{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T22:08:16Z","timestamp":1790719696771,"version":"4.1.0"},"reference-count":55,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":1124,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Deutsche Forschungsgemeinschaft, Heidelberg","award":["SFB 352"],"award-info":[{"award-number":["SFB 352"]}]},{"name":"Deutsche Forschungsgemeinschaft, Heidelberg","award":["SFB 601"],"award-info":[{"award-number":["SFB 601"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,12]]},"abstract":"<jats:sec><jats:title\/><jats:p>The Dubin\u2013Johnson syndrome is an inherited disorder characterized by conjugated hyperbilirubinemia. The deficient hepatobiliary transport of anionic conjugates is caused by the absence of a functional multidrug\u2013resistance protein 2 (MRP2, symbol ABCC2) from the apical (canalicular) membrane of hepatocytes. Mechanisms underlying this deficiency may include rapid degradation of mutated<jats:italic toggle=\"yes\">MRP2<\/jats:italic>messenger RNA (mRNA) or impaired MRP2 protein maturation and trafficking. We investigated the consequences of the mutation MRP2\u0394(R,M), which leads to the loss of 2 amino acids from the second ATP\u2013binding domain of MRP2. The MRP2\u0394(R,M) mutation is associated with the absence of the MRP2 glycoprotein from the apical membrane of hepatocytes. Transfection of mutated<jats:italic toggle=\"yes\">MRP2<\/jats:italic>complementary DNA (cDNA) led to an MRP2\u0394(R,M) protein that was only core glycosylated, sensitive to endoglycosidase H digestion, and located in the endoplasmic reticulum (ER) of transfected HEK293 and HepG2 cells. This indicated that deletion of Arg1392 and Met1393 leads to impaired maturation and trafficking of the protein from the ER to the Golgi complex. Inhibition of proteasome function resulted in a paranuclear accumulation of the MRP2\u0394(R,M) protein, suggesting that proteasomes are involved in the degradation of the mutant protein. This is the first mutation in Dubin\u2013Johnson syndrome shown to cause deficient MRP2 maturation and impaired sorting of this glycoprotein to the apical membrane.<\/jats:p><\/jats:sec>","DOI":"10.1053\/jhep.2000.19791","type":"journal-article","created":{"date-parts":[[2005,2,10]],"date-time":"2005-02-10T08:51:33Z","timestamp":1108025493000},"page":"1317-1328","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":122,"title":["Impaired Protein Maturation of the Conjugate Export Pump Multidrug Resistance Protein 2 As A Consequence of A Deletion Mutation in Dubin\u2013Johnson Syndrome"],"prefix":"10.1097","volume":"32","author":[{"given":"Verena","family":"Keitel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Kartenbeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne T.","family":"Nies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert","family":"Spring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Brom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"Keppler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1053\/jhep.2000.19791-BIB1|cit1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00005792-195409000-00001","article-title":"Chronic idiopathic jaundice with unidentified pigment in liver cells: a new clinicopathologic entity with report of 12 cases","volume":"33","author":"Dubin","year":"1954","journal-title":"Medicine"},{"key":"10.1053\/jhep.2000.19791-BIB2|cit2","doi-asserted-by":"crossref","first-page":"952","DOI":"10.7326\/0003-4819-41-5-952","article-title":"Persistent nonhemolytic hyperbilirubinemia associated with lipochrome-like pigment in liver cells: report of four cases","volume":"41","author":"Sprinz","year":"1954","journal-title":"Ann Intern Med"},{"key":"10.1053\/jhep.2000.19791-BIB3|cit3","first-page":"471","volume-title":"The Liver: Biology and Pathology","author":"Roy Chowdhury","year":"1994"},{"key":"10.1053\/jhep.2000.19791-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1002\/hep.510230519","article-title":"Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome","volume":"23","author":"Kartenbeck","year":"1996","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2000.19791-BIB5|cit5","first-page":"55","article-title":"The canalicular conjugate export pump encoded by the cmrp\/cmoat gene","volume":"14","author":"Keppler","year":"1996","journal-title":"Prog Liver Dis"},{"key":"10.1053\/jhep.2000.19791-BIB6|cit6","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/hep.510250635","article-title":"A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome","volume":"25","author":"Paulusma","year":"1997","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2000.19791-BIB7|cit7","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S0016-5085(99)70459-2","article-title":"Exon-intron