Erez","year":"2015","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib40","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.molcel.2015.10.018","article-title":"Cancer's fuel choice: new flavors for a picky eater","volume":"60","author":"DeNicola","year":"2015","journal-title":"Mol Cell"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib41","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/nrc3365","article-title":"Mitochondria and cancer","volume":"12","author":"Wallace","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib42","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.semcancer.2014.01.005","article-title":"Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth","volume":"25","author":"Martinez-Outschoorn","year":"2014","journal-title":"Semin Cancer Biol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib43","doi-asserted-by":"crossref","first-page":"242437","DOI":"10.1155\/2015\/242437","article-title":"Prognostic indications of elevated MCT4 and CD147 across cancer types: a meta-analysis","volume":"2015","author":"Bovenzi","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib44","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.cmet.2011.12.011","article-title":"Power surge: supporting cells \"fuel\" cancer cell mitochondria","volume":"15","author":"Martinez-Outschoorn","year":"2012","journal-title":"Cell Metab"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib45","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrc2542","article-title":"The biology of Hodgkin's lymphoma","volume":"9","author":"Kuppers","year":"2009","journal-title":"Nat Rev Cancer"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib46","doi-asserted-by":"crossref","first-page":"439456","DOI":"10.1155\/2011\/439456","article-title":"Recent advances in the pathobiology of Hodgkin's lymphoma: potential impact on diagnostic, predictive, and therapeutic strategies","volume":"2011","author":"Banerjee","year":"2011","journal-title":"Adv Hematol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib47","doi-asserted-by":"crossref","first-page":"269","DOI":"10.3324\/haematol.2010.031542","article-title":"Tumor-infiltrating macrophages correlate with adverse prognosis and Epstein-Barr virus status in classical Hodgkin's lymphoma","volume":"96","author":"Kamper","year":"2011","journal-title":"Haematologica"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib48","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1182\/blood-2012-04-421057","article-title":"Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial","volume":"120","author":"Tan","year":"2012","journal-title":"Blood"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib49","first-page":"518","article-title":"Hodgkin lymphoma: targeting the tumor microenvironment as a therapeutic strategy","volume":"13","author":"Montanari","year":"2015","journal-title":"Clin Adv Hematol Oncol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.semcancer.2013.07.002","article-title":"The microenvironment in classical Hodgkin lymphoma: an actively shaped and essential tumor component","volume":"24","author":"Liu","year":"2014","journal-title":"Semin Cancer Biol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib51","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJMoa1411087","article-title":"PD-1 blockade with nivolumab in relapsed or refractory Hodgkin's lymphoma","volume":"372","author":"Ansell","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib52","doi-asserted-by":"crossref","first-page":"3733","DOI":"10.1200\/JCO.2016.67.3467","article-title":"Programmed death-1 blockade with pembrolizumab in patients with classical Hodgkin lymphoma after brentuximab vedotin failure","volume":"34","author":"Armand","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib53","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1182\/blood-2005-06-2252","article-title":"FDG-PET after two cycles of chemotherapy predicts treatment failure and progression-free survival in Hodgkin lymphoma","volume":"107","author":"Hutchings","year":"2006","journal-title":"Blood"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib54","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1470-2045(15)70049-5","article-title":"PET-adapted salvage therapy in Hodgkin's lymphoma","volume":"16","author":"Tirelli","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1053\/j.seminoncol.2017.10.003_bib55","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1158\/2326-6066.CIR-16-0103","article-title":"Efficacy of PD-1 blockade is potentiated by metformin-induced reduction of tumor hypoxia","volume":"5","author":"Scharping","year":"2017","journal-title":"Cancer Immunol Res"}],"container-title":["Seminars in Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775417301343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0093775417301343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T00:04:49Z","timestamp":1535328289000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0093775417301343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6]]},"references-count":55,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["S0093775417301343"],"URL":"https:\/\/doi.org\/10.1053\/j.seminoncol.2017.10.003","relation":{},"ISSN":["0093-7754"],"issn-type":[{"value":"0093-7754","type":"print"}],"subject":[],"published":{"date-parts":[[2017,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hodgkin lymphoma: A complex metabolic ecosystem with glycolytic reprogramming of the tumor microenvironment","name":"articletitle","label":"Article Title"},{"value":"Seminars in Oncology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.seminoncol.2017.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}