{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T20:44:25Z","timestamp":1790801065070,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["seminarsinnuclearmedicine.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Nuclear Medicine"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1053\/j.semnuclmed.2018.02.008","type":"journal-article","created":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T01:46:38Z","timestamp":1521683198000},"page":"367-376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"title":["Radiation Imagers for Quantitative, Single-particle Digital Autoradiography of Alpha- and Beta-particle Emitters"],"prefix":"10.1053","volume":"48","author":[{"given":"Brian W.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0010","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1182\/blood-2014-11-612770","article-title":"Astatine-211 conjugated to an anti-CD20 monoclonal antibody eradicates disseminated B-cell lymphoma in a mouse model","volume":"125","author":"Green","year":"2015","journal-title":"Blood"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0015","doi-asserted-by":"crossref","first-page":"4231","DOI":"10.1182\/blood-2010-05-282327","article-title":"Conventional and pretargeted radioimmunotherapy using bismuth-213 to target and treat non-Hodgkin lymphomas expressing CD20: A preclinical model toward optimal consolidation therapy to eradicate minimal residual disease","volume":"116","author":"Park","year":"2010","journal-title":"Blood"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0020","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1158\/1078-0432.CCR-07-1250","article-title":"Effective treatment of established human breast tumor xenografts in immunodeficient mice with a single dose of the \u03b1-emitting radioisotope astatine-211 conjugated to anti-HER2\/neu diabodies","volume":"14","author":"Robinson","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0025","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.ijrobp.2007.06.023","article-title":"Therapeutic efficacy of astatine-211\u2013labeled trastuzumab on radioresistant SKOV-3 tumors in nude mice","volume":"69","author":"Palm","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0030","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1158\/1078-0432.CCR-10-0382","article-title":"Sequential cytarabine and \u03b1-particle immunotherapy with bismuth-213\u2013lintuzumab (HuM195) for acute myeloid leukemia","volume":"16","author":"Rosenblat","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0035","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1182\/blood.V100.4.1233.h81602001233_1233_1239","article-title":"Targeted \u03b1 particle immunotherapy for myeloid leukemia","volume":"100","author":"Jurcic","year":"2002","journal-title":"Blood"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0040","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s11899-011-0103-0","article-title":"What happened to anti-CD33 therapy for acute myeloid leukemia?","volume":"7","author":"Jurcic","year":"2012","journal-title":"Curr Hematolo Malig Rep"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0045","first-page":"1935","article-title":"Pharmacokinetics and dosimetry of an \u03b1-particle emitter labeled antibody: 213Bi-HuM195 (anti-CD33) in patients with leukemia","volume":"40","author":"Sgouros","year":"1999","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0050","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2967\/jnumed.107.046938","article-title":"Clinical experience with \u03b1-particle\u2013emitting 211At: Treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6","volume":"49","author":"Zalutsky","year":"2008","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0055","doi-asserted-by":"crossref","first-page":"311","DOI":"10.2967\/jnumed.108.058651","article-title":"MIRD pamphlet No. 22 (Abridged): Radiobiology and dosimetry of \u03b1-particle emitters for targeted radionuclide therapy","volume":"51","author":"Sgouros","year":"2010","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0060","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/jcp.1030020303","article-title":"Some effects of alpha radiation upon plant cells","volume":"2","author":"Zirkle","year":"1932","journal-title":"J Cell Comp Physiol"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0065","first-page":"1","article-title":"Relative biological effectiveness (RBE), quality factor (Q), and radiation weighting factor (w R): ICRP Publication 92","volume":"33","author":"Valentin","year":"2003","journal-title":"Ann ICRP"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0070","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1667\/RR0902.1","article-title":"Biological response to nonuniform distributions of 210Po in multicellular clusters","volume":"168","author":"Neti","year":"2007","journal-title":"Radiat Res"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0075","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.2967\/jnumed.110.077578","article-title":"The \u03b1-camera: A quantitative digital autoradiography technique using a charge-coupled device for ex vivo high-resolution bioimaging of \u03b1-particles","volume":"51","author":"B\u00e4ck","year":"2010","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0080","series-title":"Alpha-radioimmunotherapy with At-211: Evaluations and imaging on normal tissues and tumors","author":"B\u00e4ck","year":"2011"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0085","series-title":"Digital Radiography and PACS","article-title":"Chapter 4: Photostimulable phosphor image capture","author":"Carter","year":"2013"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0090","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1109\/23.682433","article-title":"Structured