{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T22:56:58Z","timestamp":1765666618050,"version":"3.37.0"},"reference-count":62,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":608,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Hereditary hemochromatosis is the most common genetic disorder occurring in persons of northern European descent, and the clinical hallmark of the disease is the gradual accumulation of iron in internal organs, especially the liver, heart, and pancreas, which ultimately leads to organ failure. HFE, the gene that is defective in the majority of cases, was identified in 1996 and, although the exact role that HFE plays in the uptake and utilization of iron is not yet clear, important aspects of HFE function are emerging. Identification and studies of new proteins involved in the absorption of iron in the gut and in somatic cells has led to a clearer picture of how humans absorb iron from the diet and regulate this absorption to meet metabolic needs and to balance body iron stores. This review focuses on the molecular aspects of iron absorption and the role that HFE may play in these processes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2002.33466","type":"journal-article","created":{"date-parts":[[2003,2,17]],"date-time":"2003-02-17T22:18:10Z","timestamp":1045520290000},"page":"993-1001","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":39,"title":["Molecular aspects of iron absorption: Insights into the role of HFE in hemochromatosis"],"prefix":"10.1097","volume":"35","author":[{"given":"Caroline C.","family":"Philpott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1053\/jhep.2002.33466-BIB1|cit1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/ng0896-399","article-title":"A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis","volume":"13","author":"Feder","year":"1996","journal-title":"Nat Genet"},{"key":"10.1053\/jhep.2002.33466-BIB2|cit2","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1073\/pnas.95.5.2492","article-title":"HFE gene knockout produces mouse model of hereditary hemochromatosis","volume":"95","author":"Zhou","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB3|cit3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0092-8674(00)81151-4","article-title":"Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor","volume":"93","author":"Lebron","year":"1998","journal-title":"Cell"},{"key":"10.1053\/jhep.2002.33466-BIB4|cit4","doi-asserted-by":"crossref","first-page":"14025","DOI":"10.1074\/jbc.272.22.14025","article-title":"The hemochromatosis founder mutation in HLA-H disrupts beta2-microglobulin interaction and cell surface expression","volume":"272","author":"Feder","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2002.33466-BIB5|cit5","doi-asserted-by":"crossref","first-page":"12384","DOI":"10.1073\/pnas.94.23.12384","article-title":"Hereditary hemochromatosis: effects of C282Y and H63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells","volume":"94","author":"Waheed","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB6|cit6","first-page":"227","volume-title":"Iron Metabolism in Health and Disease","author":"Powell","year":"1994"},{"key":"10.1053\/jhep.2002.33466-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1126\/science.1057206","article-title":"An iron-regulated ferric reductase associated with the absorption of dietary iron","volume":"291","author":"McKie","year":"2001","journal-title":"Science"},{"key":"10.1053\/jhep.2002.33466-BIB8|cit8","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/41343","article-title":"Cloning and characterization of a mammalian proton-coupled metal-ion transporter","volume":"388","author":"Gunshin","year":"1997","journal-title":"Nature"},{"key":"10.1053\/jhep.2002.33466-BIB9|cit9","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ng0897-383","article-title":"Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene","volume":"16","author":"Fleming","year":"1997","journal-title":"Nat Genet"},{"key":"10.1053\/jhep.2002.33466-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1073\/pnas.95.3.1148","article-title":"Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport","volume":"95","author":"Fleming","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB11|cit11","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/qjmed\/93.9.575","article-title":"Localization of iron transport and regulatory proteins in human cells","volume":"93","author":"Griffiths","year":"2000","journal-title":"QJM"},{"key":"10.1053\/jhep.2002.33466-BIB12|cit12","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1084\/jem.189.5.831","article-title":"The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes","volume":"189","author":"Gruenheid","year":"1999","journal-title":"J Exp