{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:14:00Z","timestamp":1787004840710,"version":"build-2736575974"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":728,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Antonia Perell\u00f3"},{"name":"Programa Nacional de Formaci\u00f3n de Personal Investigador, Ministerio de Educaci\u00f3n y Ciencia","award":["PN95\/43043126"],"award-info":[{"award-number":["PN95\/43043126"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["00\/0444"],"award-info":[{"award-number":["00\/0444"]}]},{"name":"Fondo de Investigaciones Sanitarias","award":["99\/0362"],"award-info":[{"award-number":["99\/0362"]}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,1]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Patients with Budd-Chiari syndrome (BCS) may require treatment with portal decompressive surgery or liver transplantation. Transjugular intrahepatic portosystemic shunt (TIPS) represents a new treatment alternative, but its long-term effect on BCS outcome has not been evaluated. Twenty-one patients with BCS consecutively admitted to our unit were evaluated. The mean follow-up was 4 \u00b1 3 years. Seven patients had nonprogressive forms and were successfully controlled with medical therapy; 1 case, with a short-length hepatic vein stenosis was successfully treated by angioplasty. All 8 patients are alive and asymptomatic. The remaining 13 patients, had a TIPS because of clinical deterioration (in one of them, because early TIPS thrombosis a successful side-to-side portacaval shunt [SSPCS] was performed) followed by an improvement in clinical condition. However, a patient with fulminant liver failure before TIPS insertion, died 4 months later and another patient with cirrhosis at diagnosis had liver transplantation 2 years later. The remaining 11 patients are alive and free of ascites. In 3 of these patients TIPS is patent after 3, 6, and 12 months. The remaining 8 patients developed late TIPS dysfunction. In two of these cases, after angioplasty and restenting, TIPS is patent after a follow-up of 9 and 80 months. In 5 other patients, recurring TIPS occlusion was not further corrected because no signs of portal hypertension were present. In conclusion, in patients with BCS uncontrolled with medical therapy, TIPS is a highly effective technique that is associated with long-term survival.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1053\/jhep.2002.30274","type":"journal-article","created":{"date-parts":[[2002,8,24]],"date-time":"2002-08-24T23:46:10Z","timestamp":1030232770000},"page":"132-139","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":178,"title":["TIPS is a useful long-term derivative therapy for patients with Budd-Chiari syndrome uncontrolled by medical therapy"],"prefix":"10.1097","volume":"35","author":[{"given":"Antonia","family":"Perell\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Garc\u00eda-Pag\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Gilabert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanette","family":"Su\u00e1rez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Moitinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Cervantes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Reverter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angels","family":"Escorsell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Bosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Rod\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1053\/jhep.2002.30274-BIB1|cit1","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1097\/00005792-198207000-00001","article-title":"Budd-Chiari syndrome: etiology, diagnosis and management","volume":"61","author":"Mitchell","year":"1982","journal-title":"Medicine (Baltimore)"},{"key":"10.1053\/jhep.2002.30274-BIB2|cit2","first-page":"1381","article-title":"Budd-Chiari syndrome. 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On behalf of the Subcommittee on Lupus Anticoagulant\/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH","volume":"74","author":"Brandt","year":"1995","journal-title":"Thromb Haemost"},{"key":"10.1053\/jhep.2002.30274-BIB24|cit24","first-page":"2364","article-title":"Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: results of a case-control study","volume":"96","author":"Janssen","year":"2000","journal-title":"Blood"},{"key":"10.1053\/jhep.2002.30274-BIB25|cit25","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0168-8278(96)80026-2","article-title":"Transjugular intrahepatic portosystemic stent-shunt (TIPSS) occlusion and the role of biliary venous fistulae","volume":"24","author":"Jalan","year":"1996","journal-title":"J Hepatol"},{"key":"10.1053\/jhep.2002.30274-BIB26|cit26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S1051-0443(92)72056-9","article-title":"Budd-Chiari syndrome with long segmental inferior vena cava obstruction: treatment with thrombolysis, angioplasty, and intravascular stents","volume":"3","author":"Ishiguchi","year":"1992","journal-title":"J Vasc Interv Radiol"},{"key":"10.1053\/jhep.2002.30274-BIB27|cit27","first-page":"1262","article-title":"Thrombolysis for acute Budd-Chiari syndrome: case report and literature review","volume":"91","author":"Raju","year":"1996","journal-title":"Am J Gastroenterol"},{"key":"10.1053\/jhep.2002.30274-BIB28|cit28","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1002\/hep.510270434","article-title":"Budd-Chiari syndrome in patients with hematological disease: a therapeutic challenge","volume":"27","author":"Ganguli","year":"1998","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.30274-BIB29|cit29","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1001\/archsurg.1985.01390300007001","article-title":"The Budd-Chiari syndrome. 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