{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T08:03:57Z","timestamp":1781165037830,"version":"3.54.1"},"reference-count":36,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Perinatology"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1053\/j.semperi.2019.03.006","type":"journal-article","created":{"date-parts":[[2019,3,8]],"date-time":"2019-03-08T11:17:56Z","timestamp":1552043876000},"page":"213-217","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Future research directions for prevention and treatment of obstetric venous thromboembolism"],"prefix":"10.1053","volume":"43","author":[{"given":"Joshua I.","family":"Rosenbloom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Macones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1053\/j.semperi.2019.03.006_bib0001","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1097\/AOG.0000000000002706","article-title":"Thromboembolism in pregnancy","volume":"132","year":"2018","journal-title":"Obstet Gynecol"},{"issue":"10","key":"10.1053\/j.semperi.2019.03.006_bib0002","doi-asserted-by":"crossref","first-page":"697","DOI":"10.7326\/0003-4819-143-10-200511150-00006","article-title":"Trends in the incidence of venous thromboembolism during pregnancy or postpartum: a 30-year population-based study","volume":"143","author":"Heit","year":"2005","journal-title":"Ann Intern Med"},{"issue":"2","key":"10.1053\/j.semperi.2019.03.006_bib0003","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1097\/AOG.0000000000002114","article-title":"Pregnancy-related mortality in the United States, 2011\u20132013","volume":"130","author":"Creanga","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1053\/j.semperi.2019.03.006_bib0004","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.ajog.2013.06.039","article-title":"Trends in venous thromboembolism among pregnancy-related hospitalizations, United States, 1994-2009","volume":"209","author":"Ghaji","year":"2013","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"10.1053\/j.semperi.2019.03.006_bib0005","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/AOG.0000000000002099","article-title":"Venous thromboembolism prophylaxis during antepartum admissions and postpartum readmissions","volume":"130","author":"Mardy","year":"2017","journal-title":"Obstet Gynecol"},{"key":"10.1053\/j.semperi.2019.03.006_bib0006","series-title":"Reducing the Risk of Venous Thromboembolism During Pregnancy and the Puerperium","year":"2015"},{"issue":"4","key":"10.1053\/j.semperi.2019.03.006_bib0007","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/AOG.0000000000001579","article-title":"National partnership for maternal safety: consensus bundle on venous thromboembolism","volume":"128","author":"D'Alton","year":"2016","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1053\/j.semperi.2019.03.006_bib0008","article-title":"Prophylaxis for venous thromboembolic disease in pregnancy and the early postnatal period","author":"Bain","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"10.1053\/j.semperi.2019.03.006_bib0009","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/AOG.0000000000001656","article-title":"Pharmacologic thromboprophylaxis in obstetrics: broader use demands better data","volume":"128","author":"Sibai","year":"2016","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1053\/j.semperi.2019.03.006_bib0010","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/AOG.0000000000002169","article-title":"Patient safety in obstetrics: more evidence, less emotion","volume":"130","author":"Macones","year":"2017","journal-title":"Obstet Gynecol"},{"issue":"6","key":"10.1053\/j.semperi.2019.03.006_bib0011","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1097\/AOG.0000000000000007","article-title":"Underuse of postcesarean thromboembolism prophylaxis","volume":"122","author":"Friedman","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1053\/j.semperi.2019.03.006_bib0012","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.ajog.2014.09.017","article-title":"Thromboembolism incidence and prophylaxis during vaginal delivery hospitalizations","volume":"212","author":"Friedman","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"13","key":"10.1053\/j.semperi.2019.03.006_bib0013","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1111\/1471-0528.13706","article-title":"A comparison of recommendations for pharmacologic thromboembolism prophylaxis after caesarean delivery from three major guidelines","volume":"123","author":"Palmerola","year":"2016","journal-title":"BJOG"},{"issue":"2 Suppl","key":"10.1053\/j.semperi.2019.03.006_bib0014","doi-asserted-by":"crossref","first-page":"e691S","DOI":"10.1378\/chest.11-2300","article-title":"VTE, thrombophilia, antithrombotic therapy, and pregnancy: antithrombotic therapy and prevention of thrombosis, 9th ed.: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"141","author":"Bates","year":"2012","journal-title":"Chest"},{"issue":"9","key":"10.1053\/j.semperi.2019.03.006_bib0015","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1111\/1471-0528.15150","article-title":"Postpartum venous thromboembolism prophylaxis may cause more harm than benefit: a critical analysis of international guidelines through an evidence-based lens","volume":"125","author":"Kotaska","year":"2018","journal-title":"BJOG"},{"issue":"19","key":"10.1053\/j.semperi.2019.03.006_bib0016","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1056\/NEJMra0707993","article-title":"Venous thromboembolic disease and pregnancy","volume":"359","author":"Marik","year":"2008","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1053\/j.semperi.2019.03.006_bib0017","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3324\/haematol.2012.072009","article-title":"Predicting deep venous thrombosis in pregnancy: external validation of the LEFT clinical prediction rule","volume":"98","author":"Righini","year":"2013","journal-title":"Haematologica"},{"issue":"1","key":"10.1053\/j.semperi.2019.03.006_bib0018","doi-asserted-by":"crossref","first-page":"32 e1-9","DOI":"10.1016\/j.ajog.2014.03.031","article-title":"Maternal mortality in the United States: predictability and the impact of protocols on fatal postcesarean pulmonary embolism and hypertension-related intracranial hemorrhage","volume":"211","author":"Clark","year":"2014","journal-title":"Am J Obstet Gynecol"},{"issue":"1","key":"10.1053\/j.semperi.2019.03.006_bib0019","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11239-015-1309-0","article-title":"Guidance