Med"},{"key":"10.1053\/jhep.2002.33466-BIB13|cit13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1136\/gut.46.2.270","article-title":"Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload","volume":"46","author":"Trinder","year":"2000","journal-title":"Gut"},{"key":"10.1053\/jhep.2002.33466-BIB14|cit14","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/35001596","article-title":"Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter","volume":"403","author":"Donovan","year":"2000","journal-title":"Nature"},{"key":"10.1053\/jhep.2002.33466-BIB15|cit15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1097-2765(00)80425-6","article-title":"A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation","volume":"5","author":"McKie","year":"2000","journal-title":"Mol Cell"},{"key":"10.1053\/jhep.2002.33466-BIB16|cit16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0070-2137(97)80001-5","article-title":"Regulation of iron metabolism in eukaryotes","volume":"35","author":"Rouault","year":"1997","journal-title":"Curr Top Cell Regul"},{"key":"10.1053\/jhep.2002.33466-BIB17|cit17","doi-asserted-by":"crossref","first-page":"19906","DOI":"10.1074\/jbc.M000713200","article-title":"A novel mammalian iron-regulated protein involved in intracellular iron metabolism","volume":"275","author":"Abboud","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2002.33466-BIB18|cit18","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1172\/JCI200113468","article-title":"Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene","volume":"108","author":"Montosi","year":"2001","journal-title":"J Clin Invest"},{"key":"10.1053\/jhep.2002.33466-BIB19|cit19","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/90038","article-title":"A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis","volume":"28","author":"Njajou","year":"2001","journal-title":"Nat Genet"},{"key":"10.1053\/jhep.2002.33466-BIB20|cit20","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/5979","article-title":"Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse","volume":"21","author":"Vulpe","year":"1999","journal-title":"Nat Genet"},{"key":"10.1053\/jhep.2002.33466-BIB21|cit21","doi-asserted-by":"crossref","first-page":"10812","DOI":"10.1073\/pnas.96.19.10812","article-title":"Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux","volume":"96","author":"Harris","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB22|cit22","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/hmg\/5.1.81","article-title":"Characterization of a nonsense mutation in the ceruloplasmin gene resulting in diabetes and neurodegenerative disease","volume":"5","author":"Takahashi","year":"1996","journal-title":"Hum Mol Genet"},{"key":"10.1053\/jhep.2002.33466-BIB23|cit23","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1073\/pnas.92.7.2539","article-title":"Aceruloplasminemia: molecular characterization of this disorder of iron metabolism","volume":"92","author":"Harris","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB24|cit24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/ng0395-267","article-title":"A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans","volume":"9","author":"Yoshida","year":"1995","journal-title":"Nat Genet"},{"key":"10.1053\/jhep.2002.33466-BIB25|cit25","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0092-8674(94)90346-8","article-title":"The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake","volume":"76","author":"Askwith","year":"1994","journal-title":"Cell"},{"key":"10.1053\/jhep.2002.33466-BIB26|cit26","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1126\/science.271.5255.1552","article-title":"A permease-oxidase complex involved in high-affinity iron uptake in yeast","volume":"271","author":"Stearman","year":"1996","journal-title":"Science"},{"key":"10.1053\/jhep.2002.33466-BIB27|cit27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1159\/000468745","article-title":"Coordinate post-transcriptional regulation of ferritin and transferrin receptor expression: the role of regulated RNA-protein interaction","volume":"44","author":"Harford","year":"1990","journal-title":"Enzyme"},{"key":"10.1053\/jhep.2002.33466-BIB28|cit28","doi-asserted-by":"crossref","first-page":"10218","DOI":"10.1074\/jbc.M010065200","article-title":"The role of the FRE family of plasma membrane reductases in the uptake of siderophore-iron in Saccharomyces cerevisiae","volume":"276","author":"Yun","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2002.33466-BIB29|cit29","first-page":"3964","article-title":"The