{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:45:03Z","timestamp":1790419503699,"version":"4.1.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":638,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Golden Charitable Trust, London, UK"},{"name":"Mirsky Research Fund"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"crossref","award":["RR00070"],"award-info":[{"award-number":["RR00070"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Hess Research Fund"},{"name":"H.M. Lui Research Fund"},{"name":"Mary L. Johnson Research Fund"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,4]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Hemolysis may contribute to hyperbilirubinemia in Gilbert's syndrome. The authors examined blood carboxyhemoglobin corrected for inspired CO (COHbc) to index heme catabolism and serum conjugated bilirubin fractions to reflect bilirubin conjugation. Both parameters were related to UDP-glucuronosyltransferase 1A1 (UGT) promoter polymorphism, associated with Gilbert's syndrome, in term male newborns. COHbc was expressed as percentage of total hemoglobin, and total conjugated bilirubin (TCB) value as a percentage of serum total bilirubin (STB), (TCB\/STB[%]). A production\/conjugation index, COHbc\/(TCB\/STB[%]), represented bilirubin production divided by conjugation. UGT promoter genotype was designated according to the number of promoter TA insertions in each allele: 6\/6, homozygous normal; 6\/7, heterozygous; 7\/7, homozygous variant. STB and COHbc values were higher in the 7\/7 subgroup than the other counterparts (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .01). The COHbc\/(TCB\/STB[%]) was higher in the 7\/7 than either the 6\/6 or 6\/7 subsets (1.93 [1.31-2.88] vs. 0.85 [0.51-1.72] and 0.84 [0.53-1.87], respectively; <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; .01). In conclusion, 7\/7 UGT promoter polymorphism was associated with increased blood COHbc values (unexpected finding) as well as diminished serum total conjugated bilirubin ratios (expected finding). The increased hemolysis may contribute to the pathogenesis of increased STB values seen in Gilbert's syndrome, and exacerbate neonatal hyperbilirubinemia associated with the promoter polymorphism.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2002.32526","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T03:46:10Z","timestamp":1030247170000},"page":"905-911","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":52,"title":["Hemolysis and bilirubin conjugation in association with UDP-glucuronosyltransferase 1A1 promoter polymorphism"],"prefix":"10.1097","volume":"35","author":[{"given":"Michael","family":"Kaplan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Hammerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firmino F.","family":"Rubaltelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria T.","family":"Vilei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ephrat","family":"Levy-Lahad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Renbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik J.","family":"Vreman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Stevenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Muraca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"10.1053\/jhep.2002.32526-BIB1|cit1","first-page":"323","volume-title":"A Text Book of Liver Disease","author":"Roy-Chowdhury","year":"1996"},{"key":"10.1053\/jhep.2002.32526-BIB2|cit2","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1046\/j.1440-1746.1999.01984.x","article-title":"Molecular genetic basis of Gilbert's syndrome","volume":"14","author":"Burchell","year":"1999","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/jhep.2002.32526-BIB3|cit3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0009-8981(97)00167-8","article-title":"Genetic defects of the UDP-glucuronosyltransferase-1 (UGT1) gene that cause familial non-haemolytic unconjugated hyperbilirubinaemias","volume":"266","author":"Clarke","year":"1997","journal-title":"Clin Chim Acta"},{"key":"10.1053\/jhep.2002.32526-BIB4|cit4","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1056\/NEJM199511023331802","article-title":"The gene basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome","volume":"333","author":"Bosma","year":"1995","journal-title":"N