{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T14:13:33Z","timestamp":1790691213188,"version":"4.1.0"},"reference-count":57,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Nuclear Medicine"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1053\/j.semnuclmed.2011.12.002","type":"journal-article","created":{"date-parts":[[2012,4,2]],"date-time":"2012-04-02T00:45:18Z","timestamp":1333327518000},"page":"164-170","source":"Crossref","is-referenced-by-count":99,"title":["Radioiodine: The Classic Theranostic Agent"],"prefix":"10.1053","volume":"42","author":[{"given":"Edward B.","family":"Silberstein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.semnuclmed.2011.12.002_bib1","doi-asserted-by":"crossref","first-page":"318","DOI":"10.2214\/AJR.11.6797","article-title":"Molecular theranostics: A primer for the imaging professional","volume":"197","author":"Lee","year":"2011","journal-title":"Am J Roentgenol"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib2","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1021\/ar200019c","article-title":"Theranostic nanomedicine","volume":"44","author":"Lammers","year":"2011","journal-title":"Acc Chem Res"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib3","first-page":"152","article-title":"Nuclear imaging in cancer theranostics","volume":"51","author":"Del Vecchio","year":"2007","journal-title":"Q J Nucl Med Mol Imaging"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib4","first-page":"201","article-title":"Radioactivity induced by neutron bombardment","volume":"122","author":"Fermi","year":"1934","journal-title":"Nature"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib5","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1089\/thy.1997.7.163","article-title":"Radioiodine and the treatment of hyperthyroidism: The early history","volume":"7","author":"Sawin","year":"1997","journal-title":"Thyroid"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib6","series-title":"Principles of Nuclear Medicine","article-title":"The thyroid gland","author":"Beierwaltes","year":"1968"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib7","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1096\/fasebj.9.12.7672517","article-title":"The time dimension in cell biology","volume":"9","author":"Leblond","year":"1995","journal-title":"FASEB J"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib8","doi-asserted-by":"crossref","first-page":"510","DOI":"10.3181\/00379727-38-9915P","article-title":"Radioactive iodine as an indicator in the study of thyroid physiology","volume":"38","author":"Hertz","year":"1938","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib9","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1152\/ajplegacy.1940.128.3.565","article-title":"Radioactive iodine as an indicator in thyroid physiology: Iodine collection by normal and hyperplastic thyroids in rabbits","volume":"128","author":"Hertz","year":"1940","journal-title":"Am J Physiol"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib10","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1210\/endo-29-1-82","article-title":"Radioactive iodine as an indicator in thyroid physiology","volume":"29","author":"Hertz","year":"1941","journal-title":"Endocrinologist"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib11","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1152\/ajplegacy.1940.131.1.135","article-title":"Studies in iodine metabolism by the use of a new radioactive isotope of iodine","volume":"131","author":"Hamilton","year":"1940","journal-title":"Am J Physiol"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib12","first-page":"624","article-title":"Application of radioactive iodine in therapy of Graves' disease","volume":"21","author":"Hertz","year":"1942","journal-title":"J Clin Invest"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib13","first-page":"624","article-title":"Recent clinical developments n the therapeutic applications of radio-phosphorus and radio-iodine","volume":"21","author":"Hamilton","year":"1942","journal-title":"J Clin Invest"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib14","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/jama.1946.02870190005002","article-title":"Radioactive iodine in the study of thyroid physiology VII. The use of radioactive iodine therapy in hyperthyroidism","volume":"131","author":"Hertz","year":"1946","journal-title":"JAMA"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1001\/jama.1946.02870190010003","article-title":"The treatment of hyperthyroidism with radioactive iodine","volume":"131","author":"Chapman","year":"1946","journal-title":"JAMA"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib16","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1126\/science.103.2685.697","article-title":"Availability of radioactive isotopes","volume":"103","author":"Pollard","year":"1946","journal-title":"Science"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib17","first-page":"109","article-title":"The plasma iodide clearance rate of the human thyroid","volume":"8","author":"Myant","year":"1949","journal-title":"Clin Sci"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib18","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1210\/jcem-17-7-832","article-title":"Measurement of the active iodine stores and daily hormonal output of the intact human thyroid","volume":"17","author":"Nodine","year":"1957","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib19","first-page":"331","article-title":"The