{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T16:25:51Z","timestamp":1787675151790,"version":"build-2784847793"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL-007915"],"award-info":[{"award-number":["HL-007915"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL-007954"],"award-info":[{"award-number":["HL-007954"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS-060653"],"award-info":[{"award-number":["NS-060653"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS-072338"],"award-info":[{"award-number":["NS-072338"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41-EB015893"],"award-info":[{"award-number":["P41-EB015893"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006458","name":"Children&apos;s Hospital of Philadelphia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010392","name":"June and Steve Wolfson Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","semthorcardiovascsurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2022]]},"DOI":"10.1053\/j.semtcvs.2021.08.026","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T18:20:21Z","timestamp":1631125221000},"page":"1275-1284","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association of Ongoing Cerebral Oxygen Extraction During Deep Hypothermic Circulatory Arrest With Postoperative Brain Injury"],"prefix":"10.1053","volume":"34","author":[{"given":"Jennifer M.","family":"Lynch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantine D.","family":"Mavroudis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany S.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marin","family":"Jacobwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan C.","family":"Nicolson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Montenegro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. William","family":"Gaynor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun G.","family":"Yodh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Licht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1053\/j.semtcvs.2021.08.026_bib0001","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1016\/S0735-1097(02)01886-7","article-title":"The incidence of congenital heart disease","volume":"39","author":"Hoffman","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0002","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1161\/01.cir.0000032908.33237.b1","article-title":"An MRI study on neurological injury before and after congenital heart surgery","volume":"106","author":"Mahle","year":"2002","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0003","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.neuroimage.2018.06.004","article-title":"White matter injury in term neonates with congenital heart diseases: Topology & comparison with preterm newborns","volume":"185","author":"Guo","year":"2019","journal-title":"Neuroimage"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0004","doi-asserted-by":"crossref","first-page":"13250","DOI":"10.1038\/s41598-017-13753-x","article-title":"Punctate white matter lesions associated with altered brain development and adverse motor outcome in preterm infants","volume":"7","author":"Tusor","year":"2017","journal-title":"Sci Rep"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0005","first-page":"1361","article-title":"Adolescents with d-transposition of the great arteries corrected with the atrial switch procedure","volume":"124","author":"Bellinger","year":"2011","journal-title":"Pediatr Cardiol"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0006","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/01.hco.0000153451.68212.68","article-title":"Central nervous system outcomes in children with complex congenital heart disease","volume":"20","author":"Wernovsky","year":"2005","journal-title":"Curr Opin Cardiol"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0007","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/01.DBP.0000452240.39511.d4","article-title":"Neurodevelopmental outcomes of infants born prematurely","volume":"35","author":"Aylward","year":"2014","journal-title":"J Dev Behav Pediatr"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0008","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.siny.2007.05.004","article-title":"Cognitive and behavioral outcomes following very preterm birth","volume":"12","author":"Johnson","year":"2007","journal-title":"Semin Fetal Neontal Med"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0009","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.jtcvs.2009.08.022","article-title":"Brain immaturity is associated with brain injury before and after neonatal cardiac surgery with high-flow bypass and cerebral oxygenation monitoring","volume":"139","author":"Andropoulos","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0010","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1161\/CIRCULATIONAHA.112.001089","article-title":"New white matter injury after infant heart surgery is associated with diagnostic group and use of circulatory arrest","volume":"127","author":"Beca","year":"2013","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0011","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/j.jtcvs.2014.05.081","article-title":"Time-to-surgery and pre-operative cerebral hemodynamics predict post-operative white matter injury in neonates with hypoplastic left heart syndrome","volume":"148","author":"Lynch","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0012","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1161\/CIRCULATIONAHA.107.760819","article-title":"Preoperative brain injury in transposition of the great arteries is associated with oxygenation and time to surgery, not balloon atrial septostomy","volume":"119","author":"Petit","year":"2009","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0013","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s00401-005-1077-6","article-title":"Hypoxic-ischemic brain injury in infants with congenital heart disease dying after cardiac surgery","volume":"110","author":"Kinney","year":"2005","journal-title":"Acta Neuropathol"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0014","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1161\/CIRCULATIONAHA.113.003312","article-title":"Neurological injury after neonatal cardiac surgery: A randomized controlled trial of two perfusion techniques","volume":"129","author":"Algra","year":"2014","journal-title":"Circulation"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0015","doi-asserted-by":"crossref","first-page":"076701","DOI":"10.1088\/0034-4885\/73\/7\/076701","article-title":"Diffuse optics for tissue monitoring and tomography","volume":"73","author":"Durduran","year":"2010","journal-title":"Rep Prog