{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:08:55Z","timestamp":1790482135577,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,2]],"date-time":"2016-09-02T00:00:00Z","timestamp":1472774400000},"content-version":"vor","delay-in-days":245,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["semthorcardiovascsurg.com","clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2016]]},"DOI":"10.1053\/j.semtcvs.2016.08.015","type":"journal-article","created":{"date-parts":[[2016,9,9]],"date-time":"2016-09-09T20:37:53Z","timestamp":1473453473000},"page":"757-767","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"title":["Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency"],"prefix":"10.1053","volume":"28","author":[{"given":"Jesper","family":"Hjortnaes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josh","family":"Keegan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Bruneval","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick J.","family":"Schoen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Carpentier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Levine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Hag\u00e8ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Aikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.semtcvs.2016.08.015_bib1","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1016\/S0140-6736(09)60692-9","article-title":"Mitral regurgitation","volume":"373","author":"Enriquez-Sarano","year":"2009","journal-title":"Lancet"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib2","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1161\/01.CIR.0000028933.34260.09","article-title":"Natural history of asymptomatic mitral valve prolapse in the community","volume":"106","author":"Avierinos","year":"2002","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1056\/NEJM199907013410101","article-title":"Prevalence and clinical outcome of mitral-valve prolapse","volume":"341","author":"Freed","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0002-8703(82)90204-6","article-title":"Etiology of clinically isolated, severe, chronic, pure mitral regurgitation: Analysis of 97 patients over 30 years of age having mitral valve replacement","volume":"104","author":"Waller","year":"1982","journal-title":"Am Heart J"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib5","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jtcvs.2015.04.009","article-title":"Is there an outcome penalty linked to guideline-based indications for valvular surgery? Early and long-term analysis of patients with organic mitral regurgitation","volume":"150","author":"Enriquez-Sarano","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S1054-8807(98)00021-0","article-title":"Correlation between clinical and histologic patterns of degenerative mitral valve insufficiency: A histomorphometric study of 130 excised segments","volume":"8","author":"Fornes","year":"1999","journal-title":"Cardiovasc Pathol"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib7","doi-asserted-by":"crossref","first-page":"2238","DOI":"10.1161\/CIRCULATIONAHA.105.599175","article-title":"Outcome of watchful waiting in asymptomatic severe mitral regurgitation","volume":"113","author":"Rosenhek","year":"2006","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib8","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jtcvs.2007.10.060","article-title":"Seeking a higher standard for degenerative mitral valve repair: Begin with etiology","volume":"136","author":"Adams","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/S0022-5223(19)37942-5","article-title":"Reconstructive surgery of mitral valve incompetence: Ten-year appraisal","volume":"79","author":"Carpentier","year":"1980","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib10","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0002-9149(85)90402-3","article-title":"Billowing, floppy, prolapsed or flail mitral valves?","volume":"55","author":"Barlow","year":"1985","journal-title":"Am J Cardiol"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib11","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1053\/j.semtcvs.2007.04.002","article-title":"Etiologic classification of degenerative mitral valve disease: Barlow\u05f3s disease and fibroelastic deficiency","volume":"19","author":"Anyanwu","year":"2007","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib12","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/S0022-5223(96)70332-X","article-title":"Extensive calcification of the mitral valve anulus: Pathology and surgical management","volume":"111","author":"Carpentier","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib13","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1161\/01.CIR.96.6.1819","article-title":"Early surgery in patients with mitral regurgitation due to flail leaflets: A long-term outcome study","volume":"96","author":"Ling","year":"1997","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib14","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jacc.2006.05.021","volume":"48","author":"Bonow","year":"2006","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib15","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1056\/NEJMoa041451","article-title":"Quantitative determinants of the outcome of asymptomatic mitral regurgitation","volume":"352","author":"Enriquez-Sarano","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib16","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/HCO.0b013e3282f4fe47","article-title":"The cardiologist\u05f3s role in increasing the rate of mitral valve repair in degenerative disease","volume":"23","author":"Adams","year":"2008","journal-title":"Curr Opin Cardiol"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib17","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1016\/j.jtcvs.2004.09.042","article-title":"Performance