{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:01:06Z","timestamp":1767337266097,"version":"3.37.0"},"reference-count":16,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":728,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Chronic rejection (CR) after liver transplantation is thought to be a dynamic and potentially reversible process. The Banff working group has developed recommendations for its histopathologic staging. The 1999 Banff classification of CR (<jats:italic toggle=\"yes\">i.e.,<\/jats:italic> bile duct dystrophy &gt;50% and\/or bile duct loss &gt;20%) was applied to: 1) biopsies from patients retransplanted for CR (N = 19) and pathologies other than CR (N = 21) to evaluate its specificity and sensitivity, especially of the early stage lesions of CR; and 2) biopsies from nonretransplanted patients (N = 21) to evaluate the evolution of CR lesions. Atypical forms of CR were also described. Including an early stage into the definition of CR has resulted in a much higher sensitivity for its diagnosis, as compared with the former classification (<jats:italic toggle=\"yes\">i.e.,<\/jats:italic> bile duct loss &gt;50%) (89% vs. 33%; <jats:italic toggle=\"yes\">P<\/jats:italic> = .0001), while keeping an acceptable specificity (74% vs. 100%; <jats:italic toggle=\"yes\">P<\/jats:italic> = .03). In 55% of the nonretransplanted patients, CR lesions were reversible. No histologic feature reliably predicted CR outcome. Transient lobular hepatitis, unrelated to viral infection, and veno-occlusive disease were seen significantly more often in the CR group (<jats:italic toggle=\"yes\">P<\/jats:italic> = .04 and <jats:italic toggle=\"yes\">P<\/jats:italic> = .03, respectively). We conclude that the application of the 1999 Banff classification is superior to the previous classification for the diagnosis of CR. However, limited information can be drawn regarding the outcome of CR based on histology alone. Transient lobular hepatitis, unrelated to viral infection and veno-occlusive disease, may be an unusual expression of CR.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2002.30085","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"117-125","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":34,"title":["Accuracy of bile duct changes for the diagnosis of chronic liver allograft rejection: Reliability of the 1999 Banff schema"],"prefix":"10.1097","volume":"35","author":[{"given":"Myl\u00e8ne","family":"Sebagh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Blakolmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Falissard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Roche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Francois","family":"Emile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Bismuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Didier","family":"Samuel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Reyn\u00e8s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1053\/jhep.2002.30085-BIB1|cit1","first-page":"27","article-title":"Chronic rejection. A general overview of histopathology and pathophysiology with emphasis on liver, heart and intestinal allografts","volume":"2","author":"Demetris","year":"1997","journal-title":"Ann Transplant"},{"key":"10.1053\/jhep.2002.30085-BIB2|cit2","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/hep.510250328","article-title":"Banff schema for grading liver allograft rejection: an international consensus document","volume":"25","year":"1997","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.30085-BIB3|cit3","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1002\/hep.510310337","article-title":"Update of the International Banff Schema for Liver Allograft Rejection: working recommendations for the histopathologic staging and reporting of chronic rejection. An International Panel","volume":"31","author":"Demetris","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.30085-BIB4|cit4","first-page":"648","article-title":"Anonymous. 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International Working Party","volume":"22","year":"1995","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.30085-BIB5|cit5","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1002\/hep.1840070311","article-title":"The acute vanishing bile duct syndrome (acute irreversible rejection) after orthotopic liver transplantation","volume":"7","author":"Ludwig","year":"1987","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.30085-BIB6|cit6","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1097\/00007890-199105000-00014","article-title":"Vanishing bile-duct syndrome following liver transplantation-is it reversible?","volume":"51","author":"Hubscher","year":"1991","journal-title":"Transplantation"},{"key":"10.1053\/jhep.2002.30085-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1097\/00007890-199205000-00017","article-title":"Conversion of liver allograft recipients from cyclosporine to FK506 immunosuppressive therapy-a clinicopathologic study of 96 patients","volume":"53","author":"Demetris","year":"1992","journal-title":"Transplantation"},{"key":"10.1053\/jhep.2002.30085-BIB8|cit8","first-page":"1011","article-title":"Tacrolimus (FK 506) for rescue of chronic rejection following orthotopic liver transplantation","volume":"28","author":"Sher","year":"1996","journal-title":"Transplant Proc"},{"key":"10.1053\/jhep.2002.30085-BIB9|cit9","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1097\/00000478-199911000-00003","article-title":"Analysis of the reversibility of chronic liver allograft rejection implications for a staging schema [published erratum appears in Am J Surg Pathol 2000 Jan;24(1):164]","volume":"23","author":"Blakolmer","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/jhep.2002.30085-BIB10|cit10","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0168-8278(00)80309-8","article-title":"Development of ductopaenic liver allograft rejection includes a \u201chepatitic\u201d phase prior to duct loss [In Process Citation]","volume":"33","author":"Quaglia","year":"2000","journal-title":"J Hepatol"},{"key":"10.1053\/jhep.2002.30085-BIB11|cit11","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00000478-199801000-00004","article-title":"Chronic liver allograft rejection: a National Institute of Diabetes and Digestive and Kidney Diseases interinstitutional study analyzing the reliability of current criteria and proposal of an expanded definition. National Institute of Diabetes and Digestive and Kidney Diseases Liver Transplantation Database","volume":"22","author":"Demetris","year":"1998","journal-title":"Am J Surg Pathol"},{"key":"10.1053\/jhep.2002.30085-BIB12|cit12","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/hep.1840130514","article-title":"Chronic rejection after liver transplantation: a study of clinical, histopathological and immunological features","volume":"13","author":"Freese","year":"1991","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.30085-BIB13|cit13","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1097\/00007890-200004270-00014","article-title":"Clinicopathological analysis of liver allograft biopsies with late centrilobular necrosis: a comparative study in 54 patients","volume":"69","author":"Nakazawa","year":"2000","journal-title":"Transplantation"},{"key":"10.1053\/jhep.2002.30085-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1053\/jhep.2000.20350","article-title":"Fibrous obliterative lesions of veins contribute to progressive fibrosis in chronic liver allograft rejection","volume":"32","author":"Nakazawa","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.30085-BIB15|cit15","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/hep.1840190118","article-title":"Hepatic venular stenosis after orthotopic liver transplantation","volume":"19","author":"Dhillon","year":"1994","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.30085-BIB16|cit16","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/hep.510300514","article-title":"\u201cSilent\u201d presentation of veno-occlusive disease after liver transplantation as part of the process of cellular rejection with endothelial predilection","volume":"30","author":"Sebagh","year":"1999","journal-title":"Hepatology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2002.30085","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2002.30085","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200201000-00017","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:54:23Z","timestamp":1738943663000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200201000-00017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,1]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2002]]}},"URL":"https:\/\/doi.org\/10.1053\/jhep.2002.30085","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[2002,1]]}}}