{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T19:13:40Z","timestamp":1773083620156,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1053\/j.semtcvs.2004.11.003","type":"journal-article","created":{"date-parts":[[2007,3,8]],"date-time":"2007-03-08T22:27:31Z","timestamp":1173392851000},"page":"41-50","source":"Crossref","is-referenced-by-count":31,"title":["Role of chemotherapy in the management of advanced thymic tumors"],"prefix":"10.1053","volume":"17","author":[{"given":"Tracey L.","family":"Evans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.semtcvs.2004.11.003_bib1","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1016\/j.athoracsur.2003.10.001","article-title":"Thymic tumors","volume":"77","author":"Detterbeck","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib2","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1200\/JCO.1988.6.11.1722","article-title":"Invasive thymoma","volume":"6","author":"Curran","year":"1988","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib3","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0003-4975(02)03828-6","article-title":"Adjuvant radiation therapy for stage II thymoma","volume":"74","author":"Mangi","year":"2002","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib4","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0003-4975(91)90478-9","article-title":"Thymoma","volume":"51","author":"Maggi","year":"1991","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib5","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/0003-4975(95)00669-C","article-title":"Thymoma","volume":"60","author":"Blumberg","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib6","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0167-8140(94)01493-M","article-title":"Thymoma","volume":"34","author":"Cowen","year":"1995","journal-title":"Radiother Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib7","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/1097-0142(19860801)58:3<765::AID-CNCR2820580326>3.0.CO;2-S","article-title":"Thymomas. A review of 169 cases, with particular reference to results of surgical treatment","volume":"58","author":"Maggi","year":"1986","journal-title":"Cancer"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib8","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/S0003-4975(03)00555-1","article-title":"Therapy for thymic epithelial tumors","volume":"76","author":"Kondo","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib9","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1200\/JCO.2004.10.113","article-title":"Tumor recurrence and survival in patients treated for thymomas and thymic squamous cell carcinomas","volume":"22","author":"Strobel","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib10","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1445-5994.1989.tb00282.x","article-title":"Initial chemotherapy followed by surgery in malignant thymoma","volume":"19","author":"Mackintosh","year":"1989","journal-title":"Aust N Z J Med"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib11","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/1097-0142(19910815)68:4<706::AID-CNCR2820680407>3.0.CO;2-H","article-title":"Neoadjuvant chemotherapy, surgery, and postoperative radiation therapy for invasive thymoma","volume":"68","author":"Macchiarini","year":"1991","journal-title":"Cancer"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib12","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0022-5223(19)34092-9","article-title":"Chemotherapy and operation for invasive thymoma","volume":"106","author":"Rea","year":"1993","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib13","doi-asserted-by":"crossref","first-page":"100","DOI":"10.7326\/0003-4819-129-2-199807150-00006","article-title":"A multidisciplinary approach to therapy for unresectable malignant thymoma","volume":"129","author":"Shin","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib14","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.lungcan.2003.12.010","article-title":"Phase II study of a multidisciplinary approach with induction chemotherapy, followed by surgical resection, radiation therapy, and consolidation chemotherapy for unresectable malignant thymomas","volume":"44","author":"Kim","year":"2004","journal-title":"Lung Cancer"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0360-3016(95)00079-E","article-title":"Radiotherapy and chemotherapy for invasive thymomas","volume":"32","author":"Mornex","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib16","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0277-5379(84)90036-1","article-title":"Invasive carcinoma of the thymus. A multicenter retrospective review of 56 cases","volume":"20","author":"Arriagada","year":"1984","journal-title":"Eur J Cancer Clin Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib17","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/S0003-4975(97)00629-2","article-title":"Multimodality treatment of thymoma","volume":"64","author":"Venuta","year":"1997","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib18","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/S0003-4975(03)01020-8","article-title":"Long-term outcome after multimodality treatment for stage III thymic tumors","volume":"76","author":"Venuta","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib19","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1200\/JCO.1997.15.9.3093","article-title":"Cisplatin, doxorubicin, and cyclophosphamide plus thoracic radiation therapy for limited-stage unresectable thymoma","volume":"15","author":"Loehrer","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/1097-0142(197607)38:1<49::AID-CNCR2820380109>3.0.CO;2-6","article-title":"Chemotherapy of invasive thymoma","volume":"38","author":"Boston","year":"1976","journal-title":"Cancer"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib21","series-title":"Long-term follow-up of patients with locally advanced or metastatic thymic malignancies","author":"Loehrer","year":"2004"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib22","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1200\/JCO.1994.12.6.1164","article-title":"Cisplatin plus doxorubicin plus cyclophosphamide in metastatic or recurrent thymoma","volume":"12","author":"Loehrer","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib23","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/1097-0142(19910701)68:1<30::AID-CNCR2820680106>3.0.CO;2-4","article-title":"Chemotherapy for invasive thymoma. A 13-year experience","volume":"68","author":"Fornasiero","year":"1991","journal-title":"Cancer"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib24","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1200\/JCO.1999.17.9.2737","article-title":"Treatment of invasive thymoma with single-agent ifosfamide","volume":"17","author":"Highley","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib25","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1002\/1097-0142(20010601)91:11<2010::AID-CNCR1226>3.0.CO;2-2","article-title":"Combined