{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:45:35Z","timestamp":1790527535035,"version":"4.1.0"},"reference-count":39,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","license":[{"start":{"date-parts":[[2002,5,1]],"date-time":"2002-05-01T00:00:00Z","timestamp":1020211200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T00:00:00Z","timestamp":1072742400000},"content-version":"vor","delay-in-days":608,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2002,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The morbidity and mortality from chronic biliary diseases (<jats:italic toggle=\"yes\">i.e.<\/jats:italic>, the cholangiopathies) remains substantial. End-stage liver disease from biliary causes of cirrhosis (<jats:italic toggle=\"yes\">e.g.<\/jats:italic>, primary biliary cirrhosis [PBC], and primary sclerosing cholangitis) account for approximately one third of patients referred for liver transplantation. A single-topic conference sponsored by the American Association for the Studies of Liver Diseases entitled \u201cThe Pathobiology of Biliary Epithelia\u201d brought together investigators to review the status of the field of cholangiocyte pathobiology, identify new areas of interest, and propose future directions. This information was presented in 6 sessions: \u201cStructural and Functional Characteristics of the Bile Duct System,\u201d \u201cBiological Topics from Nonbiliary Epithelia,\u201d \u201cMalignant Transformation of Cholangiocytes,\u201d \u201cCholangiocyte Proliferation and Death,\u201d \u201cTransport Mechanisms in Bile Duct Epithelia,\u201d and \u201cPathobiology of Biliary Epithelia.\u201d In the 7 years since the first symposium on this topic, major advances have been made in our understanding of ductal bile formation, including, greater insight into the hormones, intracellular signaling mechanisms, and effector proteins responsible for bile secretion and absorption. More sophisticated imaging technologies have increased our understanding of the polarity of cholangiocytes, their embryology and ultrastructural anatomy, and <jats:italic toggle=\"yes\">in vivo<\/jats:italic> human secretory responses to current medical therapy. Information on mediators of inflammation permeated many sessions, having potentially important roles in malignant transformation of cholangiocytes, cholangiocyte apoptosis, fluid and electrolyte transport, and have begun to be specifically characterized for certain biliary diseases, <jats:italic toggle=\"yes\">e.g.<\/jats:italic>, acquired immunodeficiency syndrome (AIDS) cholangiopathy and graft-versus-host disease (GVHD).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1053\/jhep.2002.33541","type":"journal-article","created":{"date-parts":[[2003,2,17]],"date-time":"2003-02-17T22:18:10Z","timestamp":1045520290000},"page":"1256-1268","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":135,"title":["The pathobiology of biliary epithelia"],"prefix":"10.1097","volume":"35","author":[{"given":"Gianfranco","family":"Alpini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James 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