{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T03:30:16Z","timestamp":1791343816457,"version":"4.3.1"},"reference-count":89,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2008,7,1]],"date-time":"2008-07-01T00:00:00Z","timestamp":1214870400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Nuclear Medicine"],"published-print":{"date-parts":[[2008,7]]},"DOI":"10.1053\/j.semnuclmed.2008.02.004","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T08:22:38Z","timestamp":1212135758000},"page":"227-239","source":"Crossref","is-referenced-by-count":121,"title":["Neuronuclear Assessment of Patients With Epilepsy"],"prefix":"10.1053","volume":"38","author":[{"given":"Karolien","family":"Goffin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Dedeurwaerdere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Van Laere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim","family":"Van Paesschen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.semnuclmed.2008.02.004_bib1","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.0013-9580.2005.66104.x","article-title":"Epileptic seizures and epilepsy: Definitions proposed by the International League Against Epilepsy (ILAE) and the International Bureau for Epilepsy (IBE)","volume":"46","author":"Fisher","year":"2005","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1157.1975.tb04721.x","article-title":"The epidemiology of epilepsy in Rochester, Minnesota, 1935 through 1967","volume":"16","author":"Hauser","year":"1975","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib3","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/0140-6736(90)92960-P","article-title":"National general practice study of epilepsy: Recurrence after a first seizure","volume":"336","author":"Hart","year":"1990","journal-title":"Lancet"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib4","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1528-1157.1981.tb06159.x","article-title":"Proposal for revised clinical and electroencephalographic classification of epileptic seizures","volume":"22","year":"1981","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib5","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/jnnp.59.4.384","article-title":"High resolution magnetic resonance imaging in adults with partial or secondary generalised epilepsy attending a tertiary referral unit","volume":"59","author":"Li","year":"1995","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib6","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1093\/brain\/124.9.1683","article-title":"Presurgical evaluation of epilepsy","volume":"124","author":"Rosenow","year":"2001","journal-title":"Brain"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib7","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/S1474-4422(04)00906-8","article-title":"Chronic epilepsy and cognition","volume":"3","author":"Elger","year":"2004","journal-title":"Lancet Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib8","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1056\/NEJM200108023450501","article-title":"A randomized, controlled trial of surgery for temporal-lobe epilepsy","volume":"345","author":"Wiebe","year":"2001","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3171\/jns.2004.101.1.0055","article-title":"Long-term outcome after epilepsy surgery for focal cortical dysplasia","volume":"101","author":"Cohen-Gadol","year":"2004","journal-title":"J Neurosurg"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib10","first-page":"171","article-title":"Technetium-99m HM-PAO stereoisomers as potential agents for imaging regional cerebral blood flow: Human volunteer studies","volume":"27","author":"Sharp","year":"1986","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib11","first-page":"599","article-title":"Technetium-99m ECD: A new brain imaging agent: in vivo kinetics and biodistribution studies in normal human subjects","volume":"30","author":"Vallabhajosula","year":"1989","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib12","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1212\/WNL.50.2.445","article-title":"Subtraction ictal SPECT co-registered to MRI improves clinical usefulness of SPECT in localizing the surgical seizure focus","volume":"50","author":"O'Brien","year":"1998","journal-title":"Neurology"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib13","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1111\/j.1528-1167.2005.06705.x","article-title":"Localizing value of ictal-interictal SPECT analyzed by SPM (ISAS)","volume":"46","author":"McNally","year":"2005","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1109\/42.563664","article-title":"Multimodality image registration by maximization of mutual information","volume":"16","author":"Maes","year":"1997","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib15","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.1111\/j.1528-1167.2006.00628.x","article-title":"Ictal perfusion patterns associated with single MRI-visible focal dysplastic lesions: implications for the noninvasive delineation of the epileptogenic zone","volume":"47","author":"Dupont","year":"2006","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib16","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1007\/s00234-006-0106-z","article-title":"Ictal SPECT in neocortical epilepsies: Clinical usefulness and factors affecting the pattern of hyperperfusion","volume":"48","author":"Lee","year":"2006","journal-title":"Neuroradiology"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib17","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/WCO.0b013e328042baf6","article-title":"The