{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T20:29:29Z","timestamp":1769632169234,"version":"3.49.0"},"reference-count":85,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Perinatology"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1053\/j.semperi.2011.09.023","type":"journal-article","created":{"date-parts":[[2012,3,10]],"date-time":"2012-03-10T17:20:21Z","timestamp":1331400021000},"page":"130-138","source":"Crossref","is-referenced-by-count":49,"title":["Managing the Patent Ductus Arteriosus in the Premature Neonate: A New Look at What We Thought We Knew"],"prefix":"10.1053","volume":"36","author":[{"given":"Cathy","family":"Hammerman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alona","family":"Bin-Nun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.semperi.2011.09.023_bib1","doi-asserted-by":"crossref","first-page":"F190","DOI":"10.1136\/adc.2004.065946","article-title":"Managing the baby with a patent ductus arteriosus","volume":"90","author":"Fowlie","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2011.09.023_bib2","doi-asserted-by":"crossref","first-page":"F498","DOI":"10.1136\/adc.2005.092734","article-title":"Patent ductus arteriosus: Lack of evidence for common treatments","volume":"92","author":"Bose","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2011.09.023_bib3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000101348","article-title":"Patent ductus arteriosus: How aggressive should we be?","volume":"91","author":"Van Overmeire","year":"2007","journal-title":"J Neonatol"},{"key":"10.1053\/j.semperi.2011.09.023_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jpedsurg.2006.09.040","article-title":"Patent ductus arteriosus ligation in premature infants: Who really benefits, and at what cost?","volume":"42","author":"Raval","year":"2007","journal-title":"J Pediatr Surg"},{"key":"10.1053\/j.semperi.2011.09.023_bib5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1097\/01.PCC.0000262886.67502.2B","article-title":"Patency of the ductus arteriosus in the newborn\u2014Now you want it, now you don't","volume":"8","author":"Hansen","year":"2007","journal-title":"Pediatr Crit Care Med"},{"key":"10.1053\/j.semperi.2011.09.023_bib6","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0022-3476(69)80103-4","article-title":"Congestive heart failure from suspected ductal closure in utero","volume":"75","author":"Arcilla","year":"1969","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0090-6980(74)90042-2","article-title":"The effects of prostaglandins, prostaglandin inhibitors, and oxygen on the closure of the ductus arteriosus, pulmonary arteries, and umbilical vessels in vitro","volume":"8","author":"Starling","year":"1974","journal-title":"Prostaglandins"},{"key":"10.1053\/j.semperi.2011.09.023_bib8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0090-6980(74)90110-5","article-title":"Studies on closure of the ductus arteriosus: Part XI","volume":"8","author":"Sharpe","year":"1974","journal-title":"Prostaglandins"},{"key":"10.1053\/j.semperi.2011.09.023_bib9","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/0090-6980(75)90034-9","article-title":"Lamb ductus arteriosus: Effect of prostaglandin synthesis inhibitors on the muscle tone and the response to prostaglandin E2","volume":"9","author":"Coceani","year":"1975","journal-title":"Prostaglandins"},{"key":"10.1053\/j.semperi.2011.09.023_bib10","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0140-6736(75)91432-4","article-title":"Medical manipulation of the ductus arteriosus","volume":"1","author":"Elliott","year":"1975","journal-title":"Lancet"},{"key":"10.1053\/j.semperi.2011.09.023_bib11","first-page":"782","article-title":"Inhibition of human premature labor by indomethacin","volume":"44","author":"Zuckerman","year":"1974","journal-title":"Obstet Gynecol"},{"key":"10.1053\/j.semperi.2011.09.023_bib12","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1056\/NEJM197609022951003","article-title":"Pharmacologic closure of patent ductus arteriosus in the premature infant","volume":"295","author":"Friedman","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semperi.2011.09.023_bib13","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1056\/NEJM197609022951004","article-title":"Closure of the ductus arteriosus in premature infants by inhibition of prostaglandin synthesis","volume":"295","author":"Heymann","year":"1976","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semperi.2011.09.023_bib14","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD000174.pub2","article-title":"Prophylactic intravenous indomethacin for