Eng J Med"},{"key":"10.1053\/jhep.2002.32526-BIB5|cit5","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/S0140-6736(96)91273-8","article-title":"Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome","volume":"347","author":"Monaghan","year":"1996","journal-title":"Lancet"},{"key":"10.1053\/jhep.2002.32526-BIB6|cit6","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1073\/pnas.95.14.8170","article-title":"Racial variability in the UDP-glucuronosyltransferase 1 (UGT1A1) promoter: a balanced polymorphism for regulation of bilirubin metabolism","volume":"95","author":"Beutler","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.32526-BIB7|cit7","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0016-5085(19)33296-2","article-title":"Defective bromsulphthalein clearance in patients with constitutional hepatic dysfunction (Gilbert's syndrome)","volume":"63","author":"Berk","year":"1972","journal-title":"Gastroenterology"},{"key":"10.1053\/jhep.2002.32526-BIB8|cit8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/hep.1840120206","article-title":"Abnormal hepatic uptake of low doses of sulfobromophthalein in Gilbert's syndrome: the role of reduced affinity of the plasma membrane carrier of organic anions","volume":"12","author":"Gentile","year":"1990","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.32526-BIB9|cit9","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1053\/jhep.2001.22499","article-title":"Hepatic uptake of organic anions affects the plasma bilirubin level in subjects with Gilbert's syndrome mutations in UGT1A1","volume":"33","author":"Persico","year":"2001","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.32526-BIB10|cit10","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00005792-195902000-00002","article-title":"Constitutional hepatic dysfunction (Gilbert's disease): its natural history and related syndromes","volume":"28","author":"Foulk","year":"1959","journal-title":"Medicine"},{"key":"10.1053\/jhep.2002.32526-BIB11|cit11","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1172\/JCI104682","article-title":"Chronic unconjugated hyperbilirubinemia without overt signs of hemolysis in adolescents and adults","volume":"41","author":"Arias","year":"1962","journal-title":"J Clin Invest"},{"key":"10.1053\/jhep.2002.32526-BIB12|cit12","first-page":"239","article-title":"Reduced red cell survival in jaundice and its relation to abnormal glutathione metabolism","volume":"24","author":"Pitcher","year":"1963","journal-title":"Clin Sci"},{"key":"10.1053\/jhep.2002.32526-BIB13|cit13","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/imj.1967.16.3.221","article-title":"An assessment of red cell survival in idiopathic unconjugated hyperbilirubinaemia (Gilbert's syndrome) by the use of radioactive isopropylfluorophosphate and chromium","volume":"16","author":"Powell","year":"1967","journal-title":"Australas Ann Med"},{"key":"10.1053\/jhep.2002.32526-BIB14|cit14","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1056\/NEJM196711232772102","article-title":"Idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome). A study of 42 families","volume":"227","author":"Powell","year":"1967","journal-title":"N Eng J Med"},{"key":"10.1053\/jhep.2002.32526-BIB15|cit15","doi-asserted-by":"crossref","first-page":"527","DOI":"10.7326\/0003-4819-77-4-527","article-title":"Detection of Gilbert's syndrome in patients with hemolysis. A method using radioactive chromium","volume":"77","author":"Berk","year":"1972","journal-title":"Ann Int Med"},{"key":"10.1053\/jhep.2002.32526-BIB16|cit16","doi-asserted-by":"crossref","first-page":"417","DOI":"10.3181\/00379727-144-37603","article-title":"Effect of low caloric diet on endogenous carbon monoxide production: normal adults and Gilbert's syndrome","volume":"144","author":"Bensinger","year":"1973","journal-title":"Proc Soc Exp Biol Med"},{"key":"10.1053\/jhep.2002.32526-BIB17|cit17","first-page":"539","article-title":"An evaluation of bilirubin kinetics with respect to the diagosis of Gilbert's syndrome","volume":"54","author":"Okolicsany","year":"1978","journal-title":"Clin Sci Mol Med"},{"key":"10.1053\/jhep.2002.32526-BIB18|cit18","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0065-3101(24)00118-X","article-title":"Carbon