use of SPECT and PET in routine clinical practice in epilepsy","volume":"20","author":"Van Paesschen","year":"2007","journal-title":"Curr Opin Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib18","first-page":"285","article-title":"SPECT brain imaging in epilepsy: A meta-analysis","volume":"39","author":"Devous","year":"1998","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1161\/01.STR.12.2.241","article-title":"Regional arm-brain mean transit time in the diagnostic evaluation of patients with cerebral vascular disease","volume":"12","author":"Bartolini","year":"1981","journal-title":"Stroke"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib20","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1212\/WNL.58.3.373","article-title":"Ictal hyperperfusion patterns according to the progression of temporal lobe seizures","volume":"58","author":"Shin","year":"2002","journal-title":"Neurology"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1590\/S0004-282X2005000600014","article-title":"Statistical voxel-wise analysis of ictal SPECT reveals pattern of abnormal perfusion in patients with temporal lobe epilepsy","volume":"63","author":"Amorim","year":"2005","journal-title":"Arq Neuropsiquiatr"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.eplepsyres.2005.09.032","article-title":"Ictal SPECT analyzed by three-dimensional stereotactic surface projection in frontal lobe epilepsy patients","volume":"68","author":"Fukuda","year":"2006","journal-title":"Epilepsy Res"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib23","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1007\/s002590050456","article-title":"Effect of injection time on postictal SPET perfusion changes in medically refractory epilepsy","volume":"26","author":"Avery","year":"1999","journal-title":"Eur J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib24","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1146\/annurev.bioeng.8.061505.095728","article-title":"Multimodality in vivo imaging systems: Twice the power or double the trouble?","volume":"8","author":"Cherry","year":"2006","journal-title":"Annu Rev Biomed Eng"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib25","first-page":"737","article-title":"18F-FDG PET studies in patients with extratemporal and temporal epilepsy: Evaluation of an observer-independent analysis","volume":"40","author":"Drzezga","year":"1999","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib26","first-page":"776","article-title":"Predicting seizure-free status for temporal lobe epilepsy patients undergoing surgery: Prognostic value of quantifying maximal metabolic asymmetry extending over a specified proportion of the temporal lobe","volume":"48","author":"Lin","year":"2007","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1111\/j.1528-1157.1996.tb00602.x","article-title":"Effect of valproate on cerebral metabolism and blood flow: An 18F-2-deoxyglucose and 15O water positron emission tomography study","volume":"37","author":"Gaillard","year":"1996","journal-title":"Epilepsia"},{"issue":"suppl 2","key":"10.1053\/j.semnuclmed.2008.02.004_bib28","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1111\/j.1528-1157.1988.tb05797.x","article-title":"Antiepileptic drugs and cerebral glucose metabolism","volume":"29","author":"Theodore","year":"1988","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib29","first-page":"950","article-title":"Simplified measurement of deoxyglucose utilization rate","volume":"37","author":"Hunter","year":"1996","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib30","first-page":"192","article-title":"Integrated software for the analysis of brain PET\/SPECT studies with partial-volume-effect correction","volume":"45","author":"Quarantelli","year":"2004","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib31","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1109\/TMI.2004.825623","article-title":"Anatomical-based FDG-PET reconstruction for the detection of hypo-metabolic regions in epilepsy","volume":"23","author":"Baete","year":"2004","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.neuroimage.2004.04.041","article-title":"Evaluation of anatomy based reconstruction for partial volume correction in brain FDG-PET","volume":"23","author":"Baete","year":"2004","journal-title":"Neuroimage"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib33","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/ana.20569","article-title":"Surgical outcome and prognostic factors of cryptogenic neocortical epilepsy","volume":"58","author":"Lee","year":"2005","journal-title":"Ann Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib34","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1212\/WNL.48.4.1047","article-title":"Effects of duration of epilepsy on the uncoupling of metabolism and blood flow in complex partial seizures","volume":"48","author":"Breier","year":"1997","journal-title":"Neurology"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib35","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S1536-1632(02)00071-9","article-title":"Positron emission tomography and epilepsy","volume":"4","author":"Casse","year":"2002","journal-title":"Mol Imaging Biol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib36","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/s00381-006-0085-8","article-title":"Surgical outcome and prognostic factors of pediatric epilepsy caused by cortical dysplasia","volume":"22","author":"Park","year":"2006","journal-title":"Childs Nerv