{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T15:21:45Z","timestamp":1788535305354,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Perinatology"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1053\/j.semperi.2004.09.002","type":"journal-article","created":{"date-parts":[[2004,12,12]],"date-time":"2004-12-12T00:47:31Z","timestamp":1102812451000},"page":"334-339","source":"Crossref","is-referenced-by-count":61,"title":["Bilirubin\u2014albumin binding and neonatal jaundice"],"prefix":"10.1053","volume":"28","author":[{"given":"Charles E.","family":"Ahlfors","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Wennberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.semperi.2004.09.002_bib1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0140-6736(52)91949-1","article-title":"Controlled trials of the treatment of hemolytic disease of the newborn","volume":"1","author":"Mollison","year":"1952","journal-title":"Lancet"},{"key":"10.1053\/j.semperi.2004.09.002_bib2","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1056\/NEJM195210302471802","article-title":"Erythroblastosis fetalis VIII","volume":"247","author":"Hsia","year":"1952","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semperi.2004.09.002_bib3","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1067\/mpd.2002.123098","article-title":"System-based approach to the management of neonatal jaundice and prevention of kernicterus","volume":"140","author":"Johnson","year":"2002","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2004.09.002_bib4","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1542\/peds.18.4.614","article-title":"A difference in mortality rate and incidence of kernicterus among premature infants allotted to two prophylactic antibacterial regimens","volume":"18","author":"Silverman","year":"1956","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib5","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1542\/peds.21.6.875","article-title":"Kernicterus in premature infants associated with low concentration of bilirubin in plasma","volume":"21","author":"Harris","year":"1958","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib6","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1172\/JCI103864","article-title":"Studies in kernicterus. I. The protein binding of bilirubin","volume":"38","author":"Odell","year":"1959","journal-title":"J Clin Invest"},{"key":"10.1053\/j.semperi.2004.09.002_bib7","first-page":"591","article-title":"Kernicterus in rats with an inherited deficiency of glucuronyl transferase","volume":"97","author":"Johnson","year":"1959","journal-title":"AMA J Dis Childh"},{"key":"10.1053\/j.semperi.2004.09.002_bib8","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1172\/JCI104858","article-title":"Metabolism and disposition of C14-bilirubin in congenital nonhemolytic jaundice","volume":"42","author":"Schmid","year":"1963","journal-title":"J Clin Invest"},{"key":"10.1053\/j.semperi.2004.09.002_bib9","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1172\/JCI105383","article-title":"Experimental bilirubin encephalopathy. The mode of entry of bilirubin-C14 into the central nervous system","volume":"45","author":"Diamond","year":"1966","journal-title":"J Clin Invest"},{"key":"10.1053\/j.semperi.2004.09.002_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3109\/10408368009105860","article-title":"Binding of bilirubin to albumin","volume":"11","author":"Brodersen","year":"1980","journal-title":"CRC Crit Rev Clin Lab Sci"},{"key":"10.1053\/j.semperi.2004.09.002_bib11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1203\/00006450-198608000-00018","article-title":"Experimental bilirubin encephalopathy","volume":"20","author":"Wennberg","year":"1986","journal-title":"Pediatr Res"},{"key":"10.1053\/j.semperi.2004.09.002_bib12","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0022-3476(98)70457-3","article-title":"Comparison of bilirubin concentration and bilirubin\/albumin ratio with the bilirubin binding ability in neonatal serum","volume":"132","author":"Robertson","year":"1998","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2004.09.002_bib13","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/clinchem\/27.7.1213","article-title":"Further studies on plasma proteins, lipids, and dye- and drug-binding in a child with analbuminemia","volume":"27","author":"Frohlich","year":"1981","journal-title":"Clin Chem"},{"key":"10.1053\/j.semperi.2004.09.002_bib14","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/S0022-3476(78)81095-6","article-title":"Clinical application of bilirubin-albumin binding determinations","volume":"93","author":"Cashore","year":"1978","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2004.09.002_bib15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-0773.1984.tb01906.x","article-title":"Serum albumin","volume":"54","author":"Brodersen","year":"1984","journal-title":"Acta Pharmacol Toxicol"},{"key":"10.1053\/j.semperi.2004.09.002_bib16","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1093\/clinchem\/20.7.783","article-title":"Determination of unbound bilirubin in the serum of newborns","volume":"33","author":"Jacobsen","year":"1974","journal-title":"Clin Chem"},{"key":"10.1053\/j.semperi.2004.09.002_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0022-3476(70)80124-X","article-title":"Studies in kernicterus. III. The saturation of serum proteins with bilirubin during neonatal life and its relationship to brain damage at five years","volume":"76","author":"Odell","year":"1970","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2004.09.002_bib18","series-title":"Phototherapy in the Newborn","first-page":"122","article-title":"Bilirubin-dependent brain damage","author":"Johnson","year":"1974"},{"key":"10.1053\/j.semperi.2004.09.002_bib19","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1542\/peds.62.4.460","article-title":"Absence of kernicterus in low-birth-weight infants from 1971 through 1976","volume":"62","author":"Pearlman","year":"1978","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1067\/mpd.2001.116281","article-title":"Benzyl alcohol, kernicterus, and unbound bilirubin","volume":"139","author":"Ahlfors","year":"2001","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2004.09.002_bib21","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1542\/peds.69.3.260","article-title":"A prospective study of free bilirubin and other risk factors in the development of kernicterus in premature infants","volume":"69","author":"Ritter","year":"1982","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib22","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1542\/peds.69.3.255","article-title":"Entry of bilirubin into brain due to opening of the blood\u2014brain