{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,31]],"date-time":"2025-03-31T05:07:17Z","timestamp":1743397637881,"version":"3.30.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5266,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Although it is generally assumed that T\u2013cell receptor (TCR) \u03b3\/\u03b4 cells participate in protection against intracellular microbial pathogens, their impact remains controversial. In our study, young (14\u2013day\u2013old) mice lacking TCR\u03b3\/\u03b4 cells were far more susceptible to <jats:italic toggle=\"yes\">Listeria monocytogenes<\/jats:italic> than wild\u2013type (WT) mice of the same age. The number of interferon gamma (IFN\u2013\u03b3) producers responsible for antilisterial resistance was significantly higher among natural killer (NK)1<jats:sup>+<\/jats:sup> TCR\u03b3\/\u03b4 cells than among NK1<jats:sup>-<\/jats:sup> TCR\u03b3\/\u03b4 cells. Endogenous IFN\u2013\u03b3 neutralization increased susceptibility of young WT mice to <jats:italic toggle=\"yes\">L. monocytogenes<\/jats:italic> infection. Liver was a major residence of peripheral NK1<jats:sup>+<\/jats:sup> TCR\u03b3\/\u03b4 cells, whereas NK1<jats:sup>-<\/jats:sup> TCR \u03b3\/\u03b4 cells were broadly distributed in various lymphoid organs. Numbers of both NK1<jats:sup>+<\/jats:sup> and NK1<jats:sup>-<\/jats:sup> TCR\u03b3\/\u03b4 cells increased in the liver of WT mice prior to TCR\u03b1\/\u03b2 cells and represented a substantial population in early life (14 days after birth). Virtually all NK1<jats:sup>+<\/jats:sup> TCR\u03b3\/\u03b4 cells expressed activation markers, whereas substantial numbers of NK1<jats:sup>-<\/jats:sup> TCR\u03b3\/\u03b4 cells showed a naive phenotype. We conclude that TCR\u03b3\/\u03b4 cells play a critical role in protection against <jats:italic toggle=\"yes\">L. monocytogenes<\/jats:italic> in the early life of mice, probably because their TCR\u03b1\/\u03b2 cell compartment is not fully competent. For this antibacterial function, we assign NK1<jats:sup>+<\/jats:sup> TCR\u03b3\/\u03b4 cells a more important role than their NK1<jats:sup>-<\/jats:sup> cognates.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2001.23504","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"887-893","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":16,"title":["A Critical Role of T\u2013Cell Receptor \u03b3\/\u03b4 Cells in Antibacterial Protection in Mice Early in Life"],"prefix":"10.1097","volume":"33","author":[{"given":"Masashi","family":"Emoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamiko","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Emoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Zerrahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan H.E.","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2001.23504","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200104000-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:28:31Z","timestamp":1733052511000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200104000-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,4]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001]]}},"URL":"https:\/\/doi.org\/10.1053\/jhep.2001.23504","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[2001,4]]}}}