Syst"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib37","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1007\/s00259-005-1844-6","article-title":"Assessment of the role of FDG PET in the diagnosis and management of children with refractory epilepsy","volume":"32","author":"Ollenberger","year":"2005","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib38","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1528-1167.2006.00470.x","article-title":"Prognostic factors in neocortical epilepsy surgery: Multivariate analysis","volume":"47","author":"Yun","year":"2006","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib39","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1007\/s00259-002-1079-8","article-title":"Extratemporal hypometabolism on FDG PET in temporal lobe epilepsy as a predictor of seizure outcome after temporal lobectomy","volume":"30","author":"Choi","year":"2003","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib40","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1002\/ana.410360620","article-title":"Hippocampal neuronal loss and regional hypometabolism in temporal lobe epilepsy","volume":"36","author":"Henry","year":"1994","journal-title":"Ann Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib41","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1528-1157.1999.tb01984.x","article-title":"Correlation of hippocampal neuronal density and FDG-PET in mesial temporal lobe epilepsy","volume":"40","author":"Foldvary","year":"1999","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib42","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/ana.410430615","article-title":"Dynamic [18F]fluorodeoxyglucose positron emission tomography and hypometabolic zones in seizures: Reduced capillary influx","volume":"43","author":"Cornford","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib43","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.neuroimage.2006.04.185","article-title":"Correlations of interictal FDG-PET metabolism and ictal SPECT perfusion changes in human temporal lobe epilepsy with hippocampal sclerosis","volume":"32","author":"Nelissen","year":"2006","journal-title":"Neuroimage"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib44","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.yebeh.2006.04.007","article-title":"The relationship of regional frontal hypometabolism to executive function: a resting fluorodeoxyglucose PET study of patients with epilepsy and healthy controls","volume":"9","author":"McDonald","year":"2006","journal-title":"Epilepsy Behav"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib45","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1111\/j.1528-1167.2006.00860.x","article-title":"Depression in temporal lobe epilepsy surgery patients: An FDG-PET study","volume":"47","author":"Salzberg","year":"2006","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib46","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1212\/01.wnl.0000242628.26978.e2","article-title":"Prefrontal hypofunction in patients with intractable mesial temporal lobe epilepsy","volume":"67","author":"Takaya","year":"2006","journal-title":"Neurology"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1177\/08830738060210011101","article-title":"Longitudinal changes in cortical glucose hypometabolism in children with intractable epilepsy","volume":"21","author":"Benedek","year":"2006","journal-title":"J Child Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib48","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1093\/brain\/awh534","article-title":"Postoperative alteration of cerebral glucose metabolism in mesial temporal lobe epilepsy","volume":"128","author":"Joo","year":"2005","journal-title":"Brain"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib49","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1111\/j.1528-1167.2007.01157.x","article-title":"Cognitive deficits during status epilepticus and time course of recovery: A case report","volume":"48","author":"Van Paesschen","year":"2007","journal-title":"Epilepsia"},{"issue":"suppl 3","key":"10.1053\/j.semnuclmed.2008.02.004_bib50","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1046\/j.1528-1157.2001.042suppl.3008.x","article-title":"GABAergic mechanisms in epilepsy","volume":"42","author":"Treiman","year":"2001","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib51","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1093\/brain\/awg138","article-title":"Grey and white matter flumazenil binding in neocortical epilepsy with normal MRI","volume":"126","author":"Hammers","year":"2003","journal-title":"Brain"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib52","first-page":"457","article-title":"Clinical utility of 11C-flumazenil positron emission tomography in intractable temporal lobe epilepsy","volume":"52","author":"Padma","year":"2004","journal-title":"Neurol India"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib53","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1093\/brain\/119.5.1677","article-title":"Cerebral benzodiazepine receptors in hippocampal sclerosis","volume":"119","author":"Koepp","year":"1996","journal-title":"Brain"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib54","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/ana.410430510","article-title":"In vivo [11C]flumazenil-PET correlates with ex vivo [3H]flumazenil autoradiography in hippocampal sclerosis","volume":"43","author":"Koepp","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib55","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1111\/j.1528-1167.2005.30904.x","article-title":"Periventricular