monoxide and carboxyhemoglobin","volume":"42","author":"Vreman","year":"1995","journal-title":"Adv Pediatr"},{"key":"10.1053\/jhep.2002.32526-BIB19|cit19","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1542\/peds.100.2.252","article-title":"Carbon monoxide and bilirubin","volume":"100","author":"Stevenson","year":"1997","journal-title":"Pediatrics"},{"key":"10.1053\/jhep.2002.32526-BIB20|cit20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1053\/sper.2001.23197","article-title":"Carbon monoxide and bilirubin production in neonates","volume":"25","author":"Stevenson","year":"2001","journal-title":"Sem Perinatol"},{"key":"10.1053\/jhep.2002.32526-BIB21|cit21","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0016-5085(87)90123-5","article-title":"Relationships between serum bilirubins and production and conjugation of bilirubin. Studies in Gilbert's syndrome, Crigler-Najjar disease, hemolytic disorders, and rat models","volume":"92","author":"Muraca","year":"1987","journal-title":"Gastroenterology"},{"key":"10.1053\/jhep.2002.32526-BIB22|cit22","first-page":"326A","article-title":"Bilirubin production and conjugation in neonatal bilirubinemia [Abstract]","volume":"49","author":"Kaplan","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1053\/jhep.2002.32526-BIB23|cit23","doi-asserted-by":"crossref","first-page":"12128","DOI":"10.1073\/pnas.94.22.12128","article-title":"Gilbert's syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose dependent genetic interaction crucial to neonatal hyperbilirubinemia","volume":"94","author":"Kaplan","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.32526-BIB24|cit24","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/BF00218277","article-title":"G6PD Mediterranean accounts for the high prevalence of G6PD deficiency in Kurdish Jews","volume":"91","author":"Oppenheim","year":"1993","journal-title":"Hum Genet"},{"key":"10.1053\/jhep.2002.32526-BIB25|cit25","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1093\/clinchem\/30.8.1382","article-title":"Carbon monoxide in blood: an improved microliter blood-sample collection system, with rapid analysis by gas chromatography","volume":"30","author":"Vreman","year":"1984","journal-title":"Clin Chem"},{"key":"10.1053\/jhep.2002.32526-BIB26|cit26","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/clinchem\/33.5.694","article-title":"Analysis for carboxyhemoglobin by gas chromatography and multicomponent spectrophotometry compared","volume":"33","author":"Vreman","year":"1987","journal-title":"Clin Chem"},{"key":"10.1053\/jhep.2002.32526-BIB27|cit27","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1203\/00006450-199406000-00018","article-title":"Direct relationship of fetal carboxyhemoglobin with hemolysis in alloimmunized pregnancies","volume":"35","author":"Widness","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1053\/jhep.2002.32526-BIB28|cit28","doi-asserted-by":"crossref","first-page":"1927","DOI":"10.1093\/clinchem\/40.10.1927","article-title":"Semiportable electrochemical instrument for determining carbon monoxide in breath","volume":"40","author":"Vreman","year":"1994","journal-title":"Clin Chem"},{"key":"10.1053\/jhep.2002.32526-BIB29|cit29","first-page":"745","article-title":"Paired determinations of blood carboxyhemoglobin concentrations and carbon monoxide excretion rate in term and preterm infants","volume":"100","author":"Ostrander","year":"1982","journal-title":"J Lab Clin Med"},{"key":"10.1053\/jhep.2002.32526-BIB30|cit30","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1093\/clinchem\/29.10.1767","article-title":"Liquid-chromatographic assay and identification of mono- and diester conjugates of bilirubin in normal serum","volume":"29","author":"Muraca","year":"1983","journal-title":"Clin Chem"},{"key":"10.1053\/jhep.2002.32526-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucl Acids Res"},{"key":"10.1053\/jhep.2002.32526-BIB32|cit32","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/S0168-8278(00)80268-8","article-title":"Association of human liver bilirubin UDP-glucuronosyltransferase activity with a polymorphism in the promoter region of the UGT1A1 gene","volume":"33","author":"Raaijmakers","year":"2000","journal-title":"J