{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T21:18:00Z","timestamp":1760908680945,"version":"build-2065373602"},"reference-count":8,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","semthorcardiovascsurg.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Seminars in Thoracic and Cardiovascular Surgery"],"published-print":{"date-parts":[[2023]]},"DOI":"10.1053\/j.semtcvs.2021.12.008","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T20:43:06Z","timestamp":1640119386000},"page":"259-260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Commentary: Neuroprotection in Hypothermic Circulatory Arrest \u2013 is Ketamine a Magic Bullet?"],"prefix":"10.1053","volume":"35","author":[{"given":"John G.","family":"Augoustides","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/j.semtcvs.2021.12.008_bib0001","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1053\/j.jvca.2020.11.035","article-title":"Brain protection in aortic arch surgery: an evolving field","volume":"35","author":"Qu","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.semtcvs.2021.12.008_bib0002","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1016\/j.jtcvs.2019.06.115","article-title":"A novel target to reduce microglial inflammation and neuronal damage after deep hypothermic circulatory arrest","volume":"159","author":"Liu","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2021.12.008_bib0003","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1053\/j.jvca.2009.05.008","article-title":"Neuroprotection by ketamine: a review of the experimental and clinical evidence","volume":"24","author":"Hudetz","year":"2010","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/j.semtcvs.2021.12.008_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.672526","article-title":"Ketamine: neuroprotective or neurotoxic?","volume":"15","author":"Choudhury","year":"2021","journal-title":"Front Neurosci"},{"key":"10.1053\/j.semtcvs.2021.12.008_bib0005","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/S0022-5223(99)70038-3","article-title":"A word of caution in extrapolating the spinal cord protective effects of memantine obtained in a rabbit model under ketamine anesthesia","volume":"118","author":"Miyamoto","year":"1999","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2021.12.008_bib0006","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1053\/j.semtcvs.2021.12.004","article-title":"Ketamine mitigates neurobehavioral deficits in a canine model of hypothermic circulatory arrest","volume":"35","author":"Giuliano","year":"2023","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2021.12.008_bib0007","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1016\/j.jtcvs.2019.12.075","article-title":"Inhaled nitric oxide reduces injury and microglial activation in porcine hippocampus after deep hypothermic circulatory arrest","volume":"161","author":"Kajimoto","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/j.semtcvs.2021.12.008_bib0008","doi-asserted-by":"crossref","first-page":"E190","DOI":"10.1016\/j.jtcvs.2020.01.005","article-title":"Commentary: Neurocognitive dysfunction after cardiopulmonary bypass: multiple modalities to rescue the microglia","volume":"160","author":"Augoustides","year":"2020","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Seminars in Thoracic and Cardiovascular Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043067921005001?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1043067921005001?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T20:34:59Z","timestamp":1760906099000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1043067921005001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":8,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023]]}},"alternative-id":["S1043067921005001"],"URL":"https:\/\/doi.org\/10.1053\/j.semtcvs.2021.12.008","relation":{},"ISSN":["1043-0679"],"issn-type":[{"type":"print","value":"1043-0679"}],"subject":[],"published":{"date-parts":[[2023]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Commentary: Neuroprotection in Hypothermic Circulatory Arrest \u2013 is Ketamine a Magic Bullet?","name":"articletitle","label":"Article Title"},{"value":"Seminars in Thoracic and Cardiovascular Surgery","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1053\/j.semtcvs.2021.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"https:\/\/doi.org\/10.1053\/j.semtcvs.2021.12.004","name":"associatedlink","label":"CrossRef DOI link to the associated document"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}