Nramp2\/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border","volume":"96","author":"Canonne-Hergaux","year":"2000","journal-title":"Blood"},{"key":"10.1053\/jhep.2002.33466-BIB30|cit30","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1073\/pnas.96.6.3143","article-title":"Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1","volume":"96","author":"Fleming","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1053\/gast.2001.24050","article-title":"Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosis","volume":"120","author":"Griffiths","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/jhep.2002.33466-BIB32|cit32","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1053\/gast.2001.24033","article-title":"Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload","volume":"120","author":"Zoller","year":"2001","journal-title":"Gastroenterology"},{"key":"10.1053\/jhep.2002.33466-BIB33|cit33","doi-asserted-by":"crossref","first-page":"G931","DOI":"10.1152\/ajpgi.2001.281.4.G931","article-title":"Cloning and gastrointestinal expression of rat hephaestin: relationship to other iron transport proteins","volume":"281","author":"Frazer","year":"2001","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1053\/jhep.2002.33466-BIB34|cit34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1038\/84859","article-title":"Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice","volume":"27","author":"LaVaute","year":"2001","journal-title":"Nat Genet"},{"key":"10.1053\/jhep.2002.33466-BIB35|cit35","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/0016-5085(95)90026-8","article-title":"Duodenal ferritin synthesis in genetic hemochromatosis","volume":"108","author":"Pietrangelo","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1053\/jhep.2002.33466-BIB36|cit36","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/0888-7543(95)80053-O","article-title":"Identification and characterization of a second mouse Nramp gene","volume":"25","author":"Gruenheid","year":"1995","journal-title":"Genomics"},{"key":"10.1053\/jhep.2002.33466-BIB37|cit37","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1006\/bcmd.1998.0186","article-title":"The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms","volume":"24","author":"Lee","year":"1998","journal-title":"Blood Cells Mol Dis"},{"key":"10.1053\/jhep.2002.33466-BIB38|cit38","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1182\/blood.V97.4.1138","article-title":"Expression of the DMT1 (NRAMP2\/DCT1) iron transporter in mice with genetic iron overload disorders","volume":"97","author":"Canonne-Hergaux","year":"2001","journal-title":"Blood"},{"key":"10.1053\/jhep.2002.33466-BIB39|cit39","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1073\/pnas.96.4.1579","article-title":"Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum","volume":"96","author":"Waheed","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB40|cit40","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1073\/pnas.94.6.2534","article-title":"Immunohistochemistry of HLA-H, the protein defective in patients with hereditary hemochromatosis, reveals unique pattern of expression in gastrointestinal tract","volume":"94","author":"Parkkila","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB41|cit41","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1073\/pnas.95.4.1472","article-title":"The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding","volume":"95","author":"Feder","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB42|cit42","doi-asserted-by":"crossref","first-page":"13198","DOI":"10.1073\/pnas.94.24.13198","article-title":"Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis","volume":"94","author":"Parkkila","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB43|cit43","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0014-5793(99)01330-7","article-title":"Overexpression of the hereditary hemochromatosis protein, HFE, in HeLa cells induces and iron-deficient phenotype","volume":"460","author":"Corsi","year":"1999","journal-title":"FEBS Lett"},{"key":"10.1053\/jhep.2002.33466-BIB44|cit44","doi-asserted-by":"crossref","first-page":"3915","DOI":"10.1182\/blood.V94.11.3915","article-title":"HFE downregulates iron uptake from transferrin and induces iron- regulatory protein activity in stably transfected cells","volume":"94","author":"Riedel","year":"1999","journal-title":"Blood"},{"key":"10.1053\/jhep.2002.33466-BIB45|cit45","doi-asserted-by":"crossref","first-page":"9022","DOI":"10.1074\/jbc.274.13.9022","article-title":"The hereditary hemochromatosis protein, HFE, specifically regulates transferrin-mediated iron uptake in HeLa cells","volume":"274","author":"Roy","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2002.33466-BIB46|cit46","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1182\/blood.V96.3.1125","article-title":"Wild-type HFE protein normalizes transferrin iron accumulation in macrophages from subjects with hereditary hemochromatosis","volume":"96","author":"Montosi","year":"2000","journal-title":"Blood"},{"key":"10.1053\/jhep.2002.33466-BIB47|cit47","doi-asserted-by":"crossref","first-page":"3117","DOI":"10.1073\/pnas.042701499","article-title":"Regulation of transferrin-mediated iron uptake by HFE, the protein defective in hereditary