CsI (Tl) scintillators for X-ray imaging applications","volume":"45","author":"Nagarkar","year":"1998","journal-title":"Nucl Sci IEEE Trans"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0095","first-page":"3540","article-title":"A low-cost approach to high-resolution, single-photon imaging using columnar scintillators and image intensifiers","volume":"vol 6","author":"Miller","year":"2006"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0100","doi-asserted-by":"crossref","first-page":"N109","DOI":"10.1088\/0031-9155\/50\/12\/N01","article-title":"Photon-counting versus an integrating CCD-based gamma camera: important consequences for spatial resolution","volume":"50","author":"Beekman","year":"2005","journal-title":"Phys Med Biol"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0105","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.nima.2006.01.063","article-title":"Fast X-ray\/gamma-ray imaging using electron multiplying CCD-based detector","volume":"563","author":"Nagarkar","year":"2006","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0115","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.nima.2014.05.070","article-title":"The iQID camera: An ionizing-radiation quantum imaging detector","volume":"767","author":"Miller","year":"2014","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.nima.2004.03.014","article-title":"Recent technologic developments on high-resolution beta imaging systems for quantitative autoradiography and double labeling applications","volume":"527","author":"Barthe","year":"2004","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0125","doi-asserted-by":"crossref","first-page":"4094","DOI":"10.1118\/1.4921997","article-title":"Quantitative single-particle digital autoradiography with alpha-particle emitters for targeted radionuclide therapy using the iQID camera","volume":"42","author":"Miller","year":"2015","journal-title":"Med Phys"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0130","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/0168-9002(88)90871-6","article-title":"Studies of light emission by continuously sensitive avalanche chambers","volume":"269","author":"Charpak","year":"1988","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0135","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S0168-9002(02)00704-0","article-title":"Light output and energy resolution of Ce3+-doped scintillators","volume":"486","author":"Dorenbos","year":"2002","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0140","first-page":"8508","article-title":"Progress in BazookaSPECT: high-resolution dynamic scintigraphy with large-area imagers","author":"Miller","year":"2012","journal-title":"Proc SPIE Int Soc Opt Eng"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0145","article-title":"Single-photon spatial and energy resolution enhancement of a columnar CsI(Tl)\/EMCCD gamma-camera using maximum-likelihood estimation","volume":"vol 6142","author":"Miller","year":"2006"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0150","first-page":"U226","article-title":"Photon-counting gamma camera based on columnar CsI(T1) optically coupled to a back-illuminated CCD","volume":"vol 6510","author":"Miller","year":"2007"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib9000","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.2967\/jnumed.107.040568","article-title":"Direct imaging of radionuclide-produced electrons and positrons with an ultrathin phosphor","volume":"49","author":"Chen","year":"2008","journal-title":"J Nucl Med"},{"issue":"suppl 2","key":"10.1053\/j.semnuclmed.2018.02.008_bib9005","first-page":"433P","article-title":"Evaluation of a digital autoradiography system based on ultra-thin phosphors and a CCD camera","volume":"48","author":"Gobar","year":"2007","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0155","series-title":"Beta Camera: Development and applications","author":"Ljunggren","year":"2003"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0160","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/0168-9002(89)90788-2","article-title":"Investigation of light emission from a parallel-plate avalanche chamber filled with noble gases and with TEA, TMAE, and H2O vapours at atmospheric pressure","volume":"277","author":"Peskov","year":"1989","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0165","author":"Biospace Lab"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0170","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.nima.2009.05.186","article-title":"The micro-pattern gas detector PIM: A multi-modality solution for novel investigations in functional imaging","volume":"610","author":"Donnard","year":"2009","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0180","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0168-9002(96)00175-1","article-title":"MICROMEGAS: a high-granularity position-sensitive gaseous detector for high particle-flux environments","volume":"376","author":"Giomataris","year":"1996","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0185","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1109\/TNS.2008.2005673","article-title":"High spatial resolution in beta-imaging with a PIM device","volume":"56","author":"Donnard","year":"2009","journal-title":"IEEE Trans Nucl Sci"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0190","author":"Beaver"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0195","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1088\/0031-9155\/56\/7\/003","article-title":"C-14 autoradiography with an energy-sensitive silicon pixel detector","volume":"56","author":"Esposito","year":"2011","journal-title":"Phys Med