rate of conversion of administered inorganic radioactive iodine into prote\u00edn-bound iodine of plasma as an aid in the evaluation of thyroid function","volume":"26","author":"Clark","year":"1949","journal-title":"Surgery"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib20","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1001\/jama.1946.02870490016004","article-title":"Radioactive iodine therapy: Effect on functioning metastases of adenocarcinoma of the thyroid","volume":"132","author":"Seidlin","year":"1946","journal-title":"JAMA"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib21","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1126\/science.110.2847.94","article-title":"Measurement of ionizing radiations in vivo","volume":"110","author":"Cassen","year":"1949","journal-title":"Science"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib22","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/170200b0","article-title":"Use of a gamma-ray pinhole camera for in vivo studies","volume":"170","author":"Anger","year":"1952","journal-title":"Nature"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib23","first-page":"149","article-title":"Radioiodine-125","volume":"1","author":"Myers","year":"1960","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib24","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1089\/thy.1997.7.183","article-title":"Dosimetric considerations in the radioiodine treatment of macrometastases and micrometastases from differentiated thyroid cancer","volume":"7","author":"Maxon","year":"1997","journal-title":"Thyroid"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/BF00257568","article-title":"Thyroid imaging with 125I and 99mTc","volume":"4","author":"Prince","year":"1979","journal-title":"Eur J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib26","first-page":"1052","article-title":"The use of iodine-125 in thyroid scintiscanning","volume":"90","author":"Charkes","year":"1963","journal-title":"Am J Roentgenol"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib27","first-page":"286","article-title":"Thyroid-uptake studies using 132I","volume":"10","author":"Levy","year":"1969","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib28","first-page":"347","article-title":"Thyroid scintigraphy with 132I","volume":"7","author":"Guntermann","year":"1966","journal-title":"Radiol Diagn (Berl)"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib29","first-page":"183","article-title":"Iodine-123","volume":"3","author":"Myers","year":"1962","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib30","first-page":"261","article-title":"Evaluation of clinical value of 123I and 131I in thyroid disease","volume":"15","author":"Nishiyama","year":"1974","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib31","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0001-2998(71)80008-9","article-title":"Radioiodine dosimetry and the use of radioiodines other than 131I in thyroid diagnosis","volume":"1","author":"Wellman","year":"1971","journal-title":"Semin Nucl Med"},{"issue":"2","key":"10.1053\/j.semnuclmed.2011.12.002_bib32","first-page":"68","article-title":"Will short-lived radionuclides come of age?","volume":"4","author":"DeNardo","year":"1982","journal-title":"Diagn Imaging"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib33","series-title":"Principles of Nuclear Medicine","first-page":"279","article-title":"The radiopharmaceutical","author":"Wagner","year":"1968"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib34","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3810\/pgm.2006.07.1740","article-title":"Radioiodine imaging in the primary care of thyroid disease","volume":"119","author":"Wu","year":"2006","journal-title":"Postgrad Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib35","first-page":"936","article-title":"A simple method to quantitate 124I contamination in 123I radiopharmaceuticals","volume":"26","author":"Palmer","year":"1985","journal-title":"J Nucl Med"},{"issue":"suppl 1","key":"10.1053\/j.semnuclmed.2011.12.002_bib36","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1007\/s00259-011-1782-4","article-title":"The production of [124I]iodine and [86Y]yttrium","volume":"38","author":"Schmitz","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"suppl 1","key":"10.1053\/j.semnuclmed.2011.12.002_bib37","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1007\/s00259-011-1768-2","article-title":"Quantitative imaging of 124I and 86Y with PET","volume":"38","author":"Lubberink","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1053\/j.semnuclmed.2010.10.004","article-title":"Thyroid stunning: Fact or fiction?","volume":"41","author":"McDougall","year":"2011","journal-title":"Semin Nucl Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib39","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.2967\/jnumed.107.040311","article-title":"Comparison of outcomes after 123I versus 131I pre-ablation imaging before radioiodine ablation in differentiated thyroid carcinoma","volume":"48","author":"Silberstein","year":"2007","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib40","first-page":"1587","article-title":"Empiric radioactive iodine dosing regimens frequently exceed maximum tolerated activity levels in elderly patients with thyroid cancer","volume":"47","author":"Tuttle","year":"2006","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib41","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1089\/thy.2006.16.1019","article-title":"The