organization of the human multidrug resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome","volume":"117","author":"Tsujii","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1053\/jhep.2000.19791-BIB8|cit8","doi-asserted-by":"crossref","first-page":"15091","DOI":"10.1074\/jbc.271.25.15091","article-title":"cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats","volume":"271","author":"B\u00fcchler","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2000.19791-BIB9|cit9","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1126\/science.271.5252.1126","article-title":"Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene","volume":"271","author":"Paulusma","year":"1996","journal-title":"Science"},{"key":"10.1053\/jhep.2000.19791-BIB10|cit10","first-page":"4124","article-title":"A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation","volume":"56","author":"Taniguchi","year":"1996","journal-title":"Cancer Res"},{"key":"10.1053\/jhep.2000.19791-BIB11|cit11","first-page":"G16","article-title":"Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR","volume":"272","author":"Ito","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1053\/jhep.2000.19791-BIB12|cit12","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1083\/jcb.131.1.137","article-title":"Expression of the MRP gene-encoded conjugate export pump in liver and its selective absence from the canalicular membrane in transport-deficient mutant hepatocytes","volume":"131","author":"Mayer","year":"1995","journal-title":"J Cell Biol"},{"key":"10.1053\/jhep.2000.19791-BIB13|cit13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/S0005-2736(99)00169-8","article-title":"Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance","volume":"1461","author":"K\u00f6nig","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/jhep.2000.19791-BIB14|cit14","doi-asserted-by":"crossref","first-page":"19279","DOI":"10.1016\/S0021-9258(17)30655-5","article-title":"ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates","volume":"265","author":"Ishikawa","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2000.19791-BIB15|cit15","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1042\/bj3270305","article-title":"ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2","volume":"327","author":"Jedlitschky","year":"1997","journal-title":"Biochem J"},{"key":"10.1053\/jhep.2000.19791-BIB16|cit16","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1172\/JCI119886","article-title":"Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA","volume":"101","author":"Evers","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1053\/jhep.2000.19791-BIB17|cit17","first-page":"929","article-title":"Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells","volume":"55","author":"Cui","year":"1999","journal-title":"Mol Pharmacol"},{"key":"10.1053\/jhep.2000.19791-BIB18|cit18","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1002\/hep.510280523","article-title":"Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B.","volume":"28","author":"Nies","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2000.19791-BIB19|cit19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0065-2571(98)00015-6","article-title":"Export pumps for anionic conjugates encoded by MRP genes","volume":"39","author":"Keppler","year":"1999","journal-title":"Advan Enzyme Regul"},{"key":"10.1053\/jhep.2000.19791-BIB20|cit20","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0005-2736(99)00168-6","article-title":"Structural, mechanistic and clinical aspects of MRP1","volume":"1461","author":"Hipfner","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/jhep.2000.19791-BIB21|cit21","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/hmg\/7.2.203","article-title":"Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II\/Dubin-Johnson syndrome","volume":"7","author":"Wada","year":"1998","journal-title":"Hum Mol Genet"},{"key":"10.1053\/jhep.2000.19791-BIB22|cit22","doi-asserted-by":"crossref","first-page":"G522","DOI":"10.1152\/ajpgi.2000.278.4.G522","article-title":"MRP2, a human conjugate export pump, is present and transports Fluo 3 into apical vacuoles of Hep G2 cells","volume":"278","author":"Cantz","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/jhep.2000.19791-BIB23|cit23","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1515\/bchm.1998.379.8-9.1121","article-title":"Human mast cells secreting leukotriene C4 express the MRP1 gene-encoded conjugate export pump","volume":"379","author":"Bartosz","year":"1998","journal-title":"Biol