{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:45:03Z","timestamp":1791276303808,"version":"4.1.0"},"reference-count":0,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":5144,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>In several allergic, autoimmune, and infectious diseases, fibrosis is a major cause of morbidity and mortality. Here, using a model of infection\u2013induced liver fibrosis, we show that interleukin (IL)\u201313 is required at all stages of <jats:italic toggle=\"yes\">Schistosomiasis mansoni<\/jats:italic> infection to induce fibrosis. IL\u20134 production was preserved in IL\u201313-deficient mice, yet failed to significantly contribute to the fibrotic response in either acute or chronic infection. Significant fibrosis develops in all infected mice, although the magnitude of the response varies widely in inbred mice. C3H\/HeN, BALB\/c, and C57BL\/6 mice develop high, intermediate, and low levels of fibrosis, respectively. Despite these differences, IL\u201313 antagonism resulted in a marked amelioration of fibrosis in all strains. The fibrotic mechanism in the high\u2013 and low\u2013responder strains was unrelated to their tissue eosinophil or mast cell responses, but did correlate with their patterns of IL\u201313, IL\u201310, and interferon gamma (IFN\u2013\u03b3) mRNA expression. Indeed, severe fibrosis correlated with a high IL\u201313 and low IFN\u2013\u03b3\/IL\u201310 mRNA response. Because fibrotic diseases are typically progressive disorders, an important issue was to determine whether IL\u201313 inactivation might be used to treat an established and ongoing fibrotic disease. Here, IL\u201313 antagonism was highly efficacious, even after fibrosis and the Th2 cytokine response were firmly established. These studies demonstrate the central role played by IL\u201313 in fibrogenesis and suggest that therapeutic approaches aimed at disrupting the IL\u201313 pathway will be highly effective at preventing fibrotic disease caused by chronic Th2\u2013mediated inflammatory reactions.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2001.26376","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"273-282","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":139,"title":["Studies of Murine Schistosomiasis Reveal Interleukin\u201313 Blockade As A Treatment for Established and Progressive Liver Fibrosis"],"prefix":"10.1097","volume":"34","author":[{"given":"Monica G.","family":"Chiaramonte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allen W.","family":"Cheever","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Malley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra D.","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Wynn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2001.26376","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200108000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:32:10Z","timestamp":1733052730000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200108000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001]]}},"URL":"https:\/\/doi.org\/10.1053\/jhep.2001.26376","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2001,8]]}}}