relative frequency in which empiric dosages of radioiodine would potentially overtreat or undertreat patients who have metastatic well-differentiated thyroid cancer","volume":"16","author":"Kulkarni","year":"2006","journal-title":"Thyroid"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib42","doi-asserted-by":"crossref","first-page":"730","DOI":"10.2214\/AJR.09.3458","article-title":"Staging of differentiated thyroid carcinoma using diagnostic 131I SPECT\/CT","volume":"195","author":"Wong","year":"2010","journal-title":"Am J Roentgenol"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib43","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.2214\/AJR.08.1218","article-title":"Incremental value of diagnostic 131I SPECT\/CT fusion imaging in the evaluation of differentiated thyroid carcinoma","volume":"191","author":"Wong","year":"2008","journal-title":"Am J Roentgenol"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib44","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2214\/ajr.117.1.195","article-title":"A comparison of 99mTc and 123I for thyroid imaging","volume":"117","author":"Atkins","year":"1973","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib45","first-page":"50","article-title":"Optimization of a scanning method using Tc-99m","volume":"22","author":"Harper","year":"1964","journal-title":"Nucleonics"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib46","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0001-2998(78)80009-9","article-title":"The treatment of thyroid carcinoma with radioactive iodine","volume":"8","author":"Beierwaltes","year":"1978","journal-title":"Semin Nucl Med"},{"issue":"suppl 1","key":"10.1053\/j.semnuclmed.2011.12.002_bib47","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1007\/s00259-011-1780-6","article-title":"Matched pairs for radionuclide-based imaging and therapy","volume":"38","author":"Bockisch","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib48","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1056\/NEJM198310203091601","article-title":"Relation between effective radiation dose and outcome of radioiodine therapy for thyroid cancer","volume":"309","author":"Maxon","year":"1983","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib49","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0167-8140(93)90180-G","article-title":"Radiation dose assessment in radioiodine therapy","volume":"28","author":"O'Connell","year":"1993","journal-title":"Radiother Oncol"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib50","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1007\/s00259-009-1261-3","article-title":"A dose-effect correlation for radioiodine ablation in differentiated thyroid cancer","volume":"37","author":"Flux","year":"2010","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib51","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1007\/s00259-002-0775-8","article-title":"Evaluation of dosimetry of radioiodine therapy in benign and malignant thyroid disorders by means of iodine-124 and PET","volume":"29","author":"Eschmann","year":"2002","journal-title":"Eur J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib52","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s00259-010-1569-z","article-title":"Molecular imaging in cancer treatment","volume":"38","author":"Michalski","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib53","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1007\/s00259-006-0338-5","article-title":"Clinical radionuclide therapy dosimetry: The quest for the \u201cHoly Gray\u201d","volume":"34","author":"Brans","year":"2007","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"suppl 1","key":"10.1053\/j.semnuclmed.2011.12.002_bib54","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1007\/s00259-011-1774-4","article-title":"Preclinical animal research on therapy dosimetry with dual isotopes","volume":"38","author":"Konijnenberg","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib55","first-page":"171","article-title":"The relation of radioiodine dosmetry to results and complications in the treatment of metastatic thyroid cancer","volume":"87","author":"Benua","year":"1962","journal-title":"Am J Roentgenol"},{"key":"10.1053\/j.semnuclmed.2011.12.002_bib56","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.2967\/jnumed.111.088666","article-title":"RADAR commentary: Evolution and current status of dosimetry in nuclear medicine","volume":"52","author":"Stabin","year":"2011","journal-title":"J Nucl Med"},{"issue":"suppl 1","key":"10.1053\/j.semnuclmed.2011.12.002_bib57","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1007\/s00259-011-1770-8","article-title":"Absolute quantification with SPECT","volume":"38","author":"Ritt","year":"2011","journal-title":"Eur J Nucl Med Mol Imaging"}],"container-title":["Seminars in Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001299811001668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001299811001668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T12:21:28Z","timestamp":1561551688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001299811001668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0001299811001668"],"URL":"https:\/\/doi.org\/10.1053\/j.semnuclmed.2011.12.002","relation":{},"ISSN":["0001-2998"],"issn-type":[{"value":"0001-2998","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}