etoposide, ifosfamide, and cisplatin in the treatment of patients with advanced thymoma and thymic carcinoma","volume":"91","author":"Loehrer","year":"2001","journal-title":"Cancer"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib26","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1378\/chest.110.4.1115","article-title":"Retreatment of recurrent invasive thymoma with platinum, doxorubicin, and cyclophosphamide","volume":"110","author":"Lara","year":"1996","journal-title":"Chest"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib27","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/sj.bmt.1703181","article-title":"High-dose carboplatin with etoposide in patients with recurrent thymoma","volume":"28","author":"Hanna","year":"2001","journal-title":"Bone Marrow Transplant"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib28","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1002\/1097-0142(19860315)57:6<1101::AID-CNCR2820570606>3.0.CO;2-A","article-title":"Chemotherapy of malignant thymoma. Case report and review of the literature","volume":"57","author":"Hu","year":"1986","journal-title":"Cancer"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0936-6555(05)80783-6","article-title":"Dramatic response of recurrent invasive thymoma to high doses of corticosteroids","volume":"4","author":"Kirkove","year":"1992","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib30","series-title":"Glucocorticoid therapy for invasive thymoma progressing after chemotherapy","author":"Basha","year":"2002"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib31","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1016\/0140-6736(90)91415-7","article-title":"Effectiveness of interleukin-2 in invasive lymphoepithelial thymoma","volume":"335","author":"Berthaud","year":"1990","journal-title":"Lancet"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib32","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1097\/00002371-199510000-00005","article-title":"A phase II trial of subcutaneously administered recombinant human interleukin-2 in patients with relapsed\/refractory thymoma","volume":"18","author":"Gordon","year":"1995","journal-title":"J Immunother Emphasis Tumor Immunol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib33","first-page":"718","article-title":"Suramin therapy for malignant thymoma","volume":"30A","author":"La Rocca","year":"1994","journal-title":"Eur J Cancer"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib34","first-page":"634","article-title":"In vivo detection of malignant thymic masses by indium-111-DTPA-D-Phe1-octreotide scintigraphy","volume":"39","author":"Lastoria","year":"1998","journal-title":"J Nucl Med"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib35","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1210\/en.140.1.373","article-title":"In vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cells","volume":"140","author":"Ferone","year":"1999","journal-title":"Endocrinology"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib36","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM199701233360405","article-title":"Successful treatment of a patient with a thymoma and pure red-cell aplasia with octreotide and prednisone","volume":"336","author":"Palmieri","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1200\/JCO.2004.02.047","article-title":"Octreotide alone or with prednisone in patients with advanced thymoma and thymic carcinoma","volume":"22","author":"Loehrer","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib38","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1002\/1097-0142(19910215)67:4<1025::AID-CNCR2820670427>3.0.CO;2-F","article-title":"Thymic carcinoma. A clinicopathologic study of 60 cases","author":"Suster","year":"1991","journal-title":"Cancer 67"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib39","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0022-5223(94)70112-1","article-title":"Thymic carcinoma. Ten years\u2019 experience in twenty patients","volume":"107","author":"Hsu","year":"1994","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib40","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1093\/jjco\/hye136","article-title":"Chemotherapy of thymic carcinoma","volume":"31","author":"Kitami","year":"2001","journal-title":"Jpn J Clin Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib41","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/1097-0142(19930215)71:4<1219::AID-CNCR2820710408>3.0.CO;2-B","article-title":"Thymic carcinoma. A distinct clinical entity responsive to chemotherapy","volume":"71","author":"Weide","year":"1993","journal-title":"Cancer"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib42","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S1010-7940(01)00666-2","article-title":"The multimodality treatment of thymic carcinoma","volume":"19","author":"Lucchi","year":"2001","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib43","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1097\/00000421-199308000-00014","article-title":"EST 2582 phase II trial of cisplatin in metastatic or recurrent thymoma","volume":"16","author":"Bonomi","year":"1993","journal-title":"Am J Clin Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib44","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1200\/JCO.1996.14.3.814","article-title":"Cisplatin and etoposide combination chemotherapy for locally advanced or metastatic thymoma. A phase II study of the European Organization for Research and Treatment of Cancer Lung Cancer Cooperative Group","volume":"14","author":"Giaccone","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib45","first-page":"208","article-title":"Intensive chemotherapy with cisplatin, doxorubicin, cyclophosphamide, etoposide and granulocyte colony-stimulating factor for advanced thymoma or thymic cancer","volume":"25","author":"Oshita","year":"1995","journal-title":"Jpn J Clin Oncol"},{"key":"10.1053\/j.semtcvs.2004.11.003_bib46","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1002\/1097-0142(19880501)61:9<1736::AID-CNCR2820610903>3.0.CO;2-T","article-title":"Combination chemotherapy with cyclophosphamide, adriamycin, and vincristine in malignant thymoma and myasthenia gravis","volume":"61","author":"Kosmidis","year":"1988","journal-title":"Cancer"}],"container-title":["Seminars in Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043067904001169?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043067904001169?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T12:06:18Z","timestamp":1587384378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043067904001169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":46,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S1043067904001169"],"URL":"https:\/\/doi.org\/10.1053\/j.semtcvs.2004.11.003","relation":{},"ISSN":["1043-0679"],"issn-type":[{"value":"1043-0679","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}