{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T22:51:14Z","timestamp":1791154274758,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5236,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Mucosal addressin cell adhesion molecule (MAdCAM\u20131) plays a pivotal role in T\u2013lymphocyte homing to the gut. Given the strong association between the autoimmune liver diseases primary sclerosing cholangitis and autoimmune hepatitis and inflammatory bowel disease, we investigated the role of MAdCAM\u20131 in recruiting mucosal lymphocytes to the liver. MAdCAM\u20131 was strongly expressed on inflamed portal vein\/sinusoidal endothelium in autoimmune mediated liver disease. In modified Stamper\u2013Woodruff assays, MAdCAM\u20131 on hepatic vessels supported adhesion of \u03b14\u03b27+ lymphocytes (<jats:italic toggle=\"yes\">i.e.<\/jats:italic>, gut\u2013derived T cells) from patients with inflammatory bowel disease and primary sclerosing cholangitis. This adhesion was inhibited by pretreatment with blocking antibodies to MAdCAM\u20131, \u03b14\u03b27, or the integrin \u03b14 chain indicating that MAdCAM\u20131 in inflamed liver is functionally active. Circulating lymphocytes from patients with primary sclerosing cholangitis showed rolling adhesion on MAdCAM\u20131 transfectants in a flow\u2013based adhesion assay that could be blocked by anti\u2013MAdCAM\u20131 or anti\u2013\u03b14\u03b27 mAbs. These findings indicate that, under certain circumstances, vessels in the human liver support adhesion of \u03b14\u03b27+ mucosal lymphocytes via binding to aberrantly expressed MAdCAM\u20131 on liver endothelium. This provides a mechanism to explain the hepatic recruitment of mucosal lymphocytes in inflammatory liver disease complicating inflammatory bowel disease.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2001.24231","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"1065-1072","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":256,"title":["Madcam\u20131 Expressed in Chronic Inflammatory Liver Disease Supports Mucosal Lymphocyte Adhesion to Hepatic Endothelium (Madcam\u20131 in Chronic Inflammatory Liver Disease)"],"prefix":"10.1097","volume":"33","author":[{"given":"Allister J.","family":"Grant","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia F.","family":"Lalor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan G.","family":"H\u00fcbscher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Briskin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2001.24231","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200105000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:32:04Z","timestamp":1733052724000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200105000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2001]]}},"URL":"https:\/\/doi.org\/10.1053\/jhep.2001.24231","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2001,5]]}}}