barrier","volume":"69","author":"Levine","year":"1982","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib23","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1542\/peds.69.3.381","article-title":"Bilirubin and brain damage","volume":"69","author":"Lucey","year":"1982","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib24","doi-asserted-by":"crossref","DOI":"10.1111\/j.1651-2227.1961.tb08191.x","article-title":"Discussion on the advisability of performing exchange transfusion in neonatal jaundice of unknown origin","volume":"50","author":"Trolle","year":"1961","journal-title":"Acta Paediatr Scand"},{"key":"10.1053\/j.semperi.2004.09.002_bib25","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1542\/peds.111.6.1303","article-title":"Infants with bilirubin levels of 30 mg\/dL or more in a large managed care organization","volume":"111","author":"Newman","year":"2003","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib26","doi-asserted-by":"crossref","first-page":"E7","DOI":"10.1542\/peds.99.5.e7","article-title":"Adverse events associated with exchange transfusion in healthy and ill newborns","volume":"99","author":"Jackson","year":"1997","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib27","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1542\/peds.26.5.745","article-title":"Mortality of exchange transfusion","volume":"26","author":"Boggs","year":"1960","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib28","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1542\/peds.89.5.809","article-title":"Evaluation and treatment of jaundice in the term newborn","volume":"89","author":"Newman","year":"1992","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib29","series-title":"The Yearbook of Neonatal and Perinatal Medicine","first-page":"17","article-title":"Loss of concern about jaundice and the re-emergence of kernicterus in full-term infants in the era of managed care","author":"Brown","year":"1996"},{"key":"10.1053\/j.semperi.2004.09.002_bib30","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0022-3476(82)80771-3","article-title":"Abnormal auditory brainstem response in a newborn infant with hyperbilirubinemia","volume":"100","author":"Wennberg","year":"1982","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2004.09.002_bib31","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1542\/peds.75.4.703","article-title":"Auditory nerve and brainstem responses in newborn infants with hyperbilirubinemia","volume":"75","author":"Nakamura","year":"1985","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib32","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1203\/00006450-198606000-00005","article-title":"Changes in the auditory brainstem response associated with intravenous infusion of unconjugated bilirubin into infant Rhesus monkeys","volume":"20","author":"Ahlfors","year":"1986","journal-title":"Pediatr Res"},{"key":"10.1053\/j.semperi.2004.09.002_bib33","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1542\/peds.93.1.50","article-title":"Vigintiphobia, unbound bilirubin, and auditory brainstem responses","volume":"93","author":"Funato","year":"1994","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib34","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1542\/peds.107.4.664","article-title":"Bilirubin and serial auditory brainstem responses in premature infants","volume":"107","author":"Amin","year":"2001","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib35","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1542\/peds.69.4.481","article-title":"Unbound bilirubin and kernicterus in low-birth-weight infants","volume":"69","author":"Cashore","year":"1982","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib36","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1111\/j.1442-200X.1992.tb01024.x","article-title":"Determination of serum unbound bilirubin for prediction of kernicterus in low birth weight infants","volume":"34","author":"Nakamura","year":"1992","journal-title":"Acta Pediatr Jpn"},{"key":"10.1053\/j.semperi.2004.09.002_bib37","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1542\/peds.114.1.297","article-title":"Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation","volume":"114","year":"2004","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib38","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1542\/peds.93.3.488","article-title":"Criteria for exchange transfusion in jaundiced newborns","volume":"93","author":"Ahlfors","year":"1994","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib39","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0022-3476(80)80860-2","article-title":"Free bilirubin concentration and bilirubin-binding affinity in term and preterm infants","volume":"96","author":"Cashore","year":"1980","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2004.09.002_bib40","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1542\/peds.114.1.229","article-title":"Research on prevention of bilirubin-induced brain injury and kernicterus","volume":"114","author":"Blackmon","year":"2004","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2004.09.002_bib41","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1067\/mpd.2000.108566","article-title":"Unbound bilirubin associated with kernicterus","volume":"137","author":"Ahlfors","year":"2000","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2004.09.002_bib42","doi-asserted-by":"crossref","first-page":"29953","DOI":"10.1074\/jbc.M104628200","article-title":"Affinity of human serum albumin for bilirubin varies with albumin concentrations and buffer composition","volume":"276","author":"Weisiger","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1053\/j.semperi.2004.09.002_bib43","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1006\/abio.2000.4485","article-title":"Measurement of plasma unbound unconjugated bilirubin","volume":"279","author":"Ahlfors","year":"2000","journal-title":"Anal Biochem"},{"key":"10.1053\/j.semperi.2004.09.002_bib44","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.aca.2003.09.003","article-title":"Zone fluidics in flow analysis","volume":"499","author":"Marshall","year":"2003","journal-title":"Anal Chim Acta"}],"container-title":["Seminars in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000504000709?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000504000709?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T21:00:37Z","timestamp":1682888437000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0146000504000709"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":44,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0146000504000709"],"URL":"https:\/\/doi.org\/10.1053\/j.semperi.2004.09.002","relation":{},"ISSN":["0146-0005"],"issn-type":[{"value":"0146-0005","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}