{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T23:35:43Z","timestamp":1772494543242,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"published-print":{"date-parts":[[2002,12]]},"DOI":"10.1053\/jcan.2002.128416","type":"journal-article","created":{"date-parts":[[2002,12,28]],"date-time":"2002-12-28T16:34:06Z","timestamp":1041093246000},"page":"695-702","source":"Crossref","is-referenced-by-count":63,"title":["Safety and preliminary efficacy of hemoglobin raffimer for patients undergoing coronary artery bypass surgery"],"prefix":"10.1053","volume":"16","author":[{"given":"Steven E.","family":"Hill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lewis I.","family":"Gottschalk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Grichnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1053\/jcan.2002.128416_bib1","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1016\/S0735-1097(99)00389-7","article-title":"ACC\/AHA guidelines for coronary artery bypass graft surgery: A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines","volume":"34","author":"Eagle","year":"1999","journal-title":"J Am Coll Cardiol"},{"key":"10.1053\/jcan.2002.128416_bib2","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00000542-199802000-00009","article-title":"Variability in transfusion practice for coronary artery bypass surgery persists despite national consensus guidelines: A 24-institution study","volume":"88","author":"Stover","year":"1998","journal-title":"Anesthesiology"},{"key":"10.1053\/jcan.2002.128416_bib3","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/00000542-199603000-00032","article-title":"Practice Guidelines for blood component therapy: A report by the American Society of Anesthesiologists Task Force on Blood Component Therapy","volume":"84","author":"Stehling","year":"1996","journal-title":"Anesthesiology"},{"key":"10.1053\/jcan.2002.128416_bib4","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1537-2995.1990.30490273432.x","article-title":"The relationship of blood transfusion, tumor staging, and cancer recurrence","volume":"30","author":"Blumberg","year":"1990","journal-title":"Transfusion"},{"key":"10.1053\/jcan.2002.128416_bib5","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1046\/j.1537-2995.1992.32692367194.x","article-title":"A clinical and immunologic study of blood transfusion and postoperative bacterial infection in spinal surgery","volume":"32","author":"Triulzi","year":"1992","journal-title":"Transfusion"},{"key":"10.1053\/jcan.2002.128416_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1046\/j.1537-2995.1992.32192116427.x","article-title":"Postoperative infections following autologous and homologous blood transfusions","volume":"32","author":"Mezrow","year":"1992","journal-title":"Transfusion"},{"key":"10.1053\/jcan.2002.128416_bib7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1097\/00005373-199211000-00010","article-title":"Association between blood transfusion and infection in injured patients","volume":"33","author":"Edna","year":"1992","journal-title":"J Trauma"},{"key":"10.1053\/jcan.2002.128416_bib8","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1046\/j.1537-2995.1999.39111169.x","article-title":"Further studies of blood infectivity in an experimental model of transmissible spongiform encephalopathy, with an explanation of why blood components do not transmit Creutzfeldt-Jakob disease in humans","volume":"39","author":"Brown","year":"1999","journal-title":"Transfusion"},{"key":"10.1053\/jcan.2002.128416_bib9","author":"American National Red Cross"},{"key":"10.1053\/jcan.2002.128416_bib10","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/0003-4975(96)00755-2","article-title":"Intraoperative autologous blood donation preserves red cell mass but does not decrease postoperative bleeding","volume":"62","author":"Helm","year":"1996","journal-title":"Ann Thorac Surg"},{"key":"10.1053\/jcan.2002.128416_bib11","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1213\/00000539-199801000-00003","article-title":"Does acute normovolemic hemodilution reduce perioperative allogeneic transfusion? A meta-analysis. The International Study of Perioperative Transfusion","volume":"86","author":"Bryson","year":"1998","journal-title":"Anesth Analg"},{"key":"10.1053\/jcan.2002.128416_bib12","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1097\/00003246-200007000-00017","article-title":"A phase I study of oxidized raffinose cross-linked human