Phys"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0016","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1038\/jcbfm.2013.214","article-title":"Cerebral oxygen metabolism in neonates with congenital heart disease quantified by MRI and optics","volume":"34","author":"Jain","year":"2014","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0017","doi-asserted-by":"crossref","first-page":"3461","DOI":"10.1364\/BOE.7.003461","article-title":"Continuous cerebral hemodynamic measurement during deep hypothermic circulatory arrest","volume":"7","author":"Busch","year":"2016","journal-title":"Biomed Opt Express"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0018","article-title":"Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging","volume":"17","author":"Buckley","year":"2012","journal-title":"J Biomed Opt"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0019","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.jtcvs.2012.09.057","article-title":"Early post-operative changes in cerebral oxygen metabolism following neonatal cardiac surgery: Effects of surgical duration","volume":"145","author":"Buckley","year":"2012","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0020","doi-asserted-by":"crossref","first-page":"37004","DOI":"10.1117\/1.3425884","article-title":"Optical measurement of cerebral hemodynamics and oxygen metabolism in neonates with congenital heart defects","volume":"15","author":"Durduran","year":"2010","journal-title":"J Biomed Opt"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0021","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/S0140-6736(86)90467-8","article-title":"Quantification of cerebral oxygenation and haemodynamics in sick newborn infants by near infrared spectrophotometry","volume":"328","author":"Wyatt","year":"1986","journal-title":"Lancet"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0022","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1364\/JOSAA.14.000192","article-title":"Spatially varying dynamical properties of turbid media probed with diffusing temporal light correlation","volume":"14","author":"Boas","year":"1997","journal-title":"J Opt Soc Am A"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0023","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1103\/PhysRevLett.60.1134","article-title":"Diffusing wave spectroscopy","volume":"60","author":"Pine","year":"1988","journal-title":"Phys Rev Lett"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0024","doi-asserted-by":"crossref","first-page":"12571","DOI":"10.1364\/OE.17.012571","article-title":"Cerebral hemodynamics in preterm infants during positional intervention measured with diffuse correlation spectroscopy and transcranial Doppler ultrasound","volume":"17","author":"Buckley","year":"2009","journal-title":"Opt Express"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0025","first-page":"45006","article-title":"Noninvasive continuous optical monitoring of absolute cerebral blood flow in critically ill adults","volume":"5","author":"He","year":"2018","journal-title":"Neurophotonics"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0026","first-page":"2716","article-title":"Quantification of cerebral blood flow in adults by contrast-enhanced near-infrared spectroscopy: Validation against MRI","author":"Milej","year":"2019","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0027","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/hbm.20868","article-title":"Noninvasive optical measures of CBV, StO(2), CBF index, and rCMRO(2) in human premature neonates\u2019 brain in the first six weeks of life","volume":"31","author":"Roche-Labarbe","year":"2010","journal-title":"Hum Brain Mapp"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0028","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/0271678X18809828","article-title":"Non-invasive optical neuromonitoring of the temperature-dependence of cerebral oxygen metabolism during deep hypothermic cardiopulmonary bypass in neonatal swine","volume":"40","author":"Ko","year":"2020","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0029","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1016\/j.athoracsur.2018.06.036","article-title":"Electroencephalographic response to deep hypothermic circulatory arrest in neonatal swine and humans","volume":"106","author":"Mavroudis","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0030","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0022-5223(19)36647-4","article-title":"The effect of hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism in neonates, infants, and children","volume":"101","author":"Greeley","year":"1991","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0031","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0003-4975(99)01322-3","article-title":"Utility of near-infrared spectroscopic measurements during deep hypothermic circulatory arrest","volume":"69","author":"Shin'oka","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0032","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.jtcvs.2018.04.098","article-title":"Pre-operative cerebral hemodynamics from birth to surgery in neonates with critical congenital heart disease","volume":"156","author":"Lynch","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0033","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1088\/0031-9155\/46\/1\/304","article-title":"Non-invasive and quantitiative near-infared haemoglobin spectrometry in the piglet brain during hypoxic stress, using a frequency-domain multidistance instrument","volume":"46","author":"Hueber","year":"2000","journal-title":"Phys Med Biol"},{"key":"10.1053\/j.semtcvs.2021.08.026_bib0034","doi-asserted-by":"crossref","first-page":"3586","DOI":"10.1364\/AO.37.003586","article-title":"Mechanisms of light scattering from biological cells relevant to noninvasive optical-tissue diagnostics","volume":"37","author":"Mourant","year":"1998","journal-title":"Appl Opt"}],"container-title":["Seminars in Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043067921004056?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043067921004056?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:33:40Z","timestamp":1760906020000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043067921004056"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022]]}},"alternative-id":["S1043067921004056"],"URL":"https:\/\/doi.org\/10.1053\/j.semtcvs.2021.08.026","relation":{},"ISSN":["1043-0679"],"issn-type":[{"value":"1043-0679","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of Ongoing Cerebral Oxygen Extraction During Deep Hypothermic Circulatory Arrest With Postoperative Brain Injury","name":"articletitle","label":"Article Title"},{"value":"Seminars in Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.semtcvs.2021.08.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}