preventing mortality and morbidity in preterm infants","author":"Fowlie","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.semperi.2011.09.023_bib15","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0022-3476(96)80123-5","article-title":"Recommendations for the postnatal use of indomethacin: An analysis of four separate treatment strategies","volume":"128","author":"Clyman","year":"1996","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1067\/mpd.2001.110528","article-title":"Early versus late indomethacin treatment for patent ductus arteriosus in premature infants with respiratory distress syndrome","volume":"138","author":"Van Overmeire","year":"2001","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib17","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1542\/peds.2007-0925","article-title":"Impact of patent ductus arteriosus and subsequent therapy with indomethacin on cerebral oxygenation in preterm infants","volume":"121","author":"Lemmers","year":"2008","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2011.09.023_bib18","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1161\/01.RES.59.5.562","article-title":"Maintenance of cerebral circulation during hemorrhagic hypotension in newborn pigs: Role of prostanoids","volume":"59","author":"Leffler","year":"1986","journal-title":"Circ Res"},{"key":"10.1053\/j.semperi.2011.09.023_bib19","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/BF00442705","article-title":"Indomethacin and cerebral blood flow in premature infants treated for patent ductus arteriosus","volume":"147","author":"Pryds","year":"1988","journal-title":"Eur J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000242860","article-title":"Effect of indomethacin on cerebral blood flow velocity of premature newborns","volume":"54","author":"Laudignon","year":"1988","journal-title":"Biol Neonate"},{"key":"10.1053\/j.semperi.2011.09.023_bib21","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0140-6736(90)93030-S","article-title":"Effects of indomethacin on cerebral haemodynamics in very preterm infants","volume":"335","author":"Edwards","year":"1990","journal-title":"Lancet"},{"key":"10.1053\/j.semperi.2011.09.023_bib22","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1542\/peds.84.5.802","article-title":"Cerebral blood flow velocity changes in preterm infants after a single dose of indomethacin: Duration of its effects","volume":"84","author":"Van Bel","year":"1989","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2011.09.023_bib23","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/j.1469-8749.1987.tb08823.x","article-title":"The effect of indomethacin on cerebral blood-flow velocity in premature infants","volume":"29","author":"Evans","year":"1987","journal-title":"Dev Med Child Neurol"},{"key":"10.1053\/j.semperi.2011.09.023_bib24","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/BF01957006","article-title":"Effects of repeated indomethacin administration on cerebral oxygenation and haemodynamics in preterm infants: Combined near infrared spectrophotometry and doppler ultrasound study","volume":"153","author":"Liem","year":"1994","journal-title":"Eur J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib25","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1203\/00006450-199308000-00015","article-title":"The influence of indomethacin on the autoregulatory ability of the cerebral vascular bed in the newborn lamb","volume":"34","author":"Van Bel","year":"1993","journal-title":"Pediatr Res"},{"key":"10.1053\/j.semperi.2011.09.023_bib26","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/0140-6736(90)93030-S","article-title":"Effects of indomethacin on cerebral haemodynamics in very preterm infants","volume":"335","author":"Edwards","year":"1990","journal-title":"Lancet"},{"key":"10.1053\/j.semperi.2011.09.023_bib27","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000283946","article-title":"Effect of indomethacin infused over 30 minutes on cerebral fractional tissue oxygen extraction in preterm newborns with a patent ductus arteriosus","volume":"98","author":"Keating","year":"2010","journal-title":"Neonatology"},{"key":"10.1053\/j.semperi.2011.09.023_bib28","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1136\/adc.67.7_Spec_No.851","article-title":"Regional cerebral blood flow velocity changes after indomethacin infusion in preterm infants","volume":"67","author":"Austin","year":"1992","journal-title":"Arch Dis Child"},{"key":"10.1053\/j.semperi.2011.09.023_bib29","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/adc.64.1_Spec_No.8","article-title":"Effect of infusion