{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T19:21:35Z","timestamp":1783106495586,"version":"3.54.6"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2013,10,1]],"date-time":"2013-10-01T00:00:00Z","timestamp":1380585600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Seminars in Ultrasound, CT and MRI"],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1053\/j.sult.2013.09.002","type":"journal-article","created":{"date-parts":[[2013,11,8]],"date-time":"2013-11-08T20:02:16Z","timestamp":1383940936000},"page":"445-458","source":"Crossref","is-referenced-by-count":23,"title":["Perineural Tumor Spread Involving the Central Skull Base Region"],"prefix":"10.1053","volume":"34","author":[{"given":"Hilda E.","family":"Stambuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1053\/j.sult.2013.09.002_bib1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/rmr.0b013e3181645a0d","article-title":"Perineural tumor spread in malignant head and neck tumors","volume":"18","author":"Nemec","year":"2007","journal-title":"Top Magn Reson Imaging"},{"issue":"1","key":"10.1053\/j.sult.2013.09.002_bib2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1212\/WNL.53.1.213","article-title":"Trigeminal neuropathy secondary to perineural invasion of head and neck carcinomas","volume":"53","author":"Boerman","year":"1999","journal-title":"Neurology"},{"issue":"4","key":"10.1053\/j.sult.2013.09.002_bib3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1002\/hed.21470","article-title":"Detecting and defining the anatomic extent of large nerve perineural spread of malignancy: Comparing \u201ctargeted\u201d MRI with the histologic findings following surgery","volume":"33","author":"Gandhi","year":"2011","journal-title":"Head Neck"},{"issue":"1","key":"10.1053\/j.sult.2013.09.002_bib4","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1148\/radiographics.18.1.9460111","article-title":"Imaging features and clinical significance of perineural spread or extension of head and neck tumors","volume":"18","author":"Caldemeyer","year":"1998","journal-title":"Radiographics"},{"issue":"15","key":"10.1053\/j.sult.2013.09.002_bib5","doi-asserted-by":"crossref","first-page":"3379","DOI":"10.1002\/cncr.24396","article-title":"Perineural invasion in cancer: A review of the literature","volume":"115","author":"Liebig","year":"2009","journal-title":"Cancer"},{"issue":"1","key":"10.1053\/j.sult.2013.09.002_bib6","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cytogfr.2009.11.001","article-title":"Molecular mechanisms of perineural invasion, a forgotten pathway of dissemination and metastasis","volume":"21","author":"Marchesi","year":"2010","journal-title":"Cytokine Growth Factor Rev"},{"issue":"14","key":"10.1053\/j.sult.2013.09.002_bib7","first-page":"5127","article-title":"Reverse transcription-PCR analysis of laser-captured cells points to potential paracrine and autocrine actions of neurotrophins in pancreatic cancer","volume":"9","author":"Ketterer","year":"2003","journal-title":"Clin Cancer Res"},{"issue":"12","key":"10.1053\/j.sult.2013.09.002_bib8","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1097\/00005537-200112000-00011","article-title":"Tumor deposition of laminin-5 and the relationship with perineural invasion","volume":"111","author":"Anderson","year":"2001","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1053\/j.sult.2013.09.002_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/jnci\/djp456","article-title":"Paracrine regulation of pancreatic cancer cell invasion by peripheral nerves","volume":"102","author":"Gil","year":"2010","journal-title":"J Natl Cancer Inst"},{"issue":"15","key":"10.1053\/j.sult.2013.09.002_bib10","doi-asserted-by":"crossref","first-page":"5291","DOI":"10.1158\/0008-5472.CAN-04-1112","article-title":"Activation of phosphatidylinositol 3-kinase and extracellular signal-regulated kinase is required for glial cell line-derived neurotrophic factor-induced migration and invasion of pancreatic carcinoma cells","volume":"64","author":"Veit","year":"2004","journal-title":"Cancer Res"},{"issue":"24","key":"10.1053\/j.sult.2013.09.002_bib11","doi-asserted-by":"crossref","first-page":"11732","DOI":"10.1158\/0008-5472.CAN-07-2343","article-title":"A role for glial cell derived neurotrophic factor induced expression by inflammatory cytokines and RET\/GFR alpha 1 receptor up-regulation in breast cancer","volume":"67","author":"Esseghir","year":"2007","journal-title":"Cancer Res"},{"issue":"6","key":"10.1053\/j.sult.2013.09.002_bib12","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1136\/jcp.2003.014498","article-title":"Inflammatory cells contribute to the generation of an angiogenic phenotype in pancreatic ductal adenocarcinoma","volume":"57","author":"Esposito","year":"2004","journal-title":"J Clin Pathol"},{"issue":"3","key":"10.1053\/j.sult.2013.09.002_bib13","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.ajpath.2011.12.009","article-title":"Plexin-B1 and semaphorin 4D cooperate to promote perineural invasion in a RhoA\/ROK-dependent manner","volume":"180","author":"Binmadi","year":"2012","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1053\/j.sult.2013.09.002_bib14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.pan.2012.05.012","article-title":"The