{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T19:01:08Z","timestamp":1778439668747,"version":"3.51.4"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5266,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Nuclear factor \u03baB (NF\u2013\u03baB) is rapidly activated during liver regeneration following partial hepatectomy or carbon tetrachloride (CCl<jats:sub>4<\/jats:sub>)\u2013mediated liver injury and is felt to be important in the antiapoptotic and regenerative responses. After partial hepatectomy, livers of mice deficient in the p50 subunit of NF\u2013\u03baB (p50<jats:sup>-\/-<\/jats:sup>) showed a loss of NF\u2013\u03baB and decreased STAT3 transcription factor DNA binding activities. However, nuclear levels of the NF\u2013\u03baB p65 subunit were increased and peaked earlier in p50<jats:sup>-\/-<\/jats:sup> livers. Both messenger RNA and cytoplasmic protein levels of the NF\u2013\u03baB inhibitor I\u03baB\u03b1 were lower in p50<jats:sup>-\/-<\/jats:sup> livers, potentially accounting for the increase in p65 protein. Small effects on gene expression posthepatectomy were observed in p50<jats:sup>-\/-<\/jats:sup> livers, but no effects were seen on hepatocyte DNA synthetic or mitotic responses, serum enzyme levels, or overall liver mass restoration. After CCl<jats:sub>4<\/jats:sub> treatment, hepatocyte DNA synthesis and mitosis and serum enzyme levels were similar in p50<jats:sup>-\/-<\/jats:sup> and p50<jats:sup>+\/+<\/jats:sup> mice, and histologic analysis indicated a slight decrease in overall damage in p50<jats:sup>-\/-<\/jats:sup> livers. After injection of Fas antibody, p50<jats:sup>-\/-<\/jats:sup> livers showed an earlier onset of nuclear changes consistent with apoptosis. These data indicate that absence of p50 affects certain protein and gene activation pathways following partial hepatectomy, CCl<jats:sub>4<\/jats:sub>, and Fas treatment but does not impair overall liver regeneration. Interleukin 6 (IL\u20136) levels were reduced but still adequate to support regeneration. We hypothesize that increased levels of the NF\u2013\u03baB p65 subunit in p50<jats:sup>-\/-<\/jats:sup> livers may provide compensation for the absence of p50, thereby allowing normal liver regeneration and repair following liver injury.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2001.23192","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"915-924","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":53,"title":["Normal Liver Regeneration in P50\/Nuclear Factor \u03baB1 Knockout Mice"],"prefix":"10.1097","volume":"33","author":[{"given":"Robert A.","family":"DeAngelis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kellen","family":"Kovalovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Drew E.","family":"Cressman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Taub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2001.23192","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200104000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:27:14Z","timestamp":1733052434000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200104000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001]]}},"URL":"https:\/\/doi.org\/10.1053\/jhep.2001.23192","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}