hemoglobin","volume":"28","author":"Carmichael","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1053\/jcan.2002.128416_bib13","article-title":"Hemodilution with Hemolink does not adversely affect LV hemodynamics or blood flow distribution in anesthetized dogs","author":"Kingma","year":"2000"},{"key":"10.1053\/jcan.2002.128416_bib14","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0304-4165(95)00077-O","article-title":"Activation of complement by human hemoglobin and by mixtures of hemoglobin and bacterial endotoxin","volume":"1245","author":"Kaca","year":"1995","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/jcan.2002.128416_bib15","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0891-5849(96)00499-6","article-title":"The toxicities of native and modified hemoglobins","volume":"22","author":"Everse","year":"1997","journal-title":"Free Radic Biol Med"},{"key":"10.1053\/jcan.2002.128416_bib16","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1213\/00000539-199405000-00029","article-title":"Cardiovascular and coronary physiology of acute isovolemic hemodilution: A review of nonoxygen-carrying and oxygen-carrying solutions","volume":"78","author":"Spahn","year":"1994","journal-title":"Anesth Analg"},{"key":"10.1053\/jcan.2002.128416_bib17","first-page":"1278","article-title":"O-raffinose cross-linking markedly reduces systemic and renal vasoconstrictor effects of unmodified human hemoglobin","volume":"288","author":"Lieberthal","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1053\/jcan.2002.128416_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/cpt197823173","article-title":"A clinical safety trial of stroma-free hemoglobin","volume":"23","author":"Savitsky","year":"1978","journal-title":"Clin Pharmacol Ther"},{"issue":"suppl 2","key":"10.1053\/jcan.2002.128416_bib19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1423-0410.1998.tb05425.x","article-title":"Modified hemoglobin-based blood substitutes: Crosslinked, recombinant and encapsulated hemoglobin","volume":"74","author":"Chang","year":"1998","journal-title":"Vox Sang"},{"key":"10.1053\/jcan.2002.128416_bib20","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1258\/0007142991902259","article-title":"Red blood cell substitutes: Fluorocarbon emulsions and haemoglobin solutions","volume":"55","author":"Remy","year":"1999","journal-title":"Br Med Bull"},{"key":"10.1053\/jcan.2002.128416_bib21","first-page":"94","article-title":"Blood substitutes: A review of clinical trials","author":"Cutcliffe","year":"1999"},{"key":"10.1053\/jcan.2002.128416_bib22","first-page":"109","article-title":"Nitric oxide: physiology, pathophysiology, and pharmacology","volume":"43","author":"Moncada","year":"1991","journal-title":"Pharmacol Rev"},{"key":"10.1053\/jcan.2002.128416_bib23","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/0016-5085(95)90584-7","article-title":"The effects of recombinant human hemoglobin on esophageal motor functions in humans","volume":"109","author":"Murray","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1053\/jcan.2002.128416_bib24","first-page":"301","article-title":"A role for endothelin and nitric oxide in the pressor response to diaspirin cross-linked hemoglobin","volume":"122","author":"Schultz","year":"1993","journal-title":"J Lab Clin Med"},{"key":"10.1053\/jcan.2002.128416_bib25","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3109\/10731199409117889","article-title":"Diaspirin cross-linked hemoglobin (DCLHB): Involvement of adrenergic mechanisms in the pressor effect","volume":"22","author":"Gulati","year":"1994","journal-title":"Artif Cells Blood Substit Immobil Biotechnol"},{"key":"10.1053\/jcan.2002.128416_bib26","first-page":"35","article-title":"Update on blood transfusions. International Anesthesia Research Society Review Course Lectures","volume":"90","author":"Miller","year":"2000","journal-title":"Anesth Analg"}],"container-title":["Journal of Cardiothoracic and Vascular Anesthesia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077002001258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1053077002001258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,8]],"date-time":"2024-01-08T12:06:53Z","timestamp":1704715613000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1053077002001258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2002,12]]}},"alternative-id":["S1053077002001258"],"URL":"https:\/\/doi.org\/10.1053\/jcan.2002.128416","relation":{},"ISSN":["1053-0770"],"issn-type":[{"value":"1053-0770","type":"print"}],"subject":[],"published":{"date-parts":[[2002,12]]}}}