{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T01:05:49Z","timestamp":1794013549241,"version":"4.8.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T00:00:00Z","timestamp":1774051200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Nuclear Medicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1053\/j.semnuclmed.2026.03.010","type":"journal-article","created":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T03:45:11Z","timestamp":1775533511000},"page":"702-708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The value of [18F]FDG PET\/CT in fever of unknown origin (FUO): an update and future aspects"],"prefix":"10.1053","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0810-6494","authenticated-orcid":false,"given":"Domenico","family":"Albano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-3898","authenticated-orcid":false,"given":"Luca","family":"Urso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9808-780X","authenticated-orcid":false,"given":"Giorgio","family":"Treglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Bertagna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1053\/j.semnuclmed.2026.03.010_bib0001","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1007\/s00259-024-06732-8","article-title":"EANM consensus document on the use of [18F]FDG PET\/CT in fever and inflammation of unknown origin","volume":"51","author":"Hess","year":"2024","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"2","key":"10.1053\/j.semnuclmed.2026.03.010_bib0002","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1007\/s00259-024-06915-3","article-title":"EANM\/SNMMI guideline\/procedure standard for [18F]FDG hybrid PET use in infection and inflammation in adults v2.0","volume":"52","author":"Abikhzer","year":"2025","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"3","key":"10.1053\/j.semnuclmed.2026.03.010_bib0003","doi-asserted-by":"crossref","first-page":"280","DOI":"10.7861\/clinmedicine.15-3-280","article-title":"Bleeker-Rovers C. Fever of unknown origin","volume":"15","author":"Mulders-Manders","year":"2015","journal-title":"Clin Med"},{"key":"10.1053\/j.semnuclmed.2026.03.010_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005792-196102000-00001","article-title":"Fever of unexplained origin: report on 100 cases","volume":"40","author":"Petersdorf","year":"1961","journal-title":"Medicine"},{"key":"10.1053\/j.semnuclmed.2026.03.010_bib0005","first-page":"35","article-title":"Fever of unknown origin\u2013reexamined and redefined","volume":"11","author":"Durack","year":"1991","journal-title":"Curr Clin Top Infect Dis"},{"issue":"2","key":"10.1053\/j.semnuclmed.2026.03.010_bib0006","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3390\/jcm11020386","article-title":"Diagnostic value of 18F-FDG PET\/CT vs. chest-abdomen-pelvis CT scan in management of patients with fever of unknown origin, inflammation of unknown origin or episodic fever of unknown origin: a comparative multicentre prospective study","volume":"11","author":"Ly","year":"2022","journal-title":"J Clin Med"},{"issue":"3","key":"10.1053\/j.semnuclmed.2026.03.010_bib0007","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.ejrad.2010.11.018","article-title":"A meta-analysis of the value of fluorodeoxyglucose-PET\/PET-CT in the evaluation of fever of unknown origin","volume":"80","author":"Dong","year":"2011","journal-title":"Eur J Radiol"},{"issue":"7","key":"10.1053\/j.semnuclmed.2026.03.010_bib0008","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/MNM.0b013e328361cd0e","article-title":"Diagnostic performance of 18F-FDG PET\/CT in patients with fever of unknown origin: a meta-analysis","volume":"34","author":"Hao","year":"2013","journal-title":"Nucl Med Commun"},{"issue":"10","key":"10.1053\/j.semnuclmed.2026.03.010_bib0009","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1007\/s00259-016-3377-6","article-title":"Contribution of (18)F-FDG PET in the diagnostic assessment of fever of unknown origin (FUO): a stratification-based meta-analysis","volume":"43","author":"Besson","year":"2016","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"9","key":"10.1053\/j.semnuclmed.2026.03.010_bib0010","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.crad.2017.04.014","article-title":"Diagnostic yield of FDG-PET\/CT in fever of unknown origin: a systematic review, meta-analysis, and Delphi exercise","volume":"72","author":"Bharucha","year":"2017","journal-title":"Clin Radiol"},{"issue":"12","key":"10.1053\/j.semnuclmed.2026.03.010_bib0011","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.2967\/jnumed.116.174391","article-title":"Nuclear