{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T09:59:49Z","timestamp":1760954389012},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2001,6,1]],"date-time":"2001-06-01T00:00:00Z","timestamp":991353600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2001,6]]},"DOI":"10.1053\/jcan.2001.23282","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"326-330","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of the effects of a cell saver and low-dose aprotinin on blood loss and homologous blood usage in patients undergoing valve surgery"],"prefix":"10.1053","volume":"15","author":[{"given":"Deepak K.","family":"Tempe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanjula","family":"Virmani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Navneet","family":"Mehta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil","family":"Panwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.S.","family":"Tomar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.K.S.","family":"Ghambeer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Nigam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/jcan.2001.23282_bib1","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1001\/jama.1989.03430140081029","article-title":"Autologous blood donation prior to elective cardiac surgery: Safety and effect on subsequent blood use","volume":"262","author":"Owings","year":"1989","journal-title":"JAMA"},{"key":"10.1053\/jcan.2001.23282_bib2","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S1053-0770(05)80012-6","article-title":"Blood conservation in small adults undergoing valve surgery","volume":"10","author":"Tempe","year":"1996","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/jcan.2001.23282_bib3","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/0003-4975(91)90912-A","article-title":"Conventional blood conservation techniques in 500 consecutive coronary artery bypass operations","volume":"52","author":"Ovrum","year":"1991","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/jcan.2001.23282_bib4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/1053-0770(91)90052-U","article-title":"High-dose aprotinin therapy: A review of the first five years' experience","volume":"6","author":"Royston","year":"1992","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/jcan.2001.23282_bib5","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S1053-0770(05)80314-3","article-title":"A comparison of the effects of tranexamic acid and low-dose aprotinin on blood loss and homologous blood usage in patients undergoing cardiac surgery","volume":"9","author":"Pugh","year":"1995","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/jcan.2001.23282_bib6","first-page":"II96","article-title":"Beneficial effect of both tranexamic acid and aprotinin on blood loss reduction in reoperative valve replacement surgery","volume":"96","author":"Jamieson","year":"1997","journal-title":"Circulation"},{"key":"10.1053\/jcan.2001.23282_bib7","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1097\/00000542-199712000-00017","article-title":"Cost benefit and efficacy of aprotinin compared with \u03f5-aminocaproic acid in patients having repeated cardiac operations","volume":"87","author":"Bennett-Guerrero","year":"1997","journal-title":"Anesthesiology"},{"key":"10.1053\/jcan.2001.23282_bib8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0003-4975(90)90305-P","article-title":"Effects of intraoperative plasmapheresis on blood loss in cardiac surgery","volume":"49","author":"Jones","year":"1990","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/jcan.2001.23282_bib9","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/S0022-5223(19)34573-8","article-title":"Reduction in blood loss and blood use after cardiopulmonary bypass with high-dose aprotinin (Trasylol)","volume":"97","author":"Bidstrup","year":"1989","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/jcan.2001.23282_bib10","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1097\/00000542-199012000-00009","article-title":"Influence of high- dose aprotinin treatment on blood loss and coagulation patterns in patients undergoing myocardial revascularization","volume":"73","author":"Dietrich","year":"1990","journal-title":"Anesthesiology"},{"key":"10.1053\/jcan.2001.23282_bib11","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0003-4975(92)90066-D","article-title":"Aprotinin therapy for reoperative myocardial revascularization: A placebo-controlled study","volume":"54","author":"Cosgrove","year":"1992","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/jcan.2001.23282_bib12","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1136\/hrt.71.4.349","article-title":"Randomised placebo-controlled double-blind study of two low-dose aprotinin regimens in cardiac surgery","volume":"71","author":"Bailey","year":"1994","journal-title":"Br Heart J"},{"key":"10.1053\/jcan.2001.23282_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1540-8191.1997.tb00083.x","article-title":"Randomized, placebo-controlled, double-blind study of an ultra-low-dose aprotinin regimen in reoperative and\/or complex cardiac operations","volume":"12","author":"Hardy","year":"1997","journal-title":"J Card Surg"},{"key":"10.1053\/jcan.2001.23282_bib14","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S1053-0770(99)90207-0","article-title":"Platelet function during cardiac surgery and cardiopulmonary bypass with low-dose aprotinin","volume":"13","author":"Basora","year":"1999","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/jcan.2001.23282_bib15","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/0003-4975(93)90035-G","article-title":"Effect of low-dose aprotinin on coagulation and fibrinolysis in cardiopulmonary bypass","volume":"55","author":"Kawasuji","year":"1993","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/jcan.2001.23282_bib16","first-page":"293","article-title":"Effect of recombinant aprotinin on platelet activation in patients undergoing open-heart surgery","volume":"23","author":"Matzdorff","year":"1993","journal-title":"Haemostasis"},{"key":"10.1053\/jcan.2001.23282_bib17","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0022-5223(19)36893-X","article-title":"Aprotinin protects platelets against the initial effect of cardiopulmonary bypass","volume":"99","author":"van Oeveren","year":"1990","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/jcan.2001.23282_bib18","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1055\/s-0038-1646477","article-title":"Haemostasis in patients undergoing extracorporeal circulation: The effect of aprotinin (Trasylol)","volume":"66","author":"Lu","year":"1991","journal-title":"Thromb Haemost"},{"key":"10.1053\/jcan.2001.23282_bib19","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/S0022-5223(19)36611-5","article-title":"Effects