Biol"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0200","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.nima.2007.08.079","article-title":"Timepix, a 65k programmable pixel readout chip for arrival time, energy and\/or photon counting measurements","volume":"581","author":"Llopart","year":"2007","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0205","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.nima.2007.01.164","article-title":"Position-sensitive spectroscopy of Cf-252 fission fragments","volume":"574","author":"Granja","year":"2007","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0210","doi-asserted-by":"crossref","first-page":"S198","DOI":"10.1016\/j.nima.2010.06.166","article-title":"Response of the pixel detector Timepix to heavy ions","volume":"633","author":"Granja","year":"2011","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0215","series-title":"Spatial- and time-correlated detection of fission fragments","author":"Granja","year":"2012"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0220","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1088\/1748-0221\/9\/04\/C04018","article-title":"Large area pixel detector WIDEPIX with full area sensitivity composed of 100 Timepix assemblies with edgeless sensors","volume":"9","author":"Jakubek","year":"2014","journal-title":"J Instrum"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0225","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/612580","article-title":"Autoradiography imaging in targeted alpha therapy with Timepix detector","author":"Al Darwish","year":"2015","journal-title":"Comput Math Methods Med"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0230","doi-asserted-by":"crossref","first-page":"6145","DOI":"10.1118\/1.4965805","article-title":"Development of a transmission alpha particle dosimetry technique using A549 cells and a Ra-223 source for targeted alpha therapy","volume":"43","author":"Al Darwish","year":"2016","journal-title":"Med Phys"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0235","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1118\/1.4905049","article-title":"Characterization of a double-sided silicon strip detector autoradiography system","volume":"42","author":"\u00d6rbom","year":"2015","journal-title":"Med Phys"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib9015","first-page":"103930P","article-title":"Applications of iQID cameras","volume":"10393","author":"Han","year":"2017","journal-title":"Radiat Detect Med Industry Nat Secur XVIII"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib9020","series-title":"Advances in iQID: Upgraded algorithms, thicker scintillators and larger area","author":"Han","year":"2015"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0240","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1109\/TNS.2009.2024745","article-title":"Time-resolved high resolution neutron imaging studies at the ORNL spallation neutron source","volume":"56","author":"Nagarkar","year":"2009","journal-title":"IEEE Trans Nucl Sci"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0245","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1109\/TNS.2006.878574","article-title":"An intensified EMCCD camera for low energy gamma ray imaging applications","volume":"53","author":"Meng","year":"2006","journal-title":"IEEE Trans Nucl Sci"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0250","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1109\/TNS.2008.2004278","article-title":"Investigation of the intrinsic spatial resolution of an intensified EMCCD scintillation camera","volume":"55","author":"Meng","year":"2008","journal-title":"IEEE Trans Nucl Sci"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0255","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.nima.2008.11.149","article-title":"An ultrahigh resolution SPECT system for I-125 mouse brain imaging studies","volume":"600","author":"Meng","year":"2009","journal-title":"Nucl Instrum Methods Phys Res A"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0265","author":"Biomolex"},{"issue":"74500C","key":"10.1053\/j.semnuclmed.2018.02.008_bib0110","doi-asserted-by":"crossref","first-page":"74500C","DOI":"10.1117\/12.843742","article-title":"Progress of BazookaSPECT","volume":"7450","author":"Miller","year":"2009","journal-title":"Proc SPIE"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0270","series-title":"IEEE Nuclear Science Symposium and Conference Records (1997)","first-page":"4004","article-title":"System integration of FastSPECT III, a dedicated SPECT rodent-brain imager based on BazookaSPECT detector technology","author":"Miller","year":"2009"},{"key":"10.1053\/j.semnuclmed.2018.02.008_bib0275","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jhazmat.2017.07.055","article-title":"Getters for improved technetium containment in cementitious waste forms","volume":"341","author":"Asmussen","year":"2018","journal-title":"J Hazard Mater"}],"container-title":["Seminars in Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001299818300163?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001299818300163?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T03:29:16Z","timestamp":1570937356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001299818300163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["S0001299818300163"],"URL":"https:\/\/doi.org\/10.1053\/j.semnuclmed.2018.02.008","relation":{},"ISSN":["0001-2998"],"issn-type":[{"value":"0001-2998","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Radiation Imagers for Quantitative, Single-particle Digital Autoradiography of Alpha- and Beta-particle Emitters","name":"articletitle","label":"Article Title"},{"value":"Seminars in Nuclear Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.semnuclmed.2018.02.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}