imaging for classic fever of unknown origin: meta-analysis","volume":"57","author":"Takeuchi","year":"2016","journal-title":"J Nucl Med"},{"issue":"6","key":"10.1053\/j.semnuclmed.2026.03.010_bib0012","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1177\/0284185118799512","article-title":"Contribution of 18F-FDG PET\/CT in a case-mix of fever of unknown origin and inflammation of unknown origin: a meta-analysis","volume":"60","author":"Kan","year":"2019","journal-title":"Acta Radiol"},{"issue":"4","key":"10.1053\/j.semnuclmed.2026.03.010_bib0013","first-page":"178","article-title":"Analysis of cost-effectiveness in the diagnosis of fever of unknown origin and the role of (18)F-FDG PET-CT: a proposal of diagnostic algorithm","volume":"31","author":"Becerra Nakayo","year":"2012","journal-title":"Revista Esp De Med Nuclear e Imagen Mol."},{"issue":"9","key":"10.1053\/j.semnuclmed.2026.03.010_bib0014","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1007\/s00259-015-3010-0","article-title":"(1)(8)F-FDG PET\/CT in inflammation of unknown origin: a cost-effectiveness pilot-study","volume":"42","author":"Balink","year":"2015","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"43","key":"10.1053\/j.semnuclmed.2026.03.010_bib0015","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000012909","article-title":"Association of 18F-FDG PET or PET\/CT results with spontaneous remission in classic fever of unknown origin: a systematic review and meta-analysis","volume":"97","author":"Takeuchi","year":"2018","journal-title":"Medicine"},{"key":"10.1053\/j.semnuclmed.2026.03.010_bib0016","article-title":"The diagnostic yield of [18F]FDG PET\/CT in FUO: an Italian multicenter study on 929 patients","volume":"125","author":"Albano","year":"2026","journal-title":"J Nucl Med"},{"issue":"2","key":"10.1053\/j.semnuclmed.2026.03.010_bib0017","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1007\/s12149-017-1226-8","article-title":"Do clinical and laboratory variables have any impact on the diagnostic performance of 18F-FDG PET\/CT in patients with fever of unknown origin?","volume":"32","author":"Garcia-Vicente","year":"2018","journal-title":"Ann Nucl Med"},{"issue":"10","key":"10.1053\/j.semnuclmed.2026.03.010_bib0018","doi-asserted-by":"crossref","first-page":"2861","DOI":"10.1007\/s10067-023-06673-x","article-title":"Rheumatology experience with FDG PET \/CT in inflammation of unknown origin: a single - centre report for determining factors associated with diagnostic precision","volume":"42","author":"P","year":"2023","journal-title":"Clin Rheumatol"},{"issue":"1","key":"10.1053\/j.semnuclmed.2026.03.010_bib0019","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/MNM.0000000000000395","article-title":"Determinants of diagnostic performance of 18F-FDG PET\/CT in patients with fever of unknown origin","volume":"37","author":"Pereira","year":"2016","journal-title":"Nucl Med Commun"},{"issue":"22","key":"10.1053\/j.semnuclmed.2026.03.010_bib0020","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2021.36.e150","volume":"36","author":"Tsuzuki","year":"2021","journal-title":"J Korean Med Sci"},{"issue":"8","key":"10.1053\/j.semnuclmed.2026.03.010_bib0021","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1007\/s10096-011-1440-6","article-title":"Place of (18)F-FDG-PET with computed tomography in the diagnostic algorithm of patients with fever of unknown origin","volume":"31","author":"Crouzet","year":"2012","journal-title":"Eur J Clin Microbiol Infect Dis"},{"issue":"1","key":"10.1053\/j.semnuclmed.2026.03.010_bib0022","doi-asserted-by":"crossref","first-page":"48","DOI":"10.23736\/S1824-4785.24.03546-5","article-title":"Fever of unknown origin in pediatrics: role of nuclear medicine","volume":"68","author":"Olianti","year":"2024","journal-title":"Q J Nucl Med Mol Imaging"},{"issue":"3","key":"10.1053\/j.semnuclmed.2026.03.010_bib0023","doi-asserted-by":"crossref","first-page":"219","DOI":"10.23736\/S1824-4785.25.03649-0","article-title":"[18F]FDG PET\/CT of FUO\/IUO in special populations","volume":"69","author":"Albano","year":"2025","journal-title":"Q J Nucl Med Mol Imaging"},{"issue":"8","key":"10.1053\/j.semnuclmed.2026.03.010_bib0024","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1007\/s00247-022-05333-7","article-title":"Quantifying the contribution of 18F-FDG PET to the diagnostic assessment of pediatric patients with fever of unknown origin: a systematic review and meta-analysis","volume":"52","author":"Li","year":"2022","journal-title":"Pediatr