rate of indomethacin on cerebrovascular responses in preterm neonates","volume":"64","author":"Colditz","year":"1989","journal-title":"Arch Dis Child"},{"key":"10.1053\/j.semperi.2011.09.023_bib30","first-page":"29","article-title":"Effects on cerebral blood flow velocities of slow and rapid infusion of indomethacin","volume":"14","author":"Simko","year":"1994","journal-title":"J Perinatol"},{"key":"10.1053\/j.semperi.2011.09.023_bib31","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1542\/peds.95.2.244","article-title":"Continuous versus multiple rapid infusions of indomethacin: Effects on cerebral blood flow velocity","volume":"95","author":"Hammerman","year":"1995","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2011.09.023_bib32","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1111\/j.1651-2227.2002.tb01668.x","article-title":"Changes in cerebral, renal and mesenteric blood flow velocity during continuous and bolus infusion of indomethacin","volume":"91","author":"Christmann","year":"2002","journal-title":"Acta Paediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib33","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1542\/peds.2005-0293","article-title":"Effectiveness and side effects of an escalating, stepwise approach to indomethacin treatment for symptomatic patent ductus arteriosus in premature infants below 33 weeks of gestation","volume":"116","author":"Sperandio","year":"2005","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2011.09.023_bib34","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jpeds.2008.01.031","article-title":"Increased indomethacin dosing for persistent patent ductus arteriosus in preterm infants: A multicenter, randomized, controlled trial","volume":"153","author":"Jegatheesan","year":"2008","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib35","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003951.pub2","article-title":"Surgical versus medical treatment with cyclooxygenase inhibitors for symptomatic patent ductus arteriosus in preterm infants","author":"Malviya","year":"2008","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.semperi.2011.09.023_bib36","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.jpeds.2008.05.009","article-title":"Indomethacin and retinopathy of prematurity: The hidden paradox","volume":"153","author":"Hammerman","year":"2008","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib37","doi-asserted-by":"crossref","first-page":"F48","DOI":"10.1136\/adc.2007.129270","article-title":"Spontaneous closure of the patent ductus arteriosus in very low birth weight infants following discharge from the neonatal unit","volume":"94","author":"Herrman","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2011.09.023_bib38","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1007\/s00246-007-9166-z","article-title":"Multiple courses of indomethacin and neonatal outcomes in premature infants","volume":"29","author":"Sangem","year":"2008","journal-title":"Pediatr Cardiol"},{"key":"10.1053\/j.semperi.2011.09.023_bib39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1203\/PDR.0b013e31817d9bb0","article-title":"Ibuprofen versus continuous indomethacin in premature neonates with patent ductus arteriosus: Is the difference in the mode of administration?","volume":"64","author":"Hammerman","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1053\/j.semperi.2011.09.023_bib40","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1542\/peds.110.1.e10","article-title":"Factors associated with permanent closure of the ductus arteriosus: A role for prolonged indomethacin therapy","volume":"110","author":"Quinn","year":"2002","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2011.09.023_bib41","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/S0022-3476(05)83342-6","article-title":"Prolonged indomethacin therapy in the prevention of recurrences of patent ductus arteriosus","volume":"117","author":"Hammerman","year":"1990","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib42","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1097\/FTD.0b013e31815b3e13","article-title":"Orogastric and intravenous indomethacin administration to very premature neonates with patent ductus arteriosus: population pharmacokinetics, absolute bioavailability, and treatment outcome","volume":"29","author":"Al Za'abi","year":"2007","journal-title":"Ther Drug Monit"},{"key":"10.1053\/j.semperi.2011.09.023_bib43","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1136\/adc.2007.118117","article-title":"Towards rational management of the patent ductus arteriosus: The need