{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:13:59Z","timestamp":1787004839757,"version":"build-2736575974"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5417,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,11]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      The NIDDK\u2013QA instrument, developed and widely used in liver transplant recipients, assesses quality of life (QOL) in four domains, including liver disease symptoms, physical function, health satisfaction, and overall well\u2013being. We investigated whether the instrument may be used as a disease\u2013specific instrument in ambulatory patients with cholestatic liver disease. The NIDDK\u2013QA instrument was administered in 96 patients with primary biliary cirrhosis (PBC) and primary sclerosing cholangitis (PSC) seen at the Mayo Clinic. The SF\u201336, a well\u2013established generic instrument, was also administered. Standard measures for test\u2013retest reliability, internal consistency, and discriminant and concurrent validity were examined. All patients were ambulatory with mostly normal levels of serum bilirubin and albumin concentrations. The reliability of the NIDDK\u2013QA, as measured by test\u2013retest correlation (Pearson coefficients: 0.82\u20130.99,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01) and by internal consistency (Cronbach's alpha: 0.87\u20130.94) exceeded conventional acceptability criteria. The correlation between domain scores of the NIDDK\u2013QA and SF\u201336 was clear and logical in that the physical function domain of NIDDK\u2013QA strongly correlated with the physical component summary score of SF\u201336 (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.86,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01). The overall well\u2013being domain of the NIDDK\u2013QA was closely associated with the mental summary score of SF\u201336 (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = 0.69,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      &lt; .01). Among PBC patients, there was a modest yet significant correlation between the Mayo risk score and overall well\u2013being (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      = -0.26,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = .03). In the assessment of QOL in patients with cholestatic liver disease, NIDDK\u2013QA is found reliable and valid. These data, combined with our previous study, demonstrate its applicability in a wide spectrum of disease severity, ranging from early, ambulatory\u2013phase disease to decompensated cirrhosis necessitating liver transplantation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1053\/jhep.2000.19067","type":"journal-article","created":{"date-parts":[[2003,6,21]],"date-time":"2003-06-21T10:16:51Z","timestamp":1056190611000},"page":"924-929","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":44,"title":["Reliability and Validity of the Niddk\u2013Qa Instrument in the Assessment of Quality of Life in Ambulatory Patients With Cholestatic Liver Disease"],"prefix":"10.1097","volume":"32","author":[{"given":"Ray W.","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith 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