white matter flumazenil binding and postoperative outcome in hippocampal sclerosis","volume":"46","author":"Hammers","year":"2005","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib56","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/sj.jcbfm.9600515","article-title":"[(11)C]Flumazenil PET in temporal lobe epilepsy: Do we need an arterial input function or kinetic modeling?","volume":"28","author":"Hammers","year":"2008","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib57","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1093\/brain\/awh470","article-title":"Seizure-related short-term plasticity of benzodiazepine receptors in partial epilepsy: A [11C]flumazenil-PET study","volume":"128","author":"Bouvard","year":"2005","journal-title":"Brain"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib58","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.nucmedbio.2004.12.004","article-title":"Biological properties of 2\u2032-[18F]fluoroflumazenil for central benzodiazepine receptor imaging","volume":"32","author":"Chang","year":"2005","journal-title":"Nucl Med Biol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib59","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1126\/science.2986292","article-title":"Endogenous anticonvulsant substance in rat cerebrospinal fluid after a generalized seizure","volume":"228","author":"Tortella","year":"1985","journal-title":"Science"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib60","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0306-4522(90)90190-F","article-title":"Stimulation of endogenous opioid release displaces mu receptor binding in rat hippocampus","volume":"37","author":"Wagner","year":"1990","journal-title":"Neuroscience"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib61","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1002\/ana.410230304","article-title":"Mu-opiate receptors measured by positron emission tomography are increased in temporal lobe epilepsy","volume":"23","author":"Frost","year":"1988","journal-title":"Ann Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib62","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ana.410300103","article-title":"Quantification of mu and non-mu opiate receptors in temporal lobe epilepsy using positron emission tomography","volume":"30","author":"Mayberg","year":"1991","journal-title":"Ann Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib63","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1002\/ana.410410311","article-title":"Imaging of delta- and mu-opioid receptors in temporal lobe epilepsy by positron emission tomography","volume":"41","author":"Madar","year":"1997","journal-title":"Ann Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib64","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1093\/brain\/awm012","article-title":"Upregulation of opioid receptor binding following spontaneous epileptic seizures","volume":"130","author":"Hammers","year":"2007","journal-title":"Brain"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib65","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0006-8993(92)91320-E","article-title":"Anticonvulsant effect of intranigral fluoxetine","volume":"593","author":"Pasini","year":"1992","journal-title":"Brain Res"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib66","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1212\/WNL.45.10.1926","article-title":"Anticonvulsant effect of fluoxetine in humans","volume":"45","author":"Favale","year":"1995","journal-title":"Neurology"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib67","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1212\/01.WNL.0000049930.93113.20","article-title":"PET imaging of 5-HT1A receptor binding in patients with temporal lobe epilepsy","volume":"60","author":"Toczek","year":"2003","journal-title":"Neurology"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib68","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1111\/j.1528-1167.2007.01089.x","article-title":"Reduced hippocampal 5HT1A PET receptor binding and depression in temporal lobe epilepsy","volume":"48","author":"Theodore","year":"2007","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib69","first-page":"1128","article-title":"5-HT 1A receptors are reduced in temporal lobe epilepsy after partial-volume correction","volume":"46","author":"Giovacchini","year":"2005","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib70","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.eplepsyres.2006.09.003","article-title":"Changes in central 5-HT(1A) receptor binding in mesial temporal epilepsy measured by positron emission tomography with [(11)C]WAY100635","volume":"73","author":"Ito","year":"2007","journal-title":"Epilepsy Res"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib71","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1002\/ana.410440603","article-title":"Imaging epileptogenic tubers in children with tuberous sclerosis complex using alpha-[11C]methyl-L-tryptophan positron emission tomography","volume":"44","author":"Chugani","year":"1998","journal-title":"Ann Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib72","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0920-1211(02)00216-4","article-title":"alpha-[11C]-Methyl-L-tryptophan PET identifies the epileptogenic tuber and correlates with interictal spike frequency","volume":"52","author":"Fedi","year":"2003","journal-title":"Epilepsy Res"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib73","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1177\/08830738050200050701","article-title":"Epilepsy