actin binding protein destrin is associated with growth and perineural invasion of pancreatic cancer","volume":"12","author":"Klose","year":"2012","journal-title":"Pancreatology"},{"issue":"4 Pt 1","key":"10.1053\/j.sult.2013.09.002_bib15","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1177\/000348948509400420","article-title":"Nerves and neurotropic carcinomas","volume":"94","author":"Batsakis","year":"1985","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"6","key":"10.1053\/j.sult.2013.09.002_bib16","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1001\/archotol.124.6.637","article-title":"Perineural invasion in squamous cell carcinoma of the head and neck","volume":"124","author":"Fagan","year":"1998","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"2","key":"10.1053\/j.sult.2013.09.002_bib17","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.urology.2012.09.034","article-title":"Evidence of perineural invasion on prostate biopsy specimen and survival after radical prostatectomy","volume":"81","author":"Delancey","year":"2013","journal-title":"Urology"},{"issue":"10","key":"10.1053\/j.sult.2013.09.002_bib18","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1288\/00005537-198610000-00015","article-title":"Prognostic implications of perineural spread in squamous carcinomas of the head and neck","volume":"96","author":"Soo","year":"1986","journal-title":"Laryngoscope"},{"key":"10.1053\/j.sult.2013.09.002_bib19","article-title":"Perineural invasion of head and neck skin cancer: Diagnostic and therapeutic implications","author":"Panizza","year":"2012","journal-title":"Curr Oncol Rep"},{"issue":"3","key":"10.1053\/j.sult.2013.09.002_bib20","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1097\/00000658-199603000-00007","article-title":"Long-term survival after curative resection for pancreatic ductal adenocarcinoma. clinicopathologic analysis of 5-year survivors","volume":"223","author":"Conlon","year":"1996","journal-title":"Ann Surg"},{"issue":"11","key":"10.1053\/j.sult.2013.09.002_bib21","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.oraloncology.2009.07.001","article-title":"Perineural invasion in adenoid cystic carcinoma of the salivary glands: A valid prognostic indicator?","volume":"45","author":"Barrett","year":"2009","journal-title":"Oral Oncol"},{"issue":"5","key":"10.1053\/j.sult.2013.09.002_bib22","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/PAS.0b013e3181d95c37","article-title":"Validation of the histologic risk model in a new cohort of patients with head and neck squamous cell carcinoma","volume":"34","author":"Brandwein-Gensler","year":"2010","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1053\/j.sult.2013.09.002_bib23","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.nic.2008.01.001","article-title":"Perineural tumor spread","volume":"18","author":"Maroldi","year":"2008","journal-title":"Neuroimaging Clin N Am"},{"issue":"3","key":"10.1053\/j.sult.2013.09.002_bib24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.mric.2012.05.006","article-title":"Patterns of perineural tumor spread in head and neck cancer","volume":"20","author":"Moonis","year":"2012","journal-title":"Magn Reson Imaging Clin N Am"},{"issue":"2","key":"10.1053\/j.sult.2013.09.002_bib25","first-page":"389","article-title":"Greater superficial petrosal nerve: Anatomy and MR findings in perineural tumor spread","volume":"17","author":"Ginsberg","year":"1996","journal-title":"Am J Neuroradiol"},{"issue":"2","key":"10.1053\/j.sult.2013.09.002_bib26","first-page":"303","article-title":"Perineural tumor spread along the auriculotemporal nerve","volume":"23","author":"Schmalfuss","year":"2002","journal-title":"Am J Neuroradiol"},{"issue":"6","key":"10.1053\/j.sult.2013.09.002_bib27","first-page":"772","article-title":"Cranial neuropathy secondary to perineural spread of cutaneous malignancies","volume":"16","author":"Catalano","year":"1995","journal-title":"Am J Otol"},{"issue":"4","key":"10.1053\/j.sult.2013.09.002_bib28","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/S0360-3016(00)01407-3","article-title":"Perineural spread of cutaneous squamous and basal cell carcinoma: CT and MR detection and its impact on patient management and prognosis","volume":"49","author":"Williams","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1","key":"10.1053\/j.sult.2013.09.002_bib29","first-page":"1","article-title":"Detection of perineural spread: Fat suppression versus no fat suppression","volume":"25","author":"Curtin","year":"2004","journal-title":"Am J Neuroradiol"}],"container-title":["Seminars in Ultrasound, CT and MRI"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887217113000838?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0887217113000838?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T09:29:08Z","timestamp":1688635748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0887217113000838"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,10]]}},"alternative-id":["S0887217113000838"],"URL":"https:\/\/doi.org\/10.1053\/j.sult.2013.09.002","relation":{},"ISSN":["0887-2171"],"issn-type":[{"value":"0887-2171","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10]]}}}