for disease staging","volume":"92","author":"McNamara","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2011.09.023_bib44","doi-asserted-by":"crossref","first-page":"F197","DOI":"10.1136\/fn.81.3.F197","article-title":"Echocardiographic flow pattern of patent ductus arteriosus: A guide to indomethacin treatment in premature infants","volume":"81","author":"Su","year":"1999","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2011.09.023_bib45","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s00431-009-0983-3","article-title":"Does echocardiography facilitate determination of hemodynamic significance attributable to the ductus arteriosus?","volume":"168","author":"Sehgal","year":"2009","journal-title":"Eur J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib46","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.earlhumdev.2010.06.012","article-title":"Echocardiography predicts closure of patent ductus arteriosus in response to ibuprofen in infants less than 28 week gestational age","volume":"86","author":"Pees","year":"2010","journal-title":"Early Hum Dev"},{"key":"10.1053\/j.semperi.2011.09.023_bib47","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jpeds.2005.03.040","article-title":"The use of a bedside assay for plasma B-type natriuretic peptide as a biomarker in the management of patent ductus arteriosus in premature neonates","volume":"147","author":"Flynn","year":"2005","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib48","doi-asserted-by":"crossref","first-page":"F257","DOI":"10.1136\/adc.2007.120691","article-title":"N-terminal pro-B-type natriuretic peptide: A measure of significant patent ductus arteriosus","volume":"93","author":"Farombi-Oghuvbu","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2011.09.023_bib49","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/j.1651-2227.2001.tb00282.x","article-title":"Plasma levels of natriuretic peptides and hemodynamic assessment of patent ductus arteriosus in preterm infants","volume":"90","author":"Holmstr\u00f6m","year":"2001","journal-title":"Acta Paediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib50","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1203\/PDR.0b013e3181799594","article-title":"B-type natriuretic peptide to predict ductus intervention in infants <28 weeks","volume":"64","author":"Czernik","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1053\/j.semperi.2011.09.023_bib51","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1042\/CS20020046","article-title":"Plasma brain natriuretic peptide as a predictor of haemodynamically significant patent ductus arteriosus in preterm infants","volume":"103","author":"Puddy","year":"2002","journal-title":"Clin Sci"},{"key":"10.1053\/j.semperi.2011.09.023_bib52","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/jp.2010.47","article-title":"How useful are B-type natriuretic peptide measurements for monitoring changes in patent ductus arteriosus shunt magnitude?","volume":"30","author":"Chen","year":"2010","journal-title":"J Perinatol"},{"key":"10.1053\/j.semperi.2011.09.023_bib53","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jpeds.2009.12.045","article-title":"B-type natriuretic peptide predicts responses to indomethacin in premature neonates with patent ductus arteriosus","volume":"157","author":"Hsu","year":"2010","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib54","doi-asserted-by":"crossref","first-page":"F178","DOI":"10.1136\/adc.2008.147587","article-title":"B-type natriuretic peptide concentrations to guide treatment of patent ductus arteriosus","volume":"94","author":"Attridge","year":"2009","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2011.09.023_bib55","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/s00246-009-9568-1","article-title":"N-terminal-Pro-B-type natriuretic peptide in premature patent ductus arteriosus: A physiologic biomarker, but Is It a clinical tool?","volume":"31","author":"Hammerman","year":"2010","journal-title":"Pediatr Cardiol"},{"key":"10.1053\/j.semperi.2011.09.023_bib56","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1542\/peds.2008-0313","article-title":"Determination of genetic predisposition to patent ductus arteriosus in preterm infants","volume":"123","author":"Dagle","year":"2009","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2011.09.023_bib57","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1056\/NEJM200009073431001","article-title":"A comparison of ibuprofen and indomethacin for closure of patent ductus arteriosus","volume":"343","author":"Van