Radiol"},{"key":"10.1053\/j.semnuclmed.2026.03.010_bib0025","doi-asserted-by":"crossref","DOI":"10.1007\/s00259-025-07759-1","article-title":"Diagnostic value of [18F]FDG PET\/CT for detection of infectious and inflammatory foci in critically ill patients: a systematic review and meta-analysis","author":"Treglia","year":"2026","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"5","key":"10.1053\/j.semnuclmed.2026.03.010_bib0026","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1016\/j.jfma.2019.09.010","article-title":"Diagnostic performance of FDG PET\/CT in critically ill patients with suspectedinfection: a systematic review and meta-analysis","volume":"119","author":"Huang","year":"2020","journal-title":"J Formos Med Assoc"},{"key":"10.1053\/j.semnuclmed.2026.03.010_bib0027","article-title":"Expert opinions in nuclear medicine: finding the \"holy grail\" in infection imaging","volume":"10","author":"Glaudemans","year":"2023","journal-title":"Front Med (Lausanne)"},{"issue":"1","key":"10.1053\/j.semnuclmed.2026.03.010_bib0028","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s41824-025-00263-7","article-title":"Emerging PET-radiotracers in cardiovascular, neuro-inflammation, lung and rheumatological diseases: a narrative review","volume":"9","author":"Albano","year":"2025","journal-title":"EJNMMI Rep"},{"issue":"6","key":"10.1053\/j.semnuclmed.2026.03.010_bib0029","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3390\/ph17060716","article-title":"The role of fibroblast activation protein inhibitor positron emission tomography in inflammatory and infectious diseases: an updated systematic review","volume":"17","author":"Albano","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1053\/j.semnuclmed.2026.03.010_bib0030","doi-asserted-by":"crossref","DOI":"10.1093\/bjr\/tqag068","article-title":"Nuclear medicine imaging to guide antibiotic therapy: an expert review","author":"Albano","year":"2026","journal-title":"Br J Radiol"},{"key":"10.1053\/j.semnuclmed.2026.03.010_bib0031a","doi-asserted-by":"crossref","unstructured":"Lauri C, Pontico M, Farina R, Signore A. Nuclear Imaging for therapy monitoring and response assessment in infectious diseases. Semin Nucl Med. Published online March 23, 2026. https:\/\/doi.org\/10.1053\/j.semnuclmed.2026.03.005","DOI":"10.1053\/j.semnuclmed.2026.03.005"},{"key":"10.1053\/j.semnuclmed.2026.03.010_bib0031","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1094929","article-title":"Infection-specific PET imaging with 18F-fluorodeoxysorbitol and 2-[18F]F-\u03c1-aminobenzoic acid: an extended diagnostic tool for bacterial and fungal diseases","volume":"14","author":"Rua","year":"2023","journal-title":"Front Microbiol"},{"key":"10.1053\/j.semnuclmed.2026.03.010_bib0032","doi-asserted-by":"crossref","DOI":"10.1007\/s00259-021-05461-6","article-title":"Long axial field of view PET scanners: a road map to implementation and new possibilities","volume":"48","author":"Slart","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"10.1053\/j.semnuclmed.2026.03.010_bib0033","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s40644-022-00507-w","article-title":"Extending the clinical capabilities of short- and long-lived positron-emitting radionuclides through high sensitivity PET\/CT","volume":"22","author":"Van Sluis","year":"2022","journal-title":"Cancer Imaging"},{"key":"10.1053\/j.semnuclmed.2026.03.010_bib0034","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s00259-022-05979-3","article-title":"Ultra-low dose infection imaging of a newborn without sedation using long axial field-of-view PET\/CT","volume":"50","author":"Van Rijsewijk","year":"2022","journal-title":"Eur J Nucl Med Mol Imaging"}],"container-title":["Seminars in Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001299826000760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0001299826000760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T12:32:26Z","timestamp":1792585946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0001299826000760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0001299826000760"],"URL":"https:\/\/doi.org\/10.1053\/j.semnuclmed.2026.03.010","relation":{},"ISSN":["0001-2998"],"issn-type":[{"value":"0001-2998","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The value of [18F]FDG PET\/CT in fever of unknown origin (FUO): an update and future aspects","name":"articletitle","label":"Article Title"},{"value":"Seminars in Nuclear Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.semnuclmed.2026.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}