{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T10:17:37Z","timestamp":1793787457098,"version":"4.6.1"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,29]],"date-time":"2024-02-29T00:00:00Z","timestamp":1709164800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22H03027"],"award-info":[{"award-number":["22H03027"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012330","name":"Okayama University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012330","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["453989101"],"award-info":[{"award-number":["453989101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["507803309"],"award-info":[{"award-number":["507803309"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Nuclear Medicine"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1053\/j.semnuclmed.2024.02.006","type":"journal-article","created":{"date-parts":[[2024,3,21]],"date-time":"2024-03-21T11:08:40Z","timestamp":1711019320000},"page":"747-752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["FAPI-PET in Cardiovascular Disease"],"prefix":"10.1053","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9711-7835","authenticated-orcid":false,"given":"Takahiro","family":"Higuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian E.","family":"Serfling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Leistner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thimoteus","family":"Speer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3372-6046","authenticated-orcid":false,"given":"Rudolf A.","family":"Werner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1053\/j.semnuclmed.2024.02.006_bib0001","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/eurheartj\/ehad486","article-title":"Inflammation in acute myocardial infarction: The good, the bad and the ugly","volume":"45","author":"Matter","year":"2024","journal-title":"Eur Heart J"},{"issue":"19","key":"10.1053\/j.semnuclmed.2024.02.006_bib0002","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1056\/NEJMoa2021372","article-title":"Colchicine in patients with chronic coronary disease","volume":"383","author":"Nidorf","year":"2020","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1053\/j.semnuclmed.2024.02.006_bib0003","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1056\/NEJMoa1707914","article-title":"Antiinflammatory therapy with canakinumab for atherosclerotic disease","volume":"377","author":"Ridker","year":"2017","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1053\/j.semnuclmed.2024.02.006_bib0004","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jcmg.2021.08.013","article-title":"CXCR4-targeted imaging of post-infarct myocardial tissue inflammation: prognostic value after reperfused myocardial infarction","volume":"15","author":"Werner","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"issue":"37","key":"10.1053\/j.semnuclmed.2024.02.006_bib0005","doi-asserted-by":"crossref","first-page":"3564","DOI":"10.1093\/eurheartj\/ehaa598","article-title":"Molecular imaging-guided repair after acute myocardial infarction by targeting the chemokine receptor CXCR4","volume":"41","author":"Hess","year":"2020","journal-title":"Eur Heart J"},{"issue":"1","key":"10.1053\/j.semnuclmed.2024.02.006_bib0006","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1755-1536-5-15","article-title":"Cardiac fibroblasts, fibrosis and extracellular matrix remodeling in heart disease","volume":"5","author":"Fan","year":"2012","journal-title":"Fibrogenesis Tissue Repair"},{"key":"10.1053\/j.semnuclmed.2024.02.006_bib0007","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.yjmcc.2015.08.016","article-title":"Fibroblast activation protein alpha expression identifies activated fibroblasts after myocardial infarction","volume":"87","author":"Tillmanns","year":"2015","journal-title":"J Mol Cell Cardiol"},{"issue":"20","key":"10.1053\/j.semnuclmed.2024.02.006_bib0008","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/eurheartj\/ehaa033","article-title":"Impact of myocardial fibrosis on left ventricular remodelling, recovery, and outcome after transcatheter aortic valve implantation in different haemodynamic subtypes of severe aortic stenosis","volume":"41","author":"Puls","year":"2020","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1053\/j.semnuclmed.2024.02.006_bib0009","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1161\/CIRCRESAHA.110.227421","article-title":"Enhanced fibroblast-myocyte interactions in response to cardiac injury","volume":"107","author":"Vasquez","year":"2010","journal-title":"Circ Res"},{"issue":"9","key":"10.1053\/j.semnuclmed.2024.02.006_bib0010","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1161\/ATVBAHA.120.314824","article-title":"Fibrosis and inflammatory markers and long-term risk of peripheral artery disease: The ARIC study","volume":"40","author":"Ding","year":"2020","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"12","key":"10.1053\/j.semnuclmed.2024.02.006_bib0011","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.2967\/jnumed.119.226993","article-title":"Molecular imaging of fibroblast activity after myocardial infarction using a (68)Ga-labeled fibroblast activation protein inhibitor, FAPI-04","volume":"60","author":"Varasteh","year":"2019","journal-title":"J Nucl Med"},{"issue":"7","key":"10.1053\/j.semnuclmed.2024.02.006_bib0012","doi-asserted-by":"crossref","first-page":"951","DOI":"10.2967\/jnumed.119.240440","article-title":"The changing face of nuclear cardiology: Guiding cardiovascular care toward molecular medicine","volume":"61","author":"Werner","year":"2020","journal-title":"J Nucl Med"},{"issue":"14","key":"10.1053\/j.semnuclmed.2024.02.006_bib0013","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.jacc.2021.02.019","article-title":"Molecular imaging identifies fibroblast activation beyond the infarct region after acute myocardial infarction","volume":"77","author":"Diekmann","year":"2021","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"10.1053\/j.semnuclmed.2024.02.006_bib0014","doi-asserted-by":"crossref","first-page":"10801","DOI":"10.1038\/s41598-017-09790-1","article-title":"Global