{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T02:28:10Z","timestamp":1793327290201,"version":"4.5.0"},"reference-count":50,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2002,2,1]],"date-time":"2002-02-01T00:00:00Z","timestamp":1012521600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":697,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Graft dysfunction associated with autoimmune phenomena has been recently described in liver transplant recipients without previous autoimmune disease. However, the natural history, diagnostic criteria, and definitive therapeutic approach of <jats:italic toggle=\"yes\">de novo<\/jats:italic> autoimmune hepatitis (<jats:italic toggle=\"yes\">de novo<\/jats:italic> AIH) are poorly understood. We report 12 cases of <jats:italic toggle=\"yes\">de novo<\/jats:italic> AIH 27.9 \u00b1 24.5 months after liver transplantation: the outcome of 7 patients treated with steroids is compared with a group of 5 nontreated patients. Nontreated patients lost the graft after 5.8 \u00b1 2.6 months from <jats:italic toggle=\"yes\">de novo<\/jats:italic> AIH onset. All treated patients were alive after 48.4 \u00b1 14 (29-65) months from <jats:italic toggle=\"yes\">de novo<\/jats:italic> AIH onset, and none of them lost the graft. However, 5 patients relapsed in relation to steroid tapering. All patients presented an atypical antiliver\/kidney cytosolic autoantibody, associated to classical autoantibodies in 10 cases. Histological study showed several degrees of lobular necrosis and inflammatory infiltrate. HLA antigen frequencies and matching were compared with 2 control groups (16 orthotopic liver transplantation [LTX] patients without <jats:italic toggle=\"yes\">de novo<\/jats:italic> AIH and 929 healthy blood donors); <jats:italic toggle=\"yes\">de novo<\/jats:italic> AIH patients showed a higher prevalence of HLA-DR3 (54.5% vs. 25.9%, <jats:italic toggle=\"yes\">P<\/jats:italic> = .04) than healthy controls, which was not observed in LTX patients without <jats:italic toggle=\"yes\">de novo<\/jats:italic> AIH. In conclusion, this new disease should be included in the differential diagnosis of unexplained graft dysfunction. In addition, treatment with steroids results in a dramatically improved outcome. However, maintenance therapy is usually required.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2002.31167","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"349-356","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":163,"title":["Response to steroids in de novo autoimmune hepatitis after liver 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