surgery outcome in children with tuberous sclerosis complex evaluated with alpha-[11C]methyl-L-tryptophan positron emission tomography (PET)","volume":"20","author":"Kagawa","year":"2005","journal-title":"J Child Neurol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib74","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.bcp.2007.06.030","article-title":"The role of the nicotinic acetylcholine receptors in sleep-related epilepsy","volume":"74","author":"Marini","year":"2007","journal-title":"Biochem Pharmacol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib75","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1093\/brain\/awl156","article-title":"Alteration of the in vivo nicotinic receptor density in ADNFLE patients: a PET study","volume":"129","author":"Picard","year":"2006","journal-title":"Brain"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib76","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1093\/brain\/awg143","article-title":"Cannabis and the brain","volume":"126","author":"Iversen","year":"2003","journal-title":"Brain"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib77","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1126\/science.1063545","article-title":"Endocannabinoid signaling in the brain","volume":"296","author":"Wilson","year":"2002","journal-title":"Science"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib78","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1126\/science.1088208","article-title":"CB1 cannabinoid receptors and on-demand defense against excitotoxicity","volume":"302","author":"Marsicano","year":"2003","journal-title":"Science"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib79","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2006.02.001","article-title":"Cannabinoids in medicine: A review of their therapeutic potential","volume":"105","author":"Ben Amar","year":"2006","journal-title":"J Ethnopharmacol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib80","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0014-2999(01)01243-2","article-title":"Assessment of the role of CB1 receptors in cannabinoid anticonvulsant effects","volume":"428","author":"Wallace","year":"2001","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib81","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0014-2999(02)02331-2","article-title":"Evidence for a physiological role of endocannabinoids in the modulation of seizure threshold and severity","volume":"452","author":"Wallace","year":"2002","journal-title":"Eur J Pharmacol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib82","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1124\/jpet.103.051920","article-title":"The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy","volume":"307","author":"Wallace","year":"2003","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib83","doi-asserted-by":"crossref","first-page":"9800","DOI":"10.1073\/pnas.0703472104","article-title":"[18F]MK-9470, a positron emission tomography (PET) tracer for in vivo human PET brain imaging of the cannabinoid-1 receptor","volume":"104","author":"Burns","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"suppl 2","key":"10.1053\/j.semnuclmed.2008.02.004_bib84","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1528-1167.2007.01063.x","article-title":"Epileptogenesis in experimental models","volume":"48","author":"Pitk\u00e4nen","year":"2007","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib85","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/76509","article-title":"In vivo imaging of neuronal activation and plasticity in the rat brain by high resolution positron emission tomography (microPET)","volume":"18","author":"Kornblum","year":"2000","journal-title":"Nat Biotechnol"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib86","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/syn.20216","article-title":"PET imaging of glucose metabolism in a mouse model of temporal lobe epilepsy","volume":"59","author":"Mirrione","year":"2006","journal-title":"Synapse"},{"issue":"suppl 1","key":"10.1053\/j.semnuclmed.2008.02.004_bib87","first-page":"51","article-title":"Imaging small animal models of epileptogenesis","volume":"12","author":"Jupp","year":"2007","journal-title":"Neurology Asia"},{"issue":"suppl 4","key":"10.1053\/j.semnuclmed.2008.02.004_bib88","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1528-1167.2007.01242.x","article-title":"Positron emission tomography in basic epilepsy research: a view of the epileptic brain","volume":"48","author":"Dedeurwaerdere","year":"2007","journal-title":"Epilepsia"},{"key":"10.1053\/j.semnuclmed.2008.02.004_bib89","first-page":"345","article-title":"PET imaging of brain 5-HT1A receptors in rat in vivo with 18F-FCWAY and improvement by successful inhibition of radioligand defluorination with miconazole","volume":"47","author":"Tipre","year":"2006","journal-title":"J Nucl Med"}],"container-title":["Seminars in Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001299808000275?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001299808000275?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T06:58:05Z","timestamp":1545980285000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001299808000275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":89,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["S0001299808000275"],"URL":"https:\/\/doi.org\/10.1053\/j.semnuclmed.2008.02.004","relation":{},"ISSN":["0001-2998"],"issn-type":[{"value":"0001-2998","type":"print"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}