fibroblast activation throughout the left ventricle but localized fibrosis after myocardial infarction","volume":"7","author":"Nagaraju","year":"2017","journal-title":"Sci Rep"},{"issue":"12","key":"10.1053\/j.semnuclmed.2024.02.006_bib0015","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.jcmg.2015.09.008","article-title":"Molecular imaging of the chemokine receptor CXCR4 after acute myocardial infarction","volume":"8","author":"Thackeray","year":"2015","journal-title":"JACC Cardiovasc Imaging"},{"issue":"9","key":"10.1053\/j.semnuclmed.2024.02.006_bib0016","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.2967\/jnumed.121.263555","article-title":"Cardiac fibroblast activation in patients early after acute myocardial infarction: Integration with MR tissue characterization and subsequent functional outcome","volume":"63","author":"Diekmann","year":"2022","journal-title":"J Nucl Med"},{"issue":"8","key":"10.1053\/j.semnuclmed.2024.02.006_bib0017","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.007131","article-title":"Myocardial fibrosis predicts 10-year survival in patients undergoing aortic valve replacement","volume":"11","author":"Herrmann","year":"2018","journal-title":"Circ Cardiovasc Imaging"},{"issue":"8","key":"10.1053\/j.semnuclmed.2024.02.006_bib0018","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.2967\/jnumed.122.265147","article-title":"Molecular imaging of myocardial fibroblast activation in patients with advanced aortic stenosis before transcatheter aortic valve replacement: A pilot study","volume":"64","author":"Diekmann","year":"2023","journal-title":"J Nucl Med"},{"issue":"5","key":"10.1053\/j.semnuclmed.2024.02.006_bib0019","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/j.ajpath.2020.01.004","article-title":"Pure E. fibroblast activation protein regulates lesion burden and the fibroinflammatory response in Apoe-deficient mice in a sexually dimorphic manner","volume":"190","author":"Monslow","year":"2020","journal-title":"Am J Pathol"},{"issue":"12","key":"10.1053\/j.semnuclmed.2024.02.006_bib0020","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/s41569-019-0227-9","article-title":"Vascular smooth muscle cells in atherosclerosis","volume":"16","author":"Basatemur","year":"2019","journal-title":"Nat Rev Cardiol"},{"issue":"7","key":"10.1053\/j.semnuclmed.2024.02.006_bib0021","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1007\/s00259-018-3973-8","article-title":"Reviewer g, Members of EC, Members of EI, Inflammation, et al: FDG-PET\/CT(A) imaging in large vessel vasculitis and polymyalgia rheumatica: joint procedural recommendation of the EANM, SNMMI, and the PET Interest Group (PIG), and endorsed by the ASNC","volume":"45","author":"Slart","year":"2018","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1053\/j.semnuclmed.2024.02.006_bib0022","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.apradiso.2012.06.034","article-title":"Comparison of Gallium-68 and Fluorine-18 imaging characteristics in positron emission tomography","volume":"76","author":"Sanchez-Crespo","year":"2013","journal-title":"Appl Radiat Isot"},{"issue":"5","key":"10.1053\/j.semnuclmed.2024.02.006_bib0023","doi-asserted-by":"crossref","first-page":"2714","DOI":"10.1021\/acs.molpharmaceut.3c00163","article-title":"Noninvasive assessment of renal fibrosis of chronic kidney disease in rats by [(68)Ga]Ga-FAPI-04 small animal PET\/CT and biomarkers","volume":"20","author":"Mao","year":"2023","journal-title":"Mol Pharm"},{"issue":"11","key":"10.1053\/j.semnuclmed.2024.02.006_bib0024","doi-asserted-by":"crossref","first-page":"3493","DOI":"10.1007\/s00259-021-05343-x","article-title":"Value of [(68)Ga]Ga-FAPI-04 imaging in the diagnosis of renal fibrosis","volume":"48","author":"Zhou","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"16","key":"10.1053\/j.semnuclmed.2024.02.006_bib0025","doi-asserted-by":"crossref","first-page":"7984","DOI":"10.7150\/thno.61423","article-title":"Molecular imaging of inflammation crosstalk along the cardio-renal axis following acute myocardial infarction","volume":"11","author":"Werner","year":"2021","journal-title":"Theranostics"},{"issue":"16","key":"10.1053\/j.semnuclmed.2024.02.006_bib0026","doi-asserted-by":"crossref","first-page":"e840","DOI":"10.1161\/CIR.0000000000000664","article-title":"Cardiorenal syndrome: Classification, pathophysiology, diagnosis, and treatment strategies: A scientific statement from the American Heart Association","volume":"139","author":"Rangaswami","year":"2019","journal-title":"Circulation"},{"issue":"4","key":"10.1053\/j.semnuclmed.2024.02.006_bib0027","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1053\/j.semnuclmed.2021.12.003","article-title":"SPECT and PET radiotracers in renal imaging","volume":"52","author":"Werner","year":"2022","journal-title":"Semin Nucl Med"},{"issue":"12","key":"10.1053\/j.semnuclmed.2024.02.006_bib0028","doi-asserted-by":"crossref","first-page":"6105","DOI":"10.7150\/thno.58682","article-title":"Current and future perspectives on functional molecular imaging in nephro-urology: Theranostics on the horizon","volume":"11","author":"Toyama","year":"2021","journal-title":"Theranostics"}],"container-title":["Seminars in Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001299824000230?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001299824000230?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T08:54:51Z","timestamp":1723798491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001299824000230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["S0001299824000230"],"URL":"https:\/\/doi.org\/10.1053\/j.semnuclmed.2024.02.006","relation":{},"ISSN":["0001-2998"],"issn-type":[{"value":"0001-2998","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FAPI-PET in Cardiovascular Disease","name":"articletitle","label":"Article Title"},{"value":"Seminars in Nuclear Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.semnuclmed.2024.02.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}