{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T04:22:51Z","timestamp":1772684571489,"version":"3.50.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Perinatology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1053\/j.semperi.2018.05.007","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T09:18:53Z","timestamp":1527153533000},"page":"243-252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":45,"title":["Evidence-based use of acetaminophen for hemodynamically significant ductus arteriosus in preterm infants"],"prefix":"10.1053","volume":"42","author":[{"given":"B.","family":"Jasani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.E.","family":"Weisz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.J.","family":"McNamara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.semperi.2018.05.007_bib1","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.siny.2015.03.004","article-title":"Preterm patent ductus arteriosus: a continuing conundrum for the neonatologist?","volume":"20","author":"Evans","year":"2015","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1053\/j.semperi.2018.05.007_bib2","article-title":"Ibuprofen for the treatment of patent ductus arteriosus in preterm or low birth weight (or both) infants","volume":"2","author":"Ohlsson","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1053\/j.semperi.2018.05.007_bib3","doi-asserted-by":"crossref","first-page":"e1618","DOI":"10.1542\/peds.2011-0359","article-title":"Ductal closure with paracetamol: a surprising new approach to patent ductus arteriosus treatment","volume":"128","author":"Hammerman","year":"2011","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2018.05.007_bib4","first-page":"178","article-title":"Paracetamol (acetaminophen) efficacy and safety in the newborn","volume":"14","author":"Cuzzolin","year":"2013","journal-title":"Curr Drug Metab"},{"key":"10.1053\/j.semperi.2018.05.007_bib5","series-title":"Paracetamol. A Critical Bibliographic Review","author":"Prescott","year":"2001"},{"key":"10.1053\/j.semperi.2018.05.007_bib6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00003495-200969010-00007","article-title":"Intravenous paracetamol (acetaminophen)","volume":"69","author":"Duggan","year":"2009","journal-title":"Drugs"},{"key":"10.1053\/j.semperi.2018.05.007_bib7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10787-013-0172-x","article-title":"The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings","volume":"21","author":"Graham","year":"2013","journal-title":"Inflammopharmacology"},{"key":"10.1053\/j.semperi.2018.05.007_bib8","doi-asserted-by":"crossref","first-page":"e623","DOI":"10.1542\/peds.2012-0499","article-title":"Thrombocytopenia in the first 24 hours after birth and incidence of patent ductus arteriosus","volume":"130","author":"Sallmon","year":"2012","journal-title":"Pediatrics"},{"key":"10.1053\/j.semperi.2018.05.007_bib9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1053\/j.semperi.2011.09.023","article-title":"Managing the patent ductus arteriosus in the premature neonate: a new look at what we thought we knew","volume":"36","author":"Hammerman","year":"2012","journal-title":"Semin Perinatol"},{"key":"10.1053\/j.semperi.2018.05.007_bib10","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.siny.2004.10.003","article-title":"The pharmacologic closure of the patent ductus arteriosus","volume":"10","author":"Van Overmeire","year":"2005","journal-title":"Semin Fetal Neonatal Med"},{"key":"10.1053\/j.semperi.2018.05.007_bib11","doi-asserted-by":"crossref","first-page":"F498","DOI":"10.1136\/adc.2005.092734","article-title":"Patent ductus arteriosus: lack of evidence for common treatments","volume":"92","author":"Bose","year":"2007","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2018.05.007_bib12","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1053\/j.semperi.2011.09.022","article-title":"Patent ductus arteriosus: are current neonatal treatment options better or worse than no treatment at all?","volume":"36","author":"Clyman","year":"2012","journal-title":"Semin Perinatol"},{"key":"10.1053\/j.semperi.2018.05.007_bib13","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1111\/j.1460-9592.2008.02764.x","article-title":"Paracetamol (acetaminophen): mechanisms of action","volume":"18","author":"Anderson","year":"2008","journal-title":"Paediatr Anaesth"},{"issue":"2","key":"10.1053\/j.semperi.2018.05.007_bib14","doi-asserted-by":"crossref","first-page":"81s","DOI":"10.18433\/J3T886","article-title":"Evolution of nonsteroidal anti-inflammatory drugs (NSAIDs): cyclooxygenase (COX) inhibition and beyond","volume":"11","author":"Rao","year":"2008","journal-title":"J Pharm Pharm Sci"},{"key":"10.1053\/j.semperi.2018.05.007_bib15","first-page":"767","article-title":"Selective inhibition of cyclooxygenase-2: risks and benefits","volume":"52","author":"Mendes","year":"2012","journal-title":"Rev Bras Reumatol"},{"key":"10.1053\/j.semperi.2018.05.007_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1432-1033.1988.tb13792.x","article-title":"Higher oxidation states of prostaglandin H