Overmeire","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semperi.2011.09.023_bib58","doi-asserted-by":"crossref","first-page":"F94","DOI":"10.1136\/adc.2007.120584","article-title":"Comparison of ibuprofen and indomethacin for early-targeted treatment of patent ductus arteriosus in extremely premature infants: A randomized controlled trial","volume":"93","author":"Su","year":"2008","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2011.09.023_bib59","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/S0022-3476(99)70093-4","article-title":"Effects of indomethacin and ibuprofen on mesenteric and renal blood flow in preterm infants with patent ductus arteriosus","volume":"135","author":"Pezzati","year":"1999","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib60","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s00431-004-1596-5","article-title":"A meta-analysis of ibuprofen versus indomethacin for closure of patent ductus arteriosus","volume":"164","author":"Thomas","year":"2005","journal-title":"Eur J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD003481.pub2","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm and\/or low birth weight infants","author":"Ohlsson","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.semperi.2011.09.023_bib62","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jpeds.2003.11.027","article-title":"Effect of ibuprofen on bilirubin-albumin binding","volume":"144","author":"Ahlfors","year":"2004","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib63","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1600-0773.1996.tb00012.x","article-title":"Does ibuprofen affect bilirubin-albumin binding in newborn infant serum?","volume":"79","author":"Cooper-Peel","year":"1996","journal-title":"Pharmacol Toxicol"},{"key":"10.1053\/j.semperi.2011.09.023_bib64","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1203\/PDR.0b013e3181da7578","article-title":"Displacement of bilirubin from albumin by ibuprofen in vitro","volume":"67","author":"Soligard","year":"2010","journal-title":"Pediatr Res"},{"key":"10.1053\/j.semperi.2011.09.023_bib65","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.earlhumdev.2010.04.006","article-title":"Effect of ibuprofen on bilirubin-albumin binding in vitro at concentrations observed during treatment of patent ductus arteriosus","volume":"86","author":"Diot","year":"2010","journal-title":"Early Hum Dev"},{"key":"10.1053\/j.semperi.2011.09.023_bib66","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1542\/peds.2008-2433","article-title":"Does ibuprofen increase neonatal hyperbilirubinemia?","volume":"124","author":"Zecca","year":"2009","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2011.09.023_bib67","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1651-2227.2008.01007.x","article-title":"Total serum bilirubin levels during cyclooxygenase inhibitor treatment for patent ductus arteriosus in preterm infants","volume":"98","author":"Rheinlaender","year":"2009","journal-title":"Acta Paediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib68","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1442-200X.2003.01797.x","article-title":"Comparison of ibuprofen and indomethacin therapy for patent ductus arteriosus in preterm infants","volume":"45","author":"Su","year":"2003","journal-title":"Pediatr Int"},{"key":"10.1053\/j.semperi.2011.09.023_bib69","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1203\/00006450-200011000-00008","article-title":"The renal hemodynamic effects of ibuprofen in the newborn rabbit","volume":"48","author":"Chamaa","year":"2000","journal-title":"Pediatr Res"},{"key":"10.1053\/j.semperi.2011.09.023_bib70","doi-asserted-by":"crossref","first-page":"F514","DOI":"10.1136\/adc.2004.060434","article-title":"Potential risk factors for the development of acute renal failure in preterm newborn infants: A case-control study","volume":"90","author":"Cataldi","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2011.09.023_bib71","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1542\/peds.2006-0272","article-title":"Doppler flow velocimetry in the superior mesenteric artery on the first day of life in preterm infants and the risk of neonatal necrotizing enterocolitis","volume":"118","author":"Murdoch","year":"2006","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2011.09.023_bib72","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1152\/jappl.1999.87.1.370","article-title":"Postnatal hemodynamic changes in very-low-birth weight infants","volume":"87","author":"Yanowitz","year":"1999","journal-title":"J Appl Physiol"},{"key":"10.1053\/j.semperi.2011.09.023_bib73","doi-asserted-by":"crossref","first-page":"F53","DOI":"10.1136\/adc.2006.093708","article-title":"Does patent ductus arteriosus affect feed tolerance in preterm neonates?","volume":"92","author":"Patole","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2011.09.023_bib74","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/00005176-200502000-00019","article-title":"Patent ductus arteriosus, indomethacin and necrotizing enterocolitis in very low birth weight infants: A population-based study","volume":"40","author":"Dollberg","year":"2005","journal-title":"J Pediatr Gastroenterol Nutr"},{"key":"10.1053\/j.semperi.2011.09.023_bib75","doi-asserted-by":"crossref","first-page":"e1262","DOI":"10.1542\/peds.2008-2045","article-title":"Effects of a patent ductus arteriosus on postprandial mesenteric perfusion in premature baboons","volume":"122","author":"McCurnin","year":"2008","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2011.09.023_bib76","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0022-3476(87)80126-9","article-title":"Cardiovascular effects of patent ductus arteriosus in preterm lambs with respiratory distress","volume":"111","author":"Clyman","year":"1987","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2011.09.023_bib77","first-page":"216A","article-title":"Patent ductus arteriosus and indomethacin and intestinal blood flow and oxygen consumption","volume":"29","author":"Meyers","year":"1990","journal-title":"Pediatr Res"},{"key":"10.1053\/j.semperi.2011.09.023_bib78","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1136\/adc.65.10_Spec_No.1067","article-title":"Gut blood flow velocities in the newborn: Effects of patent ductus arteriosus and parenteral indomethacin","volume":"65","author":"Coombs","year":"1990","journal-title":"Arch Dis Child"},{"key":"10.1053\/j.semperi.2011.09.023_bib79","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1203\/01.pdr.0000182182.49476.24","article-title":"In vivo constriction of the fetal and neonatal ductus arteriosus by a prostanoid EP4-receptor antagonist in rats","volume":"58","author":"Momma","year":"2005","journal-title":"Pediatr Res"},{"key":"10.1053\/j.semperi.2011.09.023_bib80","doi-asserted-by":"crossref","first-page":"R199","DOI":"10.1152\/ajpregu.00298.2001","article-title":"VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus","volume":"282","author":"Clyman","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1053\/j.semperi.2011.09.023_bib81","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1203\/PDR.0b013e318180a375","article-title":"The expression of VEGF and its receptors in the human ductus arteriosus","volume":"64","author":"Weber","year":"2008","journal-title":"Pediatr Res"},{"key":"10.1053\/j.semperi.2011.09.023_bib82","doi-asserted-by":"crossref","first-page":"e1618","DOI":"10.1542\/peds.2011-0359","article-title":"Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment","volume":"128","author":"Hammerman","year":"2011","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2011.09.023_bib83","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0090-6980(89)90001-4","article-title":"Pronounced reduction of in vivo prostacyclin synthesis in humans by acetaminophen (paracetamol)","volume":"37","author":"Gr\u00e8en","year":"1989","journal-title":"Prostaglandins"},{"key":"10.1053\/j.semperi.2011.09.023_bib84","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1096\/fj.04-2437fje","article-title":"Cellular mechanisms of acetaminophen: Role of cyclooxygenase","volume":"19","author":"Lucas","year":"2005","journal-title":"FASEB J"},{"key":"10.1053\/j.semperi.2011.09.023_bib85","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1203\/01.pdr.0000183659.20335.12","article-title":"Combined treatment with a nonselective nitric oxide synthase inhibitor (l-NMMA) and indomethacin increases ductus constriction in extremely premature newborns","volume":"58","author":"Keller","year":"2005","journal-title":"Pediatr Res"}],"container-title":["Seminars in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000511001698?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000511001698?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,1,2]],"date-time":"2022-01-02T14:32:46Z","timestamp":1641133966000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0146000511001698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":85,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0146000511001698"],"URL":"https:\/\/doi.org\/10.1053\/j.semperi.2011.09.023","relation":{},"ISSN":["0146-0005"],"issn-type":[{"value":"0146-0005","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}