{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:25Z","timestamp":1792454425935,"version":"4.5.0"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":697,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004346","name":"Stiftung Rheinland-Pfalz f\u00fcr Innovation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004346","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Autoantibodies to soluble liver antigen and liver pancreas (SLA\/LP) have been described as specific markers for Autoimmune Hepatitis (AIH), occurring in about 20% of patients with AIH. The high degree of specificity for SLA\/LP in autoimmune liver disease suggests a possible role in its pathogenesis. This study aims to map the exact epitope(s) recognized by SLA\/LP autoantibodies and to assess the role of molecular mimicry between microbial antigens and self-epitopes. Using SLA\/LP-reactive sera of 18 individual AIH patients and a pool of 15 patient sera, we found the dominant immune reactivity directed to peptide p395-414 and a less prominent immune response to 2 other epitopes adjacent to the dominant epitope. Immunodominance of peptide p395-414 was confirmed by absorption experiments. The SLA\/LP autoantibodies of all tested AIH patients were mainly of the IgG1 type, suggesting that SLA\/LP autoantibodies may arise by a common and specific underlying immune stimulus. Based on sequence homologies of the SLA\/LP antigenic region with viral proteins, it was hypothesized that molecular mimicry may drive autoimmunity to SLA\/LP. However, the homologous virus-derived peptides were not recognized by SLA\/LP autoantibodies. Similarly, the only known procaryotic homologue, MJ0610 of <jats:italic toggle=\"yes\">Methanococcus jannaschii,<\/jats:italic> was only weakly recognized by SLA\/LP-positive sera. Thus, no evidence could be found for molecular mimicry being the causative mechanism for the development of SLA\/LP autoantibodies. In conclusion, the exquisite epitope specificity and IgG subtype are evidence for the maturity of the SLA\/LP autoantibody response; a specific autoantigen-driven process underlying the immunopathogenesis is likely.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2002.30699","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"403-408","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":57,"title":["Fine specificity of autoantibodies to soluble liver antigen and liver\/pancreas"],"prefix":"10.1097","volume":"35","author":[{"given":"Johannes","family":"Herkel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Heidrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Nieraad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Wies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Rother","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar 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