for the treatment and prevention of obstetric-associated venous thromboembolism","volume":"41","author":"Bates","year":"2016","journal-title":"J Thromb Thrombolysis"},{"issue":"14","key":"10.1053\/j.semperi.2019.03.006_bib0020","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJMoa1311485","article-title":"Risk of a thrombotic event after the 6-week postpartum period","volume":"370","author":"Kamel","year":"2014","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1053\/j.semperi.2019.03.006_bib0021","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1001\/jamasurg.2018.0374","article-title":"What surgeons should know about non-vitamin K oral anticoagulants: a review","volume":"153","author":"Verma","year":"2018","journal-title":"JAMA Surg"},{"issue":"3","key":"10.1053\/j.semperi.2019.03.006_bib0022","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.117.007338","article-title":"Evidence gaps in the era of non-vitamin K oral anticoagulants","volume":"7","author":"Aronis","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"10","key":"10.1053\/j.semperi.2019.03.006_bib0023","doi-asserted-by":"crossref","first-page":"e604","DOI":"10.1161\/CIR.0000000000000477","article-title":"Management of patients on non-vitamin K antagonist oral anticoagulants in the acute care and periprocedural setting: a scientific statement from the American Heart Association","volume":"135","author":"Raval","year":"2017","journal-title":"Circulation"},{"issue":"2","key":"10.1053\/j.semperi.2019.03.006_bib0024","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.chest.2015.11.026","article-title":"Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report","volume":"149","author":"Kearon","year":"2016","journal-title":"Chest"},{"issue":"1","key":"10.1053\/j.semperi.2019.03.006_bib0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/1753495X15621814","article-title":"Unplanned pregnancy on a direct oral anticoagulant (rivaroxaban): a warning","volume":"9","author":"Myers","year":"2016","journal-title":"Obstet Med"},{"issue":"7","key":"10.1053\/j.semperi.2019.03.006_bib0026","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1055\/s-0036-1592304","article-title":"Direct oral anticoagulants and women","volume":"42","author":"Cohen","year":"2016","journal-title":"Semin Thromb Hemost"},{"key":"10.1053\/j.semperi.2019.03.006_bib0027","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.thromres.2018.07.022","article-title":"Efficacy and safety of direct oral anticoagulants during pregnancy; a systematic literature review","volume":"169","author":"Lameijer","year":"2018","journal-title":"Thromb Res"},{"issue":"11","key":"10.1053\/j.semperi.2019.03.006_bib0028","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1002\/phar.1662","article-title":"Possible rivaroxaban failure during the postpartum period","volume":"35","author":"Rudd","year":"2015","journal-title":"Pharmacotherapy"},{"issue":"24","key":"10.1053\/j.semperi.2019.03.006_bib0029","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1016\/j.jacc.2016.09.966","article-title":"Off-label dosing of non-vitamin K antagonist oral anticoagulants and adverse outcomes: the ORBIT-AF II registry","volume":"68","author":"Steinberg","year":"2016","journal-title":"J Am Coll Cardiol"},{"issue":"5","key":"10.1053\/j.semperi.2019.03.006_bib0030","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.ajog.2015.06.065","article-title":"Rivaroxaban transfer across the dually perfused isolated human placental cotyledon","volume":"213","author":"Bapat","year":"2015","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"10.1053\/j.semperi.2019.03.006_bib0031","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1097\/AOG.0000000000000277","article-title":"Transfer of dabigatran and dabigatran etexilate mesylate across the dually perfused human placenta","volume":"123","author":"Bapat","year":"2014","journal-title":"Obstet Gynecol"},{"issue":"2","key":"10.1053\/j.semperi.2019.03.006_bib0032","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00392-015-0893-5","article-title":"Pregnancy outcome after exposure to the novel oral anticoagulant rivaroxaban in women at suspected risk for thromboembolic events: a case series from the German Embryotox Pharmacovigilance Centre","volume":"105","author":"Hoeltzenbein","year":"2016","journal-title":"Clin Res Cardiol"},{"issue":"4","key":"10.1053\/j.semperi.2019.03.006_bib0033","first-page":"651","article-title":"Pregnancy outcome in patients exposed to direct oral anticoagulants - and the challenge of event reporting","volume":"116","author":"Beyer-Westendorf","year":"2016","journal-title":"Thromb Haemost"},{"issue":"6","key":"10.1053\/j.semperi.2019.03.006_bib0034","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1160\/th14-04-0393","article-title":"Oral anticoagulation with rivaroxaban during pregnancy: a case report","volume":"112","author":"Konigsbrugge","year":"2014","journal-title":"Thromb Haemost"},{"issue":"4","key":"10.1053\/j.semperi.2019.03.006_bib0035","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1160\/TH16-08-0602","article-title":"Direct oral anticoagulants (DOACs) and pregnancy: a plea for better information","volume":"116","author":"Ginsberg","year":"2016","journal-title":"Thromb Haemost"},{"issue":"8","key":"10.1053\/j.semperi.2019.03.006_bib0036","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1111\/jth.13366","article-title":"Management of direct oral anticoagulants in women of childbearing potential: guidance from the SSC of the ISTH","volume":"14","author":"Cohen","year":"2016","journal-title":"J Thromb Haemost"}],"container-title":["Seminars in Perinatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014600051930031X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014600051930031X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:53:56Z","timestamp":1758938036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014600051930031X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,6]]}},"alternative-id":["S014600051930031X"],"URL":"https:\/\/doi.org\/10.1053\/j.semperi.2019.03.006","relation":{},"ISSN":["0146-0005"],"issn-type":[{"value":"0146-0005","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Future research directions for prevention and treatment of obstetric venous thromboembolism","name":"articletitle","label":"Article Title"},{"value":"Seminars in Perinatology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.semperi.2019.03.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}