synthase EPR study of a transient tyrosyl radical in the enzyme during the peroxidase reaction","volume":"171","author":"Karthein","year":"1988","journal-title":"Eur J Biochem"},{"key":"10.1053\/j.semperi.2018.05.007_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.clpt.2005.09.009","article-title":"New insights into the mechanism of action of acetaminophen: its clinical pharmacologic characteristics reflect its inhibition of the two prostaglandin H2 synthases","volume":"79","author":"Aronoff","year":"2006","journal-title":"Clin Pharmacol Ther"},{"key":"10.1053\/j.semperi.2018.05.007_bib18","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.biochem.69.1.145","article-title":"Cyclooxygenases: structural, cellular, and molecular biology","volume":"69","author":"Smith","year":"2000","journal-title":"Annu Rev Biochem"},{"key":"10.1053\/j.semperi.2018.05.007_bib19","unstructured":"Acetaminophen pathway. Available at: https:\/\/www.pharmgkb.org\/pathway\/PA165986279. Accessed April 15, 2018"},{"key":"10.1053\/j.semperi.2018.05.007_bib20","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00228-015-1887-y","article-title":"Developmental changes rather than repeated administration drive paracetamol glucuronidation in neonates and infants","volume":"71","author":"Krekels","year":"2015","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1053\/j.semperi.2018.05.007_bib21","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/adc.2010.192005","article-title":"Intravenous paracetamol overdose: two case reports and a change to national treatment guidelines","volume":"96","author":"Beringer","year":"2011","journal-title":"Arch Dis Child"},{"key":"10.1053\/j.semperi.2018.05.007_bib22","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/sj.jp.7211641","article-title":"Acetaminophen-induced hepatic failure with encephalopathy in a newborn","volume":"27","author":"Walls","year":"2007","journal-title":"J Perinatol"},{"key":"10.1053\/j.semperi.2018.05.007_bib23","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/pr.2017.129","article-title":"Exposure to acetaminophen and all its metabolites upon 10, 15, and 20 mg\/kg intravenous acetaminophen in very-preterm infants","volume":"82","author":"Flint","year":"2017","journal-title":"Pediatr Res"},{"key":"10.1053\/j.semperi.2018.05.007_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/pan.12076","article-title":"The paracetamol concentration-effect relation in neonates","volume":"23","author":"Allegaert","year":"2013","journal-title":"Paediatr Anaesth"},{"key":"10.1053\/j.semperi.2018.05.007_bib25","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1007\/s002280100367","article-title":"Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy","volume":"57","author":"Anderson","year":"2001","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1053\/j.semperi.2018.05.007_bib26","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1097\/00000542-200206000-00012","article-title":"Acetaminophen developmental pharmacokinetics in premature neonates and infants: a pooled population analysis","volume":"96","author":"Anderson","year":"2002","journal-title":"Anesthesiology"},{"key":"10.1053\/j.semperi.2018.05.007_bib27","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1136\/adc.2010.204552","article-title":"The pharmacokinetics of intravenous paracetamol in neonates: size matters most","volume":"96","author":"Allegaert","year":"2011","journal-title":"Arch Dis Child"},{"key":"10.1053\/j.semperi.2018.05.007_bib28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/j.1460-9592.2008.02535.x","article-title":"Hepatic tolerance of repeated intravenous paracetamol administration in neonates","volume":"18","author":"Allegaert","year":"2008","journal-title":"Paediatr Anaesth"},{"key":"10.1053\/j.semperi.2018.05.007_bib29","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00228-010-0860-z","article-title":"Haemodynamics of intravenous paracetamol in neonates","volume":"66","author":"Allegaert","year":"2010","journal-title":"Eur J Clin Pharmacol"},{"key":"10.1053\/j.semperi.2018.05.007_bib30","doi-asserted-by":"crossref","first-page":"825","DOI":"10.3109\/14767058.2012.755162","article-title":"A different first-choice drug in the medical management of patent ductus arteriosus: oral paracetamol","volume":"26","author":"Yurttutan","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1053\/j.semperi.2018.05.007_bib31","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3109\/14767058.2013.871630","article-title":"Paracetamol effectiveness, safety and blood level monitoring during patent ductus arteriosus closure: a case series","volume":"27","author":"Kessel","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1053\/j.semperi.2018.05.007_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpeds.2018.01.024","article-title":"Paracetamol serum concentrations in neonates treated enterally for ductal closure: a pilot