{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:49:45Z","timestamp":1790876985068,"version":"4.1.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","license":[{"start":{"date-parts":[[2000,6,1]],"date-time":"2000-06-01T00:00:00Z","timestamp":959817600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":1307,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2000,6]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Although the mechanism of susceptibility to chronic persistent hepatitis B virus (HBV) infection is not well clarified, immunogenetic factors of the host may have a role. Recently, a strong association between HLA-DR13 and the self-limited course of HBV infection has been reported. To determine whether the elimination of HBV is related to a particular HLA allele, we studied the HBV markers and HLA-DR phenotypes of 1,272 Koreans who had visited Yonsei University Medical Center for renal transplantation. They included 330 renal transplant donors. Subjects were categorized into 3 different groups: the \u201cUnexposed Group\u201d (UE; n = 946) with negative HBV markers, the \u201cChronic Carrier Group\u201d (CC; n = 83), who were hepatitis B surface antigen (HBsAg)-positive, and the \u201cSpontaneously Cleared Group\u201d (SC; n = 243), who were HBsAg-negative with antibodies to HBsAg (anti-HBs) and hepatitis B core antigen (anti-HBc). HLA-DR4 was the most common type in all groups. HLA-DR6 was significantly more frequent in 69 of 243 subjects with SC (28.4%) than in 8 of 83 subjects with CC (9.6%) (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001; relative risk [RR] = 3.72). HLA-DR9 was significantly more frequent in CC than in SC (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .001; RR = 0.33). HLA-DR13 showed a stronger association with the clearance of HBV than the other HLA-DR6 subgroup. The distribution of HLA-DR phenotypes was similar regardless of renal disease. Our data indicate that HLA-DR6, especially HLA-DR13, is one of the host factors, which influences the immune response to HBV, and may be associated with self-elimination of HBV in Koreans.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2000.7988","type":"journal-article","created":{"date-parts":[[2004,3,19]],"date-time":"2004-03-19T18:37:43Z","timestamp":1079721463000},"page":"1371-1373","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":101,"title":["Association between hepatitis B virus infection and HLA-DR type in Korea"],"prefix":"10.1097","volume":"31","author":[{"given":"Sang Hoon","family":"Ahn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang-Hyub","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Youp","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun Kyon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Wook","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae Yoon","family":"Chon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu Seun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiil","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Kee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Myoung","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1053\/jhep.2000.7988-BIB1|cit1","first-page":"1130","article-title":"Cellular immunity and hepatitis associated antigen liver disease","volume":"742","author":"Dudley","year":"1972","journal-title":"Lancet"},{"key":"10.1053\/jhep.2000.7988-BIB2|cit2","first-page":"245","volume-title":"Viral Hepatitis","author":"Chisari","year":"1978"},{"key":"10.1053\/jhep.2000.7988-BIB3|cit3","first-page":"1165","article-title":"Immunological mechanisms in chronic hepatitis B virus infection","volume":"2","author":"Thomas","year":"1982","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2000.7988-BIB4|cit4","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/oxfordjournals.epirev.a036241","article-title":"The role of HLA in infection","volume":"3","author":"Kaslow","year":"1981","journal-title":"Epidemiol 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