Chem"},{"key":"10.1053\/jhep.2000.19791-BIB24|cit24","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0022-2836(80)90196-5","article-title":"Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing","volume":"143","author":"Sanger","year":"1980","journal-title":"J Mol Biol"},{"key":"10.1053\/jhep.2000.19791-BIB25|cit25","doi-asserted-by":"crossref","first-page":"22957","DOI":"10.1074\/jbc.270.39.22957","article-title":"Covalent modification of human P-glycoprotein mutants containing a single cysteine in either nucleotide-binding fold abolishes drug-stimulated ATPase activity","volume":"270","author":"Loo","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2000.19791-BIB26|cit26","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1083\/jcb.109.6.2721","article-title":"Endocytosis of simian virus 40 into the endoplasmic reticulum","volume":"109","author":"Kartenbeck","year":"1989","journal-title":"J Cell Biol"},{"key":"10.1053\/jhep.2000.19791-BIB27|cit27","first-page":"175","article-title":"A hidden Markov model for predicting transmembrane helices in protein sequences","volume":"6","author":"Sonnhammer","year":"1998","journal-title":"Ismb"},{"key":"10.1053\/jhep.2000.19791-BIB28|cit28","doi-asserted-by":"crossref","first-page":"12322","DOI":"10.1074\/jbc.271.21.12322","article-title":"Membrane topology and glycosylation of the human multidrug resistance-associated protein","volume":"271","author":"Bakos","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2000.19791-BIB29|cit29","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0005-2736(99)00161-3","article-title":"An inventory of the human ABC proteins","volume":"1461","author":"Klein","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/jhep.2000.19791-BIB30|cit30","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1096\/fasebj.11.7.9212074","article-title":"Hepatic canalicular membrane 5: expression and localization of the conjugate export pump encoded by the MRP2 (cMRP\/cMOAT) gene in liver","volume":"11","author":"Keppler","year":"1997","journal-title":"FASEB J"},{"key":"10.1053\/jhep.2000.19791-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1681\/ASN.V881213","article-title":"Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules","volume":"8","author":"Schaub","year":"1997","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/jhep.2000.19791-BIB32|cit32","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1681\/ASN.V1061159","article-title":"Expression of the MRP2 gene-encoded conjugate export pump in human kidney proximal tubules and in renal cell carcinoma","volume":"10","author":"Schaub","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"10.1053\/jhep.2000.19791-BIB33|cit33","first-page":"652","article-title":"Bile canaliculus formation in cultured HepG2 cells","volume":"68","author":"Sormunen","year":"1993","journal-title":"Lab Invest"},{"key":"10.1053\/jhep.2000.19791-BIB34|cit34","first-page":"189","volume-title":"The Liver: Biology and Pathobiology","author":"Hubbard","year":"1994"},{"key":"10.1053\/jhep.2000.19791-BIB35|cit35","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0092-8674(00)81881-4","article-title":"ER quality control: the cytoplasmic connection","volume":"88","author":"Kopito","year":"1997","journal-title":"Cell"},{"key":"10.1053\/jhep.2000.19791-BIB36|cit36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/0092-8674(95)90241-4","article-title":"Multiple proteolytic systems, including the proteasome, contribute to CFTR processing","volume":"83","author":"Jensen","year":"1995","journal-title":"Cell"},{"key":"10.1053\/jhep.2000.19791-BIB37|cit37","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0092-8674(95)90240-6","article-title":"Degradation of CFTR by the ubiquitin-proteasome pathway","volume":"83","author":"Ward","year":"1995","journal-title":"Cell"},{"key":"10.1053\/jhep.2000.19791-BIB38|cit38","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/0092-8674(90)90148-8","article-title":"Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis","volume":"63","author":"Cheng","year":"1990","journal-title":"Cell"},{"key":"10.1053\/jhep.2000.19791-BIB39|cit39","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1083\/jcb.143.7.1883","article-title":"Aggresomes: a cellular response to misfolded proteins","volume":"143","author":"Johnston","year":"1998","journal-title":"J Cell Biol"},{"key":"10.1053\/jhep.2000.19791-BIB40|cit40","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1083\/jcb.145.3.481","article-title":"Dynamic association of proteasomal machinery with the centrosome","volume":"145","author":"Wigley","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1053\/jhep.2000.19791-BIB41|cit41","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1083\/jcb.146.6.1239","article-title":"Characterization