{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:07:50Z","timestamp":1791331670597,"version":"4.3.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2016,1,1]],"date-time":"2016-01-01T00:00:00Z","timestamp":1451606400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["semthorcardiovascsurg.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2016]]},"DOI":"10.1053\/j.semtcvs.2016.10.006","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T04:34:47Z","timestamp":1476678887000},"page":"776-782","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Paradigm for Detecting Silent Thoracic Aneurysm Disease"],"prefix":"10.1053","volume":"28","author":[{"given":"John A.","family":"Elefteriades","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bulat A.","family":"Ziganshin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.semtcvs.2016.10.006_bib1","unstructured":"National Center for Injury Prevention and Control. WISQARS leading causes of death reports, 1999\u20132007. 2015. Available at: http:\/\/webappa.cdc.gov\/sasweb\/ncipc\/leadcaus10.html. Accessed April 12, 2016."},{"key":"10.1053\/j.semtcvs.2016.10.006_bib2","first-page":"564","article-title":"Aortic dissection and sudden death\u2014Statistical analysis on 1320 cases autopsied at Tokyo-to Medical Examiner Office","volume":"42","author":"Murai","year":"1988","journal-title":"Nihon Hoigaku Zasshi"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib3","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1016\/j.ahj.2013.02.028","article-title":"Temporal trends in sudden unexpected death in a general population: The Hisayama study","volume":"165","author":"Nagata","year":"2013","journal-title":"Am Heart J"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib4","doi-asserted-by":"publisher","first-page":"794","DOI":"10.1016\/j.humpath.2006.03.008","article-title":"Sudden cardiac death in younger adults: autopsy diagnosis as a tool for preventive medicine","volume":"37","author":"di Gioia","year":"2006","journal-title":"Hum Pathol"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib5","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1016\/j.cpcardiol.2008.01.004","article-title":"Thoracic aortic aneurysm: Reading the enemy\u05f3s playbook","volume":"33","author":"Elefteriades","year":"2008","journal-title":"Curr Probl Cardiol"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib6","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.pcad.2013.05.004","article-title":"Biomarkers in TAA\u2014The Holy Grail","volume":"56","author":"van Bogerijen","year":"2013","journal-title":"Prog Cardiovasc Dis"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib7","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1016\/S0140-6736(14)61005-9","article-title":"Management of acute aortic dissection","volume":"385","author":"Nienaber","year":"2015","journal-title":"Lancet"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib8","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1093\/ejcts\/ezs647","article-title":"Biological features of thoracic aortic diseases. Where are we now, where are we heading to: Established and emerging biomarkers and molecular pathways","volume":"44","author":"Parolari","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib9","doi-asserted-by":"publisher","first-page":"e1050","DOI":"10.1371\/journal.pone.0001050","article-title":"Gene expression signature in peripheral blood detects thoracic aortic aneurysm","volume":"2","author":"Wang","year":"2007","journal-title":"PLoS One"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib10","doi-asserted-by":"publisher","first-page":"e000169","DOI":"10.1136\/openhrt-2014-000169","article-title":"Guilt by association: Paradigm for detecting a silent killer (thoracic aortic aneurysm)","volume":"2","author":"Elefteriades","year":"2015","journal-title":"Open Heart"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib11","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1001\/archsurg.134.4.361","article-title":"Familial patterns of thoracic aortic aneurysms","volume":"134","author":"Coady","year":"1999","journal-title":"Arch Surg"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib12","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1016\/S0741-5214(97)70261-1","article-title":"Familial thoracic aortic dilatations and dissections: A case control study","volume":"25","author":"Biddinger","year":"1997","journal-title":"J Vasc Surg"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib13","doi-asserted-by":"publisher","first-page":"e27","DOI":"10.1016\/j.jacc.2010.02.015","volume":"55","author":"Hiratzka","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib14","doi-asserted-by":"publisher","first-page":"2873","DOI":"10.1093\/eurheartj\/ehu281","volume":"35","author":"Erbel","year":"2014","journal-title":"Eur Heart J"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib15","doi-asserted-by":"publisher","first-page":"1400","DOI":"10.1016\/j.athoracsur.2006.04.098","article-title":"Familial thoracic aortic aneurysms and dissections\u2014Incidence, modes of inheritance, and phenotypic patterns","volume":"82","author":"Albornoz","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib16","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.tcm.2013.06.004","article-title":"Successes and challenges of using whole exome sequencing to identify novel genes underlying an inherited predisposition for thoracic aortic aneurysms and acute aortic dissections","volume":"24","author":"Milewicz","year":"2014","journal-title":"Trends Cardiovasc Med"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib17","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1016\/j.athoracsur.2015.04.106","article-title":"Routine genetic testing for thoracic aortic aneurysm and dissection in a clinical setting","volume":"100","author":"Ziganshin","year":"2015","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib18","doi-asserted-by":"publisher","first-page":"1920","DOI":"10.1056\/NEJMra1207059","article-title":"Aortic dilatation in patients with bicuspid aortic valve","volume":"370","author":"Verma","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib19","doi-asserted-by":"publisher","first-page":"920","DOI":"10.1161\/01.CIR.0000155623.48408.C5","article-title":"Frequency by decades of unicuspid, bicuspid, and tricuspid aortic valves in adults having isolated aortic valve replacement for aortic stenosis, with or without associated aortic regurgitation","volume":"111","author":"Roberts","year":"2005","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib20","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1586\/14779072.6.2.235","article-title":"Bicuspid aortic valve: Clinical approach and scientific review of a common clinical entity","volume":"6","author":"Friedman","year":"2008","journal-title":"Expert Rev Cardiovasc