of high-dose aprotinin on blood loss, platelet function, fibrinolysis, complement, and renal function after cardiopulmonary bypass","volume":"101","author":"Blauhut","year":"1991","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/jcan.2001.23282_bib20","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1097\/00000542-199405000-00010","article-title":"Pharmacokinetics of aprotinin in preoperative cardiac surgical patients","volume":"80","author":"Levy","year":"1994","journal-title":"Anesthesiology"},{"key":"10.1053\/jcan.2001.23282_bib21","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1182\/blood.V77.4.694.694","article-title":"Differential redistribution of platelet glycoproteins Ib and IIb\/IIIa after plasmin stimulation","volume":"77","author":"Cramer","year":"1991","journal-title":"Blood"},{"key":"10.1053\/jcan.2001.23282_bib22","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/1053-0770(92)90150-6","article-title":"High-dose aprotinin in cardiac surgery: Three years' experience in 1784 patients","volume":"6","author":"Dietrich","year":"1992","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/jcan.2001.23282_bib23","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/S0003-4975(10)62153-4","article-title":"Effects of aprotinin on hemostatic mechanisms during cardiopulmonary bypass","volume":"44","author":"van Oeveren","year":"1987","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/jcan.2001.23282_bib24","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0022-5223(19)36879-5","article-title":"Low-dose aprotinin also allows reduction of blood loss after cardiopulmonary bypass","volume":"102","author":"Carrel","year":"1991","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/jcan.2001.23282_bib25","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/0003-4975(93)90035-G","article-title":"Effects of low-dose aprotinin on coagulation and fibrinolysis in cardiopulmonary bypass","volume":"55","author":"Kawasuji","year":"1993","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/jcan.2001.23282_bib26","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/0003-4975(92)90089-M","article-title":"Low-dose aprotinin in internal mammary artery bypass operation contributes to important blood saving","volume":"54","author":"Schonberger","year":"1992","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/jcan.2001.23282_bib27","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0140-6736(91)92485-K","article-title":"Low-dose aprotinin for reduction of blood loss after cardiopulmonary bypass","volume":"337","author":"Carrel","year":"1991","journal-title":"Lancet"},{"key":"10.1053\/jcan.2001.23282_bib28","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/1010-7940(91)90186-N","article-title":"Low-dose aprotinin as blood saver in open heart surgery","volume":"5","author":"Covino","year":"1991","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/jcan.2001.23282_bib29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S1053-0770(05)80052-7","article-title":"The use of ultra-low-dose aprotinin to reduce blood loss in cardiac surgery","volume":"9","author":"Alvarez","year":"1995","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/jcan.2001.23282_bib30","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/S0022-5223(19)35233-X","article-title":"Intraoperative autotransfusion in cardiac operations: Effect on intraoperative and postoperative transfusion requirements","volume":"96","author":"Giordano","year":"1988","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/jcan.2001.23282_bib31","first-page":"798","article-title":"The use of low-dose aprotinin, \u03f5-aminocaproic acid or tranexamic acid for prevention of mediastinal bleeding in patients receiving aspirin before coronary artery bypass operations","volume":"11","author":"Landymore","year":"1997","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1053\/jcan.2001.23282_bib32","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/S0140-6736(99)01264-7","article-title":"Pharmacological strategies to decrease excessive blood loss in cardiac surgery: A meta-analysis of clinically relevant endpoints","volume":"354","author":"Levi","year":"1999","journal-title":"Lancet"},{"key":"10.1053\/jcan.2001.23282_bib33","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1093\/bja\/72.4.422","article-title":"Formation of cytokines by retransfusion of shed whole blood","volume":"72","author":"Amestad","year":"1994","journal-title":"Br J Anaesth"},{"key":"10.1053\/jcan.2001.23282_bib34","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/S1053-0770(99)90019-8","article-title":"Intraoperative coronary thrombosis in association with low-dose aprotinin therapy","volume":"13","author":"Alvarez","year":"1999","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"10.1053\/jcan.2001.23282_bib35","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1161\/01.CIR.92.8.2236","article-title":"A multicenter, double-blind, placebo-controlled trial of aprotinin for reducing blood loss and the requirement for donor blood transfusion in patients undergoing repeat coronary artery bypass grafting","volume":"92","author":"Levy","year":"1995","journal-title":"Circulation"},{"key":"10.1053\/jcan.2001.23282_bib36","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/0003-4975(94)00813-M","article-title":"Aprotinin for coronary artery bypass grafting: Effect on postoperative renal function","volume":"59","author":"Lemmer","year":"1995","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/jcan.2001.23282_bib37","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0022-5223(96)70110-1","article-title":"Aprotinin in primary valve replacement and reconstruction: A multicenter, double-blind, placebo-controlled trial","volume":"112","author":"D'Ambra","year":"1996","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1053\/jcan.2001.23282_bib38","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/S0022-5223(97)70061-8","article-title":"Long-term follow-up of aprotinin-specific immunoglobulin G antibodies after cardiac operations","volume":"114","author":"Weipert","year":"1997","journal-title":"J Thorac Cardiovasc Surg"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077001516651?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077001516651?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T21:11:58Z","timestamp":1581023518000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077001516651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,6]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["S1053077001516651"],"URL":"https:\/\/doi.org\/10.1053\/jcan.2001.23282","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2001,6]]}}}