and dynamics of aggresome formation by a cytosolic GFP-chimera","volume":"146","author":"Garcia-Mata","year":"1999","journal-title":"J Cell Biol"},{"key":"10.1053\/jhep.2000.19791-BIB42|cit42","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0092-8674(94)90482-0","article-title":"The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B","volume":"78","author":"Palombella","year":"1994","journal-title":"Cell"},{"key":"10.1053\/jhep.2000.19791-BIB43|cit43","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1086\/302292","article-title":"Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2\/cMOAT) and mutations in the ATP-binding-cassette region in Dubin-Johnson syndrome","volume":"64","author":"Toh","year":"1999","journal-title":"Am J Hum Genet"},{"key":"10.1053\/jhep.2000.19791-BIB44|cit44","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1006\/bbrc.1998.9780","article-title":"A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome","volume":"253","author":"Kajihara","year":"1998","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1053\/jhep.2000.19791-BIB45|cit45","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1093\/emboj\/17.12.3484","article-title":"Binary specification of nonsense codons by splicing and cytoplasmic translation","volume":"17","author":"Thermann","year":"1998","journal-title":"EMBO J"},{"key":"10.1053\/jhep.2000.19791-BIB46|cit46","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1093\/hmg\/8.10.1893","article-title":"Nonsense-mediated mRNA decay in health and disease","volume":"8","author":"Frischmeyer","year":"1999","journal-title":"Hum Mol Genet"},{"key":"10.1053\/jhep.2000.19791-BIB47|cit47","first-page":"453","article-title":"When cells stop making sense: effects of nonsense codons on RNA metabolism in vertebrate cells","volume":"1","author":"Maquat","year":"1995","journal-title":"RNA"},{"key":"10.1053\/jhep.2000.19791-BIB48|cit48","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/0092-8674(93)90353-R","article-title":"Molecular mechanisms of CFTR chloride channel dysfunction in cystic fibrosis","volume":"73","author":"Welsh","year":"1993","journal-title":"Cell"},{"key":"10.1053\/jhep.2000.19791-BIB49|cit49","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1126\/science.286.5446.1882","article-title":"Setting the standards: quality control in the secretory pathway","volume":"286","author":"Ellgaard","year":"1999","journal-title":"Science"},{"key":"10.1053\/jhep.2000.19791-BIB50|cit50","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/S0304-4165(98)00130-5","article-title":"Reglucosylation of glycoproteins and quality control of glycoprotein folding in the endoplasmic reticulum of yeast cells","volume":"1426","author":"Parodi","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1053\/jhep.2000.19791-BIB51|cit51","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/0092-8674(90)90104-M","article-title":"Protein degradation in the endoplasmic reticulum","volume":"62","author":"Klausner","year":"1990","journal-title":"Cell"},{"key":"10.1053\/jhep.2000.19791-BIB52|cit52","first-page":"131","article-title":"New insights into the mechanisms and importance of the proteasome in intracellular protein degradation","volume":"378","author":"Goldberg","year":"1997","journal-title":"Biol Chem"},{"key":"10.1053\/jhep.2000.19791-BIB53|cit53","doi-asserted-by":"crossref","first-page":"S167","DOI":"10.1152\/physrev.1999.79.1.S167","article-title":"Biosynthesis and degradation of CFTR","volume":"79","author":"Kopito","year":"1999","journal-title":"Physiol Rev"},{"key":"10.1053\/jhep.2000.19791-BIB54|cit54","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/ng0892-321","article-title":"Mislocalization of delta F508 CFTR in cystic fibrosis sweat gland","volume":"1","author":"Kartner","year":"1992","journal-title":"Nat Genet"},{"key":"10.1053\/jhep.2000.19791-BIB55|cit55","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1172\/JCI5731","article-title":"DeltaF508 CFTR protein expression in tissues from patients with cystic fibrosis","volume":"103","author":"K\u00e4lin","year":"1999","journal-title":"J Clin Invest"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2000.19791","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2000.19791","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200012000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,23]],"date-time":"2024-12-23T08:05:55Z","timestamp":1734941155000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200012000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2000]]}},"URL":"https:\/\/doi.org\/10.1053\/jhep.2000.19791","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2000,12]]}}}