Hepatol"},{"key":"10.1053\/jhep.2002.32526-BIB33|cit33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0009-8981(86)90086-0","article-title":"Gilbert's syndrome: diagnosis by typical serum bilirubin pattern","volume":"154","author":"Sieg","year":"1986","journal-title":"Clin Chim Acta"},{"key":"10.1053\/jhep.2002.32526-BIB34|cit34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1203\/00006450-199903000-00011","article-title":"Antioxidant and cytotoxic effects of bilirubin on neonatal erythrocytes","volume":"45","author":"Mireles","year":"1999","journal-title":"Pediatr Res"},{"key":"10.1053\/jhep.2002.32526-BIB35|cit35","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1046\/j.1365-2362.2000.00612.x","article-title":"Assessment of bilirubin toxicity to erythrocytes. Implication in neonatal jaundice management","volume":"30","author":"Brito","year":"2000","journal-title":"Eur J Clin Invest"},{"issue":"Suppl 2","key":"10.1053\/jhep.2002.32526-BIB36|cit36","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.1007\/PL00014330","article-title":"Diagnosis and management of Crigler-Najjar syndrome","volume":"158","author":"Jansen","year":"1999","journal-title":"Eur J Pediatr"},{"key":"10.1053\/jhep.2002.32526-BIB37|cit37","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0095-5108(18)30281-1","article-title":"Hemolytic anemia in the newborn","volume":"22","author":"Matsunaga","year":"1995","journal-title":"Clin Perinatol"},{"key":"10.1053\/jhep.2002.32526-BIB38|cit38","first-page":"1045","volume-title":"Neonatology: Pathophysiology and Management of the Newborn","author":"Doyle","year":"1999"},{"key":"10.1053\/jhep.2002.32526-BIB39|cit39","first-page":"147","volume-title":"Schiff's Diseases of the Liver","author":"Berg","year":"1999"},{"key":"10.1053\/jhep.2002.32526-BIB40|cit40","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-4684-7517-3_2","volume-title":"Neonatal Jaundice. New trends in Phototherapy","author":"Muraca","year":"1984"},{"key":"10.1053\/jhep.2002.32526-BIB41|cit41","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0168-8278(86)80014-9","article-title":"What can we learn from analysis of serum bilirubin?","volume":"2","author":"Fevery","year":"1986","journal-title":"J Hepatol"},{"key":"10.1053\/jhep.2002.32526-BIB42|cit42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000243146","article-title":"Unconjugated and conjugated bilirubin pigments during perinatal development. II. Studies on serum of healthy newborns and neonates with erythroblastosis fetalis","volume":"57","author":"Muraca","year":"1990","journal-title":"Biol Neonate"},{"key":"10.1053\/jhep.2002.32526-BIB43|cit43","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0022-3476(96)80138-7","article-title":"Conjugated bilirubin in neonates with glucose-6-phosphate dehydrogenase deficiency","volume":"128","author":"Kaplan","year":"1996","journal-title":"J Pediatr"},{"key":"10.1053\/jhep.2002.32526-BIB44|cit44","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1203\/00006450-198610000-00010","article-title":"Formation of bilirubin conjugates in human newborns","volume":"20","author":"Rosenthal","year":"1986","journal-title":"Pediatr Res"},{"key":"10.1053\/jhep.2002.32526-BIB45|cit45","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1542\/peds.94.4.553","article-title":"Serum and bile bilirubin pigments in the differential diagnosis of Crigler-Najjar disease","volume":"94","author":"Rubaltelli","year":"1994","journal-title":"Pediatrics"},{"key":"10.1053\/jhep.2002.32526-BIB46|cit46","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0022-3476(87)80154-3","article-title":"Distribution of serum bilirubin conjugates in pediatric hepatobiliary disease","volume":"110","author":"Rosenthal","year":"1987","journal-title":"J Pediatr"},{"key":"10.1053\/jhep.2002.32526-BIB47|cit47","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1203\/00006450-196905000-00003","article-title":"Effects of unconjugated bilirubin on bilirubin-UDP glucuronyl transferase activity in liver of newborn rats","volume":"3","author":"Bakken","year":"1969","journal-title":"Pediatr Res"},{"key":"10.1053\/jhep.2002.32526-BIB48|cit48","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1126\/science.170.3957.555","article-title":"Substrate induced conjugation of bilirubin in genetically deficient