{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T18:59:30Z","timestamp":1783364370239,"version":"3.54.6"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5175,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Patients with cirrhosis of the liver often complain of tiredness and a lack of strength at physical exercise. Other investigators have found that muscle strength, work capacity, and maximal oxygen consumption are reduced in cirrhosis. We hypothesized that mitochondrial maximal rate of ATP synthesis in skeletal muscle may be impaired in these patients. This was tested with <jats:sup>31<\/jats:sup>P nuclear magnetic resonance spectroscopy in anterior tibial muscle of cirrhotic patients and healthy controls at rest, during exercise, and subsequent recovery. In patients with Child\u2013Pugh class B and C cirrhosis resting PCr\/P<jats:sub>i<\/jats:sub> ratio (8.3 \u00b1 1.0; n = 7) was lower than in patients with Child\u2013Pugh class A cirrhosis (12.1 \u00b1 2.1; n = 7) and controls (11. 7 \u00b1 1.1; n = 6; <jats:italic toggle=\"yes\">P<\/jats:italic> = .03), while the resting P<jats:sub>i<\/jats:sub>\/\u03b3ATP ratio was higher in Child\u2013Pugh class B and C patients (0.43, 0.30, and 0.27, respectively; <jats:italic toggle=\"yes\">P<\/jats:italic> = .03). Maximal rate of mitochondrial adenosine triphosphate (ATP) synthesis (<jats:italic toggle=\"yes\">V<\/jats:italic>\n                                 <jats:sub>max<\/jats:sub>) as calculated from the initial rate of phosphocreatine (PCr) recovery after work was lower in Child\u2013Pugh class B and C cirrhosis (0.189 mmol\/L\/s \u00b1 0.034) than in both Child\u2013Pugh class A patients (0.402 mmol\/L\/s \u00b1 0.103) and controls (0.425 mmol\/L\/s \u00b1 0.064; <jats:italic toggle=\"yes\">P<\/jats:italic> = .01). <jats:italic toggle=\"yes\">V<\/jats:italic>\n                                 <jats:sub>max<\/jats:sub> was significantly correlated to intracellular free [Mg<jats:sup>2+<\/jats:sup>] obtained from the <jats:sup>31<\/jats:sup>P nuclear magnetic resonance (NMR) spectra (<jats:italic toggle=\"yes\">P<\/jats:italic> = .003). Insufficient oxygen delivery did not seem a likely cause of reduced ATP synthesis in the patients. These findings suggest either a decreased number of mitochondria in skeletal muscle of the cirrhotic patient in Child\u2013Pugh class B and C or a defective mitochondrial function that could be related to low intracellular free [Mg<jats:sup>2+<\/jats:sup>].<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2001.25451","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"7-12","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":44,"title":["Reduced Mitochondrial Adenosine Triphosphate Synthesis in Skeletal Muscle in Patients With Child\u2013Pugh Class B and C Cirrhosis"],"prefix":"10.1097","volume":"34","author":[{"given":"Esben Bj\u00f8rn","family":"Jacobsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole","family":"Hamberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"Quistorff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Ott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2001.25451","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200107000-00003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:30:40Z","timestamp":1733052640000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200107000-00003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001]]}},"URL":"https:\/\/doi.org\/10.1053\/jhep.2001.25451","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2001,7]]}}}