{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:54:51Z","timestamp":1782978891384,"version":"3.54.5"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":1307,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Autoimmune cholangitis is an idiopathic disorder with mixed hepatocellular and cholestatic findings. Our goal was to characterize the disease prospectively by application of uniform diagnostic criteria. Twenty patients were identified and compared with 242 patients with conventional forms of autoimmune liver disease. Patients with autoimmune cholangitis were distinguished from type 1 autoimmune hepatitis (AIH) by lower serum levels of aspartate transaminase (AST), \u03b3-globulin, and immunoglobulin G; higher serum levels of alkaline phosphatase; and lower frequencies of autoantibodies. They were distinguished from primary biliary cirrhosis (PBC) by higher serum levels of AST and bilirubin, lower serum concentrations of immunoglobulin M, and greater occurrence of autoantibodies. Their female predominance, lower serum alkaline phosphatase levels, higher frequency of autoantibodies, and absence of inflammatory bowel disease differentiated them from primary sclerosing cholangitis (PSC). Laboratory findings ranged widely and did not characterize individual patients. HLA risk factors were similar to those of type 1 AIH and PBC, and different from those of PSC. Treatment responses to corticosteroids or ursodeoxycholic acid were poor. Composite histological patterns resembled mainly PBC or PSC. We conclude that autoimmune cholangitis diagnosed by prospective analysis cannot be assimilated into a single, conventional, diagnostic category. It may represent variant forms of diverse conditions, a transition stage, or a separate entity with varying manifestations.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2000.7878","type":"journal-article","created":{"date-parts":[[2004,3,19]],"date-time":"2004-03-19T18:37:43Z","timestamp":1079721463000},"page":"1231-1238","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":111,"title":["Autoimmune cholangitis within the spectrum of autoimmune liver disease"],"prefix":"10.1097","volume":"31","author":[{"given":"Albert J.","family":"Czaja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herschel A.","family":"Carpenter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula J.","family":"Santrach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Breanndan S.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1053\/jhep.2000.7878-BIB1|cit1","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1055\/s-2008-1068269","article-title":"A cholangitis with antinuclear antibodies (immunocholangitis) resembling chronic non-suppurative destructive cholangitis","volume":"112","author":"Brunner","year":"1987","journal-title":"Deutsche Med Wochenschr"},{"key":"10.1053\/jhep.2000.7878-BIB2|cit2","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1136\/gut.35.2.260","article-title":"Antimitochondrial antibody negative primary biliary cirrhosis: a distinct syndrome of autoimmune cholangitis","volume":"35","author":"Michieletti","year":"1994","journal-title":"Gut"},{"key":"10.1053\/jhep.2000.7878-BIB3|cit3","first-page":"91","article-title":"Primary autoimmune cholangitis: an alternative to antimitochondrial antibody-negative primary biliary cirrhosis","volume":"18","author":"Taylor","year":"1994","journal-title":"Am J Clin Pathol"},{"key":"10.1053\/jhep.2000.7878-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1007\/BF02065530","article-title":"Autoimmune cholangitis: a variant of primary biliary cirrhosis. 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