newborn rats","volume":"170","author":"Thaler","year":"1970","journal-title":"Science"},{"key":"10.1053\/jhep.2002.32526-BIB49|cit49","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000013972","article-title":"Unconjugated and conjugated bilirubin pigments during perinatal development. V. Effect of phototherapy on serum conjugated bilirubin in hyperbilirubinemic neonates","volume":"73","author":"Kaplan","year":"1998","journal-title":"Biol Neonate"},{"key":"10.1053\/jhep.2002.32526-BIB50|cit50","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1046\/j.1440-1746.2000.02223.x","article-title":"Bilirubin and bile acids may modulate their own metabolism via regulating uridine diphosphate-glucuronosyltransferase expression in the rat","volume":"15","author":"Li","year":"2000","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1053\/jhep.2002.32526-BIB51|cit51","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/S0022-3476(98)70356-7","article-title":"Gilbert syndrome accelerates the development of neonatal jaundice","volume":"132","author":"Bancroft","year":"1998","journal-title":"J Pediatr"},{"key":"10.1053\/jhep.2002.32526-BIB52|cit52","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1046\/j.1365-2141.1996.d01-1745.x","article-title":"Contribution of haemolysis to jaundice in Sephardic Jewish glucose-6-phosphate dehydrogenase deficient neonates","volume":"93","author":"Kaplan","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1053\/jhep.2002.32526-BIB53|cit53","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1203\/00006450-200110000-00018","article-title":"Differing pathogenesis of perinatal bilirubinemia in glucose-6-phosphate dehydrogenase-deficient versus normal neonates","volume":"50","author":"Kaplan","year":"2001","journal-title":"Pediatr Res"},{"key":"10.1053\/jhep.2002.32526-BIB54|cit54","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1182\/blood.V91.3.1093","article-title":"UGT1 promoter polymorphism accounts for increased neonatal appearance of hereditary spherocytosis","volume":"91","author":"Iolascon","year":"1998","journal-title":"Blood"},{"key":"10.1053\/jhep.2002.32526-BIB55|cit55","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000243400","article-title":"Unconjugated and conjugated bilirubin pigments during perinatal development. III. Studies on serum of breast-fed and formula-fed neonates","volume":"60","author":"Rubaltelli","year":"1991","journal-title":"Biol Neonate"},{"key":"10.1053\/jhep.2002.32526-BIB56|cit56","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1093\/clinchem\/40.10.1934","article-title":"Bilirubin production in healthy term infants as measured by carbon monoxide in breath","volume":"40","author":"Stevenson","year":"1994","journal-title":"Clin Chem"},{"key":"10.1053\/jhep.2002.32526-BIB57|cit57","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1053\/jhep.2000.18193","article-title":"Molecular diagnosis of a familial nonhemolytic hyperbilirubinemia (Gilbert's syndrome) in healthy subjects","volume":"32","author":"Borlak","year":"2000","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.32526-BIB58|cit58","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/jhep.2001.0103303le03","article-title":"Polymorphism in the promoter region of the bilirubin UDP-glucuronosyltransferase (Gilbert's syndrome) in healthy Dutch subjects","volume":"33","author":"Te Morsche","year":"2001","journal-title":"Hepatology"},{"key":"10.1053\/jhep.2002.32526-BIB59|cit59","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1056\/NEJM200102223440807","article-title":"Neonatal hyperbilirubinemia","volume":"344","author":"Dennery","year":"2001","journal-title":"N Engl J Med"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2002.32526","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2002.32526","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200204000-00022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T16:03:19Z","timestamp":1739203399000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200204000-00022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4]]},"references-count":59,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002]]}},"URL":"https:\/\/doi.org\/10.1053\/jhep.2002.32526","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2002,4]]}}}