Ther"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib21","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1001\/jama.2011.1286","article-title":"Incidence of aortic complications in patients with bicuspid aortic valves","volume":"306","author":"Michelena","year":"2011","journal-title":"J Am Med Assoc"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib22","doi-asserted-by":"publisher","first-page":"2691","DOI":"10.1161\/CIRCULATIONAHA.113.007851","article-title":"Bicuspid aortic valve: Identifying knowledge gaps and rising to the challenge from the International Bicuspid Aortic Valve Consortium (BAVCon)","volume":"129","author":"Michelena","year":"2014","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib23","doi-asserted-by":"publisher","first-page":"2776","DOI":"10.1161\/CIRCULATIONAHA.107.740878","article-title":"Natural history of asymptomatic patients with normally functioning or minimally dysfunctional bicuspid aortic valve in the community","volume":"117","author":"Michelena","year":"2008","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib24","first-page":"642","article-title":"Matrix metalloproteinase-9 in cerebral aneurysms","volume":"41","author":"Kim","year":"1997","journal-title":"Neurosurgery"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib25","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.amjcard.2009.09.049","article-title":"Concurrent intracranial and thoracic aortic aneurysms","volume":"105","author":"Kuzmik","year":"2010","journal-title":"Am J Cardiol"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib26","unstructured":"Kuzmik G, Gunel M, Bulsara K, et al. Intracranial Aneurysm Patients May Harbor Thoracic Aortic Aneurysms. In: American Association of Thoracic Surgery Aortic Sympsoium 2012. New York, NY; 2012."},{"key":"10.1053\/j.semtcvs.2016.10.006_bib27","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1159\/000342071","article-title":"\u2018Bovine\u2019 aortic arch\u2014A marker for thoracic aortic disease","volume":"123","author":"Hornick","year":"2012","journal-title":"Cardiology"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib28","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/j.crad.2011.04.004","article-title":"Bovine aortic arch: A novel association with thoracic aortic dilation","volume":"67","author":"Malone","year":"2012","journal-title":"Clin Radiol"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib29","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1016\/j.jtcvs.2015.02.019","article-title":"Atypical aortic arch branching variants: A novel marker for thoracic aortic disease","volume":"149","author":"Dumfarth","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib30","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1007\/S10016-006-9124-x","article-title":"Increased incidence of renal cysts in patients with abdominal aortic aneurysms: A common pathogenesis?","volume":"20","author":"Yaghoubian","year":"2006","journal-title":"Ann Vasc Surg"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib31","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1136\/hrt.2010.205328","article-title":"Presence of simple renal cysts is associated with increased risk of aortic dissection: A common manifestation of connective tissue degeneration?","volume":"97","author":"Kim","year":"2011","journal-title":"Heart"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib32","doi-asserted-by":"publisher","first-page":"e002248","DOI":"10.1161\/JAHA.115.002248","article-title":"Simple renal cysts as markers of thoracic aortic disease","volume":"5","author":"Ziganshin","year":"2016","journal-title":"J Am Heart Assoc"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib33","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1097\/GIM.0b013e3180423cb3","article-title":"Abdominal visceral findings in patients with Marfan syndrome","volume":"9","author":"Chow","year":"2007","journal-title":"Genet Med"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib34","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/j.jacc.2009.08.084","article-title":"Thoracic aortic aneurysm clinically pertinent controversies and uncertainties","volume":"55","author":"Elefteriades","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib35","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1097\/SLA.0b013e3181d96498","article-title":"High frequency of thoracic aneurysms in patients with abdominal aortic aneurysms","volume":"253","author":"Larsson","year":"2011","journal-title":"Ann Surg"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib36","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1016\/j.avsg.2012.01.023","article-title":"Female and elderly abdominal aortic aneurysm patients more commonly have concurrent thoracic aortic aneurysm","volume":"26","author":"Hultgren","year":"2012","journal-title":"Ann Vasc Surg"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib37","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1016\/j.jvs.2012.04.056","article-title":"Synchronous and metachronous thoracic aneurysms in patients with abdominal aortic aneurysms","volume":"56","author":"Chaer","year":"2012","journal-title":"J Vasc Surg"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib38","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"J Med Genet"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib39","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/S1078-5884(05)80059-0","article-title":"Aortic aneurysms in patients with autoimmune disorders treated with corticosteroids","volume":"10","author":"Sato","year":"1995","journal-title":"Eur J Vasc Endovasc Surg"},{"key":"10.1053\/j.semtcvs.2016.10.006_bib40","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1136\/annrheumdis-2013-204113","article-title":"The relative risk of aortic aneurysm in patients with giant cell arteritis compared with the general population of the UK","volume":"74","author":"Robson","year":"2015","journal-title":"Ann Rheum Dis"}],"container-title":["Seminars in Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043067916301356?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043067916301356?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,7]],"date-time":"2018-09-07T15:30:22Z","timestamp":1536334222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043067916301356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016]]}},"alternative-id":["S1043067916301356"],"URL":"https:\/\/doi.org\/10.1053\/j.semtcvs.2016.10.006","relation":{},"ISSN":["1043-0679"],"issn-type":[{"value":"1043-0679","type":"print"}],"subject":[],"published":{"date-parts":[[2016]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Paradigm for Detecting Silent Thoracic Aneurysm Disease","name":"articletitle","label":"Article Title"},{"value":"Seminars in Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.semtcvs.2016.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}