hemochromatosis","volume":"99","author":"Waheed","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB48|cit48","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/47417","article-title":"Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor","volume":"403","author":"Bennett","year":"2000","journal-title":"Nature"},{"key":"10.1053\/jhep.2002.33466-BIB49|cit49","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1006\/jmbi.2001.5048","article-title":"mutational analysis of the transferrin receptor reveals overlapping HFE and transferrin binding sites","volume":"313","author":"West","year":"2001","journal-title":"J Mol Biol"},{"key":"10.1053\/jhep.2002.33466-BIB50|cit50","doi-asserted-by":"crossref","first-page":"20826","DOI":"10.1074\/jbc.274.30.20826","article-title":"Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family","volume":"274","author":"Kawabata","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2002.33466-BIB51|cit51","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/75534","article-title":"The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22","volume":"25","author":"Camaschella","year":"2000","journal-title":"Nat Genet"},{"key":"10.1053\/jhep.2002.33466-BIB52|cit52","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1073\/pnas.040548097","article-title":"Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis","volume":"97","author":"Fleming","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB53|cit53","doi-asserted-by":"crossref","first-page":"38135","DOI":"10.1074\/jbc.C000664200","article-title":"Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE","volume":"275","author":"West","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2002.33466-BIB54|cit54","doi-asserted-by":"crossref","first-page":"8780","DOI":"10.1073\/pnas.151179498","article-title":"Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice","volume":"98","author":"Nicolas","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB55|cit55","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1074\/jbc.M008922200","article-title":"Hepcidin, a urinary antimicrobial peptide synthesized in the liver","volume":"276","author":"Park","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2002.33466-BIB56|cit56","doi-asserted-by":"crossref","first-page":"7811","DOI":"10.1074\/jbc.M008923200","article-title":"A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload","volume":"276","author":"Pigeon","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1053\/jhep.2002.33466-BIB57|cit57","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1034\/j.1600-0854.2001.020303.x","article-title":"Pumping iron: the strange partnership of the hemochromatosis protein, a class I MHC homolog, with the transferrin receptor","volume":"2","author":"Enns","year":"2001","journal-title":"Traffic"},{"key":"10.1053\/jhep.2002.33466-BIB58|cit58","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0140-6736(02)07447-0","article-title":"Penetrance of 845G\u2192A (C282Y) HFE hereditary haemochromatosis mutation in the USA","volume":"359","author":"Beutler","year":"2002","journal-title":"Lancet"},{"key":"10.1053\/jhep.2002.33466-BIB59|cit59","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1056\/NEJM199909023411002","article-title":"A population-based study of the clinical expression of the hemochromatosis gene","volume":"341","author":"Olynyk","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1053\/jhep.2002.33466-BIB60|cit60","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1073\/pnas.051630898","article-title":"Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis","volume":"98","author":"Fleming","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB61|cit61","doi-asserted-by":"crossref","first-page":"5170","DOI":"10.1073\/pnas.091088998","article-title":"Naturally variant autosomal and sex-linked loci determine the severity of iron overload in beta 2-microglobulin-deficient mice","volume":"98","author":"Sproule","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1053\/jhep.2002.33466-BIB62|cit62","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0016-5085(99)70244-1","article-title":"Molecular medicine and hemochromatosis: at the crossroads","volume":"116","author":"Bacon","year":"1999","journal-title":"Gastroenterology"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2002.33466","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1053%2Fjhep.2002.33466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200205000-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:40:29Z","timestamp":1738942829000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200205000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,5]]},"references-count":62,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002]]}},"URL":"https:\/\/doi.org\/10.1053\/jhep.2002.33466","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[2002,5]]}}}