of bioprostheses and mechanical prostheses assessed by composites of valve-related complications to 15 years after mitral valve replacement","volume":"129","author":"Jamieson","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib18","doi-asserted-by":"crossref","first-page":"2525","DOI":"10.1161\/hc4601.099489","article-title":"Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves","volume":"104","author":"Rabkin","year":"2001","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib19","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jtcvs.2007.06.040","article-title":"Durability of mitral valve repair in barlow disease versus fibroelastic deficiency","volume":"135","author":"Flameng","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib20","doi-asserted-by":"crossref","first-page":"987","DOI":"10.5761\/atcs.oa.13-00168","article-title":"Clinical and pathological features of degenerative mitral valve disease: Billowing mitral leaflet versus fibroelastic deficiency","volume":"20","author":"Matsumaru","year":"2014","journal-title":"Ann Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib21","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/CIRCIMAGING.109.924332","article-title":"Characterization of degenerative mitral valve disease using morphologic analysis of real-time three-dimensional echocardiographic images: Objective insight into complexity and planning of mitral valve repair","volume":"4","author":"Chandra","year":"2011","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib22","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.jacc.2013.11.017","article-title":"Gross and histological features of excised portions of posterior mitral leaflet in patients having operative repair of mitral valve prolapse and comments on the concept of missing (= ruptured) chordae tendineae","volume":"63","author":"Roberts","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib23","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1161\/ATVBAHA.114.303852","article-title":"Association between shear stress and platelet-derived transforming growth factor-beta1 release and activation in animal models of aortic valve stenosis","volume":"34","author":"Wang","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib24","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1172\/JCI200422715","article-title":"TGF-beta-dependent pathogenesis of mitral valve prolapse in a mouse model of marfan syndrome","volume":"114","author":"Ng","year":"2004","journal-title":"J Clin Invest"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib25","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1126\/science.1124287","article-title":"Losartan, an At1 antagonist, prevents aortic aneurysm in a mouse model of marfan syndrome","volume":"312","author":"Habashi","year":"2006","journal-title":"Science"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/ng1116","article-title":"Dysregulation of TGF-beta activation contributes to pathogenesis in marfan syndrome","volume":"33","author":"Neptune","year":"2003","journal-title":"Nat Genet"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib27","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1056\/NEJMoa0706585","article-title":"Angiotensin II blockade and aortic-root dilation in marfan\u05f3s syndrome","volume":"358","author":"Brooke","year":"2008","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nm1536","article-title":"Angiotensin II type 1 receptor blockade attenuates TGF-beta-induced failure of muscle regeneration in multiple myopathic states","volume":"13","author":"Cohn","year":"2007","journal-title":"Nat Med"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib29","doi-asserted-by":"crossref","first-page":"S189","DOI":"10.1161\/CIRCULATIONAHA.111.082610","article-title":"Modulation of transforming growth factor-beta signaling and extracellular matrix production in myxomatous mitral valves by angiotensin II receptor blockers","volume":"126","author":"Geirsson","year":"2012","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib30","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1126\/science.1192149","article-title":"Noncanonical tgfbeta signaling contributes to aortic aneurysm progression in marfan syndrome mice","volume":"332","author":"Holm","year":"2011","journal-title":"Science"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib31","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1126\/science.1192152","article-title":"Angiotensin II type 2 receptor signaling attenuates aortic aneurysm in mice through erk antagonism","volume":"332","author":"Habashi","year":"2011","journal-title":"Science"},{"key":"10.1053\/j.semtcvs.2016.08.015_bib32","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/01.CIR.91.4.1022","article-title":"Valve repair improves the outcome of surgery for mitral regurgitation. A multivariate analysis","volume":"91","author":"Enriquez-Sarano","year":"1995","journal-title":"Circulation"}],"container-title":["Seminars in Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043067916301046?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043067916301046?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,7,7]],"date-time":"2022-07-07T22:56:37Z","timestamp":1657234597000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043067916301046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"alternative-id":["S1043067916301046"],"URL":"https:\/\/doi.org\/10.1053\/j.semtcvs.2016.08.015","relation":{},"ISSN":["1043-0679"],"issn-type":[{"value":"1043-0679","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparative Histopathological Analysis of Mitral Valves in Barlow Disease and Fibroelastic Deficiency","name":"articletitle","label":"Article Title"},{"value":"Seminars in Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.semtcvs.2016.08.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}