study","author":"Bin-Nun","year":"2018","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2018.05.007_bib33","doi-asserted-by":"crossref","first-page":"F127","DOI":"10.1136\/archdischild-2014-307312","article-title":"Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis","volume":"101","author":"Terrin","year":"2016","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2018.05.007_bib34","doi-asserted-by":"crossref","unstructured":"Ohlsson A, Shah PS. Paracetamol (acetaminophen) for patent ductus arteriosus in preterm or low-birth-weight infants. Cochrane Database Syst Rev. 2015;(3):CD010061.","DOI":"10.1002\/14651858.CD010061.pub2"},{"key":"10.1053\/j.semperi.2018.05.007_bib35","doi-asserted-by":"crossref","first-page":"e77888","DOI":"10.1371\/journal.pone.0077888","article-title":"Comparison of oral paracetamol versus ibuprofen in premature infants with patent ductus arteriosus: a randomized controlled trial","volume":"8","author":"Dang","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1053\/j.semperi.2018.05.007_bib36","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.jpeds.2013.11.008","article-title":"Oral paracetamol versus oral ibuprofen in the management of patent ductus arteriosus in preterm infants: a randomized controlled trial","volume":"164","author":"Oncel","year":"2014","journal-title":"J Pediatr"},{"issue":"16","key":"10.1053\/j.semperi.2018.05.007_bib37","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1080\/14767058.2017.1338263","article-title":"Paracetamol versus ibuprofen for the treatment of patent ductus arteriosus in preterm neonates: a meta-analysis of randomized controlled trials","volume":"31","author":"Huang","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1053\/j.semperi.2018.05.007_bib38","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.3892\/etm.2016.3676","article-title":"Oral paracetamol vs. oral ibuprofen in the treatment of symptomatic patent ductus arteriosus in premature infants: a randomized controlled trial","volume":"12","author":"Yang","year":"2016","journal-title":"Exp Ther Med"},{"issue":"26","key":"10.1053\/j.semperi.2018.05.007_bib39","first-page":"e3975","article-title":"Comparison of oral acetaminophen versus ibuprofen in premature infants with patent ductusarteriosus","volume":"15","author":"Bagheri","year":"2016","journal-title":"Iran J Pediatr"},{"key":"10.1053\/j.semperi.2018.05.007_bib40","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s00431-016-2830-7","article-title":"Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates","volume":"176","author":"El-Mashad","year":"2017","journal-title":"Eur J Pediatr"},{"key":"10.1053\/j.semperi.2018.05.007_bib41","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1055\/s-0037-1601564","article-title":"Neurodevelopmental outcomes of preterm infants treated with oral paracetamol versus ibuprofen for patent ductus arteriosus","volume":"34","author":"Oncel","year":"2017","journal-title":"Am J Perinatol"},{"key":"10.1053\/j.semperi.2018.05.007_bib42","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1007\/s13312-015-0677-z","article-title":"Enteral paracetamol or intravenous indomethacin for closure of patent ductus arteriosus in preterm neonates: a randomized controlled trial","volume":"52","author":"Dash","year":"2015","journal-title":"Indian Pediatr"},{"key":"10.1053\/j.semperi.2018.05.007_bib43","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jpeds.2016.04.066","article-title":"Paracetamol accelerates closure of the ductus arteriosus after premature birth: a randomized trial","volume":"177","author":"H\u00e4rkin","year":"2016","journal-title":"J Pediatr"},{"key":"10.1053\/j.semperi.2018.05.007_bib44","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1177\/0300060517722698","article-title":"Oral paracetamol versus oral ibuprofen for treatment of patent ductus arteriosus","volume":"46","author":"Al-Lawama","year":"2018","journal-title":"J Int Med Res"},{"key":"10.1053\/j.semperi.2018.05.007_bib45","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.3109\/14767058.2013.854327","article-title":"Early paracetamol treatment associated with lowered risk of persistent ductus arteriosus in very preterm infants","volume":"27","author":"Aikio","year":"2014","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1053\/j.semperi.2018.05.007_bib46","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/apa.14137","article-title":"Intravenous paracetamol was associated with closure of the ductus arteriosus in extremely premature infants","volume":"107","author":"Juuj\u00e4rvi","year":"2018","journal-title":"Acta Paediatr"},{"key":"10.1053\/j.semperi.2018.05.007_bib47","unstructured":"Australian New Zealand Clinical Trials Registry [Internet]: Sydney (NSW): NHMRC Clinical Trials Centre, University of Sydney (Australia); 2011 - Identifier ACTRN12611000741987. Paracetamol Duct Action (PDA) Trial: The effect of paracetamol vs placebo on ductal closure in premature infants with a late patent ductus arteriosus; 2011 Jul 14 [cited 2018 April 01]; [1 page]. Available from https:\/\/www.anzctr.org.au\/Trial\/Registration\/TrialReview.aspx?id=343200."},{"key":"10.1053\/j.semperi.2018.05.007_bib48","first-page":"3","article-title":"A randomised blinded placebo controlled trial of paracetamol to treat later PDA [abstract]","volume":"52","author":"Kluckow","year":"2016"},{"key":"10.1053\/j.semperi.2018.05.007_bib49","doi-asserted-by":"crossref","first-page":"F253","DOI":"10.1136\/archdischild-2014-307930","article-title":"Late medical therapy of patent ductus arteriosus using intravenous paracetamol","volume":"100","author":"EL-Khuffash","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"10.1053\/j.semperi.2018.05.007_bib50","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s00431-015-2541-5","article-title":"Limited effects of intravenous paracetamol on patent ductus arteriosus in very low birth weight infants with contraindications for ibuprofen or after ibuprofen failure","volume":"174","author":"Roofthooft","year":"2015","journal-title":"Eur J Pediatr"},{"key":"10.1053\/j.semperi.2018.05.007_bib51","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/jp.2016.60","article-title":"Acetaminophen to avoid surgical ligation in extremely low gestational age neonates with persistent hemodynamically significant patent ductus arteriosus","volume":"36","author":"Weisz","year":"2016","journal-title":"J Perinatol"},{"key":"10.1053\/j.semperi.2018.05.007_bib52","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s00246-017-1745-z","article-title":"Oral paracetamol for patent ductus arteriosus rescue closure","volume":"39","author":"Pharande","year":"2018","journal-title":"Pediatr Cardiol"},{"key":"10.1053\/j.semperi.2018.05.007_bib53","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00431-016-2731-9","article-title":"Intravenous paracetamol for PDA closure in the preterm: a single-center experience","volume":"175","author":"Valerio","year":"2016","journal-title":"Eur J Pediatr"},{"key":"10.1053\/j.semperi.2018.05.007_bib54","unstructured":"ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2018 Mar 29 - Identifier NCT02002741, Adding Paracetamol to Ibuprofen for Treatment of Patent Ductus Arteriosus in Preterm Infants: A Pilot, Double Blind, Randomized, Placebo-control Trial; 2013 Dec 6 [cited 2018 Mar 29]; [about 4 screens]. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02002741."},{"key":"10.1053\/j.semperi.2018.05.007_bib55","unstructured":"ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2018 Mar 29 - Identifier NCT03103022, Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus in Premature Infants: A Pilot Study; 2017 Apr 6 [cited 2018 Mar 29]; [about 4 screens]. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03103022."},{"key":"10.1053\/j.semperi.2018.05.007_bib56","unstructured":"ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2018 Mar 29 - Identifier NCT03008876, The Efficacy of IV Acetaminophen on Patent Ductus Arteriosus Closure in Preterm Infants; 2017 Jan 4 [cited 2018 Mar 29]; [about 4 screens]. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03008876."},{"key":"10.1053\/j.semperi.2018.05.007_bib57","unstructured":"ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2018 Mar 29 - Identifier NCT02422966, Efficacy and Safety of Paracetamol in Comparison to Ibuprofen for Patent Ductus Arteriosus Treatment in Preterm Infants: A Randomized, Open Label, Comparator-controlled, Prospective Study; 2015 Apr 22 [cited 2018 Mar 29]; [about 4 screens]. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02422966."},{"key":"10.1053\/j.semperi.2018.05.007_bib58","unstructured":"ClinicalTrials.gov [Internet]. Bethesda (MD): National Library of Medicine (US). 2018 Mar 29 - Identifier NCT02056223, Paracetamol Versus Ibuprofen for Patent Ductus Arteriosus Closure in Preterm Infants. A Prospective, Randomized, Controlled, Double Blind, Multicenter Clinical Trial; 2014 Feb 5 [cited 2018 Mar 29]; [about 4 screens]. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02056223."},{"key":"10.1053\/j.semperi.2018.05.007_bib59","doi-asserted-by":"crossref","first-page":"e000143","DOI":"10.1136\/bmjpo-2017-000143","article-title":"Oral paracetamol versus oral ibuprofen for closure of haemodynamically significant patent ductus arteriosus in preterm neonates (32 weeks): a blinded, randomised, active-controlled, non-inferiority trial","volume":"1","author":"Kumar","year":"2017","journal-title":"BMJ Paediatrics Open"}],"container-title":["Seminars in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000518300314?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0146000518300314?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T12:23:38Z","timestamp":1571401418000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0146000518300314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["S0146000518300314"],"URL":"https:\/\/doi.org\/10.1053\/j.semperi.2018.05.007","relation":{},"ISSN":["0146-0005"],"issn-type":[{"value":"0146-0005","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence-based use of acetaminophen for hemodynamically significant ductus arteriosus in preterm infants","name":"articletitle